EPS-BOT-00022

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00022

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	233.8	3.1E-69	95	344	250

Status

Reviewed

Ensembl Protein

ENSBTAP00000007563

UniProt Accession

Q2PC20; Q17R15; Q2PC19;

Protein Name

Protein phosphatase 1K, mitochondrial

Protein Synonyms/Alias

Protein phosphatase 2C isoform kappa; PP2C-kappa;

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000005754	ENSBTAP00000007563	ENSBTAT00000007563

Organism

Bos taurus

Functional Description

Regulates the mitochondrial permeability transition poreand is essential for cellular survival and development (By similarity).

Protein Length

372

Protein Sequence
(FASTA)

MSTAALLTLV RSGGNQVRRR VLLRARGLQD DRWVMPTCHS STSEPKWSRF DPDGSGRPAT 60

WDNFGIWDNR LEEPILLPPS IKYGKPIPKV SLQNVGSASQ IGKRKENEDR FGFAQLTNEV 120

LYFAVYDGHG GPAAADFCHT HMEKCILDLL PKEENLETVL TLAFLEIDKT FARHAHLSAD 180

ATLLTSGTTA TVALLRDGIE LVIASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC 240

GGFVAWNSLG QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI 300

NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNTT AVVVPFGAWG KYKNSEITFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTCAACAG CTGCCTTACT TACTTTGGTA AGAAGTGGTG GGAACCAGGT GAGGAGGAGA 60

GTGCTGCTCA GAGCCCGCGG TCTGCAGGAT GACAGGTGGG TGATGCCCAC GTGCCACAGC 120

TCCACTTCAG AGCCGAAATG GTCTCGCTTT GATCCTGATG GTAGTGGCCG ACCAGCTACC 180

TGGGATAATT TTGGCATCTG GGATAACCGC CTGGAGGAGC CAATTCTGCT GCCGCCCAGC 240

ATTAAGTATG GCAAGCCAAT TCCCAAAGTC AGCTTGCAGA ATGTGGGCAG CGCATCACAG 300

ATTGGCAAAC GGAAAGAGAA TGAAGACCGG TTTGGCTTTG CTCAGCTGAC CAATGAGGTC 360

CTGTACTTTG CGGTGTATGA TGGCCACGGT GGACCTGCAG CGGCCGATTT CTGTCATACC 420

CACATGGAGA AATGCATCCT GGATTTGCTT CCTAAGGAGG AGAACTTGGA AACTGTGTTG 480

ACCTTGGCTT TTCTTGAAAT AGATAAAACC TTTGCAAGGC ACGCCCACCT ATCTGCTGAT 540

GCAACGCTTC TGACCTCTGG GACTACTGCA ACAGTAGCCC TATTGAGAGA TGGTATTGAA 600

CTGGTTATAG CTAGTGTTGG GGACAGCCGA GCTATTTTGT GCAGAAAAGG AAAACCCATG 660

AAGCTGACCA TCGACCACAC TCCAGAAAGA AAAGACGAGA AAGAAAGGAT TAAGAAATGT 720

GGGGGGTTTG TAGCTTGGAA TAGTTTGGGA CAGCCTCACG TGAACGGCAG ACTTGCAATG 780

ACAAGGAGTC TCGGAGATTT GGATCTTAAA ACCAGTGGTG TGATAGCAGA ACCTGAAACA 840

AAGAGGATTA AGCTACATCA TGCTGATGAC AGCTTCCTGG TCCTCACTAC AGATGGAATT 900

AACTTCATGG TGAACAGTCA AGAGATTTGT GACTTTGTCA ATCAGTGCCA CGATCCCAAT 960

GAAGCAGCCC ATGCAGTGAC TGAACAGGCA ATACAATATG GTACTGAAGA TAACACGACT 1020

GCAGTAGTAG TGCCTTTTGG TGCCTGGGGA AAATACAAGA ACTCTGAAAT CACCTTCTCA 1080

TTCAGCAGAA GCTTCGCCTC TAGTGGACGA TGGGCCTGA 1119

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         vg +s+ g+r+e ed++    +f++ +++   + +f+vyDGhgg  +a+fc++++++++

Q: 95    VGSASQIGKRKENEDRF----GFAQLTNE---VLYFAVYDGHGGPAAADFCHTHMEKCIL  147

         68889999999999999....67887666...78**************************

S: 63    eelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.kl  117

           l     +e++++++l+ aFl++d+ +    +++l+ d+    sG+ta+val++d  +l

Q: 148   DLLP----KEENLETVLTLAFLEIDKTF--ARHAHLSADAtlltSGTTATVALLRDGiEL  201

         **77....********************..55555555556899*************9**

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLavs  175

         ++a vGdSra+Lcr+gk+++l+ dH+p+r+dE+eRi++ gg v+ ++ g+ +v+G La++

Q: 202   VIASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSlGQpHVNGRLAMT  261

         *******************************************98889999*********

S: 176   RalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekke  233

         R+lGdl+lk + v++ePe+  ++l++ d+ fl+L +DG+  +v+++e++++v+++++

Q: 262   RSLGDLDLKtSGVIAEPETKRIKLHHADDsFLVLTTDGINFMVNSQEICDFVNQCHD---  318

         *********566************999999***************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          ++eaa+ ++++a+++g++dn++a+vv

Q: 319   -PNEAAHAVTEQAIQYGTEDNTTAVVV  344

         .************************97

Domain Sequence
(FASTA)

VGSASQIGKR KENEDRFGFA QLTNEVLYFA VYDGHGGPAA ADFCHTHMEK CILDLLPKEE 60

NLETVLTLAF LEIDKTFARH AHLSADATLL TSGTTATVAL LRDGIELVIA SVGDSRAILC 120

RKGKPMKLTI DHTPERKDEK ERIKKCGGFV AWNSLGQPHV NGRLAMTRSL GDLDLKTSGV 180

IAEPETKRIK LHHADDSFLV LTTDGINFMV NSQEICDFVN QCHDPNEAAH AVTEQAIQYG 240

TEDNTTAVVV 250

Keyword

Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Mitochondrion; Protein phosphatase; Reference proteome; Transit peptide.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005759	; C:mitochondrial matrix
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

bta:540329

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013