EKS-BOT-00400
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00400
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl545.81.7E-164563827265
StatusUnreviewed
Ensembl ProteinENSBTAP00000007664
UniProt AccessionF1N381;
Protein Name
Protein Synonyms/Alias
Gene NameMERTK
Gene Synonyms/Alias MERTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000005828ENSBTAP00000007664ENSBTAT00000007664
OrganismBos taurus
Functional Description
Protein Length975
Protein Sequence
(FASTA)
MKEGTIPNLP FSGSLPGSLQ ADHTPFFFAH TGRYQPTAVS PPIHPGTPDP GNVAFPRVTS 60
ARSELLPPLA FNHTIGHIIL SEHKDVKFNC SINIPNMYQD SATISWWKDG KELLGAHHAI 120
TQFYPDKEVT AVIASFSITS VQRSDNGSYI CKMKINSEEI VSDPIYIEVQ GLPYFTRQPE 180
SMNVTRNTAF NLTCQAVGPP EPVNIYWVQN SRRVNELPER SPSVLTVPGL TKTTIFSCEA 240
HNQKGLTVSK SVQINIKAIP SPPTEVRVHN SSAHSILISW VPGFDGYSPL SDCRIQVKEV 300
EPLSHGSVRI FNTSGSAHVY QIEQLQALAN YSISVSCMNE VGWSAISPWI LASTTEGAPS 360
VAPLNVTMFL NKSSNKVAVR WIKPPIKRQD GDLVGYHISH VWQNAETSKE LSEEVGQNSS 420
LAQLSVQVHN ATCTVRIAAV TKGGVGPFSD PVKIFIPALG SIDFAPSSTP APGNTDPVLI 480
ILGCFCGFIL IGLVLYISLA IRKRIQETKF GSAFTEEDSE LVISYMAKQS FCRQVIELTL 540
QSLGVSEELQ NKLEDVMIDR SLLILGKILG EGEFGSVMEG NLNQEDGTSQ KVAVKTMKLD 600
NFSQREIEEF LSEAACMKDF NHPNVIRLLG VCIEMSPQGI PRPMVILPFM KYGDLHTYLL 660
YSRLETGPKH IPLQTLLKFM VDIAQGMEYL SNRNFLHRDL AARNCMLRDD MTVCVADFGL 720
SKKIYSGDYY RQGRIAKMPV KWIAIESLAD RVYTSKSDVW AFGVTMWEIA TRGMTPYPGV 780
QNHEMYDYLL HGQRLKQPED CLDELYEIMH SCWRAEPLDR PPFSVLRLQL KKLLESLPAV 840
GDNAEVIYVN TQFPESAEGR AEGSALTQLD LSIHPDSIIA SCMPSATISV VTAEVHEHRP 900
QEERYILNGG NEGWEEPAMA SPATGTAEKN RVLPEDTLVR NGVSWSQSST LPLETSGPDE 960
LLFADDASEG SELLT 975
Nucleotide Sequence
(FASTA)
ATGAAGGAAG GAACCATTCC CAACCTGCCG TTCTCTGGCT CTCTCCCAGG AAGCTTACAG 60
GCTGACCACA CGCCGTTTTT CTTTGCTCAC ACTGGCCGCT ACCAGCCCAC CGCTGTGTCT 120
CCACCCATCC ACCCTGGAAC ACCAGACCCT GGAAATGTCG CCTTTCCCAG GGTGACCTCC 180
GCCAGGTCCG AGCTCCTACC ACCCCTTGCG TTTAATCACA CGATTGGCCA TATAATACTT 240
TCTGAACACA AAGATGTCAA GTTTAATTGC TCCATCAACA TACCTAACAT GTACCAGGAC 300
AGTGCAACTA TTTCTTGGTG GAAAGATGGG AAGGAATTGC TGGGGGCCCA TCATGCAATT 360
ACTCAGTTTT ATCCAGATAA AGAAGTTACA GCAGTCATCG CTTCCTTCAG CATAACCAGC 420
GTGCAGCGTT CAGACAATGG GTCGTACATC TGTAAGATGA AAATAAACAG CGAAGAGATT 480
GTGTCTGACC CCATCTACAT CGAGGTTCAA GGACTTCCTT ACTTTACGAG GCAGCCCGAG 540
AGCATGAATG TCACCAGAAA CACAGCCTTC AACCTCACCT GTCAGGCTGT GGGTCCACCC 600
GAGCCCGTCA ACATTTACTG GGTTCAAAAC AGCCGCCGTG TTAATGAACT TCCAGAAAGA 660
TCCCCCTCTG TTCTGACTGT TCCTGGTCTG ACCAAGACCA CAATCTTCAG TTGTGAGGCC 720
CACAATCAAA AAGGGCTGAC CGTGTCCAAA AGCGTGCAGA TCAACATCAA AGCAATTCCC 780
TCCCCACCTA CTGAAGTCAG GGTGCACAAC AGCTCCGCAC ACAGCATCCT CATCTCCTGG 840
GTCCCGGGTT TTGATGGCTA CTCCCCGCTC AGCGATTGCA GAATTCAGGT CAAGGAAGTT 900
GAGCCGCTGA GTCATGGCTC AGTCAGGATT TTTAACACCT CGGGTTCAGC ACATGTGTAT 960
CAAATCGAGC AGCTGCAGGC TCTGGCGAAT TACAGCATCA GTGTGTCCTG CATGAATGAA 1020
GTCGGCTGGT CTGCAATAAG CCCTTGGATT CTGGCCAGCA CAACCGAAGG AGCCCCATCA 1080
GTAGCACCTC TGAACGTCAC CATGTTTCTG AATAAGTCCA GCAACAAGGT GGCTGTTCGG 1140
TGGATCAAGC CTCCCATTAA GCGGCAGGAC GGGGATCTGG TGGGCTATCA CATCTCTCAC 1200
GTGTGGCAGA ACGCAGAGAC ATCCAAAGAG CTCTCGGAAG AAGTTGGCCA GAACAGCAGC 1260
CTTGCTCAGC TTTCTGTTCA AGTGCACAAT GCCACGTGCA CCGTGAGGAT TGCTGCCGTC 1320
ACCAAAGGGG GCGTGGGGCC CTTCAGTGAC CCGGTGAAGA TCTTCATCCC TGCACTCGGT 1380
TCGATAGATT TTGCTCCCTC ATCTACCCCA GCACCTGGCA ACACAGATCC TGTGCTCATA 1440
ATCCTGGGCT GCTTTTGTGG ATTTATTTTG ATTGGGTTGG TTTTATACAT TTCTCTGGCC 1500
ATCAGGAAAA GAATCCAGGA GACAAAGTTT GGGAGCGCCT TCACAGAGGA GGATTCAGAA 1560
TTGGTCATCA GCTACATGGC AAAGCAGTCT TTCTGCCGGC AAGTCATCGA GCTCACCCTA 1620
CAGAGCTTGG GAGTCAGTGA GGAGCTGCAG AATAAACTAG AGGATGTCAT GATTGACAGG 1680
AGCCTTCTTA TTCTTGGAAA AATTCTGGGG GAAGGAGAGT TTGGGTCTGT CATGGAAGGA 1740
AATCTTAATC AGGAAGATGG GACCTCTCAG AAGGTGGCTG TGAAAACCAT GAAGTTGGAC 1800
AACTTTTCGC AGCGAGAGAT TGAGGAATTT CTCAGTGAGG CTGCATGCAT GAAAGACTTC 1860
AACCATCCGA ACGTCATTCG GCTCCTAGGC GTATGTATAG AAATGAGCCC TCAGGGCATC 1920
CCCAGGCCCA TGGTGATTTT ACCCTTCATG AAATACGGGG ATCTGCACAC CTACCTCCTC 1980
TATTCCCGAC TGGAGACTGG ACCAAAGCAT ATCCCCCTGC AGACACTGTT GAAGTTCATG 2040
GTGGACATTG CCCAGGGAAT GGAGTATCTC AGCAACAGGA ACTTTCTTCA CCGAGATTTA 2100
GCTGCTCGAA ACTGCATGTT GCGAGATGAC ATGACTGTCT GCGTGGCGGA CTTTGGCCTC 2160
TCTAAGAAGA TCTACAGTGG TGATTACTAC CGCCAGGGCC GCATTGCGAA GATGCCTGTG 2220
AAATGGATCG CCATAGAGAG TCTCGCAGAC CGAGTCTACA CCAGTAAAAG TGATGTGTGG 2280
GCATTTGGTG TGACCATGTG GGAGATAGCC ACACGAGGAA TGACCCCCTA CCCCGGAGTC 2340
CAGAACCATG AGATGTATGA CTATCTTCTC CACGGCCAAC GGCTGAAGCA GCCCGAGGAT 2400
TGCCTGGATG AACTGTATGA GATCATGCAC TCGTGCTGGA GAGCGGAGCC CCTGGACCGC 2460
CCCCCCTTTT CAGTGCTGAG GCTGCAGCTA AAAAAGCTCT TAGAGAGTCT GCCTGCGGTT 2520
GGGGACAACG CCGAAGTCAT TTATGTCAAC ACGCAGTTTC CAGAGAGTGC GGAGGGCCGG 2580
GCCGAGGGCT CGGCACTGAC TCAGCTGGAC TTGAGCATCC ATCCCGACTC CATCATTGCT 2640
TCCTGCATGC CCAGCGCCAC CATCAGCGTG GTCACCGCGG AAGTTCATGA GCACAGACCT 2700
CAGGAGGAAC GGTACATCCT GAATGGAGGC AATGAGGGAT GGGAAGAGCC AGCTATGGCT 2760
TCCCCCGCCA CAGGAACAGC GGAAAAGAAC CGGGTTTTAC CGGAGGACAC ACTGGTAAGG 2820
AACGGGGTCT CTTGGTCCCA GTCCAGCACG TTGCCCCTGG AGACCTCAGG GCCAGATGAA 2880
CTTTTATTTG CTGATGATGC CTCGGAAGGC TCAGAACTCC TCACGTGA 2928
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         l+lgk+lgegefgsvmeg+l+qedg+++kvavkt+kld+++++eieeflseaacmk+f+h
Q: 563   LILGKILGEGEFGSVMEGNLNQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNH  622
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnvirl+gv++e+s +g +p+p+vilpfmkygdlh++llysrl+++p+++plqtl+kfmv
Q: 623   PNVIRLLGVCIEMSPQG-IPRPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV  681
         ****************9.******************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeyls+rnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk
Q: 682   DIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  741
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc
Q: 742   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGQRLKQPEDC  801
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ldely++m++cw+a+p drp fsvlr
Q: 802   LDELYEIMHSCWRAEPLDRPPFSVLR  827
         ************************99
Domain Sequence
(FASTA)
LILGKILGEG EFGSVMEGNL NQEDGTSQKV AVKTMKLDNF SQREIEEFLS EAACMKDFNH 60
PNVIRLLGVC IEMSPQGIPR PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLKFMVD 120
IAQGMEYLSN RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG QRLKQPEDCL 240
DELYEIMHSC WRAEPLDRPP FSVLR 265
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00370
EKS-ANC-00383
EKS-CAJ-00403
EKS-CAF-00399
EKS-CAP-00426
EKS-DAR-00776
EKS-EQC-00388
EKS-GAM-00236
EKS-GAG-00337
EKS-GAA-00487
EKS-GOG-00385
EKS-HOS-00401
EKS-ICT-00376
EKS-LAC-00414
EKS-LOA-00404
EKS-MAM-00397
EKS-MEG-00328
EKS-MOD-00384
EKS-MUM-00430
EKS-MUP-00389
EKS-MYL-00395
EKS-NOL-00363
EKS-ORN-00510
EKS-ORA-00346
EKS-ORC-00375
EKS-OTG-00400
EKS-PAT-00373
EKS-PES-00354
EKS-PEM-00218
EKS-POA-00390
EKS-RAN-00412
EKS-TAG-00470
EKS-TAR-00501
EKS-TAS-00047
EKS-TEN-00499
EKS-XET-00510
EKS-XIM-00502
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016028; C:rhabdomere
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0001779; P:natural killer cell differentiation
GO:0051250; P:negative regulation of lymphocyte activation
GO:0030168; P:platelet activation
GO:0050766; P:positive regulation of phagocytosis
GO:0043491; P:protein kinase B signaling cascade
GO:0060041; P:retina development in camera-type eye
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013