EKS-BOT-00435

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00435

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	365.2	2.3E-109	14	270	257

Status

Unreviewed

Ensembl Protein

ENSBTAP00000007678

UniProt Accession

F1N332;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK3

Gene Synonyms/Alias

ULK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000005838	ENSBTAP00000007678	ENSBTAT00000007678

Organism

Bos taurus

Functional Description

Protein Length

472

Protein Sequence
(FASTA)

MAGSGWGPPR LDGFILTERL GSGTYATVYK AYAKKDTREV VAIKCVAKKS LNKASVENLL 60

TEIEILKGIR HPHIVQLKDF QWDSDNIYLI MEFCAGGDLS RFIHTRRILP EKVARVFMQQ 120

LASALQFLHE RNISHLDLKP QNILLSSLEK PHLKLADFGF AQHMSPRDEK HVLRGSPLYM 180

APEMVCQRQY DARVDLWSVG VILYEALFGQ PPFASRSFSE LEEKIRSNRV IELPLRPQLS 240

HDCRDLLQRL LERDPSRRIS FQDFFAHPWV DLEHMPSGES LGRATALVVQ AVKKDQEGDA 300

AAALSLYCKA LDFFVPALHY EVDAQRKEAI KAKVGQYVSR AEELKAIVSS SNRALLRQGT 360

SARDLLREMA RDKPRLLAAL EVASAAMAKE EEAGGEQDAL ALYQHSLGEL LLLLAAEPSG 420

RRRELLHTEV QNLMARAEYL KEQVKMKESH WEAETLDKEG LSESVRSSCT LQ 472

Nucleotide Sequence
(FASTA)

ATGGCGGGGT CCGGCTGGGG CCCCCCGCGA CTGGACGGCT TCATTCTCAC TGAGCGCCTG 60

GGCAGTGGCA CGTATGCCAC GGTGTACAAG GCCTACGCCA AGAAGGATAC TCGGGAGGTG 120

GTAGCCATAA AGTGTGTGGC CAAGAAGAGT CTGAACAAGG CATCCGTGGA AAACCTCCTG 180

ACAGAAATTG AGATCCTCAA GGGCATTCGA CACCCCCACA TTGTACAGCT GAAAGACTTC 240

CAGTGGGACA GTGACAACAT CTACCTCATC ATGGAGTTCT GCGCAGGAGG TGACCTGTCT 300

CGCTTCATCC ACACCCGCAG GATTCTGCCT GAGAAGGTGG CTAGGGTCTT CATGCAGCAG 360

TTGGCCAGCG CCCTGCAGTT CTTACATGAA CGGAACATCT CTCACCTGGA CCTGAAGCCA 420

CAGAACATTC TGCTGAGCTC CCTGGAGAAG CCCCACCTTA AACTGGCAGA CTTTGGCTTT 480

GCACAGCACA TGTCCCCCCG GGATGAGAAG CACGTGCTTC GTGGCTCCCC ACTCTATATG 540

GCTCCCGAGA TGGTGTGTCA GCGGCAGTAC GATGCCCGTG TAGACCTCTG GTCTGTGGGG 600

GTCATCCTGT ATGAAGCCCT CTTCGGGCAG CCCCCCTTTG CCTCCAGGTC GTTCTCAGAG 660

CTGGAAGAGA AGATCCGGAG CAACCGGGTT ATTGAGCTCC CCCTGCGGCC CCAACTCTCC 720

CACGACTGCC GAGATCTGCT GCAGCGGCTC CTGGAGCGGG ACCCCAGCCG CCGCATCTCC 780

TTCCAGGACT TCTTCGCCCA CCCTTGGGTA GACCTGGAGC ACATGCCCAG TGGGGAGAGC 840

CTGGGACGAG CAACCGCCCT GGTGGTGCAG GCTGTGAAGA AGGACCAGGA GGGGGACGCT 900

GCGGCCGCCT TGTCTCTCTA CTGCAAGGCC CTGGACTTCT TCGTCCCCGC CCTGCACTAT 960

GAAGTGGACG CCCAGCGGAA GGAGGCAATT AAGGCAAAGG TAGGGCAGTA TGTGTCCCGG 1020

GCTGAGGAGC TCAAGGCCAT CGTCTCCTCC TCCAATCGGG CCCTGCTGAG GCAAGGGACC 1080

TCTGCCCGAG ACCTGCTCAG AGAGATGGCC CGGGACAAGC CGCGCCTCCT GGCTGCCCTG 1140

GAAGTGGCTT CGGCTGCCAT GGCCAAGGAG GAAGAGGCTG GCGGGGAGCA GGACGCACTG 1200

GCCCTGTACC AGCACAGTCT GGGGGAGCTG CTGCTGCTGC TGGCAGCGGA GCCCTCAGGC 1260

CGGAGGCGGG AGCTGCTTCA CACTGAGGTT CAGAATCTCA TGGCTCGGGC TGAGTACCTG 1320

AAGGAGCAGG TCAAGATGAA AGAGTCTCAC TGGGAAGCCG AGACCCTGGA CAAAGAGGGG 1380

CTGTCGGAGT CTGTTCGTAG CTCTTGTACT CTGCAGTGA 1419

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen  59

         ++l+e++G+G++a+vyk++++k+t++vvAik+v+kk+l k+s+enl +ei+ilk ++h++

Q: 14    FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLnKASVENLLTEIEILKGIRHPH  73

         7899**********************************999*******************

S: 60    ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki  119

         iv+l+d++++s+++yl+me+caggdL++++++++ L+e+++r+f+qqlasal++Lh+++i

Q: 74    IVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNI  133

         ************************************************************

S: 120   vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         +h DlkPqniLls      +l+k +lkladFg+a++++  ++++ l+GsplYmaPE+v++

Q: 134   SHLDLKPQNILLS------SLEKPHLKLADFGFAQHMSPRDEKHVLRGSPLYMAPEMVCQ  187

         *************......89***************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         +qyda++DlWS+G+ilye+l+G+pPfa++s+seL+eki++n+v+e+p++ ++s++++dll

Q: 188   RQYDARVDLWSVGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSHDCRDLL  247

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

         q+LL+rdp++Risf+++fahp++

Q: 248   QRLLERDPSRRISFQDFFAHPWV  270

         *********************96

Domain Sequence
(FASTA)

FILTERLGSG TYATVYKAYA KKDTREVVAI KCVAKKSLNK ASVENLLTEI EILKGIRHPH 60

IVQLKDFQWD SDNIYLIMEF CAGGDLSRFI HTRRILPEKV ARVFMQQLAS ALQFLHERNI 120

SHLDLKPQNI LLSSLEKPHL KLADFGFAQH MSPRDEKHVL RGSPLYMAPE MVCQRQYDAR 180

VDLWSVGVIL YEALFGQPPF ASRSFSELEE KIRSNRVIEL PLRPQLSHDC RDLLQRLLER 240

DPSRRISFQD FFAHPWV 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045879	; P:negative regulation of smoothened signaling pathway
GO:0045880	; P:positive regulation of smoothened signaling pathway
GO:0046777	; P:protein autophosphorylation

KEGG

bta:506063

;

InterPros

IPR011009	; Kinase-like_dom.
IPR007330	; MIT.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF04212	; MIT; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00745	; MIT; 2.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013