EKS-BOT-00443
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00443
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK461.87.1E-13945307263
StatusUnreviewed
Ensembl ProteinENSBTAP00000007691
UniProt AccessionF1N319;
Protein Name
Protein Synonyms/Alias Rho-associated protein kinase 2;
Gene NameROCK2
Gene Synonyms/Alias ROCK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000005847ENSBTAP00000007691ENSBTAT00000007691
OrganismBos taurus
Functional Description
Protein Length1341
Protein Sequence
(FASTA)
DGLNSLVLDL DFPALRKNKN IDNFLNRYEK IVKKIRGLQM KAEDYDVVKV IGRGAFGEVQ 60
LVRHKASQKV YAMKLLSKFE MIKRSDSAFF WEERDIMAFA NSPWVVQLFC AFQDDKYLYM 120
VMEYMPGGDL VNLMSNYDVP EKWAKFYTAE VVLALDAIHS MGLIHRDVKP DNMLLDKHGH 180
LKLADFGTCM KMDETGMVHC DTAVGTPDYI SPEVLKSQGG DGYYGRECDW WSVGVFLFEM 240
LVGDTPFYAD SLVGTYSKIM DHKNSLCFPE DAEISKHAKN LICAFLTDRE VRLGRNGVEE 300
IKQHPFFKND QWNWDNIRET AAPVVPELSS DIDSSNFDDI EDDKGDVETF PIPKAFVGNQ 360
LPFIGFTYYR ENLLLSDSPS CKENDSIQSR KNEESQEIQK KLYTLEEHLS TEIQAKEELE 420
QKCKSVNTRL EKVAKELEEE ITLRKNVEST LRQLEREKAL LQHKNAEYQR KADHEADKKR 480
NLENDVNSLK DQLEDLKKRN QNSQISTEKV NQLQRQLDET NALLRTESDT AARLRKTQAE 540
SSKQIQQLES NNRDLQDKNC LLETAKLKLE KEFINLQSVL ESERRDRTHG SEIINDLQGR 600
ISGLEEDVKN GKILLAKVEL EKRQLQERFT DLEKEKNNME IDMTYQLKVI QQSLEQEETE 660
HKATKARLAD KNKIYESIEE AKSEAMKEME KKLSEERTLK QKVENLLLEA EKRCSILDCD 720
LKQSQQKINE LLKQKDVLNE DVRNLTLKIE QETQKRCLTQ NDLKMQTQQV NTLKMSEKQL 780
KQENNHLLEM KMSLEKQNAE LRKERQDADG QMKELQDQLE AEQYFSTLYK TQVRELKEEC 840
EEKTKLCKEL QQKKQELQDE RDSLAAQLEI TLTKADSEQL ARSIAEEQYS DLEKEKIMKE 900
LEIKEMMARH KQELTEKDAT IASLEETNRT LTSDVANLAN EKEELNNKLK EAQEQLSRLK 960
DEEISAAAIK AQFEKQLLTE RTLKTQAVNK LAEIMNRKEP VKRGNDTDVR RKEKENRKLH 1020
MELKSEREKL TQQMIKYQKE LNEMQAQIAE ESQIRIELQM TLDSKDSDIE QLRSQLQALH 1080
IGLDSSSIGS GPGDTEADDG FPESRLEGWL SLPVRNNTKK FGWVKKYVIV SSKKILFYDS 1140
EQDKEQSNPY MVLDIDKLFH VRPVTQTDVY RADAKEIPRI FQILYANEGE SKKEQEFPVE 1200
PVGEKSNYIC HKGHEFIPTL YHFPTNCEAC MKPLWHMFKP PPALECRRCH IKCHKDHMDK 1260
KEEIIAPCKV YYDISSAKNL LLLANSTEEQ QKWVSRLVKK IPKKPPAPDP FARSSPRTSM 1320
KIQQNQSIRR PSRQLAPNKP S 1341
Nucleotide Sequence
(FASTA)
GATGGCTTAA ATTCTTTGGT CCTTGATTTG GATTTTCCTG CTTTGAGGAA AAACAAAAAT 60
ATAGATAATT TCTTAAATAG ATATGAGAAA ATTGTGAAAA AAATTAGAGG TTTACAGATG 120
AAGGCAGAAG ACTACGATGT TGTAAAAGTT ATCGGAAGAG GTGCTTTTGG TGAAGTCCAG 180
TTGGTTCGTC ATAAGGCATC ACAGAAAGTT TATGCTATGA AGCTTCTTAG TAAGTTTGAA 240
ATGATAAAAA GATCAGATTC TGCTTTTTTC TGGGAGGAAA GAGATATTAT GGCCTTTGCC 300
AACAGTCCCT GGGTGGTTCA GCTCTTTTGT GCCTTTCAAG ATGATAAGTA TCTGTACATG 360
GTAATGGAGT ACATGCCTGG TGGAGACCTT GTAAACCTTA TGAGTAACTA TGATGTACCT 420
GAAAAATGGG CCAAATTTTA TACTGCTGAA GTTGTTCTTG CTTTGGATGC CATACACTCC 480
ATGGGTTTAA TTCACAGAGA TGTGAAGCCT GACAACATGC TCTTGGATAA ACATGGGCAT 540
CTAAAATTAG CAGATTTTGG CACATGTATG AAGATGGATG AAACAGGCAT GGTGCATTGT 600
GATACAGCAG TTGGAACACC CGATTATATA TCACCCGAGG TCCTGAAATC ACAAGGGGGT 660
GATGGTTACT ATGGGCGAGA ATGTGATTGG TGGTCCGTGG GTGTTTTCCT TTTTGAAATG 720
CTGGTGGGGG ATACTCCATT TTATGCAGAT TCACTTGTAG GAACATATAG CAAAATTATG 780
GATCATAAAA ACTCACTATG TTTCCCTGAA GATGCAGAAA TTTCTAAACA TGCGAAGAAT 840
CTCATCTGTG CCTTCTTAAC AGATAGGGAG GTACGCCTTG GAAGAAACGG GGTAGAAGAA 900
ATCAAACAAC ATCCTTTCTT TAAGAATGAT CAGTGGAATT GGGATAACAT AAGAGAGACT 960
GCAGCTCCTG TGGTACCTGA ACTCAGCAGT GACATAGACA GCAGCAATTT TGATGACATT 1020
GAAGATGATA AAGGAGATGT AGAAACCTTC CCAATTCCCA AGGCTTTTGT GGGAAATCAG 1080
CTACCTTTTA TAGGATTTAC CTACTACAGA GAAAATTTGC TACTAAGTGA CTCTCCATCT 1140
TGTAAAGAAA ATGACTCAAT TCAATCAAGG AAGAATGAAG AGAGTCAAGA GATTCAGAAA 1200
AAACTGTACA CATTAGAAGA ACACCTTAGC ACTGAGATTC AGGCCAAAGA GGAACTAGAA 1260
CAGAAGTGCA AGTCTGTTAA TACTCGCTTA GAGAAAGTGG CAAAGGAGTT AGAAGAAGAG 1320
ATTACCTTAA GGAAAAATGT GGAATCAACA TTAAGACAAT TAGAAAGAGA AAAAGCACTT 1380
CTTCAGCACA AAAATGCAGA ATATCAGCGG AAAGCTGATC ATGAAGCAGA CAAGAAGCGA 1440
AATTTGGAGA ATGATGTTAA CAGTTTAAAA GATCAGCTTG AAGATTTGAA AAAAAGAAAT 1500
CAGAACTCTC AGATATCCAC TGAGAAAGTG AATCAACTCC AGAGACAACT GGATGAAACC 1560
AATGCTTTGC TGCGAACAGA ATCTGATACT GCAGCCCGGT TAAGGAAAAC ACAGGCAGAA 1620
AGTTCAAAAC AGATTCAGCA GCTGGAATCT AACAATAGAG ATCTACAAGA CAAAAATTGC 1680
CTGCTGGAGA CTGCCAAGTT AAAACTTGAA AAGGAATTTA TCAATCTTCA GTCAGTTCTA 1740
GAATCTGAAA GGAGGGACCG AACCCATGGA TCAGAGATTA TTAATGATTT ACAAGGTAGA 1800
ATATCTGGCC TAGAAGAAGA TGTAAAGAAT GGTAAAATCT TATTAGCAAA AGTAGAGCTG 1860
GAGAAGAGAC AACTACAGGA GAGATTTACT GATTTGGAAA AGGAAAAGAA CAACATGGAA 1920
ATAGATATGA CATACCAACT AAAAGTCATA CAGCAAAGTT TAGAACAAGA AGAAACTGAA 1980
CATAAGGCTA CAAAAGCACG GCTTGCAGAT AAAAACAAGA TTTATGAATC CATTGAAGAA 2040
GCTAAATCAG AAGCCATGAA AGAAATGGAG AAAAAGCTCT CGGAGGAAAG AACTTTAAAA 2100
CAGAAAGTAG AGAACTTGTT GCTGGAGGCT GAGAAAAGAT GCTCTATATT AGACTGTGAC 2160
CTCAAACAGT CACAGCAGAA AATAAATGAA CTCCTCAAAC AGAAAGATGT GCTAAATGAG 2220
GATGTTAGAA ACTTGACATT AAAAATAGAA CAGGAAACTC AGAAGCGCTG CCTTACACAA 2280
AATGACTTGA AGATGCAAAC ACAGCAAGTT AACACACTAA AAATGTCAGA AAAGCAGTTA 2340
AAGCAAGAGA ATAATCATCT CCTAGAAATG AAAATGAGCT TGGAAAAACA GAATGCTGAA 2400
CTTCGAAAAG AACGTCAAGA TGCAGATGGA CAGATGAAAG AGCTCCAGGA TCAGCTTGAA 2460
GCAGAGCAGT ATTTCTCAAC CCTCTATAAA ACACAGGTTA GGGAACTTAA GGAAGAATGT 2520
GAAGAAAAGA CCAAACTTTG TAAAGAATTA CAGCAGAAGA AGCAGGAATT ACAGGATGAA 2580
AGGGACTCCT TGGCTGCTCA ACTGGAGATT ACCTTAACCA AAGCAGATTC TGAGCAACTG 2640
GCTCGTTCAA TTGCTGAGGA ACAGTATTCT GATTTGGAAA AAGAGAAGAT CATGAAAGAG 2700
CTGGAGATCA AAGAGATGAT GGCTCGACAC AAACAGGAAC TCACCGAAAA AGATGCTACT 2760
ATTGCGTCTC TTGAAGAAAC TAATAGGACA CTAACTAGTG ATGTTGCCAA TCTTGCAAAT 2820
GAGAAAGAAG AATTAAATAA CAAACTGAAG GAAGCCCAAG AGCAACTATC AAGGTTGAAA 2880
GATGAAGAAA TAAGTGCAGC AGCTATTAAA GCACAATTTG AGAAGCAGCT GTTAACAGAG 2940
AGGACACTCA AAACTCAAGC TGTGAATAAG TTGGCTGAGA TCATGAATCG AAAGGAACCT 3000
GTTAAGCGTG GTAATGACAC AGATGTGCGG AGAAAAGAAA AGGAGAATAG AAAGCTACAT 3060
ATGGAACTTA AATCTGAACG CGAAAAACTG ACCCAGCAGA TGATCAAGTA TCAGAAAGAA 3120
CTGAATGAAA TGCAGGCTCA AATAGCTGAA GAGAGTCAGA TTCGAATTGA ACTACAGATG 3180
ACACTGGACA GTAAGGACAG TGACATTGAG CAGCTGCGCT CCCAGCTCCA GGCCTTGCAC 3240
ATTGGTTTGG ATAGTTCCAG TATAGGCAGT GGACCAGGGG ATACTGAAGC TGATGACGGT 3300
TTTCCAGAAT CAAGACTAGA AGGATGGCTT TCATTGCCTG TGCGAAACAA CACTAAGAAA 3360
TTTGGATGGG TTAAAAAGTA TGTGATTGTA AGCAGTAAGA AGATCCTTTT CTATGACAGT 3420
GAGCAAGATA AAGAACAATC TAATCCTTAC ATGGTTTTAG ATATAGACAA GTTATTTCAT 3480
GTCCGACCAG TTACACAGAC AGATGTATAT AGAGCAGATG CTAAAGAAAT TCCAAGGATA 3540
TTCCAGATTC TGTATGCCAA CGAAGGAGAA AGTAAGAAGG AACAAGAATT TCCAGTGGAG 3600
CCAGTGGGAG AAAAATCAAA TTATATTTGC CACAAGGGAC ATGAATTTAT TCCTACTCTG 3660
TATCATTTCC CAACCAACTG TGAGGCATGT ATGAAGCCAT TGTGGCACAT GTTTAAACCC 3720
CCTCCTGCTT TAGAGTGCCG TCGCTGTCAT ATTAAATGTC ATAAAGATCA CATGGACAAA 3780
AAGGAGGAAA TTATAGCGCC TTGCAAAGTG TATTATGATA TTTCATCGGC AAAGAATCTA 3840
TTGTTATTGG CAAATTCTAC AGAAGAGCAG CAAAAGTGGG TTAGTCGGTT AGTGAAAAAA 3900
ATACCTAAAA AGCCTCCAGC TCCAGACCCT TTTGCACGGT CATCTCCTAG AACGTCAATG 3960
AAAATACAAC AAAACCAGTC TATTCGACGG CCAAGTCGAC AACTTGCTCC AAACAAACCA 4020
AGCTAA 4026
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         ++++kviGrGafgev++vr+ka++kvyamk+l+k+e++kr++saff+eerd++++a+s+w
Q: 45    YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  104
         799*********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         +vql++afqd+kyly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g
Q: 105   VVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  162
         **********************************..9***********************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180
         ++hrd+kpdn+lldk+Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+
Q: 163   LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GD  221
         ********************************************************9.**
S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240
         g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl+fped+++s++ak+l
Q: 222   GYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNL  281
         ************************************************************
S: 241   ikklltsreerlgregiedlkkhpff  266
         i+++lt+re rlgr+g+e++k+hpff
Q: 282   ICAFLTDREVRLGRNGVEEIKQHPFF  307
         *************************9
Domain Sequence
(FASTA)
YDVVKVIGRG AFGEVQLVRH KASQKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60
VVQLFCAFQD DKYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120
HRDVKPDNML LDKHGHLKLA DFGTCMKMDE TGMVHCDTAV GTPDYISPEV LKSQGGDGYY 180
GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLCFPEDAEI SKHAKNLICA 240
FLTDREVRLG RNGVEEIKQH PFF 263
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00414
EKS-ANC-00429
EKS-CAJ-00447
EKS-CAF-00442
EKS-CAP-00477
EKS-CII-00252
EKS-CIS-00203
EKS-DAR-00838
EKS-DRM-00209
EKS-EQC-00434
EKS-FEC-00423
EKS-GAG-00374
EKS-GAA-00538
EKS-LAC-00457
EKS-LOA-00452
EKS-MAM-00442
EKS-MEG-00367
EKS-MOD-00431
EKS-MUM-00475
EKS-MUP-00434
EKS-MYL-00435
EKS-NOL-00404
EKS-ORN-00562
EKS-ORA-00388
EKS-ORC-00415
EKS-OTG-00448
EKS-PAT-00418
EKS-PES-00393
EKS-PEM-00242
EKS-POA-00431
EKS-RAN-00456
EKS-SAH-00409
EKS-SUS-00392
EKS-TAG-00509
EKS-TAR-00553
EKS-TEN-00556
EKS-VIP-00080
EKS-XET-00594
EKS-XIM-00554
Gene Ontology
GO:0031616; C:spindle pole centrosome
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0051298; P:centrosome duplication
GO:0000910; P:cytokinesis
GO:0035556; P:intracellular signal transduction
GO:0016525; P:negative regulation of angiogenesis
GO:0001843; P:neural tube closure
GO:0010825; P:positive regulation of centrosome duplication
GO:0045616; P:regulation of keratinocyte differentiation
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011072; HR1_rho-bd.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR020684; Rho-assoc_coiled-coil_kin.
IPR015008; Rho-bd.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF02185; HR1; 1.
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
PF08912; Rho_Binding; 1.
SMARTs
SM00109; C1; 1.
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
Created Date20-Feb-2013