EKS-BOT-00471

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00471

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	345.4	2.4E-103	20	316	297

Status

Unreviewed

Ensembl Protein

ENSBTAP00000007709

UniProt Accession

G5E577;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000005865	ENSBTAP00000007709	ENSBTAT00000007709

Organism

Bos taurus

Functional Description

Protein Length

722

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LSSVYIVQEY METDLANVLE 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL SVIPVYIRND MTEPHKPLTQ LLPGISREAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 360

QFSEHDWPIH NNFDIEEVQL DPRALSDVTD EEDVQVDPRK YLDGDREKYL EDPAFDTSYS 420

TEPCWQYPDH HENKYCDLEC SHTCNYKTRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCERNGL VKAQIALEEA SQQLAEKERE KNQGFDFDSF IAGTIQLSSQ 540

HEAADVVDKL NDLNSSVSQL ELKSLISKSV SREKQEKGMA NLAQLEALYQ SSWDSQFVGG 600

GEDCFLINQF CCEVRKDEQI EKENTYTSYL DKFFSRKEDT EMLETEPVED GKLGERGNEE 660

GFLNSSGEFL FNKQLESIGI PQFHSPVGSP LKSIQATLTP SAMKSSPQIP HKTYSSILKH 720

LN 722

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG CTCTAGGTAT 60

ATGGACTTAA AACCATTGGG TTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 120

GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTTA CTGATCCCCA GAGTGTCAAA 180

CATGCTCTAC GCGAAATCAA AATTATTAGA AGACTTGACC ACGATAACAT TGTGAAGGTG 240

TTTGAAATTC TTGGTCCTAG TGGAAGCCAG TTAACGGATG ACGTGGGCTC TCTTACCGAA 300

CTGAGCAGTG TTTACATTGT TCAGGAATAC ATGGAGACAG ACTTGGCTAA TGTGCTGGAG 360

CAGGGCCCTT TACTGGAAGA GCACGCCAGG CTTTTCATGT ATCAGCTGCT GCGTGGGCTC 420

AAATACATTC ACTCAGCAAA CGTGCTGCAC AGAGATCTCA AACCAGCTAA TCTTTTCATT 480

AATACTGAAG ACTTGGTGCT GAAGATAGGT GACTTTGGTC TTGCACGGAT CATGGATCCC 540

CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CTAAATGGTA CAGATCTCCA 600

CGTCTTTTAC TTTCTCCTAA TAATTATACT AAAGCCATTG ACATGTGGGC TGCAGGCTGC 660

ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGCTGA TTTTAGAATC TATTCCTGTT GTCCATGAGG AAGATCGTCA GGAGCTTCTC 780

AGCGTAATTC CAGTTTACAT TAGAAATGAC ATGACTGAGC CACACAAACC TTTAACTCAG 840

CTGCTTCCAG GAATTAGTCG AGAAGCACTG GATTTCCTGG AACAAATTTT GACATTCAGC 900

CCCATGGATC GGTTGACAGC AGAAGAAGCG CTTTCCCATC CTTACATGAG CATTTATTCT 960

TTTCCAATGG ATGAGCCAAT CTCAAGTCAT CCTTTTCATA TTGAAGATGA AGTTGATGAT 1020

ATTTTGCTTA TGGATGAAAC TCATAGTCAC ATTTATAACT GGGAAAGGTA CCATGATTGT 1080

CAATTTTCAG AGCATGATTG GCCTATACAT AACAACTTTG ATATTGAGGA AGTTCAACTA 1140

GACCCAAGAG CTCTGTCTGA TGTCACTGAT GAAGAAGATG TACAAGTTGA TCCTCGAAAA 1200

TATTTGGATG GAGATCGTGA AAAGTATTTG GAGGATCCTG CTTTTGACAC CAGTTACTCT 1260

ACTGAGCCTT GTTGGCAGTA CCCAGATCAT CATGAAAACA AATACTGTGA TCTGGAGTGT 1320

AGCCATACTT GTAACTACAA AACGAGGTCA TCATCATATT TAGATAACTT AGTTTGGAGA 1380

GAGAGTGAAG TTAATCATTA TTATGAACCC AAGCTTATTA TAGATCTTTC TAATTGGAAA 1440

GAACAAAGCA AAGAAAAATC TGATAAGAAG GGCAAGTCAA AATGTGAAAG GAATGGATTG 1500

GTTAAAGCCC AGATAGCTTT AGAGGAAGCA TCACAGCAAC TGGCTGAAAA AGAAAGGGAA 1560

AAGAATCAGG GATTTGACTT TGATTCCTTT ATTGCAGGAA CTATTCAACT TAGTTCACAA 1620

CATGAGGCTG CTGATGTTGT TGACAAATTA AATGACTTGA ATAGCTCAGT GTCCCAATTA 1680

GAATTGAAAA GTTTGATATC AAAGTCAGTA AGCCGAGAAA AACAGGAAAA AGGAATGGCA 1740

AATTTGGCTC AATTAGAAGC ATTGTATCAA TCTTCTTGGG ATAGCCAGTT TGTGGGTGGT 1800

GGGGAGGACT GTTTTCTCAT AAATCAGTTT TGTTGTGAGG TAAGGAAAGA TGAGCAAATT 1860

GAAAAGGAAA ACACTTATAC CAGTTACCTG GACAAGTTTT TTAGCAGGAA AGAAGATACT 1920

GAAATGCTAG AAACTGAGCC GGTAGAGGAT GGGAAGCTTG GGGAGAGAGG AAATGAGGAA 1980

GGATTTCTGA ACAGCAGTGG GGAGTTCCTC TTCAACAAGC AGCTTGAATC CATAGGCATC 2040

CCACAGTTTC ACAGTCCAGT TGGGTCACCA CTTAAGTCAA TACAGGCCAC ATTAACACCT 2100

TCTGCTATGA AATCTTCCCC TCAGATTCCT CATAAGACAT ACAGCAGCAT TCTGAAACAT 2160

CTGAACTAA 2169

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rvaikk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el++vY+v+e+metdL++v+++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELSSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yi++ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAIK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELSSVYIVQE YMETDLANVL EQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LSVIPVYIRN DMTEPHKPLT QLLPGISREA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity

KEGG

bta:538094

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013