EKS-BOT-00215
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00215
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2570.11.6E-171159515357
StatusUnreviewed
Ensembl ProteinENSBTAP00000029455
UniProt AccessionA5PJP5; F1MS87;
Protein Name
Protein Synonyms/Alias PINK1 protein;
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000006084ENSBTAP00000029455ENSBTAT00000029455
OrganismBos taurus
Functional Description
Protein Length588
Protein Sequence
(FASTA)
MAVRQALGRG LQLGRALLLR FTAKPGPAYG WGRPERPGPA AGWGRGERPG PAAGPGTEPC 60
RLGLGLPGRY RFFRQSVAGL AERLQRQFVV RARGGAGPCG RAVFLAFGLG LGLIEEKQAE 120
GRRAASACEE IQAIFTQKNK LLPDPLDTRR WQGFRLEEYL IGQSIGKGCS AAVYEAAMPV 180
LPQSLEEAES LGQLLPGKGP EILPRGEEAP APRAPAFPLA IKMMWNISAG SSSEAIFSTM 240
SQELVPASRV ALAGEYGAVT DRRPKGGPKQ LAPHPNIIRV LRAFTSSVPL LPGALVDYPD 300
VLPPRLHPAG LGHGRTLFLV MKNYPCTLRQ YLRGNTPSPR LATVMTLQLL EGVDHLVQQG 360
VAHRDLKSDN ILVELDADGC PWLVITDFGC CLADERVGLQ LPFTSWYVDR GGNGCLMAPE 420
VSTACPGPRA VIDYSKADAW AVGALAYEIF GLPNPFYGQG RAHLESRSYQ EAQLPALPEW 480
VPRDVRCLVR LLLQREVCKR PSARVAANVL HLSLWGEHTL APKNLKLDKM IAWLLQQSAA 540
TLLANRLTEK NCVETKMKML FLANLEYEAL SQAALLLDSW RAAPRQLL 588
Nucleotide Sequence
(FASTA)
ATGGCGGTGC GACAGGCGCT GGGCCGGGGC CTGCAGCTAG GCCGAGCGCT GCTCCTGCGC 60
TTCACGGCCA AGCCCGGCCC GGCCTACGGC TGGGGCCGGC CGGAGCGGCC CGGCCCCGCG 120
GCGGGCTGGG GCCGCGGAGA GCGCCCGGGC CCGGCCGCGG GACCCGGCAC GGAGCCGTGC 180
AGGCTCGGGC TCGGGCTTCC CGGCCGCTAC CGCTTCTTCC GCCAGTCGGT GGCCGGGCTG 240
GCGGAGCGGC TCCAGCGGCA GTTCGTGGTG CGGGCCCGGG GCGGTGCGGG CCCTTGCGGC 300
CGCGCTGTCT TTCTGGCCTT CGGGCTTGGG CTGGGCCTCA TCGAGGAGAA GCAAGCGGAG 360
GGCCGGCGGG CCGCCTCAGC CTGTGAGGAG ATCCAGGCAA TTTTCACCCA GAAAAACAAG 420
CTGCTCCCAG ACCCACTGGA CACCCGACGC TGGCAGGGTT TCCGGCTGGA GGAGTATCTG 480
ATCGGGCAGT CCATTGGCAA GGGCTGCAGT GCCGCCGTCT ATGAGGCCGC CATGCCTGTG 540
TTGCCCCAGA GCCTGGAGGA GGCAGAGAGC CTGGGCCAGC TTCTTCCAGG GAAGGGCCCA 600
GAGATCCTTC CACGAGGAGA GGAGGCGCCA GCCCCACGGG CCCCGGCCTT CCCCTTGGCC 660
ATCAAGATGA TGTGGAACAT CTCGGCAGGC TCATCCAGCG AAGCCATCTT TAGCACAATG 720
AGCCAGGAGC TGGTCCCAGC CAGTCGAGTG GCCTTGGCCG GGGAGTATGG AGCGGTCACT 780
GACAGAAGAC CCAAGGGAGG TCCCAAGCAG CTGGCCCCGC ACCCCAACAT CATCCGGGTC 840
TTGCGAGCCT TCACCTCGTC GGTGCCGCTG CTGCCAGGGG CCCTGGTCGA CTACCCGGAC 900
GTGCTGCCCC CGCGTCTTCA CCCCGCAGGC CTGGGCCATG GGCGGACTCT CTTCCTCGTC 960
ATGAAGAACT ACCCGTGTAC CCTGCGCCAG TACCTTCGCG GGAACACCCC GAGCCCCCGG 1020
CTGGCCACTG TGATGACTCT GCAACTCTTG GAAGGGGTGG ATCACCTGGT CCAGCAGGGC 1080
GTCGCGCACA GAGACTTGAA GTCCGACAAC ATCCTGGTGG AACTGGATGC AGATGGCTGC 1140
CCCTGGTTGG TGATCACAGA CTTTGGCTGC TGCCTAGCTG ATGAGCGCGT CGGCCTGCAG 1200
TTGCCTTTCA CCAGCTGGTA CGTGGACCGT GGCGGGAATG GCTGCCTGAT GGCTCCCGAG 1260
GTGTCCACGG CCTGCCCAGG CCCCAGGGCA GTGATCGACT ACAGCAAGGC AGATGCCTGG 1320
GCGGTGGGCG CACTCGCCTA CGAAATCTTC GGGCTCCCCA ATCCCTTTTA CGGCCAGGGC 1380
AGGGCCCACC TTGAAAGCCG CAGTTACCAG GAGGCTCAGC TGCCAGCACT GCCCGAGTGG 1440
GTGCCGCGGG ATGTGAGGTG CCTGGTGAGG TTGCTGCTGC AGCGGGAGGT CTGCAAGAGG 1500
CCATCCGCCC GAGTGGCTGC TAATGTGCTT CATTTAAGCC TCTGGGGTGA ACACACGCTC 1560
GCCCCAAAGA ACCTGAAACT AGACAAGATG ATTGCCTGGC TCCTCCAACA ATCGGCCGCC 1620
ACGCTGCTGG CCAACAGGCT GACGGAGAAG AACTGTGTGG AAACAAAAAT GAAGATGCTA 1680
TTTCTGGCCA ACCTGGAGTA TGAAGCGCTG AGCCAGGCGG CCCTCCTCCT CGACTCCTGG 1740
AGGGCAGCCC CGAGACAGCT GCTGTAG 1767
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgll..gkevtvvlaeidqesavaakkf  58
         ylig+++gkgc+aavyea ++ l+q le+a++lg l  gk+++ +l+  ++  a+ a++f
Q: 159   YLIGQSIGKGCSAAVYEAAMPVLPQSLEEAESLGQLlpGKGPE-ILPRGEEAPAPRAPAF  217
         99********************************985566665.6777788899******
S: 59    plaiklmfnieadssseallksmsqelvpasrvaldgeygav........pkllakhPni  110
         plaik+m+ni+a+sssea++++msqelvpasrval+geygav        pk+la+hPni
Q: 218   PLAIKMMWNISAGSSSEAIFSTMSQELVPASRVALAGEYGAVtdrrpkggPKQLAPHPNI  277
         ************************************************************
S: 111   vrvlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdr  170
         +rvlraf++sv+llP+al+dyPd+lp+rl+p glg+g+tl+lvmk+y++tlr+yl  +++
Q: 278   IRVLRAFTSSVPLLPGALVDYPDVLPPRLHPAGLGHGRTLFLVMKNYPCTLRQYLRGNTP  337
         ************************************************************
S: 171   strlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvd  230
         s+rla+++++qlle+vdhlv++gvahrdlksdnilveld d++P+lvi+dfGCclad+ +
Q: 338   SPRLATVMTLQLLEGVDHLVQQGVAHRDLKSDNILVELDADGCPWLVITDFGCCLADERV  397
         ************************************************************
S: 231   glrlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfy  290
         gl+lp++s++vd+GGn++lmaPe+sta pGp+avi+y+kad+WavGalayeifgl nPfy
Q: 398   GLQLPFTSWYVDRGGNGCLMAPEVSTACPGPRAVIDYSKADAWAVGALAYEIFGLPNPFY  457
         ************************************************************
S: 291   gegkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
         g+g+a+les+syqeaqlPalpe vp ++r lv+ ll+re  kr+sa++aanvl+lsl+
Q: 458   GQGRAHLESRSYQEAQLPALPEWVPRDVRCLVRLLLQREVCKRPSARVAANVLHLSLW  515
         *********************************************************9
Domain Sequence
(FASTA)
YLIGQSIGKG CSAAVYEAAM PVLPQSLEEA ESLGQLLPGK GPEILPRGEE APAPRAPAFP 60
LAIKMMWNIS AGSSSEAIFS TMSQELVPAS RVALAGEYGA VTDRRPKGGP KQLAPHPNII 120
RVLRAFTSSV PLLPGALVDY PDVLPPRLHP AGLGHGRTLF LVMKNYPCTL RQYLRGNTPS 180
PRLATVMTLQ LLEGVDHLVQ QGVAHRDLKS DNILVELDAD GCPWLVITDF GCCLADERVG 240
LQLPFTSWYV DRGGNGCLMA PEVSTACPGP RAVIDYSKAD AWAVGALAYE IFGLPNPFYG 300
QGRAHLESRS YQEAQLPALP EWVPRDVRCL VRLLLQREVC KRPSARVAAN VLHLSLW 357
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAM-00122
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
bta:510683;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013