EKS-BOT-00262
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00262
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK413.83.0E-12462314253
StatusUnreviewed
Ensembl ProteinENSBTAP00000008055
UniProt AccessionQ0VCE7;
Protein Name
Protein Synonyms/Alias Polo-like kinase 3 (Drosophila);
Gene NamePLK3
Gene Synonyms/Alias PLK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000006125ENSBTAP00000008055ENSBTAT00000008055
OrganismBos taurus
Functional Description
Protein Length647
Protein Sequence
(FASTA)
MEPAAGLLSP RPFPRAAAPP APPAGPGPPG SPKPGSEPEV LAETPAPDPG RLITDPRSGR 60
TYFKGRLLGK GGFARCYEAT DTETGNAYAV KVISQSRITK PHQREKILNE IELHRGLQHR 120
HIVRFSHHFE DADNIYIFLE LCSRKSLAHI WKARHTLLEP EVRYYLRQIL SGLKYLHQRG 180
ILHRDLKLGN FFITENMELK MGDFGLATRL EPPEHRKKTI CGTPNYVAPE VLQRQGHGPE 240
ADVWSLGCVM YTLLCGSPPF ETVDLKETYR CIKQVHYTLP ASLSLPARQL LAAILRASPQ 300
DRPSIDQILR HDFFTKGYTP DRLPVSSCVT VPDLTPLNPA RILFVKVTKS LFGRKKNKNK 360
NRPEERDEVS CLVNGLTRTS IGHQDARPEA PAASGPAPLS LVETAPEDSS PRGTLASSGD 420
GFEEGLTVAT VVESALCALR NCLAFMPPAE QNPAPLAQPE PLVWVSKWVD YSNKFGFGYQ 480
LSSRRVAVLF NNGTHMALSA NRKTVHYNPT STKHFSFSVG AVPRALQPQL GVLKYFASYM 540
EQRLMKGGDL PSVEEVEVPV PPLLLQWVKT DQALLMLFSD GTIQVNFYGD HTKLILSGWE 600
PLLVTFVARN RSACTYLASH LQQLGCSPDL RQRLHYALRL LRDRCPV 647
Nucleotide Sequence
(FASTA)
ATGGAGCCCG CGGCCGGCTT ATTGTCCCCG CGACCCTTCC CTCGTGCGGC CGCCCCGCCA 60
GCGCCCCCGG CCGGACCCGG GCCGCCTGGA AGTCCCAAGC CTGGATCTGA GCCAGAGGTG 120
CTGGCCGAGA CTCCGGCACC GGACCCTGGG CGCCTCATCA CCGACCCGCG GAGCGGCCGC 180
ACCTACTTCA AAGGCCGCCT GTTGGGCAAG GGGGGCTTTG CCCGCTGCTA CGAGGCCACT 240
GACACAGAGA CCGGCAATGC CTACGCGGTC AAAGTCATCT CGCAGAGCCG CATTACCAAG 300
CCGCATCAGC GTGAGAAGAT CCTAAACGAG ATTGAGCTGC ACCGCGGCCT GCAGCACCGC 360
CACATCGTGC GTTTCTCGCA CCACTTTGAG GATGCTGACA ACATATACAT TTTCCTGGAG 420
CTCTGCAGCC GAAAGTCCCT GGCCCACATC TGGAAGGCCC GGCACACCCT GTTGGAGCCA 480
GAGGTGCGCT ACTACCTTCG GCAGATCCTT TCCGGACTCA AGTACTTGCA CCAGCGGGGC 540
ATCTTGCACC GGGACCTCAA GCTAGGAAAT TTTTTTATCA CTGAAAACAT GGAACTGAAG 600
ATGGGGGATT TTGGACTGGC AACCCGGTTG GAGCCCCCAG AGCATAGGAA GAAGACCATC 660
TGTGGTACCC CCAACTATGT GGCCCCAGAA GTGCTGCAGA GACAGGGCCA CGGCCCGGAG 720
GCAGATGTGT GGTCCCTGGG CTGTGTCATG TACACGCTGC TATGTGGGAG TCCCCCCTTT 780
GAGACCGTTG ACCTGAAGGA GACGTACCGC TGCATCAAGC AGGTTCACTA CACGCTGCCT 840
GCCAGCCTCT CATTGCCTGC CCGGCAGCTC CTGGCCGCCA TCCTTCGAGC TTCACCCCAA 900
GACCGCCCCT CAATTGACCA GATCCTGCGC CACGACTTCT TTACCAAGGG CTACACCCCG 960
GACCGGCTCC CTGTCAGCAG CTGTGTGACA GTCCCAGACC TGACACCCCT TAACCCAGCT 1020
AGGATTCTGT TTGTCAAAGT TACCAAGAGC CTCTTTGGGA GAAAGAAGAA TAAGAATAAG 1080
AACCGTCCGG AGGAGCGGGA CGAGGTCTCC TGTTTGGTGA ATGGCCTCAC TCGGACGTCC 1140
ATCGGCCATC AGGATGCCAG GCCCGAGGCT CCAGCAGCTT CAGGTCCAGC CCCCCTCAGC 1200
CTGGTAGAGA CAGCACCTGA AGACAGTTCA CCCCGTGGGA CGCTGGCAAG CAGTGGAGAT 1260
GGGTTTGAAG AAGGTCTGAC TGTGGCCACA GTGGTGGAGT CAGCCCTCTG TGCTCTGAGA 1320
AACTGCCTGG CCTTCATGCC CCCAGCTGAA CAGAACCCAG CTCCCCTGGC ACAACCAGAA 1380
CCTCTGGTGT GGGTCAGCAA GTGGGTTGAC TACTCCAACA AGTTTGGCTT TGGGTATCAA 1440
CTGTCCAGCC GCCGTGTGGC TGTGCTCTTC AACAACGGCA CACACATGGC CCTGTCGGCC 1500
AACAGAAAGA CTGTGCACTA CAACCCCACC AGCACTAAGC ACTTCTCCTT CTCTGTGGGT 1560
GCCGTGCCTC GGGCTCTGCA GCCTCAGCTG GGTGTCCTGA AGTATTTCGC CTCCTACATG 1620
GAGCAGCGCC TCATGAAGGG TGGAGATCTG CCCAGTGTGG AAGAGGTGGA GGTGCCTGTG 1680
CCCCCACTCC TACTGCAGTG GGTCAAGACC GATCAGGCCC TACTCATGCT CTTTAGTGAT 1740
GGCACCATTC AGGTGAACTT CTACGGAGAC CACACCAAGC TGATCCTCAG TGGCTGGGAG 1800
CCCCTCCTTG TGACTTTCGT GGCCCGCAAT CGCAGTGCTT GTACTTACCT CGCTTCCCAC 1860
CTTCAGCAGC TGGGCTGCTC CCCAGATCTG CGGCAGCGGC TTCACTATGC TCTGCGCCTG 1920
CTCCGGGACC GCTGCCCGGT CTAG 1944
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y +g+llGkGgfa+cye++d+et++++avkv+++s+++k++qrek+ +eie+hr l+h++
Q: 62    YFKGRLLGKGGFARCYEATDTETGNAYAVKVISQSRITKPHQREKILNEIELHRGLQHRH  121
         789*********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         iv+++++fed++n+y++lelcsr+sla+++k+r++l epevryylrqi+sglkylh++ i
Q: 122   IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI  181
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         lhrdlklgn+f++e++e+k+gdfGlatrle++e+rkkt+cGtPny+aPevl+++gh+ e+
Q: 182   LHRDLKLGNFFITENMELKMGDFGLATRLEPPEHRKKTICGTPNYVAPEVLQRQGHGPEA  241
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         d+WslGc++ytll+G+PPfet +lkety++ik+ +y+lP+sls +a++l+a++l+++P++
Q: 242   DVWSLGCVMYTLLCGSPPFETVDLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPQD  301
         ************************************************************
S: 241   rpsleevlkdefl  253
         rps++++l+++f+
Q: 302   RPSIDQILRHDFF  314
         ************8
Domain Sequence
(FASTA)
YFKGRLLGKG GFARCYEATD TETGNAYAVK VISQSRITKP HQREKILNEI ELHRGLQHRH 60
IVRFSHHFED ADNIYIFLEL CSRKSLAHIW KARHTLLEPE VRYYLRQILS GLKYLHQRGI 120
LHRDLKLGNF FITENMELKM GDFGLATRLE PPEHRKKTIC GTPNYVAPEV LQRQGHGPEA 180
DVWSLGCVMY TLLCGSPPFE TVDLKETYRC IKQVHYTLPA SLSLPARQLL AAILRASPQD 240
RPSIDQILRH DFF 253
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00245
EKS-ANC-00251
EKS-CAJ-00268
EKS-CAF-00269
EKS-CAP-00297
EKS-CII-00157
EKS-DAR-00597
EKS-EQC-00253
EKS-FEC-00248
EKS-GAM-00162
EKS-GAG-00219
EKS-GAA-00323
EKS-GOG-00260
EKS-HOS-00269
EKS-ICT-00247
EKS-LAC-00274
EKS-LOA-00272
EKS-MAM-00264
EKS-MAE-00013
EKS-MEG-00206
EKS-MOD-00261
EKS-MUM-00293
EKS-MUP-00259
EKS-ORN-00339
EKS-ORC-00248
EKS-ORL-00316
EKS-OTG-00268
EKS-PAT-00249
EKS-PTV-00033
EKS-RAN-00277
EKS-SAH-00246
EKS-SUS-00227
EKS-TAG-00277
EKS-TEN-00330
EKS-XET-00337
EKS-XIM-00331
Gene Ontology
GO:0005813; C:centrosome
GO:0005795; C:Golgi stack
GO:0005730; C:nucleolus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0090166; P:Golgi disassembly
GO:0043066; P:negative regulation of apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:2000777; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO:0006974; P:response to DNA damage stimulus
GO:0006970; P:response to osmotic stress
GO:0009314; P:response to radiation
GO:0000302; P:response to reactive oxygen species
GO:0000084; P:S phase of mitotic cell cycle
KEGG
bta:504282;
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR020658; Ser/Thr_kinase_Plk3.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013