EKS-BOT-00123

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00123

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	478.9	4.0E-144	1079	1339	261

Status

Reviewed

Ensembl Protein

ENSBTAP00000008102

UniProt Accession

Q769I5; A4D7R6;

Protein Name

Hepatocyte growth factor receptor

Protein Synonyms/Alias

HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met;

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000006161	ENSBTAP00000008102	ENSBTAT00000008102

Organism

Bos taurus

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).

Protein Length

1384

Protein Sequence
(FASTA)

MKAPAVLAPG ILVLLFTFVQ KSNGECKEAL VKSRMNVNMQ YQLPNFTAET SIQNVVLHKH 60

HIYLGAINYI YVLNDKDLQK VAEYKTGPVL EHPDCFPCQD CSHKANLSGG VWKDNINMAL 120

LVDTYYDDQL ISCGSVHRGT CQRHVLPPNN TADIESEVHC MYSPQADEET NQCPDCVVSA 180

LGTKVLLSEK DRFINFFVGN TINSSYLPDY ILHSISVRRL KETQDGFKFL TDQSYIDVLP 240

ELRDSYPIKY VHAFESNHFI YFLTVQRETL DAQTFHTRII RFCSADSGLH SYMEMPLECI 300

LTEKRRKRST KQEVFNILQA AYVSKPGAQL ARQIGASLND DILYGVFAQS KPDSSEPMNR 360

SAVCAFPVKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRNDEYRTE 420

FTTALPRVDL FTGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQVVVSR SGSLTPHVNF 480

HLDSHPVSPE VIVEHPLNQN GYTLVVTGKK ITKIPLNGLG CEHFQSCSQC LSAPSFVQCG 540

WCHDKCVRLE ECSSGTWTQE TCLPTIYKVF PTSAPLEGGT TLTVCGWDFG FKRNNKFDLK 600

KTRVLLGNES CTLTLTESTT NMLKCTVGPA MNEHFNMSIV ISNSRGSVEY SAFSYVDPII 660

TSISPNYGPK TGGTLLTLTG KHLNSGNSRH ISIGGKTCTL KSVSHSILEC YTPAQSAPTE 720

FSVKLKIDLA NREVNSFIYR EDPIVYEIHP TKSFISGGST ITGVGKNLNS VSVLRMVINV 780

HEAGRNFTVA CQHRSNSEII CCTTPSIEQL NLQLPLKTKA FFMLDGIHSK YFDLIYVHNP 840

VFKPFEKPVM ISVGNENVLE IKGNDIDPEA VKGEVLKVGN KSCENIHSHS EAVLCTVPSD 900

LLKLNSELNI EWKQAISSTV LGKVIVQPDQ NFTGLIVGVV SISIILLLLL GLFLWLKKRK 960

QIKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNASQNG 1020

SCRQVQYPLT DLSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH 1080

FNEVIGRGHF GCVYHGTLLD NDDKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV 1140

LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMEYLASKK 1200

FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW MALESLQTQK 1260

FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DPLYEVMLKC 1320

WHPKAELRPS FSELVSRISV IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNVSGED 1380

DDDT 1384

Nucleotide Sequence
(FASTA)

ATGAAGGCCC CTGCTGTGCT TGCACCTGGC ATTCTTGTGC TTCTGTTTAC CTTCGTGCAG 60

AAGAGCAATG GGGAGTGTAA AGAGGCACTA GTAAAATCCA GGATGAATGT GAACATGCAA 120

TATCAGCTTC CTAACTTCAC TGCAGAAACA TCCATTCAGA ATGTTGTTTT GCACAAACAT 180

CACATTTACC TCGGTGCCAT TAACTACATT TACGTTTTAA ATGACAAAGA CCTTCAGAAG 240

GTTGCTGAGT ACAAGACTGG GCCTGTGCTG GAACACCCAG ATTGTTTCCC ATGTCAGGAC 300

TGCAGCCATA AAGCCAATTT ATCAGGTGGT GTTTGGAAAG ATAACATCAA CATGGCTCTG 360

CTTGTTGACA CGTACTATGA TGATCAACTC ATTAGCTGTG GCAGTGTCCA CAGAGGGACC 420

TGCCAGCGAC ACGTCCTTCC ACCCAACAAT ACTGCAGACA TAGAGTCGGA GGTTCACTGC 480

ATGTACTCTC CTCAGGCAGA CGAAGAGACC AACCAGTGTC CTGACTGTGT GGTGAGTGCC 540

CTGGGAACCA AAGTCCTACT GTCTGAAAAG GATCGATTCA TCAACTTCTT CGTGGGCAAT 600

ACCATAAATT CTTCTTACCT TCCAGATTAT ATATTGCACT CGATATCAGT GAGAAGGCTA 660

AAGGAAACAC AAGATGGTTT TAAGTTTTTG ACAGACCAAT CCTATATTGA TGTTCTACCT 720

GAACTCCGAG ATTCCTACCC CATTAAGTAT GTCCACGCCT TTGAAAGCAA CCATTTTATT 780

TACTTTTTGA CGGTCCAGCG GGAAACTCTA GATGCTCAGA CTTTTCACAC AAGAATAATC 840

AGGTTCTGTT CCGCAGACTC TGGATTGCAT TCGTACATGG AAATGCCTCT GGAGTGTATT 900

CTGACGGAAA AGAGAAGAAA GAGATCCACA AAGCAGGAAG TGTTTAATAT TCTCCAAGCT 960

GCATATGTCA GTAAGCCTGG GGCTCAGCTC GCTAGGCAAA TAGGTGCCAG CCTGAATGAT 1020

GACATTCTGT ACGGGGTGTT TGCACAAAGC AAGCCAGATT CCTCAGAACC AATGAATCGT 1080

TCTGCTGTCT GTGCATTCCC TGTCAAATAT GTCAATGAGT TCTTCAACAA AATCGTCAAC 1140

AAAAACAATG TGAGATGTCT CCAGCACTTT TATGGCCCCA ACCATGAACA CTGCTTCAAT 1200

AGGACACTTT TGAGAAATTC ATCAGGATGT GAAGTGCGCA ATGATGAATA TCGAACGGAG 1260

TTTACCACAG CTTTGCCACG CGTTGACTTA TTCACGGGCC AGTTCAACCA AGTCCTCTTA 1320

ACATCTATAT CCACCTTTAT CAAAGGAGAT CTCACCATCG CTAATCTCGG GACATCAGAA 1380

GGTCGATTCA TGCAGGTTGT GGTTTCTCGA TCAGGATCAT TAACTCCTCA TGTGAATTTT 1440

CACCTGGATT CCCACCCTGT GTCTCCAGAA GTGATTGTGG AGCACCCGCT AAACCAGAAT 1500

GGCTATACAC TGGTTGTCAC TGGGAAGAAG ATCACCAAGA TCCCGCTGAA TGGCCTGGGC 1560

TGTGAACATT TCCAGTCCTG CAGTCAGTGC CTCTCAGCCC CTTCCTTTGT GCAATGTGGC 1620

TGGTGCCATG ATAAATGTGT GCGATTGGAG GAATGCTCCA GTGGAACGTG GACTCAAGAG 1680

ACCTGTCTGC CAACAATCTA CAAGGTTTTT CCAACTAGTG CCCCCCTTGA AGGAGGGACA 1740

ACACTGACTG TTTGTGGCTG GGACTTTGGA TTCAAGAGGA ATAATAAATT TGATTTGAAG 1800

AAAACCAGAG TTCTCCTTGG CAATGAGAGC TGCACCTTAA CCTTAACTGA GAGCACAACA 1860

AACATGTTGA AATGCACAGT TGGTCCTGCA ATGAATGAAC ATTTCAATAT GTCCATAGTT 1920

ATTTCAAACA GCCGTGGGTC AGTAGAGTAT AGTGCGTTTT CCTATGTGGA TCCTATAATA 1980

ACAAGTATTT CTCCAAATTA TGGTCCAAAA ACTGGTGGCA CTTTACTTAC ATTAACTGGA 2040

AAGCACCTAA ACAGTGGAAA TTCAAGACAC ATTTCAATTG GTGGAAAAAC ATGTACTTTA 2100

AAAAGTGTTT CACATAGTAT TCTCGAATGT TATACCCCAG CCCAAAGTGC TCCAACTGAG 2160

TTTTCTGTTA AGTTGAAAAT TGACTTAGCC AACCGAGAGG TGAACAGCTT CATTTACCGG 2220

GAAGACCCCA TTGTCTATGA AATACATCCC ACCAAATCTT TTATTAGTGG TGGGAGTACA 2280

ATAACAGGTG TTGGAAAAAA CCTGAATTCA GTTAGTGTCC TAAGGATGGT AATAAATGTG 2340

CATGAAGCCG GAAGGAACTT TACAGTGGCA TGTCAACATC GCTCTAATTC AGAGATAATC 2400

TGCTGTACAA CTCCTTCAAT AGAACAGCTG AACCTACAAC TCCCCCTGAA AACCAAAGCC 2460

TTTTTCATGT TAGATGGGAT CCATTCCAAA TACTTTGATC TCATTTATGT ACATAATCCT 2520

GTGTTTAAGC CTTTTGAAAA GCCAGTGATG ATCTCAGTAG GCAATGAAAA TGTACTGGAA 2580

ATTAAGGGAA ATGATATTGA CCCTGAAGCA GTTAAAGGGG AGGTGTTAAA AGTTGGAAAT 2640

AAGAGCTGTG AAAATATACA CTCACACTCT GAAGCTGTTT TATGTACGGT CCCCAGTGAC 2700

CTGCTGAAAT TGAACAGCGA ACTAAATATA GAGTGGAAGC AAGCAATTTC TTCAACTGTT 2760

CTTGGAAAAG TGATAGTTCA ACCAGATCAG AATTTCACAG GATTGATTGT TGGTGTTGTC 2820

TCAATATCAA TAATACTCTT ACTGTTACTC GGGCTTTTCC TGTGGCTGAA AAAAAGGAAG 2880

CAAATTAAAG ATCTGGGCAG TGAATTAGTT CGCTATGATG CAAGAGTACA CACTCCACAT 2940

TTGGATAGGC TTGTCAGTGC CCGAAGTGTA AGCCCAACTA CAGAAATGGT TTCCAATGAA 3000

TCTGTAGACT ACCGAGCTAC TTTTCCAGAA GACCAGTTTC CTAATGCATC TCAGAATGGG 3060

TCATGCAGAC AAGTGCAGTA TCCTCTGACA GATCTATCCC CCATCTTAAC TAGTGGGGAC 3120

TCTGATATAT CCAGTCCATT ACTGCAAAAT ACCGTCCACA TCGACCTCAG TGCTCTAAAT 3180

CCAGAGCTGG TCCAGGCAGT TCAGCACGTA GTAATTGGGC CGAGCAGTCT GATTGTACAT 3240

TTCAATGAAG TCATAGGAAG AGGACATTTT GGGTGTGTAT ATCATGGAAC TTTGTTGGAC 3300

AACGATGATA AGAAAATTCA CTGTGCTGTG AAATCCTTGA ATAGAATCAC TGACATAGGA 3360

GAAGTTTCCC AATTTCTGAC TGAGGGAATC ATCATGAAAG ATTTTAGTCA TCCCAATGTT 3420

CTCTCACTTT TGGGAATCTG CCTTCGAAGT GAGGGGTCTC CACTGGTGGT CCTACCATAC 3480

ATGAAACACG GGGATCTTCG AAATTTCATT AGAAATGAGA CTCATAACCC AACTGTAAAA 3540

GATCTTATTG GCTTTGGTCT TCAAGTAGCC AAAGGCATGG AATATCTTGC AAGCAAAAAG 3600

TTTGTCCACA GAGACTTGGC TGCAAGAAAC TGTATGCTGG ATGAAAAATT CACCGTCAAG 3660

GTTGCTGATT TTGGTCTTGC CAGAGACGTG TATGATAAGG AATACTATAG CGTACACAAC 3720

AAAACAGGTG CAAAACTGCC AGTGAAATGG ATGGCTTTAG AAAGCCTGCA GACTCAGAAA 3780

TTTACCACCA AGTCAGATGT GTGGTCCTTT GGCGTGCTTC TCTGGGAACT GATGACAAGA 3840

GGAGCACCAC CTTATCCTGA CGTCAACACC TTTGACATAA CAGTTTACTT GTTGCAAGGA 3900

AGAAGGCTCC TACAACCTGA ATACTGCCCA GATCCCTTGT ATGAAGTGAT GCTGAAATGC 3960

TGGCACCCTA AAGCTGAACT GCGCCCATCC TTTTCTGAAC TGGTCTCCAG GATATCCGTG 4020

ATATTCTCTA CTTTCATTGG GGAGCACTAT GTCCATGTGA ATGCTACTTA CGTGAACGTC 4080

AAATGTGTCG CTCCATATCC TTCTCTGTTG TCATCACAAG ATAATGTCAG TGGCGAGGAT 4140

GATGATGACA CATGA 4155

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 1079  VHFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1138

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgmeylas

Q: 1139  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMEYLAS  1198

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlardv+dke+y+v+++++a+lpvkw+aleslqt

Q: 1199  KKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQT  1258

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 1259  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1317

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k++ rp+fs+lvs+is

Q: 1318  LKCWHPKAELRPSFSELVSRIS  1339

         ********************97

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDNDDKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMEYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DVYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKAELR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0030534	; P:adult behavior
GO:0007420	; P:brain development
GO:0048754	; P:branching morphogenesis of a tube
GO:0042593	; P:glucose homeostasis
GO:0001889	; P:liver development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0014902	; P:myotube differentiation
GO:0001890	; P:placenta development
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

bta:280855

;

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013