EKS-BOT-00011
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00011
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph431.96.4E-130631885255
StatusUnreviewed
Ensembl ProteinENSBTAP00000008354
UniProt AccessionF1MFH7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA1
Gene Synonyms/Alias EPHA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000006359ENSBTAP00000008354ENSBTAT00000008354
OrganismBos taurus
Functional Description
Protein Length982
Protein Sequence
(FASTA)
MERRWPLGLG LLLLLLLCAP LPPGARAEEV TLMDTSMAQE ELGWLLDPPE DGWSEVQQIL 60
NGTPLYMYQD CPVQEGRDTD HWLRTNWIYR GEEASRVHLE LQFTVRDCKS FPGEGGPLGC 120
KETFNLLYME SDQDVGIQLR RPLFQKVTTV AADQSFTIRD LASRAVKMNV ERCSLGRLTR 180
RGLYLAFHNP GACVALVSVR VFYQRCPETV HGLARFPNTL PGPGGLAEVA GTCLPHAHIS 240
PGPSGAPRMH CSPDGEWLVP VGRCHCEPGY EEGSSDVEEC LACPSGSYRS DVDAPQCLRC 300
PQHSTAEAEG ATECACESEH YRAPGEGPHA ACTRPPSIPR NLSFSVSGTQ LSLRWEPPAD 360
LGEREDVTYN VECSQCQGAA LDGGPCQPCG AGVRFSAGPS GLTACSVRVD GLDPHANYTF 420
NVEAQNGVSG LGASRPASAS LSINMGSAES LSGLSLRLVK KAPRQLELTW AGSRPRSPGG 480
NLSYELHVLN QDEERYQMVL EPRVLLTELQ PDTTYIVRVR MVTPLGPGPF SADHEFRTSP 540
PVSRVLTGGE IVAIIFGLLL GVALLLGMLL FRSRRAQRRR HQRQQRQRDR VADGDREDKL 600
WLKPYVDLQA YEDPAQGALD FTQELDPAWL VVDTVIGEGE FGEVYRGSLR LPSQDGKIVA 660
IKTLKDTSPE GQWWNFLREA TIMGQFNHPH ILHLEGVVTK RKPIMIITEF MENGALDAFL 720
REREDQLVPG QLVAMLQGIA SGMNYLSDHN YVHRDLAARN ILVSQNLCCK VSDFGLTRLL 780
DNFDGTYETQ GGKIPIRWTA PEAIAHRIFT TASDVWSFGI VMWEVLSFGD KPYGDMSNQE 840
VMKSIEDGYR LPPPVDCPAP LYELMKNCWA YDRVRRPTFH RLKAQLEHLH ANPHSLRTIA 900
NFDPRVTLRL PSLSGSDGIP YRSVAEWLES IRMKRYILHF RSAGLDTMEC VLDLTAEDLV 960
QMGITLPGHQ KRILYSIQGF KD 982
Nucleotide Sequence
(FASTA)
ATGGAGCGGC GCTGGCCCCT GGGGCTCGGG CTGCTGCTGC TGCTGCTGCT CTGCGCCCCG 60
CTGCCCCCGG GGGCGCGCGC CGAGGAAGTC ACTCTAATGG ATACTAGCAT GGCACAGGAA 120
GAGCTGGGCT GGCTCCTGGA TCCCCCAGAG GATGGGTGGA GTGAGGTGCA GCAGATACTG 180
AACGGGACAC CCCTGTACAT GTACCAGGAC TGCCCTGTGC AAGAAGGCAG AGACACTGAC 240
CACTGGCTTC GCACCAATTG GATCTACCGG GGAGAGGAGG CCTCTCGCGT CCACTTGGAG 300
TTGCAGTTTA CCGTGCGGGA CTGCAAGAGT TTCCCCGGGG AAGGAGGGCC TTTGGGCTGC 360
AAGGAGACCT TCAACCTCCT GTACATGGAG AGTGACCAGG ACGTGGGCAT TCAGCTCCGG 420
CGGCCCCTGT TCCAGAAGGT AACCACGGTG GCCGCCGACC AGAGCTTCAC CATCCGAGAC 480
CTTGCATCCA GAGCCGTGAA GATGAACGTG GAACGCTGCT CCTTGGGCCG CCTGACCCGC 540
CGAGGCCTCT ACCTCGCTTT CCACAACCCG GGTGCCTGCG TGGCCCTGGT GTCCGTCCGG 600
GTCTTCTACC AGCGCTGCCC TGAGACTGTG CATGGCTTGG CCCGATTCCC CAATACTCTG 660
CCTGGACCTG GGGGGTTGGC CGAAGTGGCA GGGACCTGCC TGCCCCATGC GCACATCAGC 720
CCTGGCCCCT CGGGTGCACC TCGCATGCAC TGCAGCCCCG ATGGCGAGTG GTTGGTACCG 780
GTGGGGCGGT GCCACTGTGA GCCTGGGTAT GAGGAGGGCA GCAGCGATGT TGAGGAATGC 840
CTTGCCTGCC CGAGCGGCTC CTATCGGAGT GATGTGGACG CACCCCAGTG TCTCAGGTGC 900
CCCCAACATA GCACAGCCGA GGCTGAAGGG GCCACAGAGT GTGCCTGCGA GAGTGAGCAC 960
TACCGAGCTC CTGGGGAGGG CCCCCATGCT GCGTGCACAC GTCCCCCCTC AATCCCCCGA 1020
AATCTGAGCT TCTCCGTTTC AGGGACTCAG CTCTCCCTGC GCTGGGAGCC CCCAGCAGAC 1080
CTGGGGGAAC GTGAAGATGT TACATACAAT GTGGAGTGTT CTCAGTGTCA GGGAGCAGCC 1140
CTGGACGGGG GGCCCTGCCA GCCCTGCGGG GCAGGTGTGC GCTTCTCTGC AGGCCCTAGC 1200
GGGCTGACCG CATGCTCCGT GCGTGTGGAC GGCCTCGATC CCCACGCCAA CTACACCTTC 1260
AACGTGGAAG CCCAGAATGG AGTGTCGGGG TTGGGTGCCT CCAGGCCCGC CAGCGCCTCA 1320
CTCAGCATCA ACATGGGGTC TGCAGAGTCC CTGTCAGGCT TGTCCCTGAG ACTGGTGAAG 1380
AAGGCACCAC GGCAGCTGGA GCTGACCTGG GCGGGGTCCC GGCCCCGCAG CCCCGGGGGG 1440
AACCTCAGCT ACGAGCTGCA CGTGTTGAAC CAGGACGAAG AGCGGTACCA GATGGTTCTA 1500
GAGCCCAGGG TCCTGCTGAC GGAACTGCAG CCCGACACCA CGTACATCGT CAGAGTCCGC 1560
ATGGTGACCC CTCTGGGACC CGGCCCCTTC TCCGCTGACC ACGAGTTTCG GACCAGCCCA 1620
CCAGTTTCCA GGGTCCTGAC TGGAGGCGAG ATCGTGGCCA TCATCTTCGG GCTGCTGCTG 1680
GGTGTAGCTC TGCTGCTCGG GATGCTGCTC TTCCGTTCCA GGAGAGCTCA GCGGCGGCGG 1740
CACCAGAGGC AGCAGAGGCA GCGAGATCGC GTCGCTGATG GAGACCGAGA GGACAAGCTG 1800
TGGCTGAAGC CTTACGTCGA CCTCCAGGCG TATGAAGACC CTGCCCAGGG AGCCCTGGAC 1860
TTCACCCAGG AGCTCGACCC GGCCTGGCTG GTCGTGGACA CCGTCATAGG GGAAGGAGAG 1920
TTTGGGGAAG TGTATCGGGG GTCCCTGAGA CTTCCCAGCC AGGATGGCAA GATTGTGGCT 1980
ATTAAGACCT TGAAAGATAC ATCTCCGGAA GGCCAGTGGT GGAACTTCCT TCGCGAGGCG 2040
ACTATCATGG GCCAGTTCAA CCACCCGCAC ATTCTGCACC TGGAGGGCGT GGTCACAAAG 2100
AGAAAACCCA TCATGATCAT CACGGAGTTT ATGGAGAATG GAGCCTTGGA TGCCTTCCTA 2160
AGGGAGCGGG AGGACCAGCT AGTGCCTGGG CAGCTGGTGG CCATGCTGCA GGGCATAGCA 2220
TCCGGCATGA ACTACCTCAG TGACCACAAT TATGTCCACC GGGACCTGGC CGCCAGGAAC 2280
ATCTTGGTGA GTCAGAACCT GTGCTGCAAG GTGTCTGACT TTGGCCTGAC CCGCCTCCTG 2340
GACAACTTTG ATGGCACCTA TGAAACCCAG GGAGGGAAGA TCCCCATCCG TTGGACAGCC 2400
CCAGAAGCCA TCGCCCACCG GATCTTCACT ACGGCCAGCG ACGTGTGGAG CTTTGGGATC 2460
GTGATGTGGG AGGTGCTCAG CTTCGGGGAC AAGCCCTATG GAGACATGAG CAATCAGGAG 2520
GTAATGAAGA GCATTGAGGA TGGGTACCGG CTGCCCCCGC CCGTGGACTG CCCTGCCCCC 2580
CTCTATGAAC TCATGAAGAA CTGCTGGGCC TACGACCGTG TCCGCCGGCC CACCTTCCAT 2640
CGCCTGAAGG CACAGCTGGA GCATCTGCAT GCCAACCCCC ACTCCCTGCG AACCATTGCC 2700
AACTTTGATC CCAGGGTGAC CCTTCGCCTG CCCAGCTTGA GCGGCTCCGA CGGGATCCCC 2760
TACCGAAGTG TGGCCGAGTG GCTGGAGTCC ATCCGAATGA AGCGCTACAT CCTGCACTTC 2820
CGCTCCGCCG GGCTGGACAC CATGGAGTGC GTGCTGGACC TGACAGCCGA GGACCTGGTG 2880
CAGATGGGGA TCACGCTCCC GGGCCACCAG AAGCGCATTC TTTACAGTAT TCAGGGCTTC 2940
AAGGACTGA 2949
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
          +++viG+GefGev++G+l+lp++    vaiktlk++s e q+++fl+ea+i+Gqf+hp+
Q: 631   VVDTVIGEGEFGEVYRGSLRLPSQDGKIVAIKTLKDTSPEGQWWNFLREATIMGQFNHPH  690
         5899********************************************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         i++leGvvtk+kp+mi+te+mengald+flr++++q++  qlv+ml+Giasgm+ylsd++
Q: 691   ILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSDHN  750
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilv++nl+ckvsdfGl+r l d+ + +y+t+ggkipirwtapeaia+r f
Q: 751   YVHRDLAARNILVSQNLCCKVSDFGLTRLL-DNFDGTYETQGGKIPIRWTAPEAIAHRIF  809
         ****************************98.7789*************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         t+asdvws+Giv+wevls+G++py dmsnq+v+k+ie+gyrlppp+dcpa ly+lm++cw
Q: 810   TTASDVWSFGIVMWEVLSFGDKPYGDMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCW  869
         ************************************************************
S: 242   qkdraerpkfeqivsi  257
           dr +rp+f+++++ 
Q: 870   AYDRVRRPTFHRLKAQ  885
         ***********99875
Domain Sequence
(FASTA)
VVDTVIGEGE FGEVYRGSLR LPSQDGKIVA IKTLKDTSPE GQWWNFLREA TIMGQFNHPH 60
ILHLEGVVTK RKPIMIITEF MENGALDAFL REREDQLVPG QLVAMLQGIA SGMNYLSDHN 120
YVHRDLAARN ILVSQNLCCK VSDFGLTRLL DNFDGTYETQ GGKIPIRWTA PEAIAHRIFT 180
TASDVWSFGI VMWEVLSFGD KPYGDMSNQE VMKSIEDGYR LPPPVDCPAP LYELMKNCWA 240
YDRVRRPTFH RLKAQ 255
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00011
EKS-ANC-00010
EKS-CAJ-00011
EKS-CAF-00012
EKS-CAP-00009
EKS-EQC-00012
EKS-FEC-00009
EKS-GAG-00011
EKS-GOG-00012
EKS-HOS-00012
EKS-ICT-00011
EKS-LAC-00015
EKS-LOA-00012
EKS-MAM-00010
EKS-MEG-00010
EKS-MOD-00011
EKS-MUM-00012
EKS-MUP-00012
EKS-MYL-00013
EKS-NOL-00011
EKS-OCP-00003
EKS-ORC-00011
EKS-OTG-00012
EKS-PAT-00010
EKS-POA-00009
EKS-RAN-00011
EKS-SAH-00009
EKS-SUS-00009
EKS-TAG-00011
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0032862; P:activation of Rho GTPase activity
GO:0030336; P:negative regulation of cell migration
GO:0006469; P:negative regulation of protein kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0051496; P:positive regulation of stress fiber assembly
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
bta:525946;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013