EKS-BOT-00285
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00285
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR389.31.2E-11665363299
StatusUnreviewed
Ensembl ProteinENSBTAP00000008419
UniProt AccessionF1MH00;
Protein Name
Protein Synonyms/Alias
Gene NameBMPR2
Gene Synonyms/Alias BMPR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000006420ENSBTAP00000008419ENSBTAT00000008419
OrganismBos taurus
Functional Description
Protein Length900
Protein Sequence
(FASTA)
LGPPHSFNRD ETIIIALASV SVLAVLIVAL CFGYRMLTGD RKQGLHSMNM MEAAASEPSL 60
DLDNLKLLEL IGRGRYGAVY KGSLDERPVA VKVFSFANRQ NFINEKNIYR VPLMEHDNIA 120
RFIVGDERVT ADGRMEYLLV MEYYPNGSLC KYLSLHTSDW VSSCRLAHSV TRGLAYLHTE 180
LPRGDHYKPA ISHRDLNSRN VLVKNDGTCV ISDFGLSMKL TGNRLVRPGE EDNAAISEVG 240
TIRYMAPEVL EGAVNLRDCE SALKQVDMYA LGLIYWEIFM RCTDLFPGES VPEYQMAFQT 300
EVGNHPTFED MQVLVSREKQ RPKFPEAWKE NSLAVRSLKE TIEDCWDQDA EARLTAQCAE 360
ERMAELMMIW ERNKSVSPTV NPMSTAMQNE RNLSHNRRVP KIGPYPDYSS SSYIEDSIHH 420
TDSIVKNISS EHSMSSTPLT IGEKNRNSIN YERQQAQARI PSPETSVTSL STNTTTTNTT 480
GLTPSTGMTT ISEVPYPDET SLHATNVSQP VGPTPVCLQL TEEDLETNKL DPKEVDKNLK 540
ESSDENLMEH SLKQFSGPDP LSSTSSSLLY PLIKLAVEVT GQQDFTQAAN GQACLIPDVP 600
PAQIYPLPKQ QNLPKRPTSL PLNTKNSTKE PRLKFGSKHK SNLKQVETGV AKMNTINAAE 660
PHIVTVTMNG VAGRNHSVNS HTATTQYANG VVPSGQTANT VAHRAQEMLQ NQFIGEDTRL 720
NINSSPDEHE PLLRREQQAG HDEGVLDRLV DRRERPLEGG RTNSNNNNSN PCSEQEVLTQ 780
GVPSTVADPG PSKPRRAQRP NSLDLSATNV LDGNSLQLGD STQDGKSGSG EKIKKRVKTP 840
YSLKRWRPST WVISTEPLDC EVNNNGKDRA VHSKSSTTVY LADGGTATTM VSKDIGMNCL 900
Nucleotide Sequence
(FASTA)
TTAGGTCCAC CTCATTCATT TAACCGAGAT GAGACAATAA TCATTGCATT GGCATCAGTC 60
TCTGTATTAG CTGTTTTGAT AGTTGCCTTA TGCTTTGGAT ATAGGATGCT GACAGGAGAC 120
CGCAAACAAG GTCTTCACAG TATGAATATG ATGGAGGCAG CAGCATCAGA GCCCTCTCTT 180
GACCTAGATA ATCTGAAACT GCTGGAGCTG ATTGGCCGGG GTCGATATGG AGCTGTATAT 240
AAAGGTTCCT TAGATGAACG TCCAGTTGCT GTAAAAGTAT TTTCCTTTGC AAACCGTCAG 300
AATTTTATCA ATGAGAAGAA CATTTACAGA GTGCCTTTGA TGGAACATGA CAACATTGCT 360
CGCTTTATAG TTGGAGATGA GAGAGTCACT GCAGATGGAC GCATGGAGTA TTTGCTTGTG 420
ATGGAGTATT ATCCCAATGG ATCTCTATGC AAGTATTTAA GTCTCCATAC AAGTGACTGG 480
GTAAGCTCTT GCCGTCTGGC TCATTCTGTG ACTAGAGGAT TGGCTTATCT TCATACTGAA 540
TTACCACGGG GAGATCATTA TAAACCTGCA ATTTCCCATC GAGATTTGAA CAGCAGAAAT 600
GTTCTGGTGA AAAATGATGG AACCTGCGTT ATTAGTGACT TTGGGTTGTC CATGAAGCTG 660
ACTGGAAATA GACTGGTGCG CCCAGGGGAA GAAGATAATG CAGCCATTAG TGAGGTTGGC 720
ACAATCAGAT ATATGGCACC AGAAGTTCTG GAAGGAGCTG TGAACCTTAG GGACTGTGAA 780
TCAGCTTTGA AACAAGTAGA TATGTATGCA CTTGGACTAA TTTATTGGGA GATATTTATG 840
AGATGTACAG ACCTCTTTCC AGGTGAATCT GTACCAGAAT ACCAGATGGC TTTTCAGACA 900
GAGGTTGGAA ATCATCCCAC TTTTGAAGAT ATGCAGGTTC TGGTGTCTAG GGAAAAACAG 960
AGACCCAAGT TCCCAGAAGC TTGGAAAGAA AATAGCCTGG CAGTGAGATC ACTCAAGGAG 1020
ACAATCGAAG ACTGTTGGGA CCAGGATGCA GAGGCTCGGC TTACTGCTCA GTGTGCTGAA 1080
GAGAGGATGG CTGAACTTAT GATGATATGG GAAAGAAACA AGTCTGTGAG CCCAACAGTC 1140
AATCCAATGT CTACTGCTAT GCAGAATGAG CGCAACCTGT CACACAATAG GCGTGTGCCA 1200
AAGATTGGCC CTTATCCAGA TTATTCTTCT TCCTCATACA TTGAAGATTC TATTCATCAC 1260
ACTGACAGCA TTGTGAAGAA CATTTCCTCT GAGCATTCGA TGTCCAGCAC ACCTTTGACT 1320
ATAGGGGAAA AGAACCGAAA CTCAATTAAC TATGAACGGC AGCAAGCACA AGCTCGAATC 1380
CCCAGCCCTG AAACAAGCGT CACCAGCTTG TCTACCAACA CCACAACCAC AAACACCACT 1440
GGCCTCACTC CAAGTACCGG CATGACCACT ATATCCGAGG TGCCATACCC AGATGAAACA 1500
AGTCTGCATG CCACCAATGT TTCACAGCCA GTCGGGCCAA CCCCTGTCTG CTTACAACTG 1560
ACCGAAGAAG ACTTGGAGAC CAACAAGCTG GACCCAAAAG AAGTCGATAA AAATCTCAAG 1620
GAAAGTTCTG ATGAGAATCT CATGGAGCAT TCTCTTAAAC AATTCAGTGG GCCAGACCCA 1680
CTGAGCAGTA CCAGTTCTAG CTTGCTTTAC CCACTTATAA AGCTTGCAGT TGAAGTGACT 1740
GGGCAGCAGG ACTTCACACA GGCTGCAAAT GGCCAAGCAT GTTTAATTCC TGATGTCCCA 1800
CCTGCTCAGA TCTATCCTCT CCCCAAGCAA CAGAACCTTC CTAAGAGACC TACTAGTTTG 1860
CCTTTAAACA CCAAAAATTC GACAAAGGAG CCCAGGCTGA AATTTGGCAG CAAGCACAAA 1920
TCAAACTTGA AACAAGTAGA AACTGGAGTT GCCAAGATGA ATACAATCAA TGCTGCAGAA 1980
CCTCATATAG TGACAGTCAC TATGAATGGT GTGGCAGGTA GAAACCACAG CGTTAATTCC 2040
CATACTGCCA CTACTCAGTA TGCCAATGGC GTAGTACCAT CTGGCCAGAC AGCTAACACA 2100
GTGGCACACA GAGCCCAAGA AATGCTGCAG AATCAGTTCA TTGGTGAGGA CACTCGGCTG 2160
AACATTAATT CTAGTCCTGA TGAGCATGAA CCTTTACTGA GACGAGAGCA GCAGGCTGGC 2220
CATGATGAAG GTGTTCTGGA TCGTCTTGTG GACAGGAGAG AACGGCCCCT AGAAGGCGGC 2280
CGAACTAATT CCAACAACAA CAACAGCAAT CCATGTTCTG AGCAAGAAGT TCTCACACAG 2340
GGTGTTCCAA GCACAGTAGC AGACCCCGGA CCATCAAAGC CTAGAAGAGC ACAGAGGCCT 2400
AATTCTCTGG ATCTTTCAGC CACCAATGTC CTTGATGGCA ACAGTTTGCA GTTAGGTGAC 2460
TCAACACAAG ATGGCAAATC AGGATCTGGT GAAAAGATCA AGAAACGAGT GAAAACTCCC 2520
TATTCTCTTA AGCGGTGGCG CCCTTCCACC TGGGTCATTT CCACTGAACC ACTGGACTGT 2580
GAGGTCAACA ACAATGGCAA AGACAGGGCA GTGCATTCCA AATCCAGCAC CACTGTTTAC 2640
CTTGCAGACG GAGGCACTGC CACGACGATG GTGTCTAAAG ATATAGGGAT GAACTGTCTG 2700
TGA 2703
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+
Q: 65    LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  124
         6899********************************************************
S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119
          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++  
Q: 125   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  184
         **9999**************************************************9766
S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175
          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL++kl+ ++ +    +d+aa+s+vGt R
Q: 185   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMKLTGNRLVrpgeEDNAAISEVGTIR  243
         .46**********************************9999877787999**********
S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232
         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg
Q: 244   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  303
         *****************99*****************************************
S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291
         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+
Q: 304   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  363
         ***************************9999*************************9987
Domain Sequence
(FASTA)
LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60
GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120
DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMKLTGNR LVRPGEEDNA AISEVGTIRY 180
MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240
HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00267
EKS-ANC-00273
EKS-CAJ-00291
EKS-CAF-00291
EKS-CAP-00320
EKS-DAR-00625
EKS-DRM-00145
EKS-EQC-00277
EKS-FEC-00271
EKS-GAG-00238
EKS-GAA-00349
EKS-GOG-00284
EKS-HOS-00291
EKS-ICT-00269
EKS-LAC-00296
EKS-LOA-00295
EKS-MAM-00287
EKS-MEG-00225
EKS-MOD-00280
EKS-MUM-00316
EKS-MUP-00281
EKS-MYL-00287
EKS-NOL-00263
EKS-ORN-00368
EKS-ORA-00247
EKS-ORC-00267
EKS-OTG-00290
EKS-PAT-00269
EKS-PES-00254
EKS-PEM-00153
EKS-POA-00276
EKS-PRC-00027
EKS-PTV-00041
EKS-RAN-00301
EKS-SAH-00267
EKS-SUS-00250
EKS-TAG-00297
EKS-TAR-00369
EKS-TAS-00021
EKS-TEN-00366
EKS-VIP-00019
EKS-XET-00358
EKS-XIM-00360
Gene Ontology
GO:0005901; C:caveola
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0009952; P:anterior/posterior pattern specification
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0009267; P:cellular response to starvation
GO:0048286; P:lung alveolus development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0001707; P:mesoderm formation
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0003085; P:negative regulation of systemic arterial blood pressure
GO:0045906; P:negative regulation of vasoconstriction
GO:0030513; P:positive regulation of BMP signaling pathway
GO:0030501; P:positive regulation of bone mineralization
GO:0010595; P:positive regulation of endothelial cell migration
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916; P:regulation of lung blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0006366; P:transcription from RNA polymerase II promoter
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0060841; P:venous blood vessel development
KEGG
InterPros
IPR015770; BMPRII.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013