EKS-BOT-00002
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00002
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph519.31.4E-156354611258
StatusUnreviewed
Ensembl ProteinENSBTAP00000008955
UniProt AccessionE1BJS9;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000006811ENSBTAP00000008955ENSBTAT00000008955
OrganismBos taurus
Functional Description
Protein Length716
Protein Sequence
(FASTA)
MCQACQPGFY KASDGNMKCA KCPPHSSTHE DGSVNCRCEN NYFRADKDPP SMACTRPPSA 60
PRNVISNINE TSVILDWSWP LDTGGRKDVT FNIICKKCGW NVKQCEPCSP NVRFLPRQFG 120
LTNTTVTVTD LLAHTNYTFE IDAVNGVSEL SSPPRQFAAV SITTNQAAPS PVMTIKKDRT 180
SRNSISLSWQ EPEHPNGIIL DYEVKYYEKQ EQETSYTILR ARGTNVTISS LKPGTTYVFQ 240
IRARTAAGYG TNSRKFEFET SPDSFSISGE NSQVVMIAIS AAVAIILLTV VTYVLIGRFC 300
GYHKSKHGAD EKRLHFGNGH LKLPGLRTYV DPHTYEDPTQ AVHEFAKELD ATNISIDKVV 360
GAGEFGEVCS GRLKLPSKKE ISVAIKTLKV GYTEKQRRDF LGEASIMGQF DHPNIIRLEG 420
VVTKSKPVMI VTEYMENGSL DSFLRKHDAQ FTVIQLVGML RGIASGMKYL SDMGYVHRDL 480
AARNILINSN LVCKVSDFGL SRVLEDDPEA AYTTRGGKIP IRWTSPEAIA YRKFTSASDV 540
WSYGIVLWEV MSYGERPYWE MSNQDVIKAV DEGYRLPPPM DCPAALYQLM LDCWQKDRNN 600
RPKFEQIVSI LDKLIRNPGS LKIITSAAAR PSNLLLDQSN IDITTFRTTG DWLNGVRTAQ 660
CKEIFTGVEY SSCDTIAKIS ADDMKKVGVT VVGPQKKIIS SIKVLETQSK NTPVPV 716
Nucleotide Sequence
(FASTA)
ATGTGTCAAG CTTGTCAACC AGGTTTCTAC AAGGCTTCAG ATGGTAATAT GAAGTGTGCT 60
AAGTGTCCAC CTCACAGTTC TACTCACGAA GACGGTTCAG TGAACTGCAG GTGTGAAAAT 120
AATTACTTCC GAGCAGACAA AGACCCTCCA TCCATGGCTT GTACCCGACC TCCGTCTGCA 180
CCGAGAAATG TGATATCTAA TATAAACGAG ACCTCGGTTA TCCTGGACTG GAGTTGGCCC 240
CTGGACACAG GAGGCCGGAA AGATGTTACC TTCAACATCA TATGTAAAAA ATGTGGGTGG 300
AATGTCAAAC AGTGTGAGCC GTGCAGTCCA AATGTCCGCT TCCTCCCTCG GCAGTTTGGG 360
CTCACCAACA CCACGGTGAC AGTGACAGAC CTCCTGGCAC ACACTAACTA CACCTTTGAG 420
ATCGATGCCG TTAACGGGGT GTCAGAGCTG AGCTCACCAC CCAGACAGTT TGCTGCAGTC 480
AGCATCACAA CTAACCAGGC TGCTCCATCA CCTGTCATGA CGATTAAGAA AGACCGGACA 540
TCCAGAAACA GCATTTCTTT ATCCTGGCAA GAACCTGAAC ACCCTAATGG GATCATATTG 600
GACTATGAGG TCAAATACTA TGAAAAGCAG GAACAAGAAA CAAGTTATAC GATTCTCAGG 660
GCACGAGGCA CTAATGTTAC CATCAGTAGC CTCAAGCCTG GTACTACATA TGTATTCCAA 720
ATCCGAGCCC GGACCGCAGC TGGATATGGG ACCAACAGTC GCAAGTTTGA GTTTGAAACC 780
AGTCCAGACT CTTTCTCCAT CTCTGGTGAA AATAGCCAAG TGGTAATGAT TGCCATTTCA 840
GCGGCGGTAG CAATTATCCT CCTCACAGTC GTCACCTATG TTTTGATTGG GAGGTTCTGT 900
GGCTATCATA AGTCGAAACA TGGTGCAGAT GAAAAAAGAC TTCATTTTGG GAATGGACAC 960
TTAAAACTTC CAGGTCTCAG GACTTATGTT GACCCACACA CATATGAGGA CCCTACCCAA 1020
GCAGTTCATG AGTTTGCTAA GGAATTGGAT GCCACCAACA TATCCATTGA CAAAGTTGTT 1080
GGAGCAGGTG AATTTGGAGA GGTGTGCAGC GGCCGTTTAA AACTGCCTTC AAAAAAAGAG 1140
ATTTCAGTGG CCATCAAGAC CCTAAAAGTG GGCTACACAG AAAAGCAGAG GAGAGACTTC 1200
TTAGGCGAAG CAAGCATTAT GGGACAATTT GACCATCCCA ATATCATTCG ACTGGAGGGA 1260
GTTGTTACTA AAAGTAAACC TGTTATGATT GTCACAGAAT ACATGGAGAA TGGTTCCTTG 1320
GACAGTTTCT TACGTAAACA TGATGCCCAG TTTACAGTTA TCCAGCTGGT AGGGATGCTT 1380
CGAGGCATAG CATCTGGCAT GAAGTATCTC TCAGACATGG GCTATGTTCA CCGAGACCTT 1440
GCTGCTCGCA ACATCTTGAT CAACAGTAAT TTGGTGTGTA AGGTTTCTGA TTTTGGACTT 1500
TCACGGGTTC TAGAAGATGA CCCAGAAGCT GCTTACACAA CAAGAGGAGG GAAGATCCCA 1560
ATCCGGTGGA CATCACCAGA AGCCATAGCC TACCGCAAAT TCACATCAGC CAGCGATGTA 1620
TGGAGTTACG GGATTGTTCT CTGGGAGGTG ATGTCCTATG GAGAGAGACC ATACTGGGAG 1680
ATGTCCAATC AGGATGTAAT TAAAGCTGTG GATGAAGGCT ATCGACTGCC ACCCCCCATG 1740
GACTGCCCAG CTGCGTTGTA TCAGCTGATG CTAGACTGCT GGCAGAAAGA CAGAAACAAC 1800
AGACCCAAGT TTGAGCAGAT TGTCAGCATT CTGGACAAGC TTATCCGGAA CCCAGGCAGT 1860
CTGAAGATCA TCACCAGTGC GGCAGCAAGG CCCTCAAACC TTCTCCTGGA CCAAAGTAAC 1920
ATCGACATTA CTACCTTCCG CACGACAGGT GACTGGCTTA ACGGTGTCCG AACAGCACAG 1980
TGCAAGGAAA TCTTCACAGG CGTGGAGTAC AGTTCTTGTG ACACCATAGC CAAGATTTCT 2040
GCAGACGACA TGAAAAAGGT CGGTGTCACT GTGGTTGGGC CACAGAAGAA GATCATCAGC 2100
AGTATTAAAG TTCTAGAAAC ACAATCCAAG AATACTCCAG TCCCAGTGTA A 2151
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlk g+tekqrrdfl easi+Gqfdhp
Q: 354   ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  413
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtkskpvmivteymeng+ldsflrk+d qftviqlvgmlrGiasgmkylsdm
Q: 414   NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM  473
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwt+peaiayrk
Q: 474   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK  533
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpaalyqlmldc
Q: 534   FTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC  593
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkfeqivsil
Q: 594   WQKDRNNRPKFEQIVSIL  611
         ***************986
Domain Sequence
(FASTA)
ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60
NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK 180
FTSASDVWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP AALYQLMLDC 240
WQKDRNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Ictidomys tridecemlineatus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>
EKS-AIM-00002
EKS-CAE-00001
EKS-CAF-00003
EKS-CAP-00011
EKS-EQC-00003
EKS-FEC-00004
EKS-ICT-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-ORC-00002
EKS-PES-00003
EKS-POA-00002
EKS-SAH-00002
EKS-SUS-00002
EKS-TAR-00002
EKS-TAS-00002
EKS-TUT-00001
Gene Ontology
GO:0005769; C:early endosome
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0071300; P:cellular response to retinoic acid
GO:0010976; P:positive regulation of neuron projection development
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0051893; P:regulation of focal adhesion assembly
GO:0070507; P:regulation of microtubule cytoskeleton organization
GO:0032319; P:regulation of Rho GTPase activity
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013