EKS-BOT-00158

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00158

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	614.2	2.8E-185	410	688	279

Status

Unreviewed

Ensembl Protein

ENSBTAP00000009090

UniProt Accession

F1MYG2;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000006918	ENSBTAP00000009090	ENSBTAT00000009090

Organism

Bos taurus

Functional Description

Protein Length

720

Protein Sequence
(FASTA)

GAMDELHSLD PRRQELLEAR FTGVASGSTG STGSCSVGAK ASTNNESSNH SFGSLGSLSD 60

KESETPEKKQ SESSRGRKRK AENQNESSQG KSIGGRGHKI SDYFEYQGGN GSSPVRGIPP 120

AIRSPQNSHS HSTPSSSVRP NSPSPTALAF GDHPIVQPKQ LSFKITQTDL TMLKLAALES 180

NKNQDLEKKE GRIDDLLRAN CDLRRQIDEQ QKLLEKYKER LNKCISMSKK LLIEKSTQEK 240

LSSREKSMQD RLRLGHFTTV RHGASFTEQW TDGFAFQNLV KQQEWVNQQR EDIERQRKLL 300

AKRKPPTANN SQAPSTNSES KQRKNKAVNG AENDPFVRPN LPQLLTLAEY HEQEEIFKLR 360

LGHLKKEEAE IQAELERLER VRNLHIRELK RINNEDNSQF KDHPTLNERY LLLHLLGRGG 420

FSEVYKAFDL YEQRYAAVKI HQLNKSWRDE KKENYHKHAC REYRIHKELD HPRIVKLYDY 480

FSLDTDTFCT VLEYCEGNDL DFYLKQHKLM SEKEARSIVM QIVNALRYLN EIKPPIIHYD 540

LKPGNILLVD GTACGEIKIT DFGLSKIMDD DSYGVDGMDL TSQGAGTYWY LPPECFVVGK 600

EPPKISNKVD VWSVGVIFFQ CLYGRKPFGH NQSQQDILQE NTILKATDVQ FPVKPVVSSE 660

AKAFIRRCLA YRKEDRFDVH QLANDPYLLP HMRRSNSSGN LHMAGLTASP TPPSSSILTY 720

Nucleotide Sequence
(FASTA)

GGTGCAATGG ATGAGCTTCA TAGTCTGGAT CCAAGAAGGC AAGAATTATT GGAAGCTAGA 60

TTTACAGGAG TTGCAAGTGG GAGCACGGGG AGCACGGGCA GTTGCAGTGT TGGAGCTAAA 120

GCCTCAACAA ATAATGAAAG CTCTAATCAC AGTTTTGGAA GCTTGGGATC TTTGAGTGAC 180

AAAGAATCAG AGACACCAGA GAAGAAACAA TCAGAATCAT CCAGAGGAAG AAAAAGAAAA 240

GCAGAAAACC AGAATGAAAG TAGTCAGGGA AAAAGTATTG GGGGACGTGG CCACAAAATT 300

AGCGACTATT TTGAATACCA AGGTGGAAAT GGCTCAAGTC CAGTAAGAGG CATACCTCCT 360

GCAATCCGTT CGCCTCAAAA TTCACATTCA CATTCCACGC CTTCTTCATC TGTTCGACCG 420

AATAGCCCTT CTCCTACTGC GTTAGCTTTT GGGGACCACC CTATTGTACA GCCAAAGCAG 480

TTATCCTTTA AAATTACTCA GACTGATCTT ACGATGCTGA AATTAGCAGC ATTAGAAAGT 540

AATAAAAACC AGGACCTGGA AAAGAAGGAA GGTCGCATAG ATGACTTGCT CAGGGCTAAT 600

TGTGATCTCA GACGGCAGAT AGATGAGCAA CAAAAGCTAC TTGAAAAATA CAAAGAGCGA 660

TTAAATAAGT GCATATCAAT GAGCAAGAAA CTGCTTATTG AAAAGAGTAC ACAAGAAAAA 720

CTGTCAAGCC GAGAGAAGAG CATGCAAGAC AGATTACGCC TTGGGCATTT CACAACAGTT 780

AGACATGGTG CTTCATTTAC TGAACAATGG ACAGATGGTT TTGCATTTCA GAATCTTGTA 840

AAGCAACAAG AATGGGTGAA TCAGCAAAGG GAAGATATTG AAAGGCAAAG GAAACTTCTA 900

GCCAAACGCA AACCTCCCAC AGCTAATAAT TCTCAGGCAC CCTCTACCAA TTCTGAATCA 960

AAACAAAGGA AAAACAAAGC AGTCAATGGA GCAGAAAATG ATCCCTTCGT TAGACCAAAT 1020

TTACCACAAC TGTTGACTTT GGCAGAATAT CATGAACAGG AAGAAATTTT CAAACTTAGA 1080

CTAGGACATC TCAAAAAGGA AGAGGCAGAA ATCCAGGCAG AACTTGAACG TTTGGAAAGA 1140

GTCAGAAATC TTCATATTCG AGAGCTCAAA AGAATAAATA ATGAAGATAA TTCACAGTTC 1200

AAAGATCACC CAACGTTAAA TGAAAGATAT TTATTGCTCC ATCTGCTTGG TAGAGGTGGC 1260

TTTAGTGAAG TATATAAGGC TTTTGACCTT TATGAACAAA GATATGCTGC TGTGAAGATC 1320

CACCAGCTTA ATAAAAGCTG GAGGGATGAG AAGAAGGAAA ACTACCACAA ACATGCCTGC 1380

AGAGAGTATA GAATACACAA AGAACTGGAT CACCCCAGAA TAGTTAAACT CTATGACTAT 1440

TTCTCCTTGG ATACAGATAC GTTTTGTACA GTGTTAGAAT ACTGTGAAGG CAATGACTTG 1500

GATTTCTATC TGAAGCAACA TAAGTTAATG TCAGAGAAAG AAGCTAGGTC TATTGTAATG 1560

CAAATTGTAA ATGCACTAAG ATATCTCAAT GAAATAAAAC CCCCTATTAT ACATTATGAT 1620

CTTAAGCCAG GAAACATCCT CCTGGTAGAT GGAACAGCAT GTGGAGAAAT AAAAATCACG 1680

GATTTTGGTC TGTCCAAGAT CATGGATGAT GACAGCTATG GTGTAGATGG AATGGATCTA 1740

ACATCCCAGG GGGCAGGCAC ATACTGGTAT TTACCTCCCG AATGTTTCGT AGTTGGAAAG 1800

GAACCGCCAA AGATTTCCAA CAAGGTTGAC GTGTGGTCAG TTGGAGTCAT CTTCTTTCAA 1860

TGTCTTTATG GTAGAAAGCC ATTTGGTCAC AATCAATCTC AGCAAGACAT TCTTCAAGAA 1920

AATACGATAT TAAAAGCCAC TGATGTCCAA TTCCCTGTAA AACCTGTCGT AAGCAGTGAA 1980

GCAAAGGCCT TTATAAGACG CTGTTTGGCA TACCGAAAAG AAGATAGGTT TGATGTGCAC 2040

CAACTGGCAA ATGACCCCTA CCTTCTCCCA CACATGAGAA GATCCAATTC TTCAGGCAAC 2100

TTACACATGG CTGGGCTGAC AGCATCACCC ACACCCCCTT CTTCAAGCAT ACTTACTTAC 2160

TGA 2163

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 410   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  469

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 470   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  529

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 530   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  588

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkat+

Q: 589   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATD  648

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvsseakafirrclayrkedr+dv+qla+d+yl

Q: 649   VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL  688

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATDV 240

QFPVKPVVSS EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013