EKS-BOT-00401
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00401
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR613.71.2E-184593950358
StatusUnreviewed
Ensembl ProteinENSBTAP00000009441
UniProt AccessionF1MX49;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000007173ENSBTAP00000009441ENSBTAT00000009441
OrganismBos taurus
Functional Description
Protein Length1089
Protein Sequence
(FASTA)
MGTSHWALLV LGCLFTGPSL ILCQLSLPSI LPNENERVVQ LNSSFSLRCF GESEVSWQYP 60
MSEEEYPDVE IRNEENNSGL FVTVLEVVSA SAAHTGLYTC YYNHTQMDEN EIEGRHIYIY 120
VPDPDVAFVP LGMTDSLVIV EDEDSVIIPC RTTDPETPVT LLSSEGIVPA SYDSRQGFKG 180
TFSVGLYICE ATVRGKKFQT IPFNVYAYTA TSKLDLEMES PKTVYKAGES IVVTCTVFNN 240
EVVDFQWTYP GQMKGKGITR LEETKFPSIK LVYTLRVPEA TVKDSGDYEC AAHQATKEVK 300
KMRNVTISVH EKGFIEIKPN FNLLEAVNLH EVKHFVVDVQ AYPPPKITWL KDNLTLIENL 360
TEITTDIEKI QEISYRSKLK LIRAKEEDSG HYTIVVQNED DVKSYTFELL TQVPSSILDL 420
VDDHHGSNGG QTVRCTAEGT PLPDIEWMVC KDIKKCNNET SWTVLANNVS NIITGVHPRD 480
RSTVEGQVTF AKVEETIAVR CLAKNLLGVE SRELKLVAPT LRSELTVAAA VLVLLVIVII 540
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSHHPEK PKKELDIFGL NPADESTRSY 720
VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRA LYDRPASYKK KSMLDSEVKN 780
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV ENLLPGQYKK 960
SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII 1020
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080
SDLVEDSFL 1089
Nucleotide Sequence
(FASTA)
ATGGGGACTT CCCATTGGGC ACTCCTGGTC TTAGGCTGTC TCTTCACAGG GCCGAGCCTA 60
ATCCTCTGCC AGCTTTCATT ACCCTCCATC CTGCCCAATG AAAATGAGAG GGTTGTGCAG 120
CTGAATTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAGTG AAGTGAGCTG GCAGTACCCC 180
ATGTCTGAAG AAGAGTACCC CGACGTGGAA ATCAGAAACG AGGAGAACAA CAGTGGCCTT 240
TTTGTGACAG TGCTGGAAGT GGTCAGCGCC TCGGCGGCCC ACACTGGGCT GTACACTTGC 300
TATTACAACC ACACGCAGAT GGACGAGAAC GAGATCGAGG GCAGGCACAT TTACATCTAC 360
GTGCCAGACC CAGATGTAGC CTTCGTACCT CTAGGAATGA CAGATTCCTT GGTCATCGTG 420
GAGGACGAAG ATTCGGTCAT CATCCCATGC CGCACGACTG ATCCTGAGAC TCCAGTGACC 480
TTACTCAGCA GTGAGGGGAT AGTGCCTGCC TCCTATGACA GCAGACAAGG CTTTAAAGGA 540
ACCTTCAGTG TCGGGCTCTA TATCTGTGAG GCCACGGTCA GAGGGAAGAA GTTCCAGACC 600
ATTCCATTCA ATGTTTATGC TTACACAGCA ACATCAAAAC TTGATCTGGA AATGGAATCT 660
CCTAAGACTG TGTATAAGGC AGGCGAATCA ATTGTGGTCA CCTGCACCGT CTTTAACAAC 720
GAGGTGGTTG ACTTTCAGTG GACTTACCCT GGACAAATGA AAGGCAAAGG CATCACGAGG 780
CTGGAGGAAA CCAAGTTCCC GTCCATCAAG TTGGTGTACA CTCTGAGGGT TCCCGAGGCC 840
ACGGTGAAAG ACAGTGGAGA TTACGAATGT GCTGCCCACC AGGCCACCAA GGAGGTCAAA 900
AAGATGAGGA ACGTCACCAT TTCTGTTCAC GAGAAAGGAT TTATTGAAAT CAAACCCAAC 960
TTTAACCTGT TGGAAGCTGT CAACCTGCAT GAAGTCAAGC ATTTTGTGGT GGATGTGCAG 1020
GCCTATCCCC CTCCCAAGAT AACCTGGCTA AAGGACAACC TGACTCTGAT TGAGAATCTC 1080
ACGGAGATCA CCACTGACAT AGAAAAGATT CAGGAAATAA GTTATCGAAG CAAATTAAAG 1140
CTGATCCGAG CAAAGGAAGA AGACAGCGGC CATTATACTA TTGTAGTTCA AAATGAAGAT 1200
GATGTGAAGA GCTATACTTT TGAACTCTTG ACTCAAGTTC CATCCTCCAT ACTGGACTTG 1260
GTTGACGACC ACCATGGCTC TAATGGGGGC CAGACTGTGA GATGCACAGC CGAAGGGACC 1320
CCTCTTCCTG ATATCGAGTG GATGGTTTGC AAGGATATTA AGAAATGTAA CAATGAAACT 1380
TCATGGACAG TTTTGGCCAA CAACGTTTCA AACATCATCA CAGGGGTCCA CCCCCGAGAC 1440
AGGAGCACAG TGGAAGGCCA GGTGACATTT GCCAAAGTGG AGGAGACCAT TGCAGTCCGG 1500
TGTCTGGCCA AGAACCTCCT CGGGGTGGAA AGCCGAGAGC TGAAGCTGGT GGCTCCCACT 1560
CTGCGCTCTG AGCTCACTGT GGCGGCTGCT GTCCTGGTGT TGTTGGTGAT TGTGATCATC 1620
TCACTCATTG TCCTGGTCGT CATTTGGAAA CAGAAACCAA GGTATGAAAT CCGTTGGAGG 1680
GTCATTGAAT CAATCAGCCC TGATGGACAT GAATACATTT ATGTGGACCC GATGCAGCTG 1740
CCTTACGACT CGAGATGGGA GTTTCCAAGA GATGGACTCG TGCTTGGTCG GATCCTGGGG 1800
TCTGGTGCAT TTGGGAAAGT GGTTGAAGGA ACTGCTTATG GATTAAGTCG GTCTCAACCT 1860
GTCATGAAAG TAGCAGTGAA GATGCTAAAA CCCACAGCCA GATCCAGTGA AAAACAAGCT 1920
CTCATGTCTG AACTGAAGAT AATGACCCAC CTGGGGCCAC ATTTAAACAT CGTGAACTTG 1980
CTGGGCGCCT GCACCAAGTC AGGCCCCATT TACATCATCA CTGAGTACTG CTTCTATGGG 2040
GATTTGGTCA ACTATTTGCA TAAGAATAGG GACAGCTTCC TGAGCCACCA TCCAGAGAAG 2100
CCAAAGAAAG AGCTGGACAT TTTTGGATTG AACCCGGCTG ACGAAAGCAC AAGAAGTTAC 2160
GTTATCTTAT CTTTTGAAAA TAATGGTGAC TACATGGACA TGAAGCAAGC TGACACGACA 2220
CAGTATGTCC CCATGCTGGA GAGAAAAGAG GTTTCTAAAT ACTCGGACAT CCAGAGAGCG 2280
CTGTATGATC GCCCAGCCTC GTATAAGAAG AAATCCATGT TAGACTCAGA AGTCAAAAAC 2340
CTCCTTTCAG ATGATAACTC AGAAGGCCTG ACTTTGTTGG ATTTGTTGAG CTTTACCTAT 2400
CAAGTCGCCC GAGGAATGGA GTTTTTGGCT TCAAAAAATT GTGTCCATCG GGACCTGGCG 2460
GCTCGCAACG TCCTCCTGGC GCAAGGGAAA ATCGTGAAGA TCTGTGACTT TGGCCTGGCC 2520
AGAGACATCA TGCATGATTC GAACTACGTG TCCAAAGGCA GTACCTTTCT CCCCGTGAAG 2580
TGGATGGCTC CTGAGAGCAT CTTTGACAAC CTGTACACCA CGCTGAGTGA CGTCTGGTCC 2640
TATGGCATCC TGCTCTGGGA GATCTTTTCC CTTGGTGGCA CACCCTACCC TGGCATGATG 2700
GTGGACTCTA CATTCTACAA TAAGATCAAG AGTGGATACC GGATGGCCAA GCCTGACCAT 2760
GCCACCAGTG AAGTCTACGA GATCATGGTG AAGTGCTGGA ACAGTGAGCC GGAGAAGAGA 2820
CCCTCCTTTT ACCACCTGAG TGAAATTGTG GAGAATCTGC TGCCTGGACA ATATAAAAAG 2880
AGTTATGAAA AGATCCACCT GGACTTTCTG AAGAGTGACC ATCCCGCTGT GGCACGCATG 2940
CGCGTGGACT CCGACAACGC CTACATTGGC GTCACCTACA AAAATGAGGA AGACAAGCTG 3000
AAGGACTGGG AGGGTGGCCT CGACGAGCAG AGGCTGAGTG CAGATAGCGG CTACATCATC 3060
CCTCTGCCCG ACATCGACCC TGTTCCTGAG GAGGAAGACC TGGGCAAGAG GAACAGACAC 3120
AGCTCACAGA CCTCTGAAGA GAGTGCCATT GAGACAGGTT CCAGCAGTTC TACGTTCATC 3180
AAGAGAGAGG ATGAGACCAT CGAGGACATC GACATGATGG ACGACATTGG CATAGACTCC 3240
TCGGATCTGG TGGAGGACAG CTTCCTGTAA 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---PKKELDIFG  709
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++y+d+k++                +sd++++ +d++as+k
Q: 710   LnPADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkevskYSDIQRALYDRPASYK  769
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSHHPEKPK KELDIFGLNP 120
ADESTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKEVS KYSDIQRALY DRPASYKKKS 180
MLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0055003; P:cardiac myofibril assembly
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0048701; P:embryonic cranial skeleton morphogenesis
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0060325; P:face morphogenesis
GO:0001701; P:in utero embryonic development
GO:0033327; P:Leydig cell differentiation
GO:0030324; P:lung development
GO:0001553; P:luteinization
GO:0030539; P:male genitalia development
GO:0072277; P:metanephric glomerular capillary formation
GO:0010544; P:negative regulation of platelet activation
GO:0042475; P:odontogenesis of dentin-containing tooth
GO:0060021; P:palate development
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0070527; P:platelet aggregation
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
bta:282301;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013