EKS-BOT-00292

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00292

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	299.2	2.4E-89	753	1017	265

Status

Unreviewed

Ensembl Protein

ENSBTAP00000009521

UniProt Accession

F1MWP1;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1B

Gene Synonyms/Alias

BUB1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000007237	ENSBTAP00000009521	ENSBTAT00000009521

Organism

Bos taurus

Functional Description

Protein Length

1062

Protein Sequence
(FASTA)

MAAMQKERGA PSDIMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQQES ACNTTLQQQK 60

RAFESEIRFY AGNDPLDVWD RYINWTEQNY PQGGKESNMS TLLERAVEAL QGEKRYYNDP 120

RFLSLWLKLG HLCNEPLDMY SYLHNQGIGI SLAQFYISWA EEYEARENFK KADLIFQEGI 180

EQKAEPLERL QSQHRQFQAR VSRQTLLALE KEEEEEVVGS SVPQRSTLAE LKSKGKKTAR 240

APISRVGGAL KAPSQNRGLQ NPVPQQMQSN TRIIVFDENT DEASRAEPSK PTVQPWIAPP 300

VSRGKENELQ AGPWNTGRPL EYRPRGNTAS MTAVPSMLPS FTPYVEETAQ QPVMTPCKIE 360

PSINHILSTR KPGKEEGDLL QRVQSLQQES EKKEKMMYCK EKIYAGVGEF SFEEIRAEVF 420

RKKLKERREA ELLTSAEKRA EMQKQIEEME KKLKEIQTTQ QERANEQQEE KMPTKETAEL 480

PIASESQEIS GMALSNFVCP VNSCARETSL AENVWQEQPH SKSSSVPFSI FDESLLSEKK 540

PVSPSAAPSR VLAQRRPLAI LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT 600

ICPNPEDTCD FARAARFAST PFHEIISLKD LPSDPERLLQ EEDLDMKTSE DQQTACGTIY 660

NPPLSIKKLS PIIEDSREAT HSSGFSGSSA SVTSTSSIKS LQIPEKLELT SDTADSPTQS 720

PWCPQYRRQL VKSLPELSVS TEFFVEDRPM PSLEIEKEIE LDNEEYCIRQ EYLVCEDYKL 780

FWVTPRNTAE LTIIKVSSHP VPWDFYINFK LKERLNEECD NLCSCYQYQD GCIVWHQYIN 840

CFTLQDLLQH SEFITHEMTV LIIYNLLTMV EKLHKAEIVH GDLSPRSLIL RNRIHDPYDF 900

NKNNQALKIV DFSYSVDLRA QLDVFNLSGF RTVQTLEGQK ILANCSSPYQ VDLFGIADLA 960

HLLLFKEHLQ VFWDGSLWKL SQNISELKDG ELWNKFFLRI LNASDESTVS VLGELAAEMN 1020

GVFDTTFQSH LNKAFWKVGK LISPGAFLFQ QDRQSSLSQI PA 1062

Nucleotide Sequence
(FASTA)

ATGGCGGCGA TGCAGAAGGA AAGGGGTGCT CCGAGTGACA TCATGTCCTT GGAGGGAGAT 60

GAATGGGAGC TGAGTAAAGA AAATGTCCAA CCTTTAAGGC AGGGGCGGAT CATGTCCACA 120

CTTCAGGGAG CTCTGGCACA GCAAGAATCT GCCTGTAACA CTACTCTTCA ACAACAAAAA 180

CGAGCATTTG AATCTGAAAT TCGATTTTAT GCTGGAAATG ACCCTCTGGA TGTTTGGGAT 240

AGATATATTA ACTGGACAGA GCAAAACTAT CCTCAGGGCG GGAAGGAAAG CAATATGTCA 300

ACATTACTAG AAAGAGCTGT AGAAGCACTA CAAGGAGAAA AACGATATTA TAATGATCCT 360

CGATTTCTTA GTCTCTGGCT TAAGCTGGGG CATTTATGCA ATGAACCTTT GGATATGTAC 420

AGTTATTTAC ATAACCAAGG AATTGGCATT TCACTTGCTC AGTTTTATAT CTCATGGGCT 480

GAAGAATATG AAGCTAGAGA AAACTTTAAG AAAGCAGATC TGATATTTCA AGAAGGTATT 540

GAACAGAAGG CTGAACCACT GGAAAGACTG CAGTCCCAGC ACAGACAATT CCAAGCTCGA 600

GTGTCTCGGC AAACTCTGTT GGCACTTGAG AAAGAAGAGG AGGAGGAAGT TGTGGGATCT 660

TCTGTACCAC AGCGAAGCAC ACTGGCTGAA CTAAAAAGCA AAGGGAAAAA GACAGCAAGA 720

GCTCCAATCA GCCGTGTAGG GGGTGCTCTC AAGGCTCCAA GCCAGAACAG AGGTCTCCAA 780

AATCCAGTTC CTCAACAGAT GCAAAGTAAT ACTAGAATTA TTGTTTTTGA TGAAAATACT 840

GATGAGGCTT CTAGAGCAGA GCCATCTAAG CCTACAGTCC AGCCATGGAT AGCACCTCCT 900

GTGTCCAGGG GCAAAGAGAA TGAGCTGCAA GCCGGCCCTT GGAACACAGG CAGGCCTTTG 960

GAATACAGGC CTCGAGGCAA TACAGCGTCT ATGACAGCTG TACCCTCTAT GCTTCCAAGT 1020

TTTACTCCAT ATGTGGAAGA GACTGCACAA CAGCCAGTTA TGACACCATG TAAAATTGAA 1080

CCCAGTATAA ACCACATTCT AAGCACAAGA AAGCCTGGAA AGGAAGAAGG AGATCTCCTG 1140

CAGAGAGTTC AAAGTCTTCA GCAAGAGTCT GAGAAGAAGG AGAAGATGAT GTATTGTAAG 1200

GAGAAGATTT ATGCAGGAGT GGGGGAGTTC TCCTTTGAAG AGATCCGGGC TGAGGTTTTC 1260

CGGAAGAAAT TAAAAGAGCG AAGAGAAGCT GAGCTACTGA CCAGTGCAGA GAAAAGAGCA 1320

GAAATGCAGA AACAGATTGA AGAGATGGAG AAGAAGCTAA AAGAAATCCA AACTACTCAG 1380

CAAGAAAGAG CGAATGAACA GCAAGAAGAA AAGATGCCTA CAAAGGAGAC AGCTGAACTG 1440

CCAATTGCTT CAGAGTCTCA GGAAATATCA GGAATGGCTC TGTCCAATTT TGTTTGCCCA 1500

GTAAACTCTT GTGCCAGGGA AACATCACTT GCAGAAAACG TTTGGCAAGA ACAACCTCAT 1560

TCTAAAAGTT CCAGTGTACC TTTCTCCATT TTTGATGAAT CTCTTCTTTC AGAAAAAAAG 1620

CCTGTCAGTC CTTCTGCAGC TCCCTCACGT GTTTTAGCCC AACGAAGACC TCTTGCAATT 1680

CTCAAAACTT CAGAAAGCAT CACCTCAAAT GAGGATGTAT CTCCAGATGT TTGTGATGAA 1740

TTTACAGGAA TTGAGCCCTT GAGTGAGGAT GCTATTATCA CAGGTTTCAG GAATGTAACT 1800

ATTTGTCCTA ACCCAGAAGA CACTTGTGAC TTCGCTAGAG CAGCTCGTTT TGCATCCACT 1860

CCTTTTCATG AAATAATATC CTTGAAGGAT CTCCCTTCTG ATCCTGAGAG ACTGTTGCAG 1920

GAAGAGGATC TAGATATGAA GACCTCTGAG GACCAGCAAA CTGCTTGTGG CACTATCTAC 1980

AATCCACCTC TCAGCATCAA GAAGCTGAGC CCAATTATTG AAGACAGCCG TGAAGCCACA 2040

CATTCCTCTG GGTTCTCCGG ATCTTCTGCC TCAGTTACAA GCACCTCCTC CATCAAAAGT 2100

CTTCAAATTC CTGAGAAACT GGAGCTCACT AGTGATACTG CAGACAGCCC TACTCAGTCA 2160

CCCTGGTGTC CACAGTATCG CAGACAACTG GTAAAATCCC TACCAGAGCT GAGTGTCTCT 2220

ACAGAGTTTT TTGTAGAAGA TAGACCAATG CCTAGTTTGG AAATAGAGAA GGAAATTGAA 2280

TTAGATAATG AGGAATATTG CATTAGACAA GAATACCTGG TATGTGAAGA CTACAAATTA 2340

TTCTGGGTGA CACCAAGAAA CACTGCCGAG TTAACCATAA TAAAGGTATC TTCTCATCCT 2400

GTCCCATGGG ACTTCTATAT CAACTTCAAG TTAAAGGAAC GTTTAAATGA GGAGTGTGAT 2460

AATTTGTGTA GCTGTTATCA ATACCAAGAT GGCTGTATCG TTTGGCATCA ATATATAAAC 2520

TGCTTCACCC TTCAGGATCT TCTTCAACAC AGTGAATTTA TTACCCATGA AATGACGGTA 2580

TTGATTATTT ATAACCTTTT GACAATGGTG GAGAAACTAC ACAAAGCAGA AATAGTCCAT 2640

GGTGACTTGA GTCCAAGGAG CCTGATTCTT AGAAACAGAA TCCACGATCC CTATGATTTT 2700

AATAAGAACA ATCAAGCTTT GAAGATAGTG GACTTTTCCT ACAGTGTTGA CCTTAGGGCA 2760

CAGCTAGACG TTTTTAACCT CAGTGGCTTT CGGACTGTAC AAACCCTGGA AGGACAAAAG 2820

ATCCTGGCTA ACTGTTCTTC TCCATACCAG GTAGATCTGT TTGGTATAGC AGATTTAGCA 2880

CATTTATTAT TGTTCAAGGA GCACCTACAG GTCTTCTGGG ATGGTTCCCT CTGGAAACTT 2940

AGCCAAAATA TTTCTGAGCT AAAAGATGGT GAATTGTGGA ATAAATTCTT TTTGCGGATT 3000

CTGAATGCCA GTGATGAGTC CACAGTGTCT GTTCTGGGGG AACTTGCAGC AGAAATGAAT 3060

GGGGTGTTTG ACACCACATT CCAAAGTCAC CTGAACAAAG CTTTTTGGAA AGTGGGGAAG 3120

TTAATCAGTC CTGGGGCTTT CCTCTTCCAG CAAGATAGGC AGTCAAGCCT CTCACAGATT 3180

CCTGCCTAA 3189

Domain Profile

S: 1     leiekeigeGayakvykaeh....dsk........sgelvalKvekpansWefYIclqlk  48

         leiekei+  ++++++++e+    d+k        ++el+++Kv++ +++W+fYI+ +lk

Q: 753   LEIEKEIELDNEEYCIRQEYlvceDYKlfwvtprnTAELTIIKVSSHPVPWDFYINFKLK  812

         68******************999988899999999*************************

S: 49    eRlkeeellksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvll  108

         eRl+ee      ++++s++++qd+++++++y++++tl+dl+++++ +t     +e++vl+

Q: 813   ERLNEE-----CDNLCSCYQYQDGCIVWHQYINCFTLQDLLQHSEFIT-----HEMTVLI  862

         ****99.....9************************************.....*******

S: 109   ivqllkiveklHeveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllp  168

         i++ll++veklH++eI+HgDl+P++++l+nri+d++d +k++++lk++Df++s+D++ ++

Q: 863   IYNLLTMVEKLHKAEIVHGDLSPRSLILRNRIHDPYDFNKNNQALKIVDFSYSVDLRAQL  922

         ************************************************************

S: 169   dgtkfkgkaktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkq  228

         d+++++g+++++++e++++la++s++YqvDlfg+a+++h+llf+++l+v+++g+ wkl+q

Q: 923   DVFNLSGFRTVQTLEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSLWKLSQ  982

         ************************************************************

S: 229   kikrllkkelwekiferlLNisdastlpsleelve  263

         +i++l++ elw+k+f r+LN+sd+st+++l+el++

Q: 983   NISELKDGELWNKFFLRILNASDESTVSVLGELAA  1017

         ********************************986

Domain Sequence
(FASTA)

LEIEKEIELD NEEYCIRQEY LVCEDYKLFW VTPRNTAELT IIKVSSHPVP WDFYINFKLK 60

ERLNEECDNL CSCYQYQDGC IVWHQYINCF TLQDLLQHSE FITHEMTVLI IYNLLTMVEK 120

LHKAEIVHGD LSPRSLILRN RIHDPYDFNK NNQALKIVDF SYSVDLRAQL DVFNLSGFRT 180

VQTLEGQKIL ANCSSPYQVD LFGIADLAHL LLFKEHLQVF WDGSLWKLSQ NISELKDGEL 240

WNKFFLRILN ASDESTVSVL GELAA 265

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0000940	; C:condensed chromosome outer kinetochore
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0007091	; P:mitotic metaphase/anaphase transition
GO:0034501	; P:protein localization to kinetochore

KEGG

bta:100851213	;
bta:537027	;

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013