EKS-BOT-00265
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00265
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK472.29.2E-142220533314
StatusUnreviewed
Ensembl ProteinENSBTAP00000009545
UniProt AccessionE1BG90;
Protein Name
Protein Synonyms/Alias
Gene NameDYRK2
Gene Synonyms/Alias DYRK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000007256ENSBTAP00000009545ENSBTAT00000009545
OrganismBos taurus
Functional Description
Protein Length599
Protein Sequence
(FASTA)
MLTRKPSAAA PSRYPTGRGG DSAVRQLQAS PGLGAGAPRS GVGTGPPSPI ALPPLRASNA 60
ATAAHTIGGS KHTMNDHLHV SSHGQIQVQQ LFEDNSNKRT VLTTQPNGLT TVGKTGLPVV 120
PERQLESIHR RQGSSTSLKS LEGMGKVKAT PMTPEQAMKQ YMQKLTSFEH HEIFSYPEIY 180
FLGPNAKKRQ GMTGGPNNGG YDDDQGSYVQ VPHDHVAYRY EVLKVIGKGS FGQVVKAYDH 240
KVHQHVALKM VRNEKRFHRQ AAEEIRILEH LRKQDKDNTM NVIHMLENFT FRNHICMTFE 300
LLSMNLYELI KKNKFQGFSL PLVRKFAHSI LQCLDALHKN RIIHCDLKPE NILLKQQGRS 360
GIKVIDFGSS CYEHQRVYTY IQSRFYRAPE VILGARYGMP IDMWSLGCIL AELLTGYPLL 420
PGEDEGDQLA CMIELLGMPS QKLLDASKRA KNFVSSKGYP RYCTVTTLSD GSVVLNGGRS 480
RRGKLRGPPE SREWGNALKG CDDPLFLDFL KQCLEWDPAV RMTPGQALRH PWLRRRLPKP 540
PTGEKTSVKR ITESTGAITS ISKLPPPSSS ASKLRTNLAQ MTDANGNIQQ RTVLPKLVS 599
Nucleotide Sequence
(FASTA)
ATGTTAACCA GGAAACCTTC GGCCGCCGCT CCCTCCAGGT ACCCGACCGG CCGAGGAGGG 60
GACAGCGCCG TTCGCCAGCT TCAGGCTTCC CCGGGGCTTG GTGCGGGGGC TCCCCGGAGC 120
GGAGTGGGGA CCGGCCCGCC CTCCCCCATC GCCCTGCCGC CTCTCCGAGC CAGCAACGCT 180
GCCACCGCAG CCCACACGAT TGGCGGCAGT AAGCACACAA TGAATGACCA CCTACACGTC 240
AGCAGCCACG GACAGATCCA GGTTCAGCAG CTGTTTGAGG ATAACAGTAA CAAGCGGACA 300
GTGCTCACGA CACAACCAAA TGGGCTTACC ACGGTGGGCA AAACGGGGTT GCCAGTGGTG 360
CCGGAGCGGC AGCTGGAGAG CATCCACAGA CGGCAGGGGA GTTCCACCTC TCTGAAGTCT 420
CTGGAAGGCA TGGGGAAGGT GAAAGCCACC CCCATGACTC CGGAGCAAGC GATGAAGCAA 480
TACATGCAAA AACTAACCAG CTTTGAACAC CATGAGATTT TCAGCTACCC TGAAATATAC 540
TTCTTAGGTC CAAATGCAAA GAAGCGCCAG GGCATGACAG GCGGGCCCAA CAACGGTGGC 600
TACGACGACG ACCAGGGGTC CTATGTGCAG GTGCCCCACG ATCACGTGGC TTACAGGTAC 660
GAGGTCCTCA AGGTCATTGG GAAGGGGAGC TTTGGGCAGG TGGTCAAGGC CTACGACCAC 720
AAAGTCCACC AGCACGTGGC CCTGAAGATG GTGCGGAACG AGAAGCGCTT CCACCGGCAG 780
GCGGCCGAGG AGATCCGCAT CCTGGAGCAT CTGCGCAAGC AGGACAAGGA CAACACCATG 840
AACGTCATCC ACATGTTGGA GAACTTCACC TTCCGCAACC ACATCTGCAT GACATTCGAG 900
CTGCTCAGCA TGAACCTCTA TGAGCTCATC AAGAAGAACA AGTTCCAGGG CTTTAGTCTG 960
CCTCTGGTTC GCAAGTTCGC CCACTCCATC CTGCAGTGCC TGGACGCTTT GCACAAAAAC 1020
AGGATAATTC ACTGTGACTT GAAGCCCGAG AACATTTTAT TGAAGCAGCA GGGTAGAAGC 1080
GGGATTAAAG TGATTGATTT TGGCTCCAGT TGTTATGAGC ACCAGCGGGT CTACACATAC 1140
ATCCAGTCCC GTTTCTACCG GGCCCCGGAA GTGATCCTTG GCGCCAGGTA TGGCATGCCC 1200
ATCGACATGT GGAGCCTGGG CTGCATCCTC GCAGAGCTCC TGACTGGTTA CCCCCTCTTG 1260
CCTGGGGAGG ATGAAGGGGA CCAGCTGGCC TGTATGATTG AACTGCTGGG CATGCCCTCC 1320
CAGAAACTGC TGGATGCATC CAAACGAGCC AAAAATTTTG TGAGCTCCAA GGGTTATCCT 1380
CGTTACTGCA CTGTCACGAC TCTCTCAGAC GGCTCCGTGG TCCTCAATGG TGGCCGTTCC 1440
CGGAGGGGGA AACTGAGGGG CCCACCAGAG AGCAGAGAGT GGGGGAATGC ACTGAAGGGG 1500
TGTGACGATC CCCTCTTCCT TGACTTCTTA AAACAGTGTT TAGAATGGGA TCCTGCAGTT 1560
CGCATGACCC CTGGCCAGGC TTTGCGGCAC CCCTGGCTGA GGAGGCGGCT GCCAAAGCCT 1620
CCGACGGGGG AGAAGACGTC TGTGAAGAGG ATCACTGAGA GCACTGGTGC TATCACATCC 1680
ATTTCCAAAT TACCTCCACC TTCCAGCTCA GCTTCCAAAC TGAGGACTAA TCTGGCACAG 1740
ATGACAGATG CCAATGGGAA TATTCAGCAG AGGACAGTAT TGCCAAAACT GGTTAGCTGA 1800
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++
Q: 220   YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT  279
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++
Q: 280   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  339
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180
         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y 
Q: 340   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  398
         *************************************.**********************
S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240
         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+
Q: 399   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKG  458
         ************************************************************
S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300
         +p+y+++t+ sd +++l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp
Q: 459   YPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP  518
         ************************************************************
S: 301   akRitpkealkhpfv  315
         a R+tp +al+hp++
Q: 519   AVRMTPGQALRHPWL  533
         **************6
Domain Sequence
(FASTA)
YEVLKVIGKG SFGQVVKAYD HKVHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNT 60
MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120
NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180
PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDASKR AKNFVSSKGY 240
PRYCTVTTLS DGSVVLNGGR SRRGKLRGPP ESREWGNALK GCDDPLFLDF LKQCLEWDPA 300
VRMTPGQALR HPWL 314
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00254
EKS-CAE-00237
EKS-CAJ-00271
EKS-CAF-00272
EKS-CAP-00300
EKS-CHH-00017
EKS-CII-00159
EKS-CIS-00039
EKS-DAR-00600
EKS-DAN-00013
EKS-DRM-00136
EKS-ECT-00027
EKS-EQC-00257
EKS-ERE-00019
EKS-FEC-00251
EKS-GAM-00163
EKS-GAG-00222
EKS-GAA-00325
EKS-GOG-00265
EKS-HOS-00271
EKS-ICT-00250
EKS-LAC-00277
EKS-LOA-00275
EKS-MAM-00267
EKS-MEG-00210
EKS-MUM-00296
EKS-MUP-00262
EKS-MYL-00267
EKS-NOL-00243
EKS-OCP-00023
EKS-ORN-00342
EKS-ORA-00232
EKS-ORC-00250
EKS-ORL-00319
EKS-OTG-00271
EKS-PAT-00250
EKS-PES-00235
EKS-PEM-00140
EKS-POA-00258
EKS-PTV-00034
EKS-RAN-00280
EKS-SAH-00249
EKS-SOA-00021
EKS-SUS-00230
EKS-TAG-00280
EKS-TAR-00338
EKS-TEN-00333
EKS-TUB-00020
EKS-TUT-00030
EKS-XET-00340
EKS-XIM-00334
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0030529; C:ribonucleoprotein complex
GO:0000151; C:ubiquitin ligase complex
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0007224; P:smoothened signaling pathway
KEGG
bta:514916;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013