EKS-BOT-00308

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00308

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	533.6	9.0E-161	434	703	270

Status

Unreviewed

Ensembl Protein

ENSBTAP00000053536

UniProt Accession

F1MUQ3;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000007379	ENSBTAP00000053536	ENSBTAT00000061456
ENSBTAG00000007379	ENSBTAP00000009703	ENSBTAT00000009703

Organism

Bos taurus

Functional Description

Protein Length

796

Protein Sequence
(FASTA)

WLFTTCGASG PHGPTQAQCN NAYRNSNLSV VVGSEGPLKG IQTWKVPATD TYSISGYGAA 60

GGKGGKNTMM RSHGVSVLGI FNLEKDDTLY ILVGQQGEDA CPSTNRLIQK VCIGENNVIE 120

EEIRVNKSVH EWAGGGGGGG GATYVFKMKD GVPVPLIIAA GGGGRAYGAK TDTFHPERLE 180

NNSSVLGLNG NSGAAGGGGG WSDNTSLLWS GKSLLEGATG GHSCPQAMKK WGWETRGGFG 240

GGGGGCSSGG GGGGYIGGNA ASNNDPEMDG EDGVSFINPL GILYTPALKV MEGHGEVNIK 300

HYLNCSHCEV DECHMDPESH KIICFCDHGT VLAEDGVSCI VSPTPEPHLP LSLILSVVTS 360

ALVAALVLAF SGIMIVYRRK HQELQAMQME LQSPEYKLSK LRTSTIMTDY NPNYCFAGKT 420

SSISDLKEVP RKNITLIRGL GHGAFGEVYE GQVSGMPNDP SPLQVAVKTL PEVCSEQDEL 480

DFLMEALIIS KFNHQNIVRC IGVSLQALPR FILLELMAGG DLKSFLRETR PRPNQPSSLV 540

MLDLLHVARD IACGCQYLEE NHFIHRDIAA RNCLLTRPGP GRVAKIGDFG MARDIYRASY 600

YRKGGCAMLP VKWMPPEAFM EGIFTSKTDT WSFGVLLWEI FSLGYMPYPS KSNQEVLEFV 660

TSGGRMDPPK NCPGPVYRIM TQCWQHQPED RPNFAIILER IEYCTQDPDV INTALPVEYG 720

PLVEEEEKVP MRPQDPEGIP PLLVSAAQAK REEGREPASN PPSELPQVQG SRNKPTSLWN 780

PTYGSWFTEK PTKKNT 796

Nucleotide Sequence
(FASTA)

TGGCTGTTCA CCACATGCGG GGCCAGTGGG CCCCACGGCC CCACGCAGGC CCAGTGCAAC 60

AATGCCTACC GGAACTCCAA CCTGAGCGTG GTGGTGGGCA GCGAGGGCCC CCTGAAGGGC 120

ATCCAGACTT GGAAGGTGCC AGCCACCGAC ACCTACAGCA TCTCCGGCTA TGGGGCGGCT 180

GGTGGGAAAG GTGGGAAGAA CACCATGATG CGGTCCCACG GCGTGTCTGT GCTGGGCATC 240

TTCAACCTGG AGAAGGACGA CACGTTGTAC ATCCTGGTCG GGCAGCAAGG GGAAGACGCC 300

TGCCCCAGCA CAAACCGATT AATCCAGAAA GTCTGCATTG GAGAAAACAA CGTGATAGAA 360

GAAGAAATCC GCGTGAACAA AAGCGTGCAC GAGTGGGCAG GAGGGGGCGG AGGAGGGGGA 420

GGAGCCACCT ACGTGTTTAA GATGAAGGAT GGCGTGCCGG TGCCTCTGAT CATTGCAGCC 480

GGCGGTGGTG GCAGGGCCTA TGGGGCCAAG ACAGACACAT TCCACCCAGA GAGACTGGAG 540

AATAACTCCT CAGTCCTAGG GCTGAACGGC AATTCTGGAG CTGCAGGTGG TGGAGGTGGC 600

TGGAGTGATA ACACTTCCTT GCTCTGGTCT GGAAAATCTT TACTGGAAGG TGCCACCGGA 660

GGACATTCCT GCCCCCAGGC CATGAAGAAG TGGGGGTGGG AGACAAGAGG GGGTTTCGGA 720

GGGGGTGGAG GGGGGTGCTC CTCCGGTGGA GGAGGCGGAG GATATATAGG TGGCAATGCA 780

GCCTCAAACA ATGACCCCGA GATGGACGGG GAGGACGGGG TTTCCTTCAT CAACCCACTG 840

GGCATCCTGT ACACCCCGGC TTTAAAAGTG ATGGAGGGCC ACGGGGAAGT GAACATTAAG 900

CATTACCTAA ACTGCAGCCA CTGCGAGGTA GACGAGTGCC ACATGGACCC CGAGAGCCAC 960

AAGATCATCT GCTTCTGCGA CCACGGGACC GTGCTGGCTG AGGATGGCGT CTCCTGCATT 1020

GTGTCGCCCA CCCCGGAGCC CCACCTGCCA CTCTCGCTGA TTCTGTCCGT CGTGACCTCT 1080

GCCCTTGTAG CCGCCCTCGT CCTGGCTTTC TCTGGCATCA TGATCGTGTA CCGCCGGAAG 1140

CACCAGGAGC TGCAAGCCAT GCAGATGGAG CTGCAGAGCC CAGAGTACAA GCTGAGCAAG 1200

CTCCGCACCT CCACCATCAT GACCGACTAC AATCCCAACT ACTGTTTTGC TGGCAAGACC 1260

TCCTCCATCA GTGACCTGAA GGAGGTGCCA CGGAAAAACA TCACTCTCAT CCGAGGTCTG 1320

GGCCACGGCG CATTTGGGGA GGTGTATGAA GGTCAGGTGT CTGGAATGCC CAACGACCCC 1380

AGCCCCCTGC AAGTGGCTGT AAAGACGCTG CCGGAGGTGT GCTCTGAACA GGACGAACTG 1440

GATTTCCTCA TGGAAGCCCT GATCATCAGC AAATTCAACC ACCAGAACAT CGTGCGCTGT 1500

ATTGGTGTGA GTCTGCAAGC CCTGCCCCGA TTTATCCTGC TTGAGCTCAT GGCGGGAGGA 1560

GACCTCAAGT CCTTCCTCCG GGAGACGCGT CCTCGTCCGA ACCAGCCCTC CTCCCTGGTC 1620

ATGCTGGATC TCCTGCACGT GGCTCGGGAC ATTGCCTGCG GCTGTCAGTA TCTAGAGGAG 1680

AATCACTTCA TCCACCGGGA CATTGCTGCC AGGAACTGCC TCTTGACCCG CCCAGGCCCT 1740

GGAAGAGTGG CCAAGATCGG AGACTTCGGA ATGGCCCGTG ACATCTACAG AGCGAGCTAC 1800

TACCGAAAGG GAGGCTGTGC AATGCTGCCA GTCAAGTGGA TGCCCCCAGA GGCCTTCATG 1860

GAAGGAATAT TTACTTCTAA AACAGACACG TGGTCCTTCG GAGTGCTGCT ATGGGAAATC 1920

TTCTCTCTTG GATACATGCC ATACCCTAGC AAAAGCAACC AGGAAGTCCT GGAGTTCGTC 1980

ACCAGTGGAG GACGGATGGA CCCACCTAAG AACTGCCCAG GGCCTGTATA CCGGATAATG 2040

ACCCAGTGCT GGCAACATCA GCCTGAAGAC AGGCCCAACT TTGCCATAAT TTTGGAGAGG 2100

ATTGAATACT GCACTCAGGA CCCAGATGTG ATCAACACCG CTTTGCCGGT AGAATACGGG 2160

CCCCTCGTGG AAGAGGAGGA GAAGGTGCCC ATGAGGCCCC AGGACCCCGA GGGAATCCCT 2220

CCTCTCCTGG TCTCGGCGGC CCAGGCCAAG CGAGAGGAGG GCCGCGAGCC GGCCTCCAAC 2280

CCGCCCTCGG AGCTGCCCCA AGTCCAGGGC TCCAGGAACA AGCCCACCAG CCTCTGGAAC 2340

CCCACCTACG GCTCCTGGTT TACAGAGAAA CCCACCAAAA AGAACACT 2388

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfn

Q: 434   ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  493

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+ssl+m dll+va+d+a+

Q: 494   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPSSLVMLDLLHVARDIAC  553

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll+ +Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 554   GCQYLEENHFIHRDIAARNCLLTRPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW  613

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 614   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP  673

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pedrp+f++iler+++

Q: 674   GPVYRIMTQCWQHQPEDRPNFAIILERIEY  703

         ***************************986

Domain Sequence
(FASTA)

ITLIRGLGHG AFGEVYEGQV SGMPNDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP NQPSSLVMLD LLHVARDIAC 120

GCQYLEENHF IHRDIAARNC LLTRPGPGRV AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP 240

GPVYRIMTQC WQHQPEDRPN FAIILERIEY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013