EPS-BOT-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	189.3	1.2E-55	785	1031	247

Status

Unreviewed

Ensembl Protein

ENSBTAP00000053245

UniProt Accession

E1BMD4;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP2

Gene Synonyms/Alias

PHLPP2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000007545	ENSBTAP00000053245	ENSBTAT00000061006

Organism

Bos taurus

Functional Description

Protein Length

1323

Protein Sequence
(FASTA)

MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTSS ASSSSSDLHL 60

VLCTVETPAS EICAGEGRES LYLQLHGDLV SRRLEPTERP LQIVYDYLSR LGFDDPARIQ 120

EEAANPDLGC MLRFYGEKPC QMDHLDRILL SGIYNVRKGK TQLHKWAERL VVLCGTCLIV 180

SSVKDCQTGK MHILPLVGGK VEEVKRRQYS LAFSSAGAQA QTYLVSFETL AEYQRWQRQA 240

SKVVSQRIST VDLSCHSLEE VPEHLFYSQD ITYLNLRHNF MQLERPGGLD TFYKFSQLKG 300

LNLSHNKLGS FPVLLCEIPT LTELNLSCNG FHDLPSQIGS LLNLQTLCLD GNFLTALPEE 360

LGNLQQLSSL GISFNNFSQI PEVYEKLTML DKVFMAGNRV EVLNLGVLKR MSHVKHVDLR 420

ILRMNHLKTM IIENLEGNKY ITHMDLRDNR LTDLDLSSLC NLEQLHCERN QLRELTLSGF 480

SLRTLYANSN RLTTVNVYPV PSLLTSLELS RNLLECVPDW ACEAKKIEIL DVSYNLLTEV 540

PMRILSSLSL RKLMVGHNHV QSLPTLVEHI PLEVLDVQHN LLTRLPDTLF SKALNLRYLN 600

ASANSLESLP SACAGEESLS ALQLLYLTNN LLTDQCVPVL VGHPHLRILH LANNQLQTFP 660

ASKLNKLEQL EELNLSGNKL KTIPTTIANC KRLHTLVAHS NHISIFPEIL QLPQIQFVDL 720

SCNDLTEILI PEALPATLQD LDLTGNTNLV LEHKTLDTFS HITTLKIDQK PLPTTDSTVT 780

STFWSHGLAE MAGQRNKLCV SALAVDNFAE GVGAVYGMFD GDRNEELPRL LQCTMADVLL 840

EEVQQSTNDT VFMANTFLVS HRKLGMAGQK LGCSALLCYI RPDTADPMNS FSLTVANVGT 900

CQAVLCRGGK PVPLSKVFSL EQDPEEAQRV KDQKAIITED NKVNGVTCCT RLLGCTYLYP 960

WILPKPHISS TPLTIQDELL ILGNKALWEH LSYTEAVNAV RHVQDPLAAA KKLCTLSQSY 1020

GCQDNVGAMV VYLNIGEEGC TCEMNGLTLP GPMGFASTTI IKDPPKPTTP SSSSGIASEF 1080

SSEMSTSEVS SEVGSTASDE HNTVGLDAGL LPRPERRCSL HPAPTSGVFQ RQPSCATFSS 1140

NQSDNGLDSD DDQPVEGVIT NGSKVEVEVD IHCCRGRDLE NSPTLPENSP APCPEDRSRG 1200

SLFGIRRQNS VNSGILLPVS KDRTELQKSP STSCLYGKKL SNGSIVPLED SLNLIEVATE 1260

APKKKTGYFA APTQLEPEDQ FVIPRDLEEE VKEQMKHHQE SRHEPEPSEE DRTELPEEFD 1320

TAL 1323

Nucleotide Sequence
(FASTA)

ATGAAGCGCA ATGGGAGCAG AAATTGTTTG AATAGGAGAA GTAGGTTTGG TTCTCGGGAG 60

AGAGACTGGC TGAGAGAAGA TGTGAAGAGA GGCTGTGTTT ACCTGTATGG AGCGGACACG 120

ACCACTGCCA CTACAACCAC CACTTCCTCT GCTTCCTCCT CCTCCTCTGA CTTACATCTT 180

GTCCTTTGCA CAGTAGAGAC ACCAGCATCA GAAATTTGTG CTGGAGAGGG AAGGGAAAGT 240

CTTTATTTGC AGCTTCATGG AGACCTGGTC AGCAGGAGAC TGGAACCTAC CGAACGACCT 300

CTTCAGATTG TTTATGATTA CTTATCCAGG CTGGGGTTTG ATGACCCTGC TCGAATACAA 360

GAGGAGGCAG CAAATCCTGA CCTTGGCTGT ATGCTCCGAT TTTATGGTGA AAAACCATGC 420

CAGATGGATC ATCTGGATCG AATCCTTCTG TCTGGCATCT ATAATGTACG CAAGGGAAAG 480

ACCCAGCTGC ATAAGTGGGC TGAACGCCTG GTTGTTCTCT GTGGCACCTG CCTCATCGTG 540

TCCTCAGTGA AGGATTGTCA GACTGGGAAA ATGCACATAT TGCCTCTGGT TGGGGGAAAG 600

GTAGAAGAAG TGAAGCGACG TCAGTACTCC CTTGCATTCA GCTCAGCTGG AGCCCAAGCG 660

CAGACCTATC TTGTCAGCTT TGAGACTTTG GCTGAGTACC AGAGGTGGCA GCGGCAAGCT 720

TCCAAGGTGG TGTCCCAGCG CATCAGTACT GTCGACCTCT CGTGTCACAG CCTTGAGGAG 780

GTTCCTGAGC ATCTCTTCTA CAGTCAAGAT ATCACCTACC TCAACTTGCG ACACAACTTC 840

ATGCAATTAG AAAGACCAGG GGGCCTTGAC ACTTTCTACA AATTTTCTCA GCTGAAGGGC 900

CTGAACTTGT CCCATAATAA GCTTGGGTCA TTTCCTGTAT TGTTATGTGA AATTCCTACC 960

CTGACTGAGC TCAACCTTTC CTGTAATGGA TTCCATGACC TGCCGAGTCA GATTGGCAGT 1020

CTGCTGAATC TTCAAACCCT CTGTCTTGAT GGCAACTTCC TGACCGCTTT ACCTGAAGAA 1080

CTGGGAAATC TACAACAGCT GTCCTCCCTG GGAATTTCCT TCAACAACTT TAGTCAAATT 1140

CCCGAGGTTT ATGAGAAACT CACTATGTTA GATAAAGTGT TTATGGCCGG AAACCGAGTG 1200

GAAGTGCTAA ACCTGGGGGT GCTGAAACGA ATGAGCCATG TCAAACATGT GGATTTGAGA 1260

ATATTAAGGA TGAACCATCT AAAAACCATG ATTATTGAGA ATCTGGAGGG AAATAAATAC 1320

ATCACCCACA TGGATTTGCG GGACAATCGG CTGACTGACT TAGATCTTAG CTCCTTGTGC 1380

AACTTGGAGC AGCTGCATTG TGAGCGGAAC CAGCTGAGGG AGCTGACCCT CAGTGGCTTC 1440

TCCCTTCGAA CTCTCTACGC CAATTCGAAC AGATTGACAA CAGTGAACGT CTATCCAGTA 1500

CCCAGTCTGC TCACGTCTCT AGAACTCTCC CGAAACCTGC TAGAGTGTGT CCCTGACTGG 1560

GCCTGTGAAG CAAAGAAGAT AGAAATACTA GACGTGAGCT ATAATCTCCT GACAGAGGTT 1620

CCCATGAGAA TCCTTAGTAG CTTGAGTCTT AGGAAACTAA TGGTGGGACA CAATCATGTG 1680

CAGAGCCTTC CCACGCTGGT GGAGCACATC CCTCTGGAGG TGTTGGATGT CCAGCATAAC 1740

CTGCTCACCA GGCTGCCAGA TACTCTCTTC TCTAAGGCCT TAAATCTCAG ATACTTGAAT 1800

GCATCTGCAA ATAGTCTGGA GTCTCTGCCA TCTGCCTGTG CTGGGGAGGA GAGTCTGAGT 1860

GCGTTACAGC TGCTCTACCT GACCAACAAC CTCCTGACAG ATCAGTGTGT GCCCGTCCTG 1920

GTGGGGCATC CGCACCTGCG CATCCTGCAT CTTGCAAACA ACCAGCTACA GACGTTTCCT 1980

GCAAGCAAAC TAAATAAATT GGAGCAGTTG GAGGAACTAA ACCTAAGTGG TAACAAGCTT 2040

AAAACCATCC CCACGACCAT TGCGAACTGC AAAAGGCTGC ACACTCTGGT GGCCCACTCC 2100

AACCACATCA GTATTTTTCC AGAAATACTG CAGTTGCCTC AGATCCAGTT TGTAGACCTA 2160

AGTTGCAATG ACTTGACTGA AATCCTGATT CCAGAGGCTC TGCCTGCTAC TTTACAAGAC 2220

CTGGACCTGA CTGGAAATAC AAATCTTGTT CTGGAACACA AGACACTGGA CACATTTAGC 2280

CATATCACCA CCCTGAAAAT TGATCAGAAA CCTTTGCCAA CAACTGATTC TACAGTTACA 2340

TCAACCTTTT GGAGCCACGG ACTGGCTGAG ATGGCAGGAC AGAGAAACAA GTTATGTGTA 2400

TCTGCTCTAG CTGTGGATAA CTTTGCAGAG GGGGTGGGAG CTGTGTATGG CATGTTTGAT 2460

GGTGACCGGA ATGAGGAGCT CCCTCGCCTT CTCCAGTGTA CCATGGCAGA TGTGCTTTTG 2520

GAAGAGGTAC AGCAGTCAAC AAATGACACA GTTTTCATGG CTAACACCTT CTTGGTATCT 2580

CACAGGAAAT TAGGAATGGC TGGCCAGAAA CTAGGCTGTT CAGCTCTCCT TTGTTACATC 2640

CGTCCTGACA CTGCCGATCC AATGAATAGC TTTAGCTTGA CTGTGGCTAA TGTTGGCACA 2700

TGCCAAGCAG TCCTGTGTCG AGGTGGGAAG CCAGTGCCAC TCTCTAAAGT CTTCAGCCTG 2760

GAACAGGATC CAGAGGAGGC TCAGAGGGTG AAGGACCAAA AAGCCATCAT AACAGAGGAC 2820

AACAAAGTGA ATGGGGTGAC CTGCTGTACC CGGCTGCTGG GCTGTACATA CCTCTACCCT 2880

TGGATCCTCC CCAAGCCCCA CATATCTTCC ACTCCACTCA CCATTCAGGA TGAGCTGCTG 2940

ATTCTGGGAA ACAAAGCGTT GTGGGAACAC TTGTCATATA CAGAAGCGGT CAACGCAGTA 3000

CGCCATGTGC AAGACCCATT AGCAGCTGCC AAGAAGCTGT GCACATTATC CCAGAGCTAT 3060

GGTTGTCAGG ATAATGTGGG GGCGATGGTG GTTTATTTGA ACATTGGTGA GGAAGGCTGT 3120

ACTTGTGAAA TGAATGGGCT CACGCTCCCA GGTCCTATGG GATTTGCTTC AACCACCATC 3180

ATCAAAGACC CACCCAAGCC GACCACTCCT TCCTCCAGTA GTGGTATTGC CTCTGAGTTC 3240

AGTAGCGAGA TGTCCACTTC AGAAGTGAGT AGCGAGGTGG GGTCCACTGC TTCTGATGAA 3300

CATAACACTG TTGGCCTGGA TGCTGGCTTG CTTCCGAGGC CAGAGAGGCG CTGCAGCCTC 3360

CACCCAGCAC CTACTTCGGG GGTGTTCCAG CGCCAGCCCT CTTGTGCGAC TTTCTCGAGT 3420

AACCAGTCTG ACAATGGCCT GGACAGTGAT GATGACCAGC CGGTAGAAGG GGTCATAACA 3480

AACGGCAGCA AGGTGGAAGT AGAAGTAGAT ATCCACTGCT GTCGGGGGAG GGATCTTGAG 3540

AACTCGCCCA CCCTTCCAGA GAATTCTCCT GCCCCGTGCC CTGAGGACCG TTCTAGAGGA 3600

TCGTTATTTG GGATCCGAAG ACAGAACAGT GTGAACAGTG GCATCCTTCT GCCAGTGAGC 3660

AAAGACCGGA CCGAGTTACA GAAGTCTCCC TCCACTTCCT GTCTCTATGG AAAGAAGCTC 3720

TCCAATGGCT CTATTGTACC CCTGGAAGAC AGCCTGAACC TCATCGAGGT GGCCACCGAA 3780

GCACCCAAGA AGAAAACCGG CTATTTTGCT GCCCCCACTC AGCTGGAGCC AGAGGACCAG 3840

TTTGTTATAC CTCGTGACCT AGAAGAAGAA GTGAAGGAAC AAATGAAACA CCACCAGGAA 3900

AGCAGGCACG AGCCTGAGCC CAGTGAAGAG GATCGGACCG AGCTCCCGGA GGAGTTTGAC 3960

ACGGCACTGT AG 3972

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++++ g+rn+++ ++ +++nf++  +     a++g++DG++++e  + +++++ ++l

Q: 785   SHGLAEMAGQRNKLCVSALAVDNFAEGVG-----AVYGMFDGDRNEELPRLLQCTMADVL  839

         6899*********************9877.....59************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++    ++++ + ++a++Fl  +++l       ++ +k G++a++++i+++

Q: 840   LEEVQ----QSTNDTVFMANTFLVSHRKL------GMAGQKLGCSALLCYIRPDtadpmn  889

         ***99....77888889************......89***************9999999*

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsre.dEleRieeaggsvilkdgaRvlGvL  172

           +l+vanvG ++avLcr+gk+v+ls+ ++ +++ +E +R++++++ +++++  +v+Gv+

Q: 890   sfSLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDpEEAQRVKDQKAIITEDN--KVNGVT  947

         ******************************99866**********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R lG++yl+p++ p+P+++s++lt +de liL+ + lw+++s  eav++vr+v +

Q: 948   CCTRLLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQD--  1005

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           + +aakkL++l++++g++dnv a+vv

Q: 1006  --PLAAAKKLCTLSQSYGCQDNVGAMVV  1031

         ..************************97

Domain Sequence
(FASTA)

SHGLAEMAGQ RNKLCVSALA VDNFAEGVGA VYGMFDGDRN EELPRLLQCT MADVLLEEVQ 60

QSTNDTVFMA NTFLVSHRKL GMAGQKLGCS ALLCYIRPDT ADPMNSFSLT VANVGTCQAV 120

LCRGGKPVPL SKVFSLEQDP EEAQRVKDQK AIITEDNKVN GVTCCTRLLG CTYLYPWILP 180

KPHISSTPLT IQDELLILGN KALWEHLSYT EAVNAVRHVQ DPLAAAKKLC TLSQSYGCQD 240

NVGAMVV 247

Keyword

Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0003824	; F:catalytic activity
GO:0005543	; F:phospholipid binding
GO:0008152	; P:metabolic process

KEGG

InterPros

IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR001932	; PP2C-like.

Pfam

PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF00481	; PP2C; 1.

SMARTs

SM00369	; LRR_TYP; 1.
SM00332	; PP2Cc; 1.

Prosites

PS51450	; LRR; 17.
PS50003	; PH_DOMAIN; 1.

Prints

Created Date

20-Feb-2013