EKS-BOT-00407
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00407
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK395.31.7E-11873351279
StatusUnreviewed
Ensembl ProteinENSBTAP00000033611
UniProt AccessionB3FXL5; F1N2G2;
Protein Name
Protein Synonyms/Alias Interleukin-1 receptor-associated kinase M transcript variant 3;
Gene NameIrakM
Gene Synonyms/Alias IrakM; IRAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000007636ENSBTAP00000055425ENSBTAT00000064078
ENSBTAG00000007636ENSBTAP00000033611ENSBTAT00000033701
OrganismBos taurus
Functional Description
Protein Length517
Protein Sequence
(FASTA)
MGHHRAIHLI ANYGATLNPI EQSHREKEFP NMLQKETANV TVDNVLIPER NEKGILLKSS 60
ISFHSIVEGT KNFHKDFLIG EGEIFEVYRV EIQNRTYAIK LFKQGGKMQC KKQWKRFLSE 120
LEVLLLFRHP NILELAAYFT ESEKFCLVYP YMRNGSLFDR LQCVGDTAPL SWHIRIGVLI 180
GTSKAIQYLH NTELCSVICG SISSANILLD DQFQPKLTDF AMAHFRPHLE PQSSAISMTS 240
SSSKHVWYMP EEYIRQGKLS IKTDIYSFGI VIMEVLTGCK VVLDEPKHIQ LRDLLIELME 300
KRGLDSCISF LDKKVPPCPQ NFSAKLFSLA GRCAATRAKL RPSMDEVLNI LESTQASLYF 360
AEDPPTSLKS FRSPSPLFFD NVPSIPVEDD ENQNNPSPPH DQSLRKDRMT QKTPFECSQS 420
EVTFLGFDKK TGSRGNEDSS SRSGSPCEES WSPKCATPSL DLRAPSVHTD TSAEAPGHSY 480
RSRPVETSCS SIFSWNECKL YKKASVSDED KEESKNC 517
Nucleotide Sequence
(FASTA)
ATGGGGCATC ATCGAGCTAT CCATTTAATT GCAAATTATG GAGCAACCTT GAATCCTATA 60
GAGCAGAGTC ATCGGGAGAA AGAATTTCCA AACATGTTAC AAAAGGAAAC AGCCAATGTC 120
ACAGTGGATA ATGTTCTTAT TCCTGAACGT AATGAAAAAG GAATATTGCT AAAATCCTCC 180
ATCAGCTTTC ACAGCATCGT AGAAGGAACC AAAAATTTCC ACAAAGACTT TTTAATCGGA 240
GAAGGGGAAA TTTTTGAGGT ATACAGAGTG GAAATCCAAA ACCGAACATA TGCCATTAAA 300
TTATTTAAAC AGGGGGGAAA GATGCAATGT AAGAAACAAT GGAAGAGGTT TTTGTCTGAG 360
CTTGAAGTTT TGCTACTGTT CCGTCATCCG AACATACTGG AGTTGGCTGC ATATTTTACA 420
GAGAGTGAAA AGTTTTGCCT GGTTTATCCA TATATGAGAA ATGGATCACT CTTTGACAGA 480
TTACAGTGTG TAGGTGACAC AGCCCCACTG TCTTGGCACA TTCGAATCGG TGTATTAATA 540
GGAACATCTA AAGCCATCCA GTACTTGCAC AACACGGAAC TCTGCTCCGT CATCTGTGGC 600
AGTATATCCA GTGCAAACAT ACTTCTGGAT GATCAGTTTC AACCCAAACT AACTGATTTT 660
GCCATGGCAC ACTTCCGACC TCACCTAGAA CCTCAAAGCT CTGCCATAAG CATGACCAGC 720
AGCAGCAGTA AGCATGTGTG GTACATGCCA GAAGAGTATA TCAGACAAGG CAAACTTTCC 780
ATTAAAACAG ACATCTACAG CTTTGGAATT GTAATAATGG AAGTTCTGAC AGGTTGTAAA 840
GTGGTGTTAG ATGAGCCAAA GCATATCCAG CTGCGGGATC TTCTTATAGA ATTGATGGAG 900
AAAAGAGGCC TCGATTCATG TATCTCCTTT CTAGATAAGA AAGTACCTCC CTGTCCACAG 960
AATTTTTCTG CCAAGCTGTT CTCTTTGGCA GGCCGGTGTG CTGCAACACG GGCGAAATTA 1020
AGACCATCGA TGGATGAAGT CCTAAATATT CTTGAAAGTA CTCAAGCCAG CTTGTATTTT 1080
GCGGAAGATC CTCCCACATC CCTCAAGTCC TTCAGGAGTC CTTCTCCTCT GTTCTTCGAT 1140
AATGTTCCGA GCATTCCAGT GGAAGATGAC GAAAACCAGA ATAATCCATC GCCGCCTCAT 1200
GATCAAAGTT TGAGAAAAGA TAGAATGACT CAGAAGACTC CCTTTGAATG CAGCCAGTCT 1260
GAGGTCACAT TCCTGGGCTT TGACAAAAAG ACGGGTAGTA GGGGGAATGA GGACTCTTCC 1320
AGTAGGTCCG GGTCTCCTTG TGAGGAAAGC TGGTCTCCAA AGTGTGCAAC TCCATCCCTG 1380
GACTTGAGGG CCCCCAGTGT GCATACGGAC ACTTCTGCAG AAGCTCCAGG CCATTCCTAT 1440
AGGAGCAGGC CAGTGGAGAC TAGCTGTTCC TCCATATTTT CATGGAATGA ATGCAAACTG 1500
TACAAAAAGG CATCGGTTTC TGATGAGGAT AAAGAAGAAA GCAAGAATTG CTGA 1554
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         f++d+ igeG+++evyr+e++n ++a+k +k+  ++++k+ +++fl+El+vl+ frH+ni
Q: 73    FHKDFLIGEGEIFEVYRVEIQNRTYAIKLFKQGGKMQCKKQWKRFLSELEVLLLFRHPNI  132
         89**********************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120
         lel++y++esek+cLvY+ym+nGsL+drLqc ++++pLsW++R+ +l+Gt++ai++LH++
Q: 133   LELAAYFTESEKFCLVYPYMRNGSLFDRLQCVGDTAPLSWHIRIGVLIGTSKAIQYLHNT  192
         ************************************************************
S: 121   sp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpee  179
         +  s+i+g+i+saNiLLD++++pKl+Df++a+f+p+ e qss++ +ts+ +++++Y+pee
Q: 193   ELcSVICGSISSANILLDDQFQPKLTDFAMAHFRPHLEPQSSAISMTSSSSKHVWYMPEE  252
         999*********************************************************
S: 180   firvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfld  239
         +ir+g+l++k+D+ySfGiV++EvltG+++v +++k+ +L+dll e +e+++++++ +fld
Q: 253   YIRQGKLSIKTDIYSFGIVIMEVLTGCKVVLDEPKHIQLRDLLIELMEKRGLDSCISFLD  312
         ************************************************************
S: 240   kkagkleeellealielalaclaekakkrPtmsqvlell  278
         kk+++++++++++l++la++c+a++ak rP+m++vl+ l
Q: 313   KKVPPCPQNFSAKLFSLAGRCAATRAKLRPSMDEVLNIL  351
         ***********************************9876
Domain Sequence
(FASTA)
FHKDFLIGEG EIFEVYRVEI QNRTYAIKLF KQGGKMQCKK QWKRFLSELE VLLLFRHPNI 60
LELAAYFTES EKFCLVYPYM RNGSLFDRLQ CVGDTAPLSW HIRIGVLIGT SKAIQYLHNT 120
ELCSVICGSI SSANILLDDQ FQPKLTDFAM AHFRPHLEPQ SSAISMTSSS SKHVWYMPEE 180
YIRQGKLSIK TDIYSFGIVI MEVLTGCKVV LDEPKHIQLR DLLIELMEKR GLDSCISFLD 240
KKVPPCPQNF SAKLFSLAGR CAATRAKLRP SMDEVLNIL 279
KeywordComplete proteome; Kinase; Receptor; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00378
EKS-CAJ-00410
EKS-CAF-00407
EKS-CAP-00435
EKS-DAR-00794
EKS-ECT-00006
EKS-EQC-00399
EKS-FEC-00390
EKS-GAA-00494
EKS-HOS-00413
EKS-ICT-00386
EKS-LAC-00422
EKS-LOA-00416
EKS-MAM-00405
EKS-MOD-00398
EKS-MUM-00439
EKS-MUP-00401
EKS-MYL-00402
EKS-NOL-00370
EKS-OCP-00086
EKS-ORA-00355
EKS-ORC-00382
EKS-OTG-00409
EKS-PAT-00385
EKS-PEM-00222
EKS-POA-00397
EKS-RAN-00421
EKS-SAH-00378
EKS-SUS-00359
EKS-TUT-00121
EKS-VIP-00063
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0045824; P:negative regulation of innate immune response
GO:0010936; P:negative regulation of macrophage cytokine production
GO:0043407; P:negative regulation of MAP kinase activity
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0042177; P:negative regulation of protein catabolic process
GO:0043242; P:negative regulation of protein complex disassembly
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0010933; P:positive regulation of macrophage tolerance induction
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0043330; P:response to exogenous dsRNA
GO:0032496; P:response to lipopolysaccharide
GO:0032494; P:response to peptidoglycan
KEGG
bta:510342;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013