EKS-BOT-00238
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00238
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMKL387.33.0E-11620271252
StatusUnreviewed
Ensembl ProteinENSBTAP00000013818
UniProt AccessionA6QNL2;
Protein Name
Protein Synonyms/Alias MARK2 protein;
Gene NameMARK2
Gene Synonyms/Alias MARK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000007825ENSBTAP00000013818ENSBTAT00000013818
OrganismBos taurus
Functional Description
Protein Length691
Protein Sequence
(FASTA)
MLRGRNSATS ADEQPHIGNY RLLKTIGKGN FAKVKLARHI LTGKEVAVKI IDKTQLNSSS 60
LQKLFREVRI MKVLNHPNIV KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR 120
AKFRQIVSAV QYCHQKFIVH RDLKAENLLL DADMNIKIAD FGFSNEFTFG NKLDTFCGSP 180
PYAAPELFQG KKYDGPEVDV WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM 240
STDCENLLKK FLILNPSKRG TLEQIMKDRW MNVGHEDDEL KPYVEPLPDY KDPRRTELMV 300
SMGYTREEIQ DSLVSQRYNE VMATYLLLGY KSSELEGDTI TLKPRPSADL ANSSAPSPSH 360
KVQRSVSANP KQRRFSDQAG PAIPTSNSYS KKTQSSNAEN KRPEEDRESG RKASSTAKVP 420
ASPLPGLERK KTTPTPSTNS VLSTSTNRSR NSPLLERASL GQASIQNGKD STAPQRVPVA 480
SPSAHNISSS GGAPDRTNFP RGVSSRSTFH AGQLRQVRDQ QNLPYGVTPA SPSGNSQGRR 540
GASGSIFSKF TSKFVRRNLN EPESKDRLET HRPHVVGSGG NDKEKEDFRE AKPRSLRFTW 600
SMKTTSSMEP NEMMREIRKV LDANSCQSEL HEKYMLLCMH GTPGHESFVQ WEMEVCKLPR 660
LSLNGVRFKR ISGTSMAFKN IASKIANELK L 691
Nucleotide Sequence
(FASTA)
ATGCTGCGGG GCCGCAACTC AGCCACCTCT GCTGACGAGC AGCCCCATAT CGGCAACTAC 60
CGGCTCCTCA AGACCATCGG CAAGGGTAAC TTCGCCAAGG TGAAGCTGGC TCGGCATATC 120
CTGACTGGGA AAGAGGTAGC TGTAAAGATC ATTGACAAGA CGCAGCTGAA TTCCTCCAGC 180
CTCCAGAAAC TGTTCCGTGA AGTAAGAATA ATGAAGGTTC TGAACCATCC CAACATAGTT 240
AAGTTATTTG AAGTGATCGA GACTGAGAAA ACGCTCTACC TGGTCATGGA GTACGCCAGT 300
GGAGGAGAGG TGTTTGATTA CCTAGTGGCT CATGGCAGGA TGAAAGAAAA AGAGGCTCGA 360
GCCAAATTCC GCCAGATAGT GTCTGCTGTG CAGTACTGTC ACCAGAAGTT TATTGTTCAT 420
AGAGACCTAA AGGCAGAAAA CCTGCTCTTG GATGCTGATA TGAACATCAA GATTGCAGAC 480
TTTGGCTTCA GCAATGAATT CACCTTTGGG AACAAGCTGG ATACCTTCTG TGGCAGTCCT 540
CCTTATGCTG CCCCAGAGCT CTTCCAGGGC AAAAAGTACG ACGGACCCGA GGTGGATGTG 600
TGGAGCCTGG GAGTTATCCT GTACACACTG GTCAGCGGAT CCCTGCCTTT TGATGGACAG 660
AACCTCAAGG AGCTACGGGA GCGGGTACTG AGGGGGAAAT ACCGTATTCC ATTCTACATG 720
TCCACAGACT GTGAAAACCT GCTCAAGAAA TTTCTCATTC TCAATCCCAG CAAGAGAGGC 780
ACTTTAGAGC AAATCATGAA AGATCGGTGG ATGAATGTGG GTCATGAAGA TGATGAATTA 840
AAGCCTTATG TGGAGCCACT CCCTGACTAC AAGGACCCCC GGCGGACAGA GTTGATGGTG 900
TCCATGGGTT ACACGCGGGA AGAGATCCAG GACTCACTGG TGAGCCAGAG GTACAACGAG 960
GTGATGGCCA CCTATCTGCT CCTGGGCTAC AAGAGCTCCG AGCTGGAGGG CGACACCATC 1020
ACCTTGAAGC CCCGGCCTTC AGCTGATCTG GCCAATAGCA GTGCCCCCTC CCCCTCCCAC 1080
AAGGTACAGC GCAGCGTCTC CGCCAACCCC AAGCAGCGGC GCTTCAGTGA CCAGGCTGGC 1140
CCTGCCATCC CCACTTCCAA TTCCTACTCT AAGAAGACTC AGAGCAGCAA CGCAGAAAAC 1200
AAGCGGCCTG AGGAGGACCG GGAGTCAGGA CGGAAGGCCA GCAGCACAGC CAAAGTGCCT 1260
GCCAGCCCCC TGCCTGGCCT GGAGAGGAAG AAGACCACCC CGACGCCCTC CACGAACAGC 1320
GTCCTCTCCA CCAGCACAAA CCGAAGCAGG AATTCCCCAC TCCTGGAGAG GGCCAGCCTT 1380
GGCCAGGCCT CCATCCAGAA TGGCAAAGAC AGCACAGCCC CACAGCGTGT CCCTGTCGCC 1440
TCCCCCTCCG CCCACAACAT CAGCAGCAGT GGTGGAGCCC CAGACCGAAC TAATTTCCCC 1500
CGGGGTGTGT CCAGTCGAAG CACCTTCCAC GCTGGACAGC TCCGGCAGGT GCGGGACCAG 1560
CAGAATTTGC CCTACGGTGT CACCCCAGCC TCTCCCTCTG GCAACAGCCA GGGCCGGCGG 1620
GGGGCCTCGG GGAGCATCTT CAGCAAATTC ACCTCCAAGT TTGTGCGCAG GAACCTGAAT 1680
GAACCTGAAA GCAAAGACCG ATTGGAGACG CACAGACCTC ACGTGGTGGG CAGCGGTGGC 1740
AACGACAAAG AGAAGGAAGA CTTTCGGGAG GCCAAGCCCC GCTCACTGCG CTTCACGTGG 1800
AGCATGAAGA CCACGAGCTC CATGGAGCCC AACGAGATGA TGCGGGAGAT CCGCAAGGTG 1860
CTGGACGCCA ACAGCTGCCA GAGCGAGCTG CACGAGAAGT ACATGCTGCT GTGCATGCAC 1920
GGCACGCCTG GCCACGAGAG CTTCGTGCAG TGGGAGATGG AGGTGTGCAA ACTGCCGCGC 1980
CTGTCTCTCA ACGGCGTTCG GTTTAAGCGG ATATCAGGCA CCTCCATGGC CTTCAAAAAC 2040
ATTGCCTCCA AAATAGCCAA CGAGCTTAAG CTTTAA 2076
Domain Profile
S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60
         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni
Q: 20    YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  79
         99**********************************************************
S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120
         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv
Q: 80    VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV  139
         ************************************************************
S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180
         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD
Q: 140   HRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  199
         ************************************************************
S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240
         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR
Q: 200   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  259
         ************************************************************
S: 241   atieeilkhewl  252
          t+e+i+k++w+
Q: 260   GTLEQIMKDRWM  271
         ***********8
Domain Sequence
(FASTA)
YRLLKTIGKG NFAKVKLARH ILTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60
VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKFIV 120
HRDLKAENLL LDADMNIKIA DFGFSNEFTF GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180
VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240
GTLEQIMKDR WM 252
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00223
EKS-ANC-00231
EKS-CAE-00215
EKS-CAJ-00245
EKS-CAF-00248
EKS-CAP-00264
EKS-CII-00144
EKS-DAR-00554
EKS-DIO-00007
EKS-DRM-00122
EKS-EQC-00234
EKS-ERE-00008
EKS-FEC-00224
EKS-GAA-00294
EKS-GOG-00236
EKS-HOS-00248
EKS-ICT-00228
EKS-LAC-00252
EKS-LOA-00236
EKS-MAM-00241
EKS-MAE-00008
EKS-MIM-00008
EKS-MUM-00246
EKS-MUP-00238
EKS-MYL-00240
EKS-NOL-00221
EKS-OCP-00013
EKS-ORC-00215
EKS-ORL-00292
EKS-OTG-00246
EKS-PES-00213
EKS-POA-00233
EKS-PTV-00013
EKS-RAN-00236
EKS-SUS-00207
EKS-TUT-00018
EKS-XET-00316
EKS-XIM-00301
Gene Ontology
GO:0045180; C:basal cortex
GO:0016020; C:membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0030010; P:establishment of cell polarity
GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0007243; P:intracellular protein kinase cascade
GO:0010976; P:positive regulation of neuron projection development
GO:0050770; P:regulation of axonogenesis
GO:0006979; P:response to oxidative stress
KEGG
bta:535197;
InterPros
IPR001772; Kinase-assoc_KA1.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF02149; KA1; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
SM00165; UBA; 1.
Prosites
PS50032; KA1; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50030; UBA; 1.
Prints
Created Date20-Feb-2013