EKS-BOT-00369
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00369
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src439.44.0E-132260509250
StatusUnreviewed
Ensembl ProteinENSBTAP00000051020
UniProt AccessionF1MWN2;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000007932ENSBTAP00000051020ENSBTAT00000056914
ENSBTAG00000007932ENSBTAP00000037156ENSBTAT00000037322
OrganismBos taurus
Functional Description
Protein Length524
Protein Sequence
(FASTA)
LGGRSSCEDP GCPPEEERAP RMGCVKSKFL RNGGKVSKTE PNTNPHSPLY VPDPTSSGKR 60
WPDSSNGNPP GSTEGSEDII VVALYDYDAI HHEDLSFQKG DQMVVLEESG EWWRARSLAT 120
RKEGYIPSNY VARVNSLETE EWFFKGISRK DAERQLLAPG NVLGSFMIRD SETTKGSYSL 180
SVRDYDPQHR DTVKHYKIRT LDNGGFYISP RSTFGSLQEL VAHYKKASDG LCQKLTVPCM 240
SSKPQKPWEK DAWEIPRESL KMEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF 300
LAEANLMKTL QHDKLVKLHA VVTEEPIYII TEFMAKGSLL DFLKSEEGSR QPLPKLIDFS 360
AQIAEGMAFI ERRNYIHRDL RAANILVSAS LVCKIADFGL ARVIEDNEYT AREGAKFPIK 420
WTAPEAINFG SFTIKSDVWS FGILLMEIVT YGRIPYPGMS NPEVIRALER GYRMPRPDNC 480
PEELYNIMTR CWKNRPEERP TFEYIQSVLD DFYTATESQY QQQP 524
Nucleotide Sequence
(FASTA)
CTGGGGGGGC GCTCGAGCTG CGAGGATCCG GGCTGCCCGC CGGAAGAGGA GCGGGCGCCC 60
AGGATGGGAT GCGTGAAGTC CAAGTTCCTC CGGAATGGAG GCAAGGTCTC AAAAACCGAG 120
CCCAACACCA ACCCACACAG CCCCTTGTAC GTGCCGGATC CCACGTCCTC GGGCAAGCGG 180
TGGCCTGACA GCAGCAACGG CAACCCGCCA GGGTCCACAG AGGGTTCTGA GGATATCATT 240
GTGGTTGCCC TGTATGATTA TGATGCCATT CACCATGAAG ACCTCAGTTT CCAAAAGGGG 300
GACCAGATGG TGGTCCTGGA GGAGTCTGGG GAGTGGTGGA GAGCGCGATC TCTGGCCACC 360
CGGAAAGAGG GCTACATCCC AAGCAACTAC GTTGCCCGCG TCAACTCTCT GGAGACGGAG 420
GAGTGGTTCT TCAAGGGCAT CAGCCGAAAA GATGCAGAGC GCCAACTCCT GGCCCCTGGC 480
AACGTGCTGG GCTCCTTCAT GATCCGGGAC AGTGAGACCA CCAAAGGGAG CTACTCTTTG 540
TCCGTGCGAG ACTACGACCC CCAGCACAGG GACACGGTGA AACATTACAA GATCCGCACG 600
CTGGACAATG GGGGTTTCTA CATCTCGCCC CGGAGCACCT TCGGCAGCCT GCAGGAACTG 660
GTGGCCCACT ATAAGAAGGC GAGCGACGGA CTCTGCCAGA AGCTGACAGT GCCCTGCATG 720
TCCTCCAAGC CCCAGAAACC TTGGGAGAAA GACGCCTGGG AGATTCCCCG GGAGTCCCTC 780
AAGATGGAGA AGAAACTTGG AGCTGGGCAG TTTGGGGAAG TCTGGATGGC CACCTACAAC 840
AAGCACACCA AGGTGGCCGT GAAGACGATG AAGCCTGGGA GCATGTCCGT GGAGGCCTTC 900
CTGGCAGAAG CCAACCTGAT GAAGACTCTG CAGCATGACA AGCTGGTGAA GCTGCACGCT 960
GTGGTCACAG AGGAGCCCAT CTACATCATC ACGGAGTTCA TGGCCAAAGG CAGCCTGCTG 1020
GACTTCCTGA AAAGTGAAGA AGGTAGCAGG CAGCCACTGC CCAAACTCAT CGACTTCTCA 1080
GCCCAGATTG CAGAAGGCAT GGCCTTCATC GAGAGGAGGA ACTACATCCA CCGAGACCTT 1140
CGAGCTGCCA ACATCTTGGT GTCTGCATCC CTGGTGTGCA AGATCGCTGA CTTCGGTTTG 1200
GCGCGGGTCA TCGAGGACAA CGAGTACACA GCTCGGGAAG GGGCCAAGTT CCCCATCAAG 1260
TGGACAGCTC CTGAAGCCAT CAACTTTGGC TCCTTCACCA TCAAGTCAGA TGTCTGGTCC 1320
TTCGGTATCC TGCTGATGGA GATTGTCACC TATGGCCGGA TCCCTTACCC AGGGATGTCA 1380
AACCCCGAGG TGATCCGTGC ACTGGAGCGT GGATACCGGA TGCCTCGACC AGACAACTGC 1440
CCGGAAGAGC TCTACAACAT CATGACTCGC TGCTGGAAGA ACCGACCTGA GGAACGGCCC 1500
ACCTTTGAAT ACATCCAGAG CGTGCTGGAT GACTTCTACA CGGCCACCGA GAGCCAGTAC 1560
CAACAGCAGC CGTGA 1575
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lk++kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 260   LKMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLH  319
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv+e ePiyi+te+makGslldflk+eeg++++lpkl+d++aq+aeGma++e++n+ihr
Q: 320   AVVTE-EPIYIITEFMAKGSLLDFLKSEEGSRQPLPKLIDFSAQIAEGMAFIERRNYIHR  378
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 379   DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  438
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGm+n ev++++ergyr+prp++cpeely+++++cwk++pee
Q: 439   WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPDNCPEELYNIMTRCWKNRPEE  498
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 499   RPTFEYIQSVL  509
         *******9976
Domain Sequence
(FASTA)
LKMEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 60
AVVTEEPIYI ITEFMAKGSL LDFLKSEEGS RQPLPKLIDF SAQIAEGMAF IERRNYIHRD 120
LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPDN CPEELYNIMT RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013