EPS-BOT-00123

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00123

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	615.0	2.3E-185	185	496	312

Status

Unreviewed

Ensembl Protein

ENSBTAP00000010538

UniProt Accession

F1N719;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000008014	ENSBTAP00000010538	ENSBTAT00000010538

Organism

Bos taurus

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 60

NAIYYGNRSL AYLRTECYGY ALADATRAVE MDKKYIKGYY RRAASNMALG KFRAALRDYE 120

TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK 180

LEDGRVTITF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC 240

GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 300

RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 360

VTLDDIRKIE RSRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENKL 420

DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAA YIHLRGADLR PQFHQFTAVP 480

HPDVKPMAYA STLLQLGMM 499

Nucleotide Sequence
(FASTA)

ATGGCGATGG CGGAGGGCGA GCGGACTGAG TGTGCTGAGC CCCCCCGGGA CGAGCCCCCG 60

GCTGATGGCG CTCTGAAGAG GGCAGAGGAG CTCAAGACGC AGGCCAACGA CTACTTCAAA 120

GCCAAGGACT ACGAGAACGC CATCAAGTTC TACAGCCAGG CCATCGAGCT GAACCCCAGC 180

AACGCCATCT ACTATGGCAA CCGCAGCCTG GCCTACCTGC GCACCGAGTG CTACGGCTAC 240

GCGCTGGCCG ACGCCACGCG GGCCGTCGAG ATGGACAAGA AGTACATCAA GGGCTACTAC 300

CGCCGGGCTG CCAGCAACAT GGCGCTGGGC AAGTTCCGGG CCGCCCTGCG TGACTACGAG 360

ACGGTGGTGA AGGTGAAGCC ACATGACAAG GATGCCAAGA TGAAGTACCA GGAGTGCAAC 420

AAGATCGTGA AGCAGAAGGC CTTTGAGCGG GCCATTGCGG GCGACGAGCA CAAGCGCTCT 480

GTCGTGGACT CACTCGACAT CGAGAGCATG ACCATCGAGG ATGAGTACAG TGGGCCCAAG 540

CTGGAGGACG GCAGGGTGAC AATCACCTTC ATGAAGGAGC TCATGCAGTG GTACAAGGAC 600

CAGAAGAAGC TGCACCGGAA GTGCGCCTAC CAGATTCTAG TACAGGTCAA AGAGGTCCTC 660

TCCAAGCTGA GCACACTTGT GGAGACCACA CTCAAAGAGA CAGAGAAGAT TACAGTGTGC 720

GGGGACACCC ACGGCCAGTT CTATGACCTC CTGAACATAT TTGAGCTCAA CGGTTTACCC 780

TCGGAGACCA ACCCCTACAT ATTTAATGGC GACTTTGTGG ATCGTGGCTC CTTCTCCGTA 840

GAAGTGATCC TCACCCTTTT TGGCTTTAAG CTCTTGTACC CAGATCACTT TCACTTACTT 900

CGAGGCAACC ATGAGACGGA CAACATGAAC CAGATCTATG GCTTCGAGGG GGAGGTGAAG 960

GCCAAGTACA CAGCCCAGAT GTACGAGCTC TTCAGCGAGG TGTTCGAGTG GCTCCCGCTG 1020

GCCCAGTGCA TCAATGGCAA AGTGCTGATC ATGCACGGGG GCTTGTTCAG TGAAGACGGC 1080

GTCACCCTGG ACGACATCAG GAAGATCGAG CGGAGTCGGC AGCCCCCAGA TTCAGGTCCC 1140

ATGTGCGACC TGCTCTGGTC CGACCCGCAG CCGCAGAACG GGCGCTCGGT CAGCAAGCGG 1200

GGCGTGAGCT GCCAGTTCGG GCCCGATGTC ACCAAGGCCT TCCTGGAGGA GAACAAGCTG 1260

GATTACATCA TCCGCAGCCA CGAGGTCAAG GCCGAGGGCT ACGAGGTGGC GCACGGCGGC 1320

CGCTGCGTCA CCGTCTTCTC TGCCCCCAAC TACTGCGACC AGATGGGGAA CAAAGCCGCC 1380

TACATCCACC TCCGGGGCGC TGACCTGCGG CCCCAGTTCC ACCAGTTCAC AGCAGTGCCT 1440

CACCCCGACG TCAAGCCCAT GGCCTACGCC AGCACGCTGC TGCAGTTAGG GATGATGTGA 1500

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         +v+i f+k+l++++k++kkl+rk+a++ilv+v++vl+kl++++e+++ke++kitvcGdth

Q: 185   RVTITFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTH  244

         6899********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 245   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  304

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 305   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  364

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkier +qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleenkldyii

Q: 365   DIRKIERSRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENKLDYII  424

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+a++ih+r+ dlr+++++f+av+hpdv

Q: 425   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKAAYIHLRGADLRPQFHQFTAVPHPDV  484

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+ +ll+l

Q: 485   KPMAYASTLLQL  496

         ********9987

Domain Sequence
(FASTA)

RVTITFMKEL MQWYKDQKKL HRKCAYQILV QVKEVLSKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERSRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENKLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKAAYIHL RGADLRPQFH QFTAVPHPDV 300

KPMAYASTLL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0043278	; P:response to morphine

KEGG

bta:510245

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013