EKS-BOT-00176
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00176
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC436.63.7E-131349603255
StatusUnreviewed
Ensembl ProteinENSBTAP00000011487
UniProt AccessionF1MZX0;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCD
Gene Synonyms/Alias PRKCD;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000008719ENSBTAP00000011487ENSBTAT00000011487
OrganismBos taurus
Functional Description
Protein Length676
Protein Sequence
(FASTA)
MAPFLRISFN SYELGSLKAA DEASQPFCAV KMKEALSTDR GKTLVQKKPT MYPEWKSTFD 60
AHIYEGRVIQ IVLMRAAEEP MSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120
FLEDVDCKQS MRGEDEAKFP TMNRRGAIKQ AKIHYIRHHE FIATFFGQPT FCSVCREFVW 180
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVYNYMS 240
PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCQMKVANLC GINQKLLAEA LNQVSQRSVK 300
KETETQDTVG IYQNFEKKPG VSGDDLTGKE TGTYGKIWES STKCNIDNFT FIKVLGKGSF 360
GKVLLAELKG KKEFFAIKAL KKDVVLIDDD VECTMVEKRV LALAGDHPFL THLFCTFQTK 420
DHLFFVMEFL NGGDLMYHIQ DKGRFELSRA TFYAAEIVCG LQFLHQKGII YRDLKLDNVL 480
LDHSGHIKIA DFGMCKENMS GDRQASTFCG TPDYIAPEIL QGLKYSFSVD WWSFGVLLYE 540
MLIGQSPFHG DDEDELFESI RLDSPYYPRW ITKESKDILE KLLERDVSKR LGVTGNIKIH 600
PFFKTINWVL LEKRAVEPPF KPKVKSPGDF SNFDQEFLNE KPRLSYSDKN LIESMDQTAF 660
AGFSFVNPKF ERLLEN 676
Nucleotide Sequence
(FASTA)
ATGGCACCGT TCCTGCGCAT CTCCTTCAAC TCCTACGAGC TGGGCTCCCT GAAGGCCGCG 60
GACGAGGCAA GCCAGCCCTT CTGTGCTGTG AAGATGAAGG AGGCTCTCAG CACAGATCGC 120
GGGAAGACGC TGGTGCAGAA GAAGCCCACC ATGTACCCTG AGTGGAAGTC CACATTCGAT 180
GCTCACATCT ACGAGGGCCG CGTTATCCAG ATAGTGCTGA TGCGAGCCGC CGAAGAGCCA 240
ATGTCGGAGG TGACGGTGGG TGTGTCAGTG CTAGCCGAGC GCTGCAAGAA GAACAATGGC 300
AAGGCCGAGT TCTGGCTGGA CTTGCAACCC CAGGCCAAGG TGCTGATGTC GGTGCAGTAT 360
TTCCTGGAAG ACGTAGATTG CAAGCAGTCT ATGCGGGGTG AAGACGAGGC CAAGTTCCCA 420
ACAATGAACC GCCGTGGAGC TATCAAACAG GCCAAAATTC ACTACATCAG GCACCACGAG 480
TTCATCGCCA CCTTCTTTGG GCAGCCCACA TTCTGCTCCG TGTGCAGAGA GTTTGTTTGG 540
GGTCTCAACA AGCAAGGCTA CAAGTGCAGG CAATGTAATG CTGCCATCCA CAAGAAATGC 600
ATCGACAAGA TCATCGGCCG GTGTACAGGC ACTGCAGCCA ACAGTCGGGA CACCATATTC 660
CAGAAAGAAC GTTTCAACAT CGACATGCCG CACCGGTTCA AGGTTTATAA CTACATGAGC 720
CCCACCTTCT GTGACCACTG TGGCAGCCTG CTCTGGGGGC TGGTGAAGCA GGGATTAAAG 780
TGTGAAGACT GTGGCATGAA CGTGCATCAC AAGTGCCAGA TGAAAGTGGC CAACCTCTGT 840
GGCATCAACC AGAAGCTCTT GGCCGAGGCC TTGAACCAAG TTAGCCAGAG ATCTGTAAAG 900
AAGGAAACAG AGACCCAAGA CACTGTTGGG ATCTACCAGA ATTTTGAGAA GAAGCCAGGA 960
GTCTCTGGAG ATGATCTCAC AGGTAAAGAA ACTGGGACCT ACGGCAAGAT CTGGGAGAGC 1020
AGCACCAAGT GCAACATTGA CAACTTCACC TTCATCAAGG TCCTGGGCAA AGGCAGCTTC 1080
GGGAAGGTGC TGCTCGCAGA GCTGAAGGGC AAAAAGGAAT TCTTCGCCAT CAAGGCTCTC 1140
AAGAAAGACG TGGTCTTGAT CGATGACGAC GTGGAGTGCA CCATGGTGGA GAAGCGGGTG 1200
CTGGCCCTCG CCGGGGATCA TCCGTTTCTC ACCCACCTCT TCTGCACCTT CCAGACAAAG 1260
GACCACCTGT TCTTTGTGAT GGAGTTCCTC AATGGGGGCG ACCTGATGTA CCACATCCAG 1320
GACAAAGGCC GCTTCGAGCT CTCCCGTGCC ACGTTTTACG CAGCTGAGAT AGTCTGTGGA 1380
CTACAGTTTC TGCACCAGAA AGGGATCATT TACAGGGACC TCAAGCTGGA CAACGTGTTG 1440
CTGGACCACA GTGGCCACAT CAAGATTGCC GACTTCGGCA TGTGCAAGGA GAACATGTCC 1500
GGGGACAGAC AGGCCAGCAC CTTCTGCGGC ACCCCTGACT ACATCGCCCC CGAGATCCTG 1560
CAGGGCCTGA AATACTCGTT CTCCGTGGAC TGGTGGTCCT TCGGAGTCCT TCTCTATGAG 1620
ATGCTCATTG GTCAGTCCCC CTTCCATGGT GATGATGAGG ACGAACTCTT CGAGTCCATC 1680
CGTTTAGACT CACCATACTA TCCTCGCTGG ATCACCAAGG AGTCCAAGGA CATCCTGGAG 1740
AAGCTGCTTG AACGGGATGT AAGCAAGAGG CTGGGAGTGA CAGGGAACAT CAAAATCCAC 1800
CCCTTCTTCA AGACCATCAA CTGGGTTCTG CTGGAGAAAC GTGCAGTGGA GCCACCCTTC 1860
AAGCCCAAAG TGAAGTCGCC TGGAGACTTC AGCAACTTCG ACCAGGAGTT CCTGAATGAG 1920
AAGCCGCGCC TCTCCTACAG CGACAAGAAC CTCATCGAGT CCATGGACCA AACAGCATTT 1980
GCTGGCTTCT CCTTCGTGAA CCCCAAATTT GAGAGGCTCC TGGAAAACTG A 2031
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+++kvlGkGsfgkvllaelk+++e++aik lkkdvvl dddve+t+vekrvlala ++p
Q: 349   FTFIKVLGKGSFGKVLLAELKGKKEFFAIKALKKDVVLIDDDVECTMVEKRVLALAGDHP  408
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl++lf++fqt+d+lffv+e++nGGdlm+hiq++++++ +ra+fyaaei+++l+flh+kg
Q: 409   FLTHLFCTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELSRATFYAAEIVCGLQFLHQKG  468
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvlld+ Ghik+adfG+cke++  ++++stfcGtPdyiaPeil++ +y++s
Q: 469   IIYRDLKLDNVLLDHSGHIKIADFGMCKENMSGDRQASTFCGTPDYIAPEILQGLKYSFS  528
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP++++ke+++il++ll++d +
Q: 529   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRLDSPYYPRWITKESKDILEKLLERDVS  588
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlGv  +g  +ik h+ff
Q: 589   KRLGV--TG--NIKIHPFF  603
         *****..56..79999998
Domain Sequence
(FASTA)
FTFIKVLGKG SFGKVLLAEL KGKKEFFAIK ALKKDVVLID DDVECTMVEK RVLALAGDHP 60
FLTHLFCTFQ TKDHLFFVME FLNGGDLMYH IQDKGRFELS RATFYAAEIV CGLQFLHQKG 120
IIYRDLKLDN VLLDHSGHIK IADFGMCKEN MSGDRQASTF CGTPDYIAPE ILQGLKYSFS 180
VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRLDSPYYP RWITKESKDI LEKLLERDVS 240
KRLGVTGNIK IHPFF 255
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00166
EKS-ANC-00168
EKS-CAE-00133
EKS-CAJ-00179
EKS-CAF-00183
EKS-CAP-00173
EKS-CIS-00207
EKS-DAR-00469
EKS-DRM-00086
EKS-EQC-00174
EKS-FEC-00164
EKS-GAM-00094
EKS-GAG-00150
EKS-GAA-00213
EKS-GOG-00175
EKS-HOS-00182
EKS-ICT-00169
EKS-LAC-00183
EKS-LOA-00173
EKS-MAM-00172
EKS-MEG-00108
EKS-MOD-00172
EKS-MUM-00180
EKS-MYL-00181
EKS-NOL-00169
EKS-OCP-00109
EKS-ORN-00221
EKS-ORC-00160
EKS-ORL-00208
EKS-OTG-00181
EKS-PES-00154
EKS-PEM-00089
EKS-POA-00169
EKS-RAN-00172
EKS-SAH-00166
EKS-SUS-00150
EKS-TAG-00204
EKS-TAR-00227
EKS-TEN-00221
EKS-XET-00163
EKS-XIM-00214
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005829; C:cytosol
GO:0005783; C:endoplasmic reticulum
GO:0016363; C:nuclear matrix
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0008047; F:enzyme activator activity
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0006915; P:apoptotic process
GO:0042100; P:B cell proliferation
GO:0090398; P:cellular senescence
GO:0016064; P:immunoglobulin mediated immune response
GO:0032613; P:interleukin-10 production
GO:0032615; P:interleukin-12 production
GO:0035556; P:intracellular signal transduction
GO:0030837; P:negative regulation of actin filament polymerization
GO:0051490; P:negative regulation of filopodium assembly
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0043407; P:negative regulation of MAP kinase activity
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0090331; P:negative regulation of platelet aggregation
GO:0042119; P:neutrophil activation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:2000304; P:positive regulation of ceramide biosynthetic process
GO:2000753; P:positive regulation of glucosylceramide catabolic process
GO:1900163; P:positive regulation of phospholipid scramblase activity
GO:0035307; P:positive regulation of protein dephosphorylation
GO:2001022; P:positive regulation of response to DNA damage stimulus
GO:2000755; P:positive regulation of sphingomyelin catabolic process
GO:0032930; P:positive regulation of superoxide anion generation
GO:0023021; P:termination of signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013