EKS-BOT-00366
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00366
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.47.0E-135276525250
StatusUnreviewed
Ensembl ProteinENSBTAP00000011767
UniProt AccessionE1BIM8;
Protein Name
Protein Synonyms/Alias
Gene NameSRC
Gene Synonyms/Alias SRC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000008938ENSBTAP00000011767ENSBTAT00000011767
OrganismBos taurus
Functional Description
Protein Length542
Protein Sequence
(FASTA)
MGSNKSKPKD ASQRRRSLES AENTHGGGGG GGGGGGAFPS SQTPSKPASS DGHRGPNTAF 60
APAAAEPKLF GGFNSSDTVT SPQRAGPLSG GVTTFVALYD YESRTETDLS FKKGERLQIV 120
NNTEGDWWLA HSLSTGQTGY IPSNYVAPSD SIQAEEWYFG KITRRESERL LLNAENPRGT 180
FLVRESETTK GAYCLSVSDF DNAKGLNVKH YKIRKLDSGG FYITSRTQFN SLQQLVAYYS 240
KHADGLCHRL TTVCPTSKPQ TQGLAKDAWE IPRESLRLEV KLGQGCFGEV WMGTWNGTTR 300
VAIKTLKPGT MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYM SKGSLLDFLK 360
GETGKYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN ILVGESLVCK VADFGLARLI 420
EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL LTELTTKGRV PYPGMVNREV 480
LDQVERGYRM PCPPECPESL HDLMCQCWRK DPEERPTFEY LQAFLEDYFT STEPQYQPGE 540
NL 542
Nucleotide Sequence
(FASTA)
ATGGGCAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAGC GGCGCCGCAG CCTGGAGTCT 60
GCTGAGAACA CCCACGGAGG CGGCGGCGGC GGCGGCGGCG GTGGGGGTGC CTTCCCCTCC 120
TCGCAGACCC CCAGCAAGCC AGCCTCCTCT GATGGCCACC GCGGCCCCAA CACGGCCTTC 180
GCCCCTGCAG CCGCTGAGCC CAAGCTGTTC GGAGGCTTCA ACTCCTCGGA CACAGTCACC 240
TCCCCGCAGA GGGCGGGGCC CCTGTCTGGC GGAGTGACCA CCTTCGTGGC CCTCTATGAC 300
TATGAGTCGC GGACAGAGAC TGACCTGTCT TTCAAGAAAG GGGAGCGGCT TCAGATTGTC 360
AACAACACAG AGGGAGACTG GTGGCTGGCC CACTCGCTCA GCACAGGACA GACGGGCTAC 420
ATCCCCAGCA ACTACGTGGC ACCCTCTGAC TCCATCCAGG CTGAAGAGTG GTACTTTGGC 480
AAGATCACCA GACGGGAGTC AGAGCGGTTA CTGCTCAATG CAGAGAACCC AAGAGGGACC 540
TTCCTAGTGC GAGAAAGCGA GACCACGAAA GGCGCCTACT GCCTCTCGGT GTCTGACTTC 600
GACAACGCCA AGGGCCTCAA CGTGAAGCAC TACAAAATCC GCAAGCTGGA CAGCGGAGGC 660
TTCTACATCA CCTCCCGCAC CCAGTTCAAC AGCCTGCAGC AGCTGGTGGC CTACTACTCC 720
AAACACGCTG ACGGCCTCTG CCACCGCCTC ACCACTGTGT GCCCCACGTC CAAGCCGCAG 780
ACTCAAGGCT TGGCCAAAGA TGCCTGGGAG ATCCCCCGGG AGTCGCTGCG GCTGGAGGTC 840
AAGCTGGGCC AGGGCTGCTT CGGAGAGGTG TGGATGGGTA CCTGGAACGG CACCACCAGG 900
GTGGCCATCA AAACCCTGAA GCCTGGTACG ATGTCTCCGG AGGCCTTCCT GCAGGAGGCC 960
CAGGTTATGA AGAAACTGAG GCATGAAAAA CTCGTGCAGC TGTACGCCGT GGTGTCCGAA 1020
GAGCCCATCT ACATTGTCAC GGAGTACATG AGCAAGGGGA GTTTGCTGGA CTTTCTCAAG 1080
GGGGAGACAG GCAAGTACCT GCGGCTGCCT CAGCTGGTGG ACATGGCTGC ACAGATCGCC 1140
TCAGGCATGG CTTATGTGGA ACGGATGAAC TATGTCCACC GAGACCTCCG GGCTGCCAAC 1200
ATCCTGGTTG GAGAGAGCCT CGTATGCAAA GTGGCTGACT TCGGGCTGGC TCGACTCATT 1260
GAAGACAACG AATACACAGC CCGGCAAGGT GCCAAATTCC CCATCAAGTG GACAGCTCCG 1320
GAAGCTGCCC TCTATGGCCG GTTCACCATC AAATCAGACG TGTGGTCCTT TGGGATCCTG 1380
CTGACGGAGC TCACAACAAA GGGACGGGTG CCCTACCCTG GGATGGTGAA CCGGGAGGTG 1440
CTGGACCAGG TGGAGCGGGG CTACCGGATG CCCTGCCCTC CTGAGTGTCC CGAGTCATTG 1500
CATGACCTGA TGTGCCAGTG CTGGCGGAAG GACCCGGAGG AACGGCCCAC CTTCGAGTAC 1560
CTGCAGGCCT TCCTGGAGGA CTATTTCACG TCCACCGAGC CCCAGTACCA GCCCGGAGAG 1620
AACCTATAG 1629
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 276   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  335
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 336   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  394
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvgeslv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 395   DLRAANILVGESLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  454
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+kdpee
Q: 455   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEE  514
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 515   RPTFEYLQAFL  525
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE SLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKDPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-CII-00206
EKS-CIS-00121
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00475
EKS-ORC-00344
EKS-ORL-00435
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-POA-00356
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
bta:535742;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013