EKS-BOT-00387
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00387
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11364.44.5E-109674930257
StatusUnreviewed
Ensembl ProteinENSBTAP00000011949
UniProt AccessionF1MXH6;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000009065ENSBTAP00000011949ENSBTAT00000011949
OrganismBos taurus
Functional Description
Protein Length1366
Protein Sequence
(FASTA)
MSAEAGEGIT FSVPPFAEGG SYRRGGAATA AEGEENQLPP PPPGSFWNVE SAAAPGAGCP 60
SATSGSSATR CRGNSGGGGG RRTTVAYVIN EASQGQLVVA ESEALQCLRE ACETVGAALE 120
TLHFGKLDFG ETAVLDRFYN ADIAVVEMSD AFRQPSLFYH LGVRESFSMA NNIILYCDTN 180
SDSLQSLKEI ICQKNTMCTG NYTFIPYMIT PHSKVYCCDS SFMKGLTELM QPNFELLLGP 240
ICLPLVDRFI QLLKVAQASS SQYFRESILN DIRKARNLYT GKELAAELAR IRQRVDNIEV 300
LTADIVINLL LSYRDIQDYD SIVKLVETLE KLPTFDLASH HHVKFHYAFA LNRRNLPGDR 360
AKALDIMIPL VQNEEQVASD MYCLVGRIYK DMFLDSNFMD TESRDHGASW FKKAFESEPT 420
LQSGINYAVL LLASGHQFES SFELRKVGVK LSSLLGKKGN LEKLQSYWEV GFFLGASVLA 480
NDHLRVIQAS EKLFKLKTPA WYLKSIVETI LIYKHFVKLT SEQPVAKQEL VDFWMDFLVE 540
ATKTDVTVVR FPVLILEPTK IYQPSYLSIN NEVEEKTISI WHVLPDDKKG IHEWNFSASS 600
VRGVSISKFE ERCCFLYVLH NSDDFQIYFC TELHCKKFFE MVNTITEEKG KNTEEGDCEG 660
DSLEYDYEYD ENGDRVVLGK GTYGIVYAGR DLSNQVRIAI KEIPERDSRY SQPLHEEIAL 720
HKHLKHKNIV QYLGSFSENG FIKIFMEQVP GGSLSALLRS KWGPLKDNEQ TIGFYTKQIL 780
EGLKYLHDNQ IVHRDIKGDN VLINTYSGVL KISDFGTSKR LAGINPCTET FTGTLQYMAP 840
EIIDKGPRGY GKAADIWSLG CTIIEMATGK PPFYELGEPQ AAMFKVGMFK VHPEIPESMS 900
AEAKAFILKC FEPDPDKRDC ANDLLMDEFL KVSSKKKKTQ PKLSALSAGS NEYLRSISLP 960
VPVLVEDTSS SSEYGSVSPD TELKVDPFSF KTRAKSCGEK DVKGIRTLFL GIPDENFEDH 1020
SAPPSPEEKD SGFFMLRKDS ERRATLHRIL TEDQDKVVRN LMESLAQGAE EPKLKWEHIT 1080
TLVASLREFV RSTDRKIIAT TLSKLKLELD FDSHGISQVQ VVLFGFQDAV NKVLRNHNIK 1140
PHWMFALDSI IRKAVQTAIT ILVPELRPHF SLASESDTAD QEDLDAEGDH DERPSDQTVR 1200
RPHAVLEDAV ATSGVSTLSS TVSHDSQSAH RSLNVQLGRM KIETNRLLEE LVQKEKELQA 1260
LLHQAIEEKD QEIKHLKLKS QPIDVPGLPG CHSSSPGTNT EDSELTDWLR ENGADEDTIS 1320
RFLAEDYSLM DVLYYVTRDD LKCLRLRGGM LCTLWKAITD FRDKQA 1366
Nucleotide Sequence
(FASTA)
ATGAGCGCGG AGGCGGGCGA GGGCATCACT TTCTCCGTGC CACCCTTCGC CGAGGGCGGC 60
AGCTACCGGA GGGGAGGAGC GGCGACGGCG GCCGAGGGCG AGGAGAACCA GCTGCCACCG 120
CCGCCACCGG GCAGCTTCTG GAACGTGGAA AGTGCCGCCG CTCCCGGCGC CGGGTGTCCC 180
AGTGCCACCT CCGGGAGCAG CGCCACCCGG TGCCGGGGCA ACTCTGGGGG CGGAGGCGGC 240
CGACGGACCA CGGTGGCCTA TGTCATCAAC GAGGCGAGCC AGGGGCAGCT GGTGGTGGCC 300
GAGAGCGAGG CCCTGCAGTG CCTGCGGGAG GCGTGCGAGA CGGTGGGCGC CGCCCTGGAG 360
ACCCTGCATT TTGGGAAACT GGACTTTGGG GAAACTGCGG TGCTGGACCG ATTTTACAAT 420
GCAGATATCG CCGTGGTGGA GATGAGTGAT GCCTTCCGAC AACCATCCTT ATTTTACCAC 480
CTTGGAGTGA GAGAAAGTTT CAGCATGGCC AACAACATCA TCCTCTACTG TGATACTAAT 540
TCAGACTCTC TGCAGTCGCT GAAGGAGATC ATTTGCCAGA AGAATACTAT GTGCACTGGA 600
AACTACACAT TTATCCCTTA CATGATAACG CCGCACAGCA AGGTCTACTG CTGTGACAGC 660
AGCTTCATGA AGGGCTTGAC TGAGCTCATG CAGCCGAACT TTGAGCTGCT TCTGGGACCC 720
ATCTGCTTAC CTCTCGTGGA TCGTTTCATT CAGCTTTTGA AGGTGGCACA AGCAAGTTCC 780
AGCCAGTATT TCCGGGAGTC TATACTCAAC GATATCAGGA AAGCTCGTAA CTTATATACT 840
GGCAAAGAAT TGGCAGCTGA ATTGGCAAGA ATTCGACAGC GAGTGGATAA TATTGAAGTC 900
TTGACAGCAG ATATTGTCAT AAATCTGTTA CTTTCATATA GAGATATCCA GGACTATGAT 960
TCTATTGTGA AGCTGGTAGA GACTTTAGAA AAGCTTCCAA CGTTTGATTT GGCCTCCCAT 1020
CACCATGTGA AGTTTCATTA TGCCTTTGCA CTGAATAGGA GAAACCTCCC TGGAGATAGA 1080
GCAAAAGCTC TTGACATTAT GATTCCCCTG GTGCAAAATG AAGAGCAGGT TGCTTCAGAT 1140
ATGTATTGCC TCGTTGGTCG AATCTACAAA GATATGTTTT TGGACTCTAA TTTCATGGAC 1200
ACTGAAAGTA GAGACCATGG AGCTTCTTGG TTCAAAAAGG CATTTGAATC AGAGCCAACA 1260
CTACAGTCAG GAATTAATTA TGCGGTCCTC CTCCTGGCAT CTGGGCACCA GTTTGAATCT 1320
TCCTTTGAGC TCCGAAAAGT TGGGGTGAAG CTAAGTAGTC TTCTTGGTAA AAAGGGAAAC 1380
TTGGAAAAAC TCCAGAGCTA CTGGGAAGTT GGATTTTTCC TGGGGGCCAG TGTCCTGGCC 1440
AATGACCACT TGAGAGTCAT TCAAGCATCT GAAAAGCTTT TTAAACTGAA GACACCTGCA 1500
TGGTACCTCA AGTCTATCGT AGAGACAATT TTGATATATA AGCATTTTGT GAAACTGACT 1560
TCGGAACAGC CTGTGGCCAA ACAGGAACTT GTGGACTTCT GGATGGATTT CCTGGTCGAG 1620
GCCACAAAGA CAGATGTCAC TGTAGTTAGG TTTCCAGTAT TAATATTAGA ACCAACCAAA 1680
ATCTATCAAC CTTCGTATTT GTCTATCAAC AATGAAGTTG AGGAGAAGAC AATATCTATT 1740
TGGCACGTGC TTCCTGATGA CAAGAAAGGT ATACATGAGT GGAATTTTAG TGCTTCTTCT 1800
GTCAGGGGTG TGAGTATTTC TAAATTTGAA GAACGATGCT GTTTTCTGTA CGTGCTTCAC 1860
AATTCTGACG ATTTCCAAAT CTACTTCTGT ACAGAACTTC ACTGTAAAAA GTTTTTTGAA 1920
ATGGTGAACA CCATTACTGA AGAGAAGGGG AAAAACACAG AGGAAGGAGA TTGTGAAGGT 1980
GACTCCCTGG AGTATGACTA TGAATACGAT GAAAATGGTG ACAGAGTCGT TTTAGGAAAA 2040
GGCACTTATG GGATAGTTTA TGCAGGTCGA GATCTGAGCA ACCAAGTCAG AATCGCCATT 2100
AAGGAAATCC CAGAGAGAGA CAGCAGATAC TCCCAGCCCC TGCATGAAGA AATAGCCTTG 2160
CATAAGCATC TGAAGCACAA AAATATTGTC CAGTATCTGG GCTCTTTCAG TGAAAACGGT 2220
TTCATTAAAA TCTTCATGGA GCAGGTCCCA GGAGGAAGTC TTTCTGCTCT CCTTCGTTCC 2280
AAATGGGGCC CACTGAAAGA CAATGAGCAA ACAATTGGCT TTTATACAAA GCAAATACTG 2340
GAAGGATTAA AATACCTCCA TGATAATCAG ATAGTTCACC GGGATATAAA GGGTGACAAT 2400
GTGTTGATTA ATACCTACAG CGGTGTTCTC AAGATTTCTG ATTTCGGAAC ATCAAAGAGG 2460
CTTGCTGGCA TAAATCCATG TACTGAAACT TTTACTGGTA CCCTCCAGTA TATGGCACCA 2520
GAAATAATAG ATAAAGGACC AAGAGGCTAT GGAAAGGCAG CAGACATTTG GTCTCTGGGC 2580
TGCACGATCA TTGAAATGGC CACTGGAAAA CCACCCTTTT ATGAACTGGG GGAACCACAA 2640
GCAGCTATGT TCAAGGTGGG GATGTTTAAA GTCCACCCAG AGATCCCAGA GTCCATGTCA 2700
GCAGAGGCCA AGGCGTTCAT ATTGAAGTGT TTCGAACCAG ACCCTGACAA GAGAGACTGT 2760
GCTAACGACT TGCTTATGGA TGAGTTCTTA AAAGTTTCAA GCAAAAAGAA AAAGACACAA 2820
CCTAAGCTTT CAGCTCTTTC AGCTGGATCG AATGAGTACC TCAGGAGTAT CTCCTTGCCA 2880
GTGCCAGTCC TGGTGGAGGA CACGAGCAGC AGCAGTGAGT ACGGCTCAGT TTCCCCTGAC 2940
ACAGAGTTGA AGGTGGACCC CTTCTCTTTC AAAACAAGAG CCAAGTCCTG TGGAGAAAAG 3000
GATGTCAAAG GCATCCGGAC GCTGTTTCTG GGCATCCCTG ATGAAAATTT TGAAGACCAC 3060
AGTGCTCCAC CTTCTCCAGA AGAAAAAGAT TCCGGATTCT TTATGCTGAG GAAGGACAGT 3120
GAGAGACGGG CCACGCTTCA CAGGATTCTG ACGGAAGACC AAGACAAAGT TGTGAGAAAC 3180
TTAATGGAAT CCTTGGCTCA GGGGGCTGAA GAACCTAAAC TGAAATGGGA ACACATCACA 3240
ACTCTGGTCG CAAGCCTCAG AGAATTTGTG AGGTCCACGG ACCGGAAGAT CATAGCCACC 3300
ACCCTGTCCA AGCTGAAGCT GGAGCTGGAC TTCGACAGCC ACGGGATCAG TCAGGTCCAG 3360
GTGGTGCTCT TTGGTTTCCA AGATGCTGTC AATAAAGTTC TTCGGAATCA TAACATCAAG 3420
CCACACTGGA TGTTTGCCTT AGACAGTATC ATCCGAAAGG CGGTACAGAC AGCTATTACC 3480
ATTCTGGTTC CAGAACTGAG GCCGCATTTC AGCCTTGCAT CTGAGAGTGA TACTGCCGAT 3540
CAAGAAGACT TGGATGCAGA AGGTGACCAT GACGAACGGC CTTCAGATCA AACTGTCCGA 3600
AGACCTCATG CCGTCCTTGA AGACGCGGTG GCCACCTCAG GGGTGAGCAC GCTCAGTTCT 3660
ACTGTATCCC ATGACTCCCA GAGTGCTCAC CGATCACTGA ATGTACAGCT TGGAAGGATG 3720
AAAATAGAAA CAAATAGATT ACTGGAAGAA TTGGTTCAGA AAGAGAAAGA ATTACAAGCA 3780
CTCCTTCATC AAGCTATTGA AGAGAAAGAC CAAGAAATTA AACACCTGAA GCTTAAGTCC 3840
CAACCAATAG ATGTTCCTGG GTTGCCTGGG TGTCACTCCA GTTCTCCTGG CACAAACACT 3900
GAAGATTCGG AACTTACTGA CTGGCTGAGA GAGAACGGAG CTGATGAAGA CACTATAAGT 3960
CGGTTTTTGG CTGAGGATTA TTCATTAATG GATGTTCTCT ACTATGTTAC ACGTGATGAT 4020
TTAAAATGCC TGAGACTAAG GGGCGGGATG CTGTGCACAC TGTGGAAAGC CATCACTGAC 4080
TTCCGAGACA AACAGGCTTG A 4101
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 674   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  728
         5789**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 729   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  788
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k
Q: 789   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  845
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+
Q: 846   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  905
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         f+ kc+e dp+kr +a++LL++efl
Q: 906   FILKCFEPDPDKRDCANDLLMDEFL  930
         **********************996
Domain Sequence
(FASTA)
DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180
ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240
DPDKRDCAND LLMDEFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00361
EKS-ANC-00378
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-EQC-00380
EKS-FEC-00376
EKS-GAG-00327
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-LAC-00401
EKS-LOA-00395
EKS-MAM-00386
EKS-MEG-00320
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-NOL-00355
EKS-ORN-00500
EKS-ORA-00336
EKS-ORC-00364
EKS-ORL-00460
EKS-OTG-00390
EKS-PES-00346
EKS-POA-00379
EKS-RAN-00402
EKS-SAH-00359
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-XET-00502
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013