EKS-BOT-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	363.7	6.9E-109	67	328	262

Status

Unreviewed

Ensembl Protein

ENSBTAP00000012092

UniProt Accession

E1BLQ5;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000009175	ENSBTAP00000012092	ENSBTAT00000012092

Organism

Bos taurus

Functional Description

Protein Length

485

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE PELSPADACP LAELRAAGLE PVGHYEEVEL TESSVNPGPE 60

RIGPHCFELL RVLGKGNYGK VFQVRKVQGS NLGKIYAMKV LRKAKIVRNA KDTAHTRAER 120

NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLSEITL 180

ALGHLHSQGI IYRDLKPENI MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI 240

LVRSGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIRGKLELPP YLTPDARDLV 300

KKFLKRNPNQ RIGGGPGDAA DVQRHPFFRH VNWDDLLARR VDPPFRPSLQ SEEDVSQFDS 360

HFTKQTPVDS PDDTTLSESA NQAFLGFTYV APSVLDSIKE AFSFQPKLRS PRRLNSSPRT 420

PVSPLKFSPF EGFRPSPGPQ ELVEPPLPPL LPPPPPPPPS STAPLPIRPP SGTKKSKRGR 480

GRPGR 485

Nucleotide Sequence
(FASTA)

ATGGCGGCGG TGTTTGACCT GGACCTGGAG ACAGAGGAAG GCAGCGAAGG CGAGGGCGAG 60

CCAGAGCTCA GCCCCGCGGA CGCGTGTCCC CTCGCGGAGT TGAGGGCGGC TGGCCTGGAG 120

CCTGTGGGAC ACTATGAGGA GGTGGAGCTG ACTGAGAGCA GTGTGAACCC GGGCCCCGAG 180

CGCATCGGTC CCCACTGCTT TGAGCTGCTG CGTGTGCTGG GCAAGGGGAA CTATGGCAAG 240

GTGTTCCAGG TGCGAAAGGT ACAGGGCAGC AATCTGGGCA AAATATATGC CATGAAAGTC 300

CTGAGGAAGG CCAAAATTGT GCGCAACGCC AAGGACACGG CACACACGCG GGCCGAGCGG 360

AACATTCTGG AGTCGGTGAA GCACCCCTTC ATTGTGGAAC TGGCCTATGC CTTCCAGACT 420

GGCGGCAAAC TGTACCTCAT CCTCGAGTGC CTCAGCGGTG GTGAGCTTTT CACGCACCTG 480

GAGCGAGAAG GCATCTTCCT AGAAGACACG GCCTGTTTCT ACCTGTCGGA GATCACACTG 540

GCCCTGGGCC ATCTCCACTC CCAAGGCATC ATCTACCGGG ACCTCAAACC TGAAAACATC 600

ATGCTCAGCA GCCAGGGCCA CATCAAACTG ACGGACTTTG GCCTCTGCAA GGAGTCGATC 660

CACGAGGGCG CCGTGACCCA CACCTTCTGC GGCACCATCG AGTACATGGC CCCTGAGATT 720

CTGGTGCGCA GTGGCCACAA CCGGGCGGTG GACTGGTGGA GCTTGGGGGC CCTGATGTAC 780

GACATGCTCA CTGGATCGCC GCCCTTCACT GCAGAGAACC GGAAGAAAAC CATGGACAAG 840

ATCATCAGAG GGAAGCTGGA ACTGCCCCCC TACCTCACCC CGGATGCCCG GGATCTTGTC 900

AAAAAGTTCC TGAAGCGGAA TCCTAACCAG CGGATTGGAG GGGGCCCCGG GGATGCTGCT 960

GACGTGCAGA GGCACCCCTT CTTCCGGCAC GTTAATTGGG ATGACCTCCT GGCCCGCCGT 1020

GTGGACCCCC CTTTCCGGCC TTCCCTGCAG TCGGAGGAGG ACGTGAGCCA GTTTGACTCC 1080

CACTTCACGA AGCAGACGCC GGTGGACAGT CCAGACGACA CGACGCTCAG TGAGAGTGCC 1140

AACCAGGCCT TCCTGGGCTT CACGTACGTG GCGCCCTCCG TCCTGGATAG CATCAAGGAG 1200

GCCTTCTCCT TCCAGCCCAA GCTGCGCTCG CCCAGGCGCC TCAACAGCAG CCCCCGGACC 1260

CCTGTCAGCC CCCTGAAGTT CTCGCCCTTC GAGGGGTTCC GGCCCAGCCC TGGCCCACAG 1320

GAGCTCGTGG AGCCCCCACT ACCTCCTCTG CTGCCACCGC CGCCACCACC ACCGCCCTCG 1380

AGCACTGCCC CTCTCCCCAT CCGACCCCCC TCGGGGACCA AGAAGTCCAA GAGGGGCCGC 1440

GGGCGCCCTG GGCGCTAA 1458

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 67    FELLRVLGKGNYGKVFQVRKVQGSNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  126

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+l+e++lal +lH

Q: 127   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLSEITLALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 187   SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i +gk  l+lp +  l+++a+dlvk

Q: 246   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGK--LELPPY--LTPDARDLVK  301

         ****************************************..******..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 302   KFLKRNPNQRIGGgpgDAADVQRHPFF  328

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG NYGKVFQVRK VQGSNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLS EITLALGHLH 120

SQGIIYRDLK PENIMLSSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIRGKL ELPPYLTPDA RDLVKKFLKR 240

NPNQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade

KEGG

bta:506083

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013