EPS-BOT-00020

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00020

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	267.2	2.0E-79	61	373	313

Status

Unreviewed

Ensembl Protein

ENSBTAP00000012404

UniProt Accession

E1BD03;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1D

Gene Synonyms/Alias

PPM1D;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000009427	ENSBTAP00000012404	ENSBTAT00000012404

Organism

Bos taurus

Functional Description

Protein Length

605

Protein Sequence
(FASTA)

MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPAAEEELS SRRSPSRPPP PPRSPPPPAG 60

GEVAGRGAAG AAREARAAPP DAGASPAPGR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL 120

WGFIKKQRGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII 180

RGLKMYVAHV GDSGVVLGIQ DDPKDDFIRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG 240

VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT 300

LDPQKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ 360

RMLRADNTSA IVICISPGVD SQGHFTSEDE LYLNLTDSPS YNSQETCVMT PSPCSTPPVK 420

PLEEDPWPRL NSKDHIPALI RSNAFSENYL EVPPEIARGN VQAAVISSKD PEPLEENCTK 480

ALTLRIHDSL NNSLSVGLVP TNSTNTITDQ KNVKISSPGQ MKAQEVERTP PANFKRTLEE 540

SNSGPLMKKH RRNGLSRSSG AQPASLPTTS QRKNSVKLTV RRRLRGQKKI GNPLLHQHRK 600

TVCVC 605

Nucleotide Sequence
(FASTA)

ATGGCGGGGC TGTACTCGCT GGGAGTGAGC GTCTTCTCCG ACCAGGGCGG GAGGAAGTAC 60

ATGGAGGACG TTACTCAGAT CGTTGTGGAG CCCGAGCCGG CGGCCGAGGA AGAGCTCTCG 120

TCGCGGCGAT CGCCCTCGCG CCCGCCGCCT CCGCCGCGGT CACCGCCGCC CCCGGCCGGC 180

GGCGAAGTGG CGGGGAGAGG CGCCGCGGGG GCCGCCCGGG AGGCTCGCGC CGCGCCGCCC 240

GACGCCGGGG CCTCGCCGGC TCCCGGCCGC TGCTGCCGCC GCCGCTCCTC GGTGGCCTTC 300

TTCGCCGTGT GCGACGGGCA CGGCGGGCGG GAGGCGGCGC AGTTCGCCCG CGAGCACCTG 360

TGGGGTTTCA TTAAGAAGCA GAGGGGCTTC ACGTCGTCCG AGCCGGCGAA GGTGTGCGCC 420

GCCATCCGCA AAGGCTTCCT CGCCTGTCAT CTCGCCATGT GGAAGAAGCT GGCAGAATGG 480

CCAAAGACTA TGACAGGTCT TCCCAGCACG TCAGGGACAA CTGCCAGCGT GGTCATCATC 540

CGAGGCTTGA AGATGTATGT TGCTCACGTG GGCGACTCAG GGGTGGTTCT TGGAATTCAG 600

GATGACCCCA AGGATGATTT TATCCGAGCT GTGGAGGTGA CACAGGACCA TAAGCCAGAA 660

CTTCCCAAGG AAAGAGAACG AATTGAAGGA CTTGGTGGGA GTGTGATGAA CAAGTCTGGG 720

GTGAACCGTG TGGTTTGGAA ACGGCCTCGG CTCACTCACA ATGGACCTGT GAGGAGGAGC 780

ACAGTCATTG ACCAGATTCC CTTTCTGGCA GTAGCCAGAG CACTTGGTGA TTTGTGGAGC 840

TATGATTTCT TCAGTGGCGA GTTTGTGGTG TCACCTGAAC CAGACACAAG CGTCCACACT 900

CTTGACCCCC AGAAGCACAA GTATATTATC TTGGGAAGTG ATGGGCTTTG GAATATGATC 960

CCACCTCAAG ACGCCATCTC CATGTGCCAG GACCAAGAGG AGAAAAAATA CCTGATGGGT 1020

GAGCATGGAC AGTCTTGTGC CAAAATGCTT GTGAATCGAG CCCTAGGCCG CTGGAGGCAG 1080

CGAATGCTTC GAGCAGATAA TACTAGTGCC ATAGTAATCT GCATCTCTCC GGGAGTGGAC 1140

AGTCAGGGAC ATTTCACCAG TGAAGATGAG CTCTATCTGA ACCTGACTGA TAGCCCTTCC 1200

TATAACAGTC AAGAAACCTG CGTGATGACT CCTTCTCCGT GTTCTACACC ACCAGTCAAG 1260

CCCCTGGAGG AGGACCCATG GCCAAGGCTG AACTCCAAGG ACCATATACC TGCCCTTATC 1320

CGTAGTAATG CCTTCTCAGA GAATTATTTA GAAGTCCCAC CTGAGATAGC TCGAGGGAAT 1380

GTCCAGGCTG CAGTCATATC CTCAAAAGAT CCAGAGCCAC TAGAAGAAAA TTGCACTAAA 1440

GCCCTGACTT TAAGGATACA CGATTCTTTG AATAATAGCC TGTCCGTTGG CCTGGTGCCT 1500

ACCAATTCAA CAAACACCAT CACGGACCAA AAAAATGTGA AGATATCGAG CCCGGGTCAA 1560

ATGAAAGCCC AGGAAGTTGA AAGAACCCCT CCGGCAAACT TCAAAAGGAC ATTGGAAGAA 1620

TCCAACTCCG GCCCTCTAAT GAAGAAGCAC AGGCGGAATG GTTTAAGTCG TAGTAGTGGT 1680

GCTCAGCCTG CAAGCCTCCC CACAACCTCC CAGCGCAAGA ACTCTGTTAA ACTTACCGTG 1740

CGACGCAGAC TCAGGGGCCA GAAGAAAATT GGAAATCCTT TACTTCACCA GCACAGAAAA 1800

ACTGTTTGTG TTTGCTGA 1818

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr......laffgvyDGhggsevakfcsekl  57

         g v++ g     ++a+++ p++++sp+  ++      +aff+v+DGhgg+e+a+f++e+l

Q: 61    GEVAGRGAAGAAREARAAPPDAGASPAPGRCcrrrssVAFFAVCDGHGGREAAQFAREHL  120

         67888999999999*************99999****************************

S: 58    heilaeelesseseerkvkkalakaFlstdeel.....kvleeksldidksGstavvali  112

         + +++++  +++se +kv++a++k+Fl+++ ++     +++++++  +++sG+ta+v++i

Q: 121   WGFIKKQRGFTSSEPAKVCAAIRKGFLACHLAMwkklaEWPKTMTGLPSTSGTTASVVII  180

         ************************************************************

S: 113   kdsklyvanvGdSravLcrngk.......avelssdHkpsredEleRieeaggsvilkdg  165

         ++ k+yva+vGdS++vL+ +++       ave+++dHkp+ ++E+eRie  ggsv++k+g

Q: 181   RGLKMYVAHVGDSGVVLGIQDDpkddfirAVEVTQDHKPELPKERERIEGLGGSVMNKSG  240

         *******************77656999999******************************

S: 166   a.Rv.....................lGvLavsRalGdlylk......pyvtpePevtshr  197

         + Rv                     +++Lav+RalGdl+++      ++v+peP++++h+

Q: 241   VnRVvwkrprlthngpvrrstvidqIPFLAVARALGDLWSYdffsgeFVVSPEPDTSVHT  300

         ************************************************************

S: 198   ltsede.fliLasDGlwdvvsneeavslvrdvle....kkeaeqeaakkLvklalargsk  252

         l+++++ ++iL+sDGlw+++++++a+s+++d++e    ++e+ q++ak+Lv++al r+++

Q: 301   LDPQKHkYIILGSDGLWNMIPPQDAISMCQDQEEkkylMGEHGQSCAKMLVNRALGRWRQ  360

         ************************************************************

S: 253   .....dnvsaivv  260

              dn+saiv+

Q: 361   rmlraDNTSAIVI  373

         ***********97

Domain Sequence
(FASTA)

GEVAGRGAAG AAREARAAPP DAGASPAPGR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL 60

WGFIKKQRGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII 120

RGLKMYVAHV GDSGVVLGIQ DDPKDDFIRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG 180

VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT 240

LDPQKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ 300

RMLRADNTSA IVI 313

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0009617	; P:response to bacterium

KEGG

bta:514005

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013