EPS-BOT-00060
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-BOT-00060
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/PTEN257.87.4E-771151151
StatusUnreviewed
Ensembl ProteinENSBTAP00000012499
UniProt AccessionF1MDX9;
Protein Name
Protein Synonyms/Alias
Gene NamePTEN
Gene Synonyms/Alias PTEN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000009498ENSBTAP00000012499ENSBTAT00000012499
OrganismBos taurus
Functional Description
Protein Length369
Protein Sequence
(FASTA)
MGFPAERLEG VYRNNIDDVV RFLDSKHKNH YKIYNLCAER HYDTAKFNCR VAQYPFEDHN 60
PPQLELIKPF CEDLDQWLSE DDNHVAAIHC KAGKGRTGVM ICAYLLHRGK FLKAQEALDF 120
YGEVRTRDKK GVTIPSQRRY VYYYSYLLKN HLDYRPVALL FHKMMFETIP MFSGGTCNPQ 180
FVVCQLKVKI YSSNSGPTRR EDKFMYFEFP QPLPVCGDIK VEFFHKQNKM LKKDKMFHFW 240
VNTFFIPGPE ETSEKVENGS LCDQEIDSIC SIERADNDKE YLVLTLTKND LDKANKDKAN 300
RYFSPNFKVK LYFTKTVEES SNPEASSSTS VTPDVSDNEP DHYRYSDTTD SDPENEPFDE 360
DQHTQITKV 369
Nucleotide Sequence
(FASTA)
ATGGGCTTTC CTGCAGAAAG ACTTGAAGGT GTATACAGGA ACAATATAGA TGATGTAGTA 60
AGGTTTTTGG ATTCAAAGCA TAAAAACCAT TACAAGATAT ACAATCTATG TGCTGAAAGA 120
CATTATGATA CCGCCAAATT TAATTGCAGA GTTGCACAGT ATCCCTTTGA AGACCATAAT 180
CCACCACAGT TAGAACTTAT CAAACCCTTT TGTGAAGATC TTGACCAATG GCTAAGTGAA 240
GATGACAATC ATGTTGCAGC AATTCACTGT AAAGCTGGAA AGGGACGAAC TGGTGTAATG 300
ATTTGTGCAT ATTTGTTACA TCGGGGCAAA TTTTTAAAGG CACAAGAGGC CCTAGATTTC 360
TATGGGGAAG TAAGGACCAG AGACAAAAAG GGAGTAACTA TTCCCAGTCA GAGGCGCTAT 420
GTGTATTATT ATAGCTACCT GTTAAAGAAT CATCTGGATT ATAGACCAGT GGCACTGTTG 480
TTTCACAAGA TGATGTTTGA AACTATTCCA ATGTTCAGTG GTGGAACTTG CAATCCTCAG 540
TTTGTGGTCT GCCAGCTAAA GGTGAAGATA TATTCCTCCA ATTCAGGACC CACACGACGG 600
GAAGACAAGT TCATGTACTT TGAGTTCCCT CAGCCATTGC CTGTGTGTGG TGACATCAAA 660
GTAGAGTTCT TCCACAAACA GAACAAGATG CTAAAAAAGG ACAAAATGTT TCACTTTTGG 720
GTAAACACAT TCTTCATACC AGGACCAGAG GAAACCTCAG AAAAAGTAGA AAATGGAAGT 780
CTATGTGATC AAGAAATTGA TAGTATTTGC AGTATAGAGC GTGCAGATAA TGACAAGGAA 840
TATCTAGTAC TCACTTTAAC AAAAAATGAT CTCGACAAAG CAAATAAAGA CAAGGCCAAC 900
CGATACTTTT CTCCAAATTT TAAGGTGAAG CTGTACTTCA CAAAAACAGT AGAGGAGTCA 960
TCAAATCCAG AGGCTAGCAG TTCAACTTCT GTAACACCAG ATGTTAGTGA CAATGAACCT 1020
GATCATTATA GATATTCTGA CACCACTGAC TCTGATCCAG AGAATGAACC TTTTGATGAA 1080
GATCAGCATA CACAAATTAC AAAAGTCTGA 1110
Domain Profile
S: 22    vsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltklnakvaefgiedln  81
         ++fPae+ e+vyrnn+++vvr+ldskh+n+yk+ynlc+er+yd++k+n++va++++ed+n
Q: 1     MGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHN  60
         89**********************************************************
S: 82    aPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayllaseisakadealdt  141
         +P+le ++++c++ld+Wlsedd++v+++hck+gkgr+Gv++cayll++++++ka+eald+
Q: 61    PPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDF  120
         ************************************************************
S: 142   fgerrtredkvagvkqPsqrryvsyfsqllkgs  174
         +ge+rtr++k  gv++Psqrryv+y+s+llk++
Q: 121   YGEVRTRDKK--GVTIPSQRRYVYYYSYLLKNH  151
         **********..******************986
Domain Sequence
(FASTA)
MGFPAERLEG VYRNNIDDVV RFLDSKHKNH YKIYNLCAER HYDTAKFNCR VAQYPFEDHN 60
PPQLELIKPF CEDLDQWLSE DDNHVAAIHC KAGKGRTGVM ICAYLLHRGK FLKAQEALDF 120
YGEVRTRDKK GVTIPSQRRY VYYYSYLLKN H 151
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EPS-AIM-00070
EPS-ANC-00070
EPS-CAE-00090
EPS-CAJ-00060
EPS-CAF-00075
EPS-CAP-00056
EPS-CHH-00018
EPS-CII-00031
EPS-CIS-00020
EPS-DAR-00103
EPS-DIO-00023
EPS-DRM-00027
EPS-EQC-00058
EPS-ERE-00015
EPS-FEC-00070
EPS-GAM-00057
EPS-GAG-00064
EPS-GAA-00095
EPS-GOG-00071
EPS-HOS-00056
EPS-ICT-00059
EPS-LAC-00074
EPS-LOA-00054
EPS-MAM-00059
EPS-MEG-00066
EPS-MOD-00058
EPS-MUM-00056
EPS-MYL-00058
EPS-NOL-00066
EPS-ORN-00073
EPS-ORA-00063
EPS-ORC-00054
EPS-ORL-00083
EPS-OTG-00058
EPS-PAT-00053
EPS-PES-00071
EPS-POA-00072
EPS-RAN-00059
EPS-SAH-00057
EPS-SUS-00058
EPS-TAG-00068
EPS-TAR-00092
EPS-TAS-00020
EPS-TEN-00069
EPS-VIP-00021
EPS-XET-00068
EPS-XIM-00102
EPS-SCP-00017
Gene Ontology
GO:0042995; C:cell projection
GO:0005737; C:cytoplasm
GO:0009898; C:internal side of plasma membrane
GO:0035749; C:myelin sheath adaxonal region
GO:0005634; C:nucleus
GO:0043220; C:Schmidt-Lanterman incisure
GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287; F:magnesium ion binding
GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438; F:phosphatidylinositol-3-phosphatase activity
GO:0004722; F:protein serine/threonine phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0007092; P:activation of mitotic anaphase-promoting complex activity
GO:0001525; P:angiogenesis
GO:0060070; P:canonical Wnt receptor signaling pathway
GO:0048738; P:cardiac muscle tissue development
GO:0032286; P:central nervous system myelin maintenance
GO:0021955; P:central nervous system neuron axonogenesis
GO:0060997; P:dendritic spine morphogenesis
GO:0021542; P:dentate gyrus development
GO:0043542; P:endothelial cell migration
GO:0048853; P:forebrain morphogenesis
GO:0006917; P:induction of apoptosis
GO:0046855; P:inositol phosphate dephosphorylation
GO:0007611; P:learning or memory
GO:0045475; P:locomotor rhythm
GO:0060291; P:long-term synaptic potentiation
GO:0060179; P:male mating behavior
GO:0042711; P:maternal behavior
GO:0033555; P:multicellular organismal response to stress
GO:0043066; P:negative regulation of apoptotic process
GO:0050771; P:negative regulation of axonogenesis
GO:0090344; P:negative regulation of cell aging
GO:0030336; P:negative regulation of cell migration
GO:0045792; P:negative regulation of cell size
GO:0031658; P:negative regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0061002; P:negative regulation of dendritic spine morphogenesis
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential
GO:0051895; P:negative regulation of focal adhesion assembly
GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle
GO:0031642; P:negative regulation of myelination
GO:0046621; P:negative regulation of organ growth
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0090071; P:negative regulation of ribosome biogenesis
GO:2000808; P:negative regulation of synaptic vesicle clustering
GO:0007270; P:neuron-neuron synaptic transmission
GO:0046856; P:phosphatidylinositol dephosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential
GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107; P:postsynaptic density assembly
GO:0060134; P:prepulse inhibition
GO:0097105; P:presynaptic membrane assembly
GO:0060736; P:prostate gland growth
GO:0043491; P:protein kinase B signaling cascade
GO:0050821; P:protein stabilization
GO:0002902; P:regulation of B cell apoptotic process
GO:0033032; P:regulation of myeloid cell apoptotic process
GO:0060024; P:rhythmic synaptic transmission
GO:0035176; P:social behavior
GO:0060074; P:synapse maturation
KEGG
InterPros
IPR017361; Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR014019; Phosphatase_tensin-typ.
IPR014020; Tensin_phosphatase_C2-dom.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
PF10409; PTEN_C2; 1.
SMARTs
Prosites
PS51182; C2_TENSIN; 1.
PS51181; PPASE_TENSIN; 1.
PS00383; TYR_PHOSPHATASE_1; 1.
Prints
Created Date20-Feb-2013