EPS-BOT-00127

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00127

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	565.7	2.4E-170	119	450	332

Status

Unreviewed

Ensembl Protein

ENSBTAP00000012557

UniProt Accession

F1MBQ1;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF1

Gene Synonyms/Alias

PPEF1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000009545	ENSBTAP00000012557	ENSBTAT00000012557

Organism

Bos taurus

Functional Description

Protein Length

647

Protein Sequence
(FASTA)

SNCFSLSFIS CGSAALKAAL VIQNWYRGYS ARLKTRQRYA LTIFQSIEYA DEQGQLQLSN 60

FFSFMLENYT NVPEKEPVLD NYNLNSIQDK DRQDYLGLIE IPDSYCGPRL QFPLTFTDID 120

LLIEAFKQQQ ILHAYYVLEV LFETKKVLQQ MPNFTHTNTS PSKEITICGD LHGKLDDLFL 180

IFYKNGLPSV TNPYVFNGDF VDRGKNSMEI LMILFVSFLV YPNDLHLNRG NHEDFMMNMR 240

YGFTKEILHK YKLHGKKILQ ILEEVYTWLP IGTIIDNEVL VIHGGISEST DLNLLHRIER 300

NKMRSVLMPP IPMDGDRAEK KNKLGTATVA LGIRTSGSFS EQLTKQEWEQ VIDILWSDPR 360

GKRGCYPNTN RGGGCYFGPD ITSKILNKYQ LKMLVRSHEC KPEGYEICHD GKVITVFSAS 420

NYYEEGSNRG AYIRMSSGTT PRFFQYQITK ATCFRPLYQR VNAIESSAIR MLKERMISRK 480

TDLIRAFQLQ DRNKSGKLSM GQWAFSMENV LGLNLPWRSL SSHLVTTDKD GNIDYMSGFQ 540

DVHIQKPVKE VQSSLIETVY RYRSDLQIIF NIIDSDHSGL ISMEEFRSMW RLFKSHYSVH 600

IDDSQFDELA ERMDLNKDGS IDFNEFLKAF YVVHKFDQLN KSDTKLA 647

Nucleotide Sequence
(FASTA)

AGTAACTGTT TTTCTTTGTC TTTCATATCC TGTGGGTCTG CAGCACTAAA AGCCGCATTG 60

GTCATACAGA ACTGGTACCG AGGTTACAGC GCCCGGTTGA AGACCAGACA GCGCTATGCC 120

CTCACTATCT TCCAGTCCAT CGAATACGCT GATGAGCAAG GCCAGTTGCA GCTCTCAAAC 180

TTCTTCTCCT TCATGTTGGA AAACTATACA AATGTGCCGG AGAAAGAGCC AGTTTTAGAT 240

AATTACAATT TGAACAGCAT CCAGGACAAG GATAGACAAG ACTATTTGGG GTTGATAGAA 300

ATCCCAGACT CCTACTGTGG TCCTCGGCTG CAATTTCCTC TCACTTTTAC GGACATTGAT 360

TTACTTATTG AGGCCTTCAA GCAACAACAG ATACTTCATG CTTATTATGT CTTAGAGGTG 420

CTGTTTGAAA CCAAGAAAGT CCTGCAGCAA ATGCCGAATT TCACTCATAC AAACACATCT 480

CCATCCAAAG AGATAACAAT CTGTGGTGAT TTGCATGGGA AGCTAGATGA CCTTTTTCTG 540

ATCTTCTATA AGAATGGTCT CCCCTCAGTG ACCAACCCAT ATGTTTTTAA TGGTGATTTT 600

GTAGATCGAG GAAAAAATTC CATGGAGATC CTAATGATCC TGTTTGTGAG TTTTCTTGTG 660

TACCCAAATG ACCTGCACTT GAACAGAGGC AACCATGAGG ATTTTATGAT GAATATGAGG 720

TATGGCTTCA CGAAAGAAAT TTTACATAAA TATAAGCTGC ATGGAAAAAA AATCTTACAA 780

ATCTTGGAAG AGGTCTATAC CTGGCTCCCA ATTGGTACAA TCATTGACAA TGAAGTCCTG 840

GTCATACATG GAGGGATATC AGAGTCCACA GACTTGAATT TACTCCACCG TATAGAAAGA 900

AACAAAATGA GATCTGTGCT GATGCCGCCA ATTCCAATGG ATGGAGACCG TGCTGAGAAG 960

AAAAATAAAC TGGGTACAGC CACTGTGGCT CTGGGAATCA GAACAAGTGG ATCCTTTTCT 1020

GAACAATTAA CAAAGCAGGA ATGGGAGCAG GTTATCGATA TCCTTTGGAG TGATCCCAGA 1080

GGCAAAAGAG GCTGCTACCC AAACACGAAC CGAGGAGGGG GCTGCTACTT TGGACCAGAC 1140

ATTACCTCCA AGATTCTTAA TAAATACCAG TTGAAGATGC TTGTTAGATC TCATGAGTGT 1200

AAGCCTGAAG GGTATGAAAT CTGCCACGAT GGGAAGGTTA TTACTGTATT TTCTGCGTCT 1260

AATTATTATG AAGAAGGTAG CAATCGAGGA GCTTACATCA GAATGAGTTC TGGTACGACC 1320

CCTCGATTTT TCCAGTACCA AATAACTAAG GCAACATGCT TCAGGCCTCT TTACCAAAGG 1380

GTGAATGCTA TTGAAAGTAG TGCCATCAGG ATGTTAAAAG AGAGAATGAT TTCACGAAAA 1440

ACTGACCTCA TTCGAGCTTT CCAACTTCAA GACCGCAATA AATCAGGAAA ACTTTCAATG 1500

GGCCAGTGGG CTTTTTCAAT GGAGAATGTT TTGGGGCTGA ACTTACCATG GAGATCACTG 1560

AGTTCTCATC TGGTAACCAC AGACAAAGAT GGAAATATTG ACTACATGTC TGGCTTCCAG 1620

GATGTCCACA TTCAGAAACC TGTGAAAGAG GTTCAGTCTT CTCTAATTGA AACAGTGTAC 1680

AGATACCGAT CTGACCTGCA AATCATCTTT AATATCATTG ACTCTGATCA CTCAGGCCTG 1740

ATCTCCATGG AAGAATTTCG TAGCATGTGG AGACTTTTCA AAAGTCACTA CAGTGTCCAT 1800

ATTGATGATT CCCAGTTTGA TGAGCTCGCC GAAAGGATGG ACTTAAACAA AGATGGAAGC 1860

ATTGACTTTA ATGAGTTTTT AAAGGCTTTC TATGTAGTGC ATAAATTTGA CCAGTTGAAC 1920

AAATCAGACA CCAAGCTTGC ATAA 1944

Domain Profile

S: 1     idlllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddl  60

         idll+e+fk+++ilha yvlevlfe+kkvl+q+pn++h +t++ske+t++GdlhGklddl

Q: 119   IDLLIEAFKQQQILHAYYVLEVLFETKKVLQQMPNFTHTNTSPSKEITICGDLHGKLDDL  178

         8***********************************************************

S: 61    llvlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmn  120

         +l+++knGlPs +npyvfnGdfvdrGk+++e+l++l ++flv+Pn+++lnrGnhed++mn

Q: 179   FLIFYKNGLPSVTNPYVFNGDFVDRGKNSMEILMILFVSFLVYPNDLHLNRGNHEDFMMN  238

         ************************************************************

S: 121   aryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksv  180

         +ryGf+ke+l+kyk +gk+il+ileevy+wlP+g+i+d++vlv+hGG+sest+l+ll+++

Q: 239   MRYGFTKEILHKYKLHGKKILQILEEVYTWLPIGTIIDNEVLVIHGGISESTDLNLLHRI  298

         ************************************************************

S: 181   erkkrksvllpPeessrd.............lgrldtdgepreslteteweqiidilwsd  227

         er+k++svl+pP + + d                ++t g+ +e+lt++eweq+idilwsd

Q: 299   ERNKMRSVLMPPIPMDGDraekknklgtatvALGIRTSGSFSEQLTKQEWEQVIDILWSD  358

         *************988889999***99998855699************************

S: 228   PratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvtifs  287

         Pr++ G++Pnt rG+G+yfGPd+t+++l+ky+lk+++rsheckpegyei+hdgkv+t+fs

Q: 359   PRGKRGCYPNTNRGGGCYFGPDITSKILNKYQLKMLVRSHECKPEGYEICHDGKVITVFS  418

         ************************************************************

S: 288   asnyyeegsnkgayiklnsqltprfvqyivak  319

         asnyyeegsn+gayi+++s++tprf+qy+++k

Q: 419   ASNYYEEGSNRGAYIRMSSGTTPRFFQYQITK  450

         *****************************986

Domain Sequence
(FASTA)

IDLLIEAFKQ QQILHAYYVL EVLFETKKVL QQMPNFTHTN TSPSKEITIC GDLHGKLDDL 60

FLIFYKNGLP SVTNPYVFNG DFVDRGKNSM EILMILFVSF LVYPNDLHLN RGNHEDFMMN 120

MRYGFTKEIL HKYKLHGKKI LQILEEVYTW LPIGTIIDNE VLVIHGGISE STDLNLLHRI 180

ERNKMRSVLM PPIPMDGDRA EKKNKLGTAT VALGIRTSGS FSEQLTKQEW EQVIDILWSD 240

PRGKRGCYPN TNRGGGCYFG PDITSKILNK YQLKMLVRSH ECKPEGYEIC HDGKVITVFS 300

ASNYYEEGSN RGAYIRMSSG TTPRFFQYQI TK 332

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013