EKS-BOT-00463

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00463

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	430.5	2.9E-129	25	308	284

Status

Unreviewed

Ensembl Protein

ENSBTAP00000013198

UniProt Accession

Q5E9Q6;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase 13;

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000010007	ENSBTAP00000013198	ENSBTAT00000013198

Organism

Bos taurus

Functional Description

Protein Length

366

Protein Sequence
(FASTA)

MSFTRKKGFY KQDVNKTAWE LPKTYVSLTH IGSGAYGSVC SAIDKRSGEK VAIKKLSRPF 60

QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF HDFYLVMPFM QTDLQKIMGM 120

EFSEDKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHTDVEMT 180

GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG 240

VPGAEFVQKL NDKAAKSYIQ SLPQSPKKDF SQLFPRASPQ ATDLLEKMLE LDVDKRLTAS 300

QALAHPFFEP FRDPEEETEA QQPLEDSLER EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR 360

SGMKLQ 366

Nucleotide Sequence
(FASTA)

ATGAGCTTCA CCCGGAAAAA GGGCTTCTAC AAGCAGGACG TCAACAAGAC CGCCTGGGAG 60

CTGCCCAAGA CCTACGTGTC CCTGACGCAC ATAGGCAGCG GGGCCTACGG CTCAGTGTGC 120

TCAGCCATCG ACAAGCGGTC AGGGGAGAAG GTGGCCATCA AGAAGCTGAG CCGGCCCTTC 180

CAGTCCGAGA TCTTTGCCAA GCGGGCTTAT CGGGAGCTGC TGCTGCTGAA ACACATGCAG 240

CATGAAAACG TCATCGGGCT TCTGGATGTC TTCACCCCAG CCTCCTCCCT GCGCAACTTC 300

CATGACTTCT ACCTGGTGAT GCCCTTCATG CAGACGGACC TGCAGAAGAT CATGGGGATG 360

GAGTTCAGTG AGGACAAGAT CCAGTACCTG GTGTACCAGA TGCTCAAGGG TCTTAAGTAC 420

ATCCACTCAG CTGGGGTCGT CCACAGGGAC CTGAAGCCGG GCAACCTCGC TGTGAATGAG 480

GACTGTGAGC TGAAGATCTT GGATTTTGGG TTGGCACGGC ATACGGATGT GGAGATGACG 540

GGTTACGTGG TGACCCGCTG GTACCGGGCC CCTGAGGTGA TTCTCAGCTG GATGCATTAC 600

AATCAGACTG TGGACATCTG GTCTGTGGGC TGTATCATGG CAGAGATGCT GACAGGGAAG 660

ACGCTGTTCA AGGGGAAAGA CTACCTGGAC CAGCTGACCC AGATTCTGAA AGTGACCGGG 720

GTGCCGGGTG CAGAGTTTGT GCAGAAGCTC AATGACAAGG CGGCCAAATC CTACATCCAG 780

TCCCTGCCAC AAAGCCCCAA AAAGGATTTC TCTCAGCTAT TCCCGCGTGC CAGCCCCCAG 840

GCCACAGACC TGCTGGAGAA GATGCTGGAG CTGGACGTGG ACAAGCGCCT GACGGCCTCG 900

CAGGCCCTCG CCCACCCCTT CTTTGAGCCC TTCCGGGACC CTGAGGAGGA GACAGAGGCC 960

CAGCAGCCGC TCGAGGATTC CTTAGAACGC GAGAAACTCA CAGTGGACGA ATGGAAGCAG 1020

CACATCTACA AGGAGATCGT GAACTTCAGC CCCATTGCCC GGAAGGACTC TCGGCGCCGG 1080

AGTGGCATGA AGCTGCAGTG A 1101

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y sl+++g+Gayg v+sa+dkr++e+vaikklsrpfq+e+ akr++REl llk+++heN+

Q: 25    YVSLTHIGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV  84

         678999******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp+++l++++d+Ylv+ +m+tdL+k++ ++ +s+++i++l+yq+l+glky+Hs

Q: 85    IGLLDVFTPASSLRNFHDFYLVMPFMQTDLQKIMGME-FSEDKIQYLVYQMLKGLKYIHS  143

         ***********************************99.9*********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a+v+HrDlKP+Nl+vnedcelkildFGlar++d e    +t+yv+trwYraPe++ls+++

Q: 144   AGVVHRDLKPGNLAVNEDCELKILDFGLARHTDVE----MTGYVVTRWYRAPEVILSWMH  199

         *********************************99....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI+aE+ltgk+lf+gkd++dql++il+v+g p +ef++k++++ a++yi

Q: 200   YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLNDKAAKSYI  259

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +slp+ +kkdf++lfp+as++a dLlek+L+ld dkR+++++aL+hp++

Q: 260   QSLPQSPKKDFSQLFPRASPQATDLLEKMLELDVDKRLTASQALAHPFF  308

         ***********************************************95

Domain Sequence
(FASTA)

YVSLTHIGSG AYGSVCSAID KRSGEKVAIK KLSRPFQSEI FAKRAYRELL LLKHMQHENV 60

IGLLDVFTPA SSLRNFHDFY LVMPFMQTDL QKIMGMEFSE DKIQYLVYQM LKGLKYIHSA 120

GVVHRDLKPG NLAVNEDCEL KILDFGLARH TDVEMTGYVV TRWYRAPEVI LSWMHYNQTV 180

DIWSVGCIMA EMLTGKTLFK GKDYLDQLTQ ILKVTGVPGA EFVQKLNDKA AKSYIQSLPQ 240

SPKKDFSQLF PRASPQATDL LEKMLELDVD KRLTASQALA HPFF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032755	; P:positive regulation of interleukin-6 production
GO:0006970	; P:response to osmotic stress

KEGG

bta:535327

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013