EPS-BOT-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	241.0	1.9E-71	90	366	277

Status

Reviewed

Ensembl Protein

ENSBTAP00000013428

UniProt Accession

Q0IIF0;

Protein Name

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Protein Synonyms/Alias

ILKAP;

Gene Name

ILKAP

Gene Synonyms/Alias

ILKAP;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000010176	ENSBTAP00000013428	ENSBTAT00000013428

Organism

Bos taurus

Functional Description

Protein phosphatase that may play a role in regulationof cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity).

Protein Length

370

Protein Sequence
(FASTA)

MDLFGDLPEP ERSPRPAAGS GGPLLFDDLP PASSGDSGSL DTSLSEEVKN EGKGAKRKAS 60

DEEKNGSEEL VEKKVCKASS VIFSLKGYVA ERKGEREEMQ DAHVILNDIT AECQPPSALV 120

TRVSYFAVFD GHGGIRASKF AAQNLHQNLI RKFPKGDGIS VEKTVKRCLL DTFKHTDEEF 180

LKQASSQKPA WKDGSTATCV LAVDNTLYIA NLGDSRAILC RYNEESQKHA ALSLSKEHNP 240

TQYEERMRIQ KAGGNVRDGR VLGVLEVSRS IGDGQYKRCG VTSVPDIRRC QLTPNDRFIL 300

LACDGLFKVF TPEEAVNFIL SCLEDEKIQR REGKPTVDAR YEAACNRLAN KAVQRGSADN 360

VTVMVVRIGL 370

Nucleotide Sequence
(FASTA)

ATGGACCTGT TCGGGGACCT GCCGGAGCCC GAGCGCTCGC CGCGGCCGGC TGCTGGCTCT 60

GGGGGACCTT TGCTTTTTGA CGATCTCCCG CCAGCCAGCA GTGGCGATTC AGGTTCTCTT 120

GACACTTCGT TATCCGAGGA GGTAAAGAAT GAAGGGAAAG GAGCAAAGAG AAAAGCCTCT 180

GATGAAGAGA AGAATGGGAG TGAAGAGCTT GTGGAAAAGA AAGTTTGTAA AGCCTCTTCG 240

GTGATCTTCA GCCTGAAAGG CTACGTGGCT GAGCGGAAGG GCGAGCGGGA AGAGATGCAG 300

GATGCCCACG TCATCCTGAA CGACATCACC GCGGAGTGCC AGCCCCCGTC CGCTCTCGTC 360

ACCCGGGTTT CATACTTTGC TGTTTTTGAT GGACATGGAG GAATTCGAGC CTCAAAATTC 420

GCCGCACAGA ATTTGCATCA GAACTTAATC AGGAAATTTC CTAAAGGAGA TGGAATCAGC 480

GTAGAGAAAA CGGTGAAAAG GTGCCTTCTG GACACCTTCA AGCATACTGA TGAAGAGTTC 540

CTTAAGCAAG CCTCAAGCCA GAAACCTGCC TGGAAAGATG GGTCCACTGC CACGTGTGTG 600

CTGGCCGTAG ACAACACTCT TTACATCGCC AACCTGGGGG ACAGTCGGGC AATCCTTTGT 660

CGTTACAATG AGGAGAGTCA AAAACACGCG GCCTTAAGCC TCAGCAAGGA GCATAATCCA 720

ACCCAGTATG AAGAACGAAT GAGAATACAG AAGGCCGGAG GGAATGTCAG GGACGGGCGT 780

GTCCTGGGTG TGCTGGAGGT GTCCCGCTCC ATCGGGGACG GGCAGTACAA GCGCTGCGGG 840

GTCACCTCGG TGCCGGACAT CAGACGCTGC CAGCTGACCC CCAACGACAG GTTTATTTTG 900

CTGGCCTGTG ATGGCCTCTT CAAGGTCTTT ACCCCAGAAG AAGCCGTGAA CTTCATCTTG 960

TCCTGCCTGG AGGACGAGAA GATCCAAAGG CGGGAAGGGA AGCCCACTGT GGATGCCCGC 1020

TACGAAGCCG CCTGCAACAG GCTGGCCAAC AAGGCGGTGC AGCGGGGCTC GGCGGACAAC 1080

GTCACCGTGA TGGTGGTGCG GATAGGGCTC TGA 1113

Domain Profile

S: 6     vsvngrrnemedavtsspnflkspekkdr....laffgvyDGhggsevakfcseklheil  61

         ++ +g+r+em+da+ + +++ ++++  +     +++f+v+DGhgg +++kf++++lh+ l

Q: 90    AERKGEREEMQDAHVILNDITAECQPPSAlvtrVSYFAVFDGHGGIRASKFAAQNLHQNL  149

         567899**************9998887778899***************************

S: 62    aeele..sseseerkvkkalakaFlstdeelkvleeksldidk..sGstavvalikdskl  117

          +++   ++ s e+ vk++l ++F++tdee+  l+++s+++ +   Gsta+++l  d++l

Q: 150   IRKFPkgDGISVEKTVKRCLLDTFKHTDEEF--LKQASSQKPAwkDGSTATCVLAVDNTL  207

         ***9988889999******************..666666655577***************

S: 118   yvanvGdSravLcr.ngk.....avelssdHkpsredEleRieeaggsvilkdgaRvlGv  171

         y+an+GdSra+Lcr n++     a++ls++H+p++ +E+ Ri++agg+v +    RvlGv

Q: 208   YIANLGDSRAILCRyNEEsqkhaALSLSKEHNPTQYEERMRIQKAGGNVRDG---RVLGV  264

         **************7666799*****************************99...*****

S: 172   LavsRalGdlylk.pyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle  230

         L+vsR++Gd+++k   vt+ P++  ++lt++d+f+ La+DGl++v+++eeav+++ ++le

Q: 265   LEVSRSIGDGQYKrCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLE  324

         *************555********************************************

S: 231   ............kkeaeqeaakkLvklalargskdnvsaivv  260

                      +++ ++a+++L++ a++rgs dnv+++vv

Q: 325   dekiqrregkptVDARYEAACNRLANKAVQRGSADNVTVMVV  366

         **************************************9997

Domain Sequence
(FASTA)

AERKGEREEM QDAHVILNDI TAECQPPSAL VTRVSYFAVF DGHGGIRASK FAAQNLHQNL 60

IRKFPKGDGI SVEKTVKRCL LDTFKHTDEE FLKQASSQKP AWKDGSTATC VLAVDNTLYI 120

ANLGDSRAIL CRYNEESQKH AALSLSKEHN PTQYEERMRI QKAGGNVRDG RVLGVLEVSR 180

SIGDGQYKRC GVTSVPDIRR CQLTPNDRFI LLACDGLFKV FTPEEAVNFI LSCLEDEKIQ 240

RREGKPTVDA RYEAACNRLA NKAVQRGSAD NVTVMVV 277

Keyword

Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

bta:514223

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013