EKS-BOT-00391
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00391
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11347.46.9E-104651907257
StatusUnreviewed
Ensembl ProteinENSBTAP00000013549
UniProt AccessionE1BBJ8;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K6
Gene Synonyms/Alias MAP3K6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000010254ENSBTAP00000013549ENSBTAT00000013549
OrganismBos taurus
Functional Description
Protein Length1302
Protein Sequence
(FASTA)
MAGPSPRSGA LERAGSCWQD PLAEALSRGR PLAASPGRGC ARSRPLSVVY VLTREPLPEV 60
EPETGAEAEP LPLRCLREAC AQLPGPRPRP QLHSLPFGTL ALGDTAALDS FYNADVVVLE 120
VSSSLAQPSL FYHLGVRESF SMTNNVLLCS QADLPDLQAL REDIFQKNSD CIGSYTLIPY 180
VVTATGRVLC GDAGLLRGLA DGLLQAGVGT EALLTPLVGR LAHLLEATPT DSCGYFRETI 240
RQDIRRARER FSGLQLRQEL ARLQRRLDSV ELLSPDIIMN LLLSYRDVQD YSAIIDLVET 300
LQALPTCDVA EQHNVCFHYT FALNRRNRPG DREKALAVLL PLVQVEGPVA PDLYCMCGRI 360
YKDMFFSSRF QDAGHREQAY HWYRKAFDIE PSLHSGINAA VLLIADGQRF EDSEELRLIG 420
MKLGCLLARK GCVEKMQYYW DVGFYLGAQI LANDLTQVAL AAEQLYKLNA PIWYLVSVME 480
TFLLYQHFRP TLELPGEAPH GAHFWLHFLL QSCQPLKTAC PQGDQCLVLV LEMNKVLLPA 540
RLEVQGTNPV SAVTLSLLEP EKQDVPSSWT FQVASISGVS VSKRDERCCF LYAPPPAQDV 600
QLCFPSAGHC QWFCGLIQAL VKSPDSGAPA EETEGAGEVL EFDYEYTESG ERLVLGKGTY 660
GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL GSVSQGGYLK 720
IFMEEVPGGS LSSLLRSVWG PLQDNESTIS FYTRQILQGL SYLHDNHIVH RDIKGDNVLI 780
NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA ADIWSLGCTV 840
IEMATGHPPF HELGSPQAAM FQVGMYKVHP PMPGSLSAEA QAFLLRTFEP DPRLRASAQA 900
LLADPFLQPG KRSRSPGSPR QALRSSEAPS ASLAPSADST SQSQTFPRPQ APSQHPPSPP 960
KRCLSYGDTS QLRVPEEPGA DEPASPEESS GLSLLHQESR RRATLATVLE QELPALAESL 1020
RLEQEQDPSF PSQGPRLERS HVEQLLLCLR AHIHTPNRRQ LAQELRGLQG QLRAQGLEPE 1080
LLQGPLFAFP DEVKQVLRRR QIRPHWMFVL DSLLSRAVRA ALAVLAPEVE EEAVLPKSEE 1140
ASNAEESEPK QQETPAEPSP LLGEPEQGTP SLMVQLGLLR AETDRLRDVL AEKERECQAL 1200
VQLALQRVSG EARTCALASE PPAALAVDQG LVQWLQELNV DSGTIQTLLN HRKNLHALLT 1260
CATRDDLIYT GIRGGMICRI WRAILAQRTR STPVTPGPQE AE 1302
Nucleotide Sequence
(FASTA)
ATGGCAGGGC CGAGCCCGCG GTCCGGAGCT CTGGAGCGCG CCGGCAGCTG CTGGCAAGAC 60
CCGCTGGCCG AGGCGCTGAG CCGGGGCCGG CCGCTCGCGG CGTCCCCGGG TCGGGGCTGT 120
GCGCGAAGCC GGCCGCTCAG CGTGGTCTAC GTGCTGACCC GGGAGCCGCT GCCAGAGGTA 180
GAACCCGAGA CGGGAGCCGA GGCGGAGCCG CTGCCTCTGC GCTGCCTGCG TGAGGCCTGC 240
GCGCAGCTCC CCGGACCGCG GCCGCGACCT CAGTTGCACA GCCTGCCTTT TGGAACCCTG 300
GCGCTGGGAG ACACCGCAGC TCTCGATTCG TTCTACAACG CGGATGTGGT GGTGCTTGAG 360
GTGAGCAGCT CCCTGGCACA GCCCTCCCTG TTCTACCACC TGGGTGTGAG GGAGAGCTTC 420
AGCATGACCA ACAACGTGCT CCTCTGCTCC CAGGCCGACC TCCCTGACCT GCAGGCCCTG 480
CGGGAGGACA TTTTCCAGAA GAACTCGGAT TGCATTGGCA GCTACACGCT GATCCCCTAC 540
GTGGTGACAG CCACCGGTCG GGTGCTATGT GGTGATGCGG GCCTCCTGAG GGGCCTGGCT 600
GACGGGCTGC TCCAGGCTGG GGTGGGCACA GAGGCCCTGC TCACACCCCT GGTGGGCCGG 660
CTGGCCCACC TGCTGGAAGC CACACCCACG GACTCTTGTG GCTACTTCCG GGAGACCATT 720
CGGCAGGACA TCCGGAGGGC TCGGGAGCGG TTCAGTGGGC TACAGCTGCG GCAGGAGCTG 780
GCTCGCCTGC AGCGGAGACT GGACAGTGTG GAGCTGCTGA GCCCCGACAT CATCATGAAC 840
CTGCTGCTCT CCTACCGGGA CGTGCAGGAC TATTCAGCCA TCATTGACCT GGTGGAGACC 900
CTGCAGGCCT TGCCCACCTG TGACGTGGCC GAGCAGCATA ATGTCTGCTT CCACTACACC 960
TTTGCCCTCA ACCGGAGGAA CAGGCCTGGG GACCGGGAGA AGGCACTGGC CGTGCTGCTG 1020
CCACTGGTAC AGGTAGAGGG CCCCGTGGCA CCTGATCTGT ACTGCATGTG TGGCCGTATC 1080
TACAAGGACA TGTTCTTCAG CTCTCGCTTC CAGGATGCTG GGCACCGGGA GCAGGCATAT 1140
CACTGGTATC GCAAGGCTTT TGACATAGAG CCCAGCCTTC ACTCGGGCAT CAATGCCGCT 1200
GTGCTCCTCA TTGCTGACGG GCAGCGCTTT GAGGACTCCG AGGAGCTCCG GCTCATAGGC 1260
ATGAAGCTGG GCTGCCTGCT GGCCCGAAAA GGCTGCGTGG AGAAGATGCA GTATTACTGG 1320
GATGTAGGCT TCTACCTGGG AGCTCAGATC CTTGCCAATG ACCTCACTCA GGTGGCACTG 1380
GCCGCAGAGC AGCTGTACAA GCTCAACGCC CCCATATGGT ACCTGGTGTC CGTGATGGAA 1440
ACCTTCCTGC TGTATCAGCA CTTCAGACCC ACACTAGAGC TTCCTGGAGA AGCCCCCCAC 1500
GGCGCCCACT TCTGGCTCCA CTTCTTGCTA CAGTCCTGCC AGCCACTCAA GACAGCTTGT 1560
CCCCAAGGGG ACCAGTGCTT GGTGCTGGTC CTGGAGATGA ATAAGGTGCT GCTGCCCGCC 1620
AGGCTGGAGG TTCAGGGTAC AAACCCGGTG AGCGCGGTGA CCCTGAGCCT GCTGGAGCCG 1680
GAGAAGCAGG ACGTTCCCTC CAGCTGGACC TTCCAGGTGG CCTCCATCAG CGGCGTCAGC 1740
GTCTCCAAGC GGGACGAGCG CTGCTGCTTC CTCTACGCGC CTCCTCCGGC TCAGGACGTC 1800
CAGCTGTGCT TCCCCAGCGC CGGGCACTGC CAGTGGTTCT GCGGCCTGAT CCAGGCCTTG 1860
GTGAAGAGTC CAGACTCCGG GGCGCCCGCA GAGGAGACGG AGGGCGCTGG GGAGGTGTTG 1920
GAGTTTGATT ACGAGTACAC GGAGTCGGGT GAGCGGCTGG TGCTGGGCAA GGGCACGTAC 1980
GGGGTGGTGT ACGCTGGCCG CGATCGACAC ACTCGCGTGC GCATCGCCAT CAAGGAGATC 2040
CCGGAGCGGG ACAGCAGGTT CTCTCAGCCG CTGCATGAAG AGATCGCTCT GCACAAACGC 2100
CTACGCCACA AGAACATTGT GCGCTATCTG GGCTCCGTCA GCCAGGGCGG CTACCTCAAG 2160
ATTTTCATGG AGGAAGTGCC TGGAGGCAGC CTGTCTTCCT TGCTGCGATC GGTGTGGGGA 2220
CCCCTGCAGG ACAACGAGAG CACCATCAGT TTCTACACCC GCCAGATCCT GCAGGGACTC 2280
AGCTACCTGC ACGACAACCA CATTGTGCAT CGAGATATCA AGGGGGACAA CGTGCTGATC 2340
AACACCTTCA GCGGGTTGCT CAAGATTTCT GACTTTGGCA CCTCCAAGCG ACTAGCAGGC 2400
ATCACACCCT GCACTGAGAC CTTCACAGGG ACCCTACAAT ATATGGCCCC AGAAATCATT 2460
GACCAGGGCC CACGAGGGTA TGGGAAGGCA GCAGACATCT GGTCACTGGG CTGCACAGTC 2520
ATCGAGATGG CCACAGGTCA CCCACCCTTC CACGAGCTAG GGAGCCCGCA GGCTGCCATG 2580
TTTCAGGTGG GCATGTACAA GGTGCATCCG CCAATGCCCG GTTCTCTGTC AGCTGAGGCT 2640
CAAGCCTTCC TCCTCCGAAC TTTTGAGCCC GACCCCCGTC TCCGAGCCAG TGCTCAAGCA 2700
CTGCTGGCAG ACCCCTTCCT GCAGCCCGGG AAGAGGAGCC GCAGCCCGGG CTCCCCCAGA 2760
CAGGCTCTAA GGTCCTCAGA GGCGCCATCC GCAAGCCTTG CTCCTTCAGC AGACTCCACC 2820
TCCCAGTCCC AGACATTCCC GCGCCCTCAG GCACCCTCTC AGCACCCTCC CAGTCCCCCC 2880
AAGCGCTGCC TCAGTTATGG GGACACCAGC CAGCTCCGGG TGCCCGAGGA GCCTGGGGCT 2940
GACGAGCCCG CGTCCCCTGA GGAGAGTTCG GGGCTGAGCC TCTTGCATCA AGAGAGTAGG 3000
CGCCGGGCCA CGCTGGCCAC GGTTCTGGAG CAGGAGCTGC CGGCGCTGGC GGAGAGCCTG 3060
CGCCTGGAGC AGGAACAGGA CCCTTCTTTT CCTTCCCAGG GTCCCCGTCT GGAGAGGAGT 3120
CACGTGGAAC AGCTACTGCT CTGCCTCAGG GCGCACATCC ATACTCCCAA CCGTCGGCAG 3180
CTGGCCCAGG AGCTGCGGGG ACTCCAAGGG CAGCTTCGGG CCCAGGGCCT TGAGCCCGAG 3240
CTTCTGCAAG GACCGCTCTT CGCCTTCCCG GATGAGGTGA AGCAGGTCCT CCGCAGGCGC 3300
CAGATCCGCC CACACTGGAT GTTCGTGCTG GACTCGCTGC TCAGCCGTGC TGTGCGGGCA 3360
GCCCTGGCAG TGCTGGCCCC AGAGGTGGAG GAGGAGGCGG TCCTACCGAA GTCGGAAGAG 3420
GCCAGTAATG CAGAGGAGTC CGAGCCCAAG CAGCAGGAGA CCCCAGCCGA GCCGAGCCCT 3480
CTCCTGGGGG AACCGGAGCA GGGTACCCCT TCTCTGATGG TGCAGCTGGG CCTCTTGCGA 3540
GCAGAGACCG ATAGGCTTCG AGATGTTCTG GCTGAGAAGG AAAGGGAATG CCAGGCCTTG 3600
GTGCAACTAG CCCTCCAGCG GGTCAGTGGG GAGGCCAGGA CCTGTGCCCT GGCTTCAGAG 3660
CCCCCAGCGG CTCTCGCGGT GGACCAGGGC CTGGTGCAGT GGTTACAGGA ACTGAATGTG 3720
GATTCAGGCA CCATCCAGAC GCTACTGAAC CACAGAAAAA ACCTCCATGC CCTACTGACC 3780
TGTGCCACTA GAGATGACCT CATCTACACA GGCATCAGGG GGGGGATGAT ATGCCGCATC 3840
TGGAGAGCCA TCTTGGCACA GCGAACAAGA TCCACGCCAG TTACCCCTGG CCCCCAGGAG 3900
GCTGAATGA 3909
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d +t+ ++a+Ke+   pe++s+   +++l+eEi+l+k+l+H+n
Q: 651   ERLVLGKGTYGVVYAGRDRHTRVRIAIKEI---PERDSR--FSQPLHEEIALHKRLRHKN  705
         5779**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ ++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl+yLH+
Q: 706   IVRYLGSVSQGGYLKIFMEEVPGGSLSSLLRsVWGPLQdnESTISFYTRQILQGLSYLHD  765
         *******************************99****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++
Q: 766   NHIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  822
         *****************9*********************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mf+vg+ k++P++p +ls+e+++
Q: 823   GPRGYGKAADIWSLGCTVIEMATGHPPFHELGSPQAAMFQVGMYKVHPPMPGSLSAEAQA  882
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         fl +++e dp+ r+sa+ LL ++fl
Q: 883   FLLRTFEPDPRLRASAQALLADPFL  907
         **********************996
Domain Sequence
(FASTA)
ERLVLGKGTY GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL 60
GSVSQGGYLK IFMEEVPGGS LSSLLRSVWG PLQDNESTIS FYTRQILQGL SYLHDNHIVH 120
RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180
ADIWSLGCTV IEMATGHPPF HELGSPQAAM FQVGMYKVHP PMPGSLSAEA QAFLLRTFEP 240
DPRLRASAQA LLADPFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00364
EKS-ANC-00380
EKS-CAJ-00392
EKS-CAF-00391
EKS-CAP-00420
EKS-EQC-00382
EKS-FEC-00381
EKS-GAA-00477
EKS-HOS-00398
EKS-ICT-00368
EKS-LOA-00400
EKS-MAM-00388
EKS-MAE-00046
EKS-MIM-00057
EKS-MOD-00378
EKS-MUM-00422
EKS-MUP-00384
EKS-MYL-00387
EKS-ORC-00368
EKS-OTG-00392
EKS-PAT-00368
EKS-POA-00382
EKS-RAN-00404
EKS-SUS-00342
EKS-TUT-00109
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013