EKS-BOT-00299
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00299
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR455.84.3E-137708964257
StatusUnreviewed
Ensembl ProteinENSBTAP00000013790
UniProt AccessionA6QR62; F1MLJ4;
Protein Name
Protein Synonyms/Alias ERBB3 protein;
Gene NameERBB3
Gene Synonyms/Alias ERBB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000010444ENSBTAP00000013790ENSBTAT00000013790
OrganismBos taurus
Functional Description
Protein Length1336
Protein Sequence
(FASTA)
MRVNRALQVL GFLLSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLH KLYEKCEVVM 60
GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120
LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNEKLCHMDT IDWRDIVRDR DAEIVVKNNG 180
KTCPPCHEAC KGRCWGPGPE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQN 240
TDCFACRLFN DSGACVRQCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 300
CVRACPPDKM EVDKNGLKIC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG FVNCTKILGN 360
LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420
RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRIYISANR QLCYHHSLNW TRLLRGPSEE 480
RLDIKHNRPR RDCVAEGKVC DPLCSGGCWG PGPGQCLSCR NYSRGGVCVT HCNFLNGEPR 540
EFAHEAECFS CHQECQPMEG TVTCNGSGSD ACAQCAHFRD GPHCVSSCPF GVLGAKGPIY 600
KYPDAQNECR PCHENCTQGC KGPELQDCLG QLLPLISKTH LAMALTVVVG LAVTFLILGS 660
TFLYWRGRKI QNKRAMRRYL ERGESVEPLD PSEKANKVLA RVFKETELRK LKVLGSGIFG 720
TVHKGVWIPE GESIKIPVCI KVIEDKSGRQ SFQAVTDHML AIGSLDHAHI VRLLGLCPGS 780
SLQLVTQYLP LGSLLDHVRQ HRGALGPQLL LNWGVQIAKG MYYLEEHGMV HRNLAARNVL 840
LKSPSQVQVA DFGVADLLPP DDKQLLYNEA KTPIKWMALE SIHFGKYTHQ SDVWSYGVTV 900
WELMTFGAEP YAGLRLAEIP DLLEKGERLA QPQICTIDVY MVMVKCWMID ENIRPTFKEL 960
ANEFTRMARD PPRYLVIKRE SGPGITPGAE PPPLTNKELE EVELEPELDL DLELEAEEEN 1020
LATTLGSALS LPIGTLNRPR GSQSLVSPSS GYMPMNQGNL GEVGQESAVF GGNERYPRPA 1080
SLHPMPRGRL ASESSEGHVT GSEAELQEKV SMCRSQSRSP RPRGDSAYHS QRHSLLTPVT 1140
PQSPPGLEEE DVNGYVMPDT HIKGTSSREG TLSSVGLSSV LGTEDDDDEE YEYMNRRRRC 1200
SPSRPPRPSS LEELGYEYMD VGSDLSASLG STQSCPLNPV PNMPNASTTP DEDYEYMNRR 1260
RGGGGPGGDY AAMDACPASE QGYEEMRAFQ GPVLHGPQVH YARLKTLRSL EATDSAFDNP 1320
DYWHSRLFPK ANAQRI 1336
Nucleotide Sequence
(FASTA)
ATGAGGGTGA ACCGGGCTCT GCAGGTGCTG GGTTTCCTCC TCAGCCTGGC CCGGGGCTCC 60
GAGGTGGGCA ACTCGCAGGC AGTGTGCCCT GGGACTCTGA ATGGGCTGAG TGTGACTGGC 120
GATGCTGAGA ACCAATACCA GACACTGCAC AAGCTCTATG AGAAGTGTGA GGTGGTGATG 180
GGGAACCTGG AGATTGTGCT CACAGGACAC AACGCTGACC TCTCCTTTCT GCAGTGGATC 240
CGAGAAGTGA CCGGCTATGT CCTTGTGGCC ATGAACGAGT TCTCTACACT GCCACTGCCC 300
AACCTCCGAG TGGTGCGGGG GACCCAGGTC TACGATGGGA AGTTTGCCAT CTTTGTCATG 360
TTGAACTACA ACACCAACTC TAGCCACGCT CTGCGCCAGC TCCGCCTTAC TCAGCTCACT 420
GAGATTCTGT CAGGGGGTGT TTACATTGAG AAGAACGAGA AACTTTGTCA CATGGACACA 480
ATCGACTGGA GGGACATCGT GCGGGACCGA GATGCTGAGA TAGTAGTGAA GAACAATGGC 540
AAGACCTGTC CCCCCTGTCA TGAGGCCTGC AAGGGGCGAT GCTGGGGTCC TGGACCAGAA 600
GACTGTCAGA CATTAACCAA GACTATCTGT GCCCCACAGT GTAATGGTCA CTGCTTTGGG 660
CCCAACCCCA ACCAGTGCTG CCATGACGAG TGTGCAGGGG GCTGCTCAGG CCCTCAGAAC 720
ACAGACTGCT TTGCCTGCCG ACTCTTCAAT GACAGTGGGG CCTGTGTACG CCAGTGTCCA 780
CAGCCTCTAG TCTACAACAA GCTAACCTTC CAGTTGGAAC CCAATCCCCA TACCAAGTAT 840
CAGTATGGAG GAGTGTGTGT AGCCAGCTGT CCCCATAACT TTGTGGTGGA TCAGACGTCT 900
TGTGTCAGGG CCTGTCCTCC TGACAAGATG GAAGTAGATA AAAATGGACT CAAGATATGT 960
GAACCTTGTG GGGGTCTGTG CCCGAAAGCC TGTGAGGGGA CAGGCTCCGG GAGCCGCTTC 1020
CAGACTGTGG ACTCGAGCAA CATTGATGGA TTCGTGAACT GCACCAAGAT CCTGGGCAAC 1080
CTGGACTTTC TTATCACTGG CCTCAATGGG GACCCCTGGC ACAAGATCCC TGCTCTGGAC 1140
CCTGAGAAGC TCAATGTCTT TCGGACAGTG CGGGAGATCA CAGGTTACCT GAACATCCAA 1200
TCCTGGCCTC CTCACATGCA CAACTTCAGT GTCTTTTCCA ACCTGACGAC CATTGGGGGC 1260
CGAAGCCTCT ACAACCGGGG CTTCTCACTG TTGATCATGA AGAACTTGAA TGTAACATCT 1320
CTGGGCTTCC GATCCCTGAA AGAAATTAGT GCTGGGCGTA TCTACATCAG TGCCAACAGG 1380
CAGCTCTGCT ACCACCATTC CCTGAACTGG ACCAGGCTGC TTCGGGGGCC TTCAGAAGAG 1440
AGGCTGGACA TCAAGCATAA TCGGCCCCGC AGAGACTGCG TGGCAGAGGG CAAAGTGTGT 1500
GATCCACTGT GCTCTGGAGG ATGCTGGGGC CCAGGCCCTG GCCAGTGCCT ATCTTGCCGG 1560
AACTACAGCC GAGGAGGTGT CTGTGTCACC CACTGCAACT TCTTGAACGG GGAGCCTCGT 1620
GAGTTTGCCC ATGAAGCTGA GTGTTTCTCC TGCCACCAGG AATGCCAACC CATGGAGGGC 1680
ACTGTCACGT GCAATGGCTC GGGCTCTGAT GCTTGTGCCC AGTGTGCCCA TTTTCGAGAT 1740
GGGCCCCACT GTGTGAGCAG CTGCCCCTTT GGAGTCCTCG GTGCCAAGGG CCCCATCTAC 1800
AAGTACCCAG ATGCTCAGAA TGAATGTCGG CCCTGTCATG AGAACTGCAC CCAGGGGTGT 1860
AAGGGACCAG AGCTACAAGA CTGTTTAGGC CAACTGCTGC CACTAATCAG CAAAACCCAC 1920
CTGGCAATGG CCTTAACAGT GGTAGTCGGG TTGGCAGTGA CTTTCCTGAT CCTGGGCAGC 1980
ACTTTTCTCT ACTGGCGTGG ACGCAAGATT CAGAATAAGA GGGCTATGAG GCGCTACCTG 2040
GAACGGGGGG AGAGCGTAGA GCCTCTGGAT CCCAGTGAGA AGGCTAACAA AGTCTTGGCC 2100
CGAGTCTTCA AAGAAACAGA GCTGAGGAAG CTTAAAGTGC TGGGCTCCGG CATCTTTGGA 2160
ACTGTACACA AAGGCGTGTG GATTCCTGAG GGTGAATCAA TCAAGATTCC AGTCTGCATT 2220
AAAGTCATTG AGGACAAGAG CGGACGGCAA AGTTTTCAAG CTGTGACAGA CCACATGCTG 2280
GCCATTGGCA GCCTTGACCA TGCCCACATT GTACGGCTGC TGGGACTGTG TCCAGGGTCA 2340
TCTCTGCAGC TTGTCACTCA GTATTTGCCT CTGGGCTCCC TGCTGGATCA CGTGAGACAA 2400
CACCGTGGGG CGCTGGGGCC GCAGCTGCTG CTCAACTGGG GAGTACAAAT TGCCAAAGGA 2460
ATGTACTACC TTGAGGAACA TGGCATGGTG CACAGGAACC TGGCTGCCCG AAATGTGCTA 2520
CTAAAATCAC CCAGCCAGGT TCAGGTGGCA GATTTTGGGG TTGCTGACTT GCTGCCCCCT 2580
GATGATAAGC AGCTACTGTA CAATGAAGCC AAGACTCCAA TTAAATGGAT GGCCCTGGAG 2640
AGTATCCATT TTGGGAAATA CACACACCAG AGTGACGTCT GGAGCTATGG AGTGACAGTT 2700
TGGGAGCTGA TGACCTTTGG GGCAGAGCCC TATGCAGGGC TGCGACTGGC TGAAATACCA 2760
GACCTGCTGG AGAAGGGGGA GCGGTTGGCA CAGCCCCAGA TCTGTACCAT TGATGTCTAC 2820
ATGGTCATGG TCAAGTGTTG GATGATTGAT GAGAACATTC GCCCGACCTT TAAAGAACTA 2880
GCCAATGAGT TCACCAGGAT GGCCCGAGAC CCACCACGAT ATCTGGTCAT AAAGAGAGAG 2940
AGTGGGCCTG GAATTACCCC TGGGGCAGAG CCCCCACCTC TGACAAACAA GGAACTGGAG 3000
GAAGTAGAGC TGGAGCCAGA ACTAGACCTG GACCTGGAGT TGGAGGCAGA GGAGGAGAAT 3060
CTGGCAACCA CACTAGGCTC TGCCCTTAGC CTGCCAATTG GAACACTTAA TAGACCACGT 3120
GGGAGCCAGA GCCTTGTAAG TCCATCATCT GGATATATGC CTATGAACCA GGGAAATCTT 3180
GGGGAGGTTG GCCAGGAGTC TGCAGTTTTT GGAGGCAATG AACGGTACCC CCGTCCAGCC 3240
TCTCTGCACC CAATGCCACG GGGACGCCTG GCATCAGAAT CATCGGAGGG CCATGTGACA 3300
GGCTCCGAGG CCGAGCTCCA GGAGAAGGTG TCTATGTGTA GAAGCCAGAG CCGGAGCCCA 3360
CGGCCAAGAG GAGACAGTGC CTACCATTCC CAGCGCCACA GCCTGCTTAC TCCTGTCACC 3420
CCACAGTCCC CACCAGGGTT AGAGGAAGAG GATGTCAATG GTTATGTCAT GCCAGATACA 3480
CACATCAAAG GTACCTCCTC CCGGGAAGGC ACCCTTTCTT CAGTGGGTCT CAGTTCTGTT 3540
CTGGGTACAG AAGACGACGA TGATGAGGAA TATGAATACA TGAACCGGAG GAGAAGGTGC 3600
AGTCCATCTC GTCCTCCTAG GCCAAGTTCC CTCGAGGAGC TGGGTTATGA GTACATGGAT 3660
GTGGGATCAG ACCTCAGTGC CTCCCTGGGC AGCACACAGA GTTGCCCGCT CAACCCTGTG 3720
CCCAACATGC CCAATGCCAG CACAACTCCA GATGAGGACT ATGAATATAT GAATCGGCGA 3780
CGTGGTGGAG GAGGTCCTGG GGGGGACTAT GCAGCCATGG ATGCATGCCC AGCCTCTGAG 3840
CAAGGGTATG AAGAAATGAG AGCTTTCCAG GGGCCTGTAC TCCATGGTCC CCAGGTCCAC 3900
TATGCCCGCC TCAAAACTTT ACGTAGTTTA GAAGCCACTG ACTCTGCCTT TGATAACCCT 3960
GATTACTGGC ATAGCAGGCT TTTCCCCAAA GCAAATGCCC AGAGAATATA A 4011
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k+g++++++++d++l+++sldh
Q: 708   LRKLKVLGSGIFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDH  767
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+
Q: 768   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH  827
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky
Q: 828   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYNEAKTPIKWMALESIHFGKY  887
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGa+py+g++++eipdllekGerlaqp+ictidvymv+vkcw
Q: 888   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCW  947
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 948   MIDENIRPTFKELANEF  964
         ****************9
Domain Sequence
(FASTA)
LRKLKVLGSG IFGTVHKGVW IPEGESIKIP VCIKVIEDKS GRQSFQAVTD HMLAIGSLDH 60
AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHRGALGP QLLLNWGVQI AKGMYYLEEH 120
GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLY NEAKTPIKWM ALESIHFGKY 180
THQSDVWSYG VTVWELMTFG AEPYAGLRLA EIPDLLEKGE RLAQPQICTI DVYMVMVKCW 240
MIDENIRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00281
EKS-ANC-00291
EKS-CAE-00255
EKS-CAJ-00306
EKS-CAF-00306
EKS-CAP-00335
EKS-DAR-00648
EKS-DRM-00152
EKS-EQC-00291
EKS-FEC-00285
EKS-GAM-00190
EKS-GAA-00372
EKS-ICT-00282
EKS-LAC-00311
EKS-LOA-00310
EKS-MAM-00303
EKS-MOD-00294
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-OCP-00048
EKS-ORN-00391
EKS-ORC-00282
EKS-ORL-00362
EKS-OTG-00305
EKS-POA-00291
EKS-PTV-00063
EKS-RAN-00316
EKS-SAH-00281
EKS-SUS-00263
EKS-TAR-00393
EKS-TEN-00390
EKS-TUT-00065
EKS-XET-00373
EKS-XIM-00382
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016328; C:lateral plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0030296; F:protein tyrosine kinase activator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004888; F:transmembrane signaling receptor activity
GO:0021545; P:cranial nerve development
GO:0003197; P:endocardial cushion development
GO:0007162; P:negative regulation of cell adhesion
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0051048; P:negative regulation of secretion
GO:0009968; P:negative regulation of signal transduction
GO:0051402; P:neuron apoptotic process
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0042127; P:regulation of cell proliferation
GO:0014037; P:Schwann cell differentiation
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
bta:785655;
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013