EKS-BOT-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	334.5	3.8E-100	56	307	252

Status

Unreviewed

Ensembl Protein

ENSBTAP00000013805

UniProt Accession

E1B9B6;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK1

Gene Synonyms/Alias

NUAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000010457	ENSBTAP00000013805	ENSBTAT00000013805

Organism

Bos taurus

Functional Description

Protein Length

662

Protein Sequence
(FASTA)

MEGAAAPAAG PDLGPGAPGS PPEAGASAAP SAATPEPRKP HGVKRHHHKH NLKHRYELQE 60

TLGKGTYGKV KRATERFSGR VVAIKSIRKD KIKDEQDMVH IRREIEIMSS LNHPHIISIY 120

EVFENKDKIV IIMEYASKGE LYDYISERRR LSERETRHFF RQIVSAVHYC HKNGVVHRDL 180

KLENILLDDN CNIKIADFGL SNLYQKDKFL QTFCGSPLYA SPEIVNGRPY RGPEVDSWAL 240

GVLLYTLVYG TMPFDGFDHK NLIRQISSGE YREPTQPSDA RGLIRWMLMV NPDRRATIED 300

IANHWWVNWG YKSSVCDCDA LHSSESPLLA RIIDWHHRST GLQAEAEAKV KGLAKPGAPE 360

VVLERQRSLK KSKKENDFPQ SGQDSVPESP SKLSSKRPKG ILKKRSNSEH RSHSTGFIEG 420

VVSPALPPTF KLEQDLCRTA VPLPSPPEAE VPGKLSPKQS ATMPKKGILK KTQQRESGYY 480

SSPERSESSE LLDSNDGLGS SIPSPSPPDP ARVPSHSLSC RRKGILKHNS KYSAGTMDPA 540

LASPEMPTLE SLLEPGVPSE GLSRSYSRPS SVISDDSVLS SDSFDLLDLQ ENRPTRQRIR 600

SCVSAENFLQ IQDFEGLQNR PRPQYLKRYR NRLADSSFSL LTDMDDVTQV YKKALEICNK 660

LN 662

Nucleotide Sequence
(FASTA)

ATGGAGGGGG CCGCTGCGCC CGCGGCCGGC CCGGACTTGG GGCCGGGGGC GCCAGGCTCT 60

CCGCCGGAGG CGGGGGCGAG TGCAGCCCCC TCGGCGGCGA CCCCGGAACC CAGGAAGCCG 120

CACGGTGTGA AGCGGCATCA CCACAAACAC AACTTGAAGC ACCGCTACGA GCTGCAGGAG 180

ACCCTGGGCA AAGGCACCTA CGGCAAAGTC AAGCGGGCCA CCGAGAGGTT TTCGGGCCGA 240

GTGGTGGCTA TAAAATCCAT TCGTAAGGAC AAAATTAAGG ATGAACAAGA CATGGTTCAC 300

ATCAGACGAG AGATTGAGAT CATGTCATCC CTCAACCATC CTCATATCAT CAGTATTTAT 360

GAAGTGTTTG AGAACAAAGA TAAGATTGTG ATCATCATGG AGTACGCCAG TAAAGGGGAG 420

CTGTACGACT ACATCAGCGA GCGGCGGCGC CTCAGCGAGC GGGAGACCAG ACACTTCTTC 480

CGGCAGATCG TCTCCGCCGT GCACTATTGT CACAAGAATG GTGTGGTCCA CCGGGACTTG 540

AAGCTGGAAA ATATACTGCT CGATGACAAC TGTAATATTA AGATTGCGGA CTTTGGGCTT 600

TCCAACCTGT ACCAGAAGGA CAAGTTCTTG CAAACGTTCT GTGGGAGCCC ACTCTACGCC 660

TCTCCTGAAA TTGTCAATGG GAGGCCTTAC CGAGGGCCAG AGGTGGACAG CTGGGCCTTG 720

GGCGTACTGC TTTACACTCT TGTTTACGGA ACGATGCCCT TCGATGGTTT CGATCACAAG 780

AACCTCATCC GGCAGATCAG CAGTGGTGAA TATCGGGAGC CCACGCAGCC CTCAGATGCT 840

CGAGGCCTCA TTCGGTGGAT GCTGATGGTG AATCCCGACC GCCGGGCCAC CATCGAGGAC 900

ATCGCCAACC ATTGGTGGGT GAATTGGGGC TACAAGAGCA GTGTCTGCGA CTGTGACGCC 960

CTTCACAGCT CCGAGTCCCC ACTCTTGGCC CGCATTATCG ACTGGCACCA CCGTTCCACA 1020

GGGTTGCAGG CTGAAGCCGA AGCCAAAGTT AAAGGCTTGG CCAAACCTGG GGCCCCTGAG 1080

GTCGTGCTGG AGCGTCAGCG GTCGCTGAAG AAGTCCAAGA AAGAGAACGA CTTCCCTCAG 1140

TCTGGCCAGG ACTCGGTGCC CGAGAGCCCA TCCAAGCTGA GCTCCAAGCG GCCCAAAGGG 1200

ATCCTGAAGA AGCGGAGCAA CAGCGAGCAT CGCTCCCACA GCACTGGCTT CATTGAGGGT 1260

GTCGTCAGCC CGGCCTTACC ACCCACTTTC AAGCTGGAAC AGGACTTGTG CCGGACTGCT 1320

GTGCCCCTGC CAAGCCCCCC AGAGGCCGAA GTGCCAGGTA AACTCAGCCC CAAACAGTCG 1380

GCCACGATGC CCAAGAAAGG CATCCTGAAA AAGACCCAGC AGAGAGAATC GGGTTACTAT 1440

TCATCCCCGG AGCGCAGCGA GTCTTCGGAG CTGCTTGACA GTAACGATGG GCTTGGCAGC 1500

AGCATCCCCT CCCCCAGTCC CCCGGACCCG GCCAGGGTGC CATCCCACAG CCTCTCCTGT 1560

CGCAGGAAGG GCATCTTGAA GCACAACAGC AAGTACTCAG CGGGCACCAT GGACCCGGCC 1620

CTGGCCAGCC CCGAAATGCC CACACTGGAA TCCTTGCTAG AGCCGGGCGT CCCCTCTGAG 1680

GGCCTCTCCC GGAGCTACAG CCGGCCTTCC AGCGTCATCA GCGATGACAG CGTCCTGTCC 1740

AGCGACTCCT TCGACTTGCT CGACTTGCAG GAGAACCGCC CCACCCGCCA GCGCATCCGC 1800

AGCTGCGTCT CTGCCGAGAA CTTCCTCCAG ATCCAGGACT TTGAGGGGCT CCAGAACCGG 1860

CCCCGGCCCC AGTACCTGAA GCGGTACCGG AACCGGCTGG CAGACAGCAG CTTCTCCCTC 1920

CTCACAGACA TGGATGACGT GACTCAGGTC TACAAGAAGG CGCTAGAGAT CTGCAACAAG 1980

CTCAACTAG 1989

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+l++tlG+g++gkVk a+++  ++ va+K i+k+k+ +e+ + +i+rEiei+++l+hp+

Q: 56    YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIkDEQDMVHIRREIEIMSSLNHPH  115

         99**********************************95667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++++eyas+geL+dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 116   IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV  175

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld++ nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 176   VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  235

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+lv+g++Pfd+ + k+l ++i++g+++ p++  ++++ L+r +L+v+p++

Q: 236   DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDR  294

         ***************************************99.7789**************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 295   RATIEDIANHWWV  307

         ************6

Domain Sequence
(FASTA)

YELQETLGKG TYGKVKRATE RFSGRVVAIK SIRKDKIKDE QDMVHIRREI EIMSSLNHPH 60

IISIYEVFEN KDKIVIIMEY ASKGELYDYI SERRRLSERE TRHFFRQIVS AVHYCHKNGV 120

VHRDLKLENI LLDDNCNIKI ADFGLSNLYQ KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLVYGTMPFD GFDHKNLIRQ ISSGEYREPT QPSDARGLIR WMLMVNPDRR 240

ATIEDIANHW WV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030155	; P:regulation of cell adhesion
GO:2000772	; P:regulation of cellular senescence
GO:0035507	; P:regulation of myosin-light-chain-phosphatase activity

KEGG

bta:519892

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013