EKS-BOT-00149
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00149
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR526.99.0E-159466742277
StatusUnreviewed
Ensembl ProteinENSBTAP00000013942
UniProt AccessionF1MN51;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000010543ENSBTAP00000013942ENSBTAT00000013942
OrganismBos taurus
Functional Description
Protein Length800
Protein Sequence
(FASTA)
MRLLLVLLGV LLGAPGAPAL SFEASEETEL EPCLAPSPEQ QEQELTVALG QPVRLCCGRA 60
ERSGHWYKEG SRLTPAGRVR GWRGRLEIAS FLPEDAGQYL CLSRGSLLLH NVTLVVDDSM 120
TSSNGDEDPK IHRGPLNGHV YPQQAPYWTH PQRMEKKLHA VPAGNTVKFR CPAAGNPMPT 180
IRWLKDGQDF HGEHRIGGIR LRHQHWSLVM ESVVPSDRGT YTCLVENSLG SIRYSYLLDV 240
LERSPHRPIL QAGLPANTTA VVGSDVELLC KVYSDAQPHI QWLKHIVING SSFGADGFPY 300
VQVLKTADIN SSEVEVLYLR NVSAEDAGEY TCLAGNSIGL SYQSAWLTVL PEEDLTWTAT 360
APEGRYTDII LYSSGSLALI VFLLLVGLYR RQTLLTRHHR QPATVQKLSR FPLARQFSLE 420
SGSSAKSSLS LVRGVRLSSS GPPLLAGLVS LDLPLDPLWE FPRDRLVLGK PLGEGCFGQV 480
VCAEAFGMDP TRPDQASTVA VKMLKDNASD KDLADLVSEM EVMKLIGRHK NIINLLGVCT 540
QEGPLYVIVE CAAKGNLREF LRARRPPGPD LSPDGPRSSE GPLSFPALVS CAYQVARGMQ 600
YLESRKCIHR DLAARNVLVT EDNVMKIADF GLARGIHHID YYKKTSNGRL PVKWMAPEAL 660
FDRVYTHQSD VWSFGILLWE IFTLGGSPYP GIPVEELFSL LREGHRMDRP PHCPPELYGL 720
MRECWHAAPS QRPTFKQLVE ALDKVLLAVS EEYLDLRLTF GPYSPAGGDA SSTCSSSDSV 780
FSHDPLPLRP SSFSFPGVQT 800
Nucleotide Sequence
(FASTA)
ATGCGGCTGC TGTTGGTCCT CCTGGGGGTC CTGCTGGGGG CACCTGGGGC TCCAGCTTTG 60
TCCTTTGAGG CCTCTGAGGA AACGGAGCTG GAGCCCTGCC TGGCCCCCAG CCCGGAGCAG 120
CAAGAGCAGG AGTTGACGGT GGCCCTTGGG CAGCCTGTGC GGTTATGCTG CGGGCGGGCT 180
GAGCGCAGTG GCCACTGGTA CAAGGAGGGC AGTCGCCTGA CACCTGCTGG CCGGGTACGA 240
GGCTGGAGAG GCCGCTTGGA GATTGCCAGC TTCCTACCCG AGGATGCTGG CCAGTACCTC 300
TGCCTATCAC GAGGCTCCTT GCTTCTGCAC AACGTCACCT TGGTTGTGGA CGACTCCATG 360
ACCTCCAGCA ATGGCGACGA GGACCCCAAG ATCCACAGGG GCCCCTTGAA TGGGCACGTT 420
TACCCCCAGC AAGCACCCTA CTGGACGCAC CCCCAGCGCA TGGAGAAGAA ACTGCATGCT 480
GTGCCTGCCG GGAACACCGT CAAGTTCCGC TGTCCAGCTG CAGGCAACCC CATGCCCACC 540
ATCCGCTGGC TCAAGGATGG ACAGGACTTC CACGGGGAGC ATCGCATTGG AGGCATTCGG 600
CTGCGCCACC AGCACTGGAG CCTGGTGATG GAAAGCGTGG TGCCCTCTGA CCGTGGCACT 660
TACACCTGCC TCGTGGAGAA TTCTTTGGGC AGCATTCGCT ATAGCTACCT GCTGGACGTG 720
CTGGAGCGGT CCCCGCACCG GCCCATCCTT CAGGCAGGGC TCCCAGCCAA CACCACGGCT 780
GTGGTGGGCA GTGACGTGGA ACTGCTCTGC AAGGTGTACA GCGACGCCCA GCCCCACATC 840
CAGTGGCTGA AGCACATCGT CATCAACGGC AGCAGCTTCG GTGCCGACGG CTTCCCCTAT 900
GTGCAAGTCT TAAAGACAGC GGACATCAAT AGCTCAGAGG TGGAGGTCTT GTACCTTCGG 960
AATGTATCTG CTGAGGATGC AGGCGAGTAC ACCTGCCTGG CGGGCAACTC CATCGGCCTT 1020
TCCTACCAGT CGGCCTGGCT CACGGTGCTG CCAGAGGAGG ATCTCACGTG GACAGCGACA 1080
GCACCCGAAG GCAGGTACAC GGACATCATC CTGTACTCGT CAGGCTCTCT GGCTTTGATC 1140
GTGTTCCTGC TGCTGGTCGG GCTATATCGC AGGCAGACGC TCCTCACCCG ACACCACCGA 1200
CAGCCCGCCA CCGTGCAGAA GTTGTCTCGC TTTCCTCTGG CCCGACAGTT CTCGCTGGAG 1260
TCAGGCTCCT CAGCCAAGTC AAGCTTGTCC CTGGTGCGGG GTGTCCGTCT CTCCTCCAGC 1320
GGCCCCCCCT TGCTCGCTGG CCTCGTGAGT CTCGACCTGC CTCTTGACCC ACTGTGGGAG 1380
TTCCCCCGGG ACAGGCTGGT GCTGGGAAAG CCCCTGGGCG AGGGCTGCTT TGGGCAGGTG 1440
GTGTGCGCAG AGGCCTTCGG CATGGACCCC ACCCGGCCAG ACCAAGCCAG CACCGTGGCT 1500
GTCAAGATGC TTAAGGACAA CGCCTCCGAC AAGGACTTGG CAGACCTGGT CTCTGAGATG 1560
GAGGTGATGA AGCTGATTGG CCGACACAAG AACATTATCA ACCTGCTGGG TGTCTGCACC 1620
CAGGAAGGGC CCTTGTACGT GATCGTGGAG TGTGCTGCCA AGGGCAACCT GCGGGAGTTC 1680
CTGCGGGCCC GCCGCCCCCC AGGCCCTGAC CTCAGCCCTG ACGGGCCTCG GAGCAGCGAG 1740
GGGCCGCTCT CCTTCCCTGC CCTGGTCTCC TGCGCCTACC AGGTGGCCCG GGGCATGCAG 1800
TACCTGGAGT CCCGGAAGTG CATCCACCGG GACCTGGCTG CCCGCAATGT ACTGGTGACC 1860
GAGGACAATG TGATGAAGAT TGCAGACTTC GGGCTGGCCC GTGGCATCCA CCACATTGAC 1920
TACTACAAGA AAACTAGCAA CGGCCGCCTG CCTGTCAAGT GGATGGCACC AGAGGCCTTG 1980
TTTGACAGAG TCTACACACA CCAGAGTGAT GTGTGGTCGT TTGGAATCCT GCTGTGGGAG 2040
ATCTTCACCC TCGGGGGCTC CCCATACCCT GGCATCCCCG TGGAGGAGCT GTTCTCGCTG 2100
CTACGAGAGG GGCATCGGAT GGACCGGCCC CCACACTGCC CCCCAGAGCT ATACGGGCTG 2160
ATGCGCGAGT GCTGGCACGC AGCACCCTCT CAGAGGCCCA CTTTCAAGCA ACTGGTAGAG 2220
GCACTGGACA AGGTCCTGCT GGCCGTCTCT GAGGAGTACC TCGACCTCCG CCTAACCTTT 2280
GGACCCTACT CCCCTGCCGG CGGGGACGCC AGCAGCACCT GCTCCTCTAG CGACTCTGTC 2340
TTCAGCCACG ACCCCCTACC ACTGAGGCCC AGCTCCTTCT CCTTCCCTGG GGTGCAGACG 2400
TGA 2403
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl
Q: 466   LVLGKPLGEGCFGQVVCAEAFGMDPTRPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  525
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++
Q: 526   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF  585
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar++h+idyykkt
Q: 586   PALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGIHHIDYYKKT  645
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh
Q: 646   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  705
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p +c+ ely lmrecwha++s+rptfkqlve+l
Q: 706   RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL  742
         **********************************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVCAEA FGMDPTRPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60
IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PRSSEGPLSF 120
PALVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNVM KIADFGLARG IHHIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPPHCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00141
EKS-ANC-00141
EKS-CAF-00157
EKS-CAP-00150
EKS-EQC-00148
EKS-FEC-00139
EKS-GAM-00077
EKS-GAA-00174
EKS-ICT-00143
EKS-LOA-00148
EKS-MOD-00149
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-ORC-00140
EKS-PAT-00140
EKS-RAN-00148
EKS-SAH-00144
EKS-SUS-00130
EKS-TAG-00178
EKS-TAR-00193
EKS-TEN-00185
EKS-XET-00138
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0061144; P:alveolar secondary septum development
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
bta:317696;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013