EKS-BOT-00229
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00229
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE7381.13.0E-11464325262
StatusUnreviewed
Ensembl ProteinENSBTAP00000013983
UniProt AccessionA4IFH7;
Protein Name
Protein Synonyms/Alias MAP2K3 protein;
Gene NameMAP2K3
Gene Synonyms/Alias MAP2K3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000010576ENSBTAP00000013983ENSBTAT00000013983
OrganismBos taurus
Functional Description
Protein Length347
Protein Sequence
(FASTA)
MESPAPSPPA GVPTSKGKSR RKKDLRISCM SKPPAPSPTL PRNLDSRAFI TIGDRNFEVE 60
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDVNMRTVDC 120
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKGMT IPEDILGEIA VSIVRALEHL 180
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 240
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 300
FTAQCLRKNP AERMSYLELM EHPFFTSHKT KKTDIAAFVK EILGEDS 347
Nucleotide Sequence
(FASTA)
ATGGAGTCCC CTGCCCCGAG CCCGCCCGCC GGCGTGCCCA CGTCCAAAGG AAAGTCCAGG 60
AGGAAAAAGG ATTTACGAAT CTCCTGCATG TCCAAGCCGC CGGCGCCCAG CCCCACGCTC 120
CCCCGGAACC TGGACTCCCG GGCATTCATC ACCATTGGAG ACAGGAACTT TGAGGTGGAG 180
GCGGATGACC TGGTGACCAT TTCAGAGCTG GGCCGAGGTG CCTATGGGGT GGTGGAGAAG 240
GTGCGGCATG CCCAGAGTGG CACCATCATG GCCGTGAAGC GCATCCGGGC CACCGTGAAC 300
TCTCAGGAGC AGAAGCGCCT GCTCATGGAC CTAGATGTCA ACATGCGCAC GGTGGACTGT 360
TTCTACACCG TCACCTTCTA TGGGGCCCTC TTTAGAGAGG GAGACGTGTG GATCTGCATG 420
GAGCTCATGG ACACGTCCCT GGACAAGTTC TATCGGAAGG TGCTAGACAA GGGCATGACG 480
ATCCCAGAAG ACATTCTCGG GGAGATCGCT GTGTCTATCG TGAGGGCCCT GGAACACCTG 540
CACAGCAAGC TGTCCGTGAT CCACAGAGAT GTGAAGCCGT CCAATGTCCT TATCAACAAG 600
GAGGGCCACG TGAAGATGTG TGACTTTGGG ATCAGTGGTT ACTTGGTGGA TTCCGTGGCC 660
AAGACAATGG ATGCTGGCTG CAAACCCTAC ATGGCCCCTG AGAGAATCAA CCCAGAACTG 720
AACCAGAAAG GCTACAATGT CAAGTCCGAT GTCTGGAGCC TCGGCATCAC CATGATCGAG 780
ATGGCCATTC TGCGATTTCC TTACGAGTCC TGGGGGACCC CCTTCCAGCA GCTGAAGCAG 840
GTGGTAGAGG AGCCGTCCCC CCAGCTCCCA GCTGACCGTT TCTCCCCTGA GTTTGTGGAC 900
TTTACTGCAC AGTGCCTGAG AAAGAACCCC GCGGAACGCA TGAGCTACCT GGAGCTGATG 960
GAGCACCCTT TCTTCACCTC GCACAAAACC AAGAAGACTG ACATCGCTGC CTTCGTGAAG 1020
GAGATCCTGG GAGAGGACTC GTAG 1044
Domain Profile
S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60
         l +++elG+G++gvVekv+h +sg+i+avK+ir++++++eqk++l++l+v +++ ++ y+
Q: 64    LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDVNMRTVDCFYT  123
         56899*******************************************************
S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120
         v+fyGa+++egdv+icmelmd tsldk+++kvl+k  +ipe++lg+iav++v+ale+l++
Q: 124   VTFYGALFREGDVWICMELMD-TSLDKFYRKVLDKGMTIPEDILGEIAVSIVRALEHLHS  182
         *********************.**************************************
S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...k  176
         kl++iHRDvKPsN+L+n++G+vK+CDFG+sg+lvds+Ak++ +G+k+YmaPEri++   +
Q: 183   KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMdAGCKPYMAPERINPelnQ  242
         ********************************************************9999
S: 177   kkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpeeefseefqefv  236
         k Y+vksdvWslG+t++e+a+ r+pye++ +++++lk++v+e++p+lp+++fs+ef++f 
Q: 243   KGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFT  302
         9***********************************************************
S: 237   skClkkdekeRpklkellkhafi  259
         ++Cl+k+++eR+++ el++h+f+
Q: 303   AQCLRKNPAERMSYLELMEHPFF  325
         *********************96
Domain Sequence
(FASTA)
LVTISELGRG AYGVVEKVRH AQSGTIMAVK RIRATVNSQE QKRLLMDLDV NMRTVDCFYT 60
VTFYGALFRE GDVWICMELM DTSLDKFYRK VLDKGMTIPE DILGEIAVSI VRALEHLHSK 120
LSVIHRDVKP SNVLINKEGH VKMCDFGISG YLVDSVAKTM DAGCKPYMAP ERINPELNQK 180
GYNVKSDVWS LGITMIEMAI LRFPYESWGT PFQQLKQVVE EPSPQLPADR FSPEFVDFTA 240
QCLRKNPAER MSYLELMEHP FF 262
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>
EKS-AIM-00210
EKS-ANC-00216
EKS-CAF-00236
EKS-CAP-00255
EKS-CII-00133
EKS-CIS-00010
EKS-EQC-00220
EKS-FEC-00215
EKS-GAG-00191
EKS-GOG-00226
EKS-HOS-00236
EKS-ICT-00215
EKS-LAC-00240
EKS-LOA-00225
EKS-MAM-00230
EKS-MAE-00005
EKS-MIM-00004
EKS-MOD-00227
EKS-MUM-00234
EKS-MUP-00230
EKS-NOL-00215
EKS-ORA-00197
EKS-ORC-00205
EKS-OTG-00233
EKS-PAT-00218
EKS-PES-00204
EKS-POA-00221
EKS-RAN-00226
EKS-SAH-00214
EKS-TAG-00244
EKS-TUB-00008
EKS-TUT-00011
Gene Ontology
GO:0005524; F:ATP binding
GO:0004708; F:MAP kinase kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0060048; P:cardiac muscle contraction
GO:0006954; P:inflammatory response
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042035; P:regulation of cytokine biosynthetic process
KEGG
bta:516039;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013