EKS-BOT-00230

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00230

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	364.8	2.9E-109	98	358	261

Status

Unreviewed

Ensembl Protein

ENSBTAP00000014063

UniProt Accession

F1N664;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K7

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000010639	ENSBTAP00000014063	ENSBTAT00000014063

Organism

Bos taurus

Functional Description

Protein Length

497

Protein Sequence
(FASTA)

PHPVIVITLS PAPAPSQRAA LQLPLANDGG SRSPSSESSP QHPTPPARPR HMLGLPSTLF 60

TPRSMESIEI DQKLQEIMKQ TGYLTIGGQR YQAEINDLEN LGEMGSGTCG QVWKMRFRKT 120

GHVIAVKQMR RSGNKEENKR ILMDLDVVLK SHDCPYIVQC FGTFITNTDV FIAMELMGTC 180

AEKLKKRMQG PIPERILGKM TVAIVKALYY LKEKHGVIHR DVKPSNILLD ERGQIKLCDF 240

GISGRLVDSK AKTRSAGCAA YMAPERIDPP DPTKPDYDIR ADVWSLGISL VELATGQFPY 300

KNCKTDFEVL TKVLQEEPPL LPGHMGFSGD FQSFVKDCLT KDHRKRPKYN KLLEHSFIKR 360

YETLEVDVAS WFKDVMAKTE SPRTSGVLSQ HHLPFFRAPV PCGARALAAP TPFQSGAVRR 420

GGRLPAPCGA ARGPSGQPRV CAGGPGPSLP TLGPGPARLL RNTFLAPGPG PRPGAAARGL 480

LRRLLGHLPA TAAAPRC 497

Nucleotide Sequence
(FASTA)

CCCCATCCAG TTATTGTGAT CACTCTAAGC CCTGCTCCTG CCCCGTCCCA ACGAGCAGCC 60

CTGCAGCTCC CACTGGCCAA CGATGGGGGC AGCCGCTCAC CGTCCTCCGA GAGCTCCCCA 120

CAGCACCCCA CGCCCCCCGC CCGGCCCCGC CACATGCTGG GGCTGCCTTC AACCTTGTTC 180

ACACCCCGCA GCATGGAGAG CATCGAGATT GACCAGAAGC TGCAGGAGAT CATGAAACAG 240

ACGGGCTACC TGACCATCGG GGGCCAGCGC TACCAGGCGG AGATCAATGA CCTGGAGAAC 300

CTGGGGGAGA TGGGCAGCGG CACTTGCGGC CAGGTGTGGA AGATGCGCTT CCGGAAGACG 360

GGGCACGTCA TCGCTGTCAA GCAAATGCGG CGCTCGGGGA ATAAGGAGGA GAACAAGAGG 420

ATCCTCATGG ATTTGGATGT GGTGCTCAAG AGCCACGACT GCCCCTACAT TGTGCAGTGC 480

TTCGGGACTT TCATCACCAA TACGGACGTC TTCATCGCCA TGGAGCTCAT GGGCACGTGC 540

GCGGAGAAGC TCAAGAAGCG GATGCAGGGC CCCATCCCCG AGCGGATCCT GGGCAAGATG 600

ACGGTGGCAA TTGTGAAGGC GCTCTACTAC CTGAAGGAGA AGCATGGCGT GATCCACCGT 660

GACGTCAAGC CCTCCAACAT CCTGCTGGAC GAGCGGGGCC AGATCAAGCT CTGTGACTTC 720

GGCATCAGCG GCCGCCTGGT CGACTCCAAA GCCAAAACGC GGAGTGCGGG CTGTGCCGCC 780

TACATGGCAC CTGAGCGCAT CGACCCCCCG GATCCCACCA AGCCCGACTA CGACATCCGG 840

GCCGATGTGT GGAGCCTGGG CATCTCCTTG GTGGAGCTGG CGACAGGACA GTTCCCCTAC 900

AAGAACTGCA AGACAGACTT TGAGGTCCTC ACCAAAGTCC TCCAAGAGGA GCCCCCGCTC 960

CTGCCCGGAC ACATGGGCTT CTCGGGGGAC TTCCAGTCCT TCGTCAAAGA CTGCCTTACT 1020

AAAGATCACA GGAAGAGACC AAAGTATAAT AAGCTACTTG AACACAGCTT CATCAAGCGC 1080

TACGAGACGC TGGAGGTGGA TGTGGCGTCC TGGTTCAAGG ATGTCATGGC GAAGACCGAG 1140

TCACCGAGGA CAAGCGGGGT CCTGAGCCAG CACCACCTGC CCTTCTTCAG AGCCCCCGTT 1200

CCCTGCGGCG CCCGGGCCCT GGCTGCGCCG ACCCCTTTTC AATCTGGAGC TGTCAGACGC 1260

GGAGGACGCC TTCCCGCGCC GTGCGGGGCC GCTCGAGGTC CCAGCGGACA GCCGCGTGTT 1320

TGTGCAGGCG GCCCTGGCCC GTCCCTCCCC ACGCTGGGGC CTGGCCCTGC ACGGCTGCTC 1380

CGTAACACCT TCCTCGCGCC CGGCCCTGGG CCCCGCCCTG GCGCTGCTGC GCGGGGGCTG 1440

CTCCGCCGAC TCCTCGGTCA CCTTCCCGCC ACCGCGGCCG CTCCTCGGTG C 1491

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         le+l+e+G+G++g+V+k++++k+g+++avK++r++ +kee+k+il++l+v+ ks+++pyi

Q: 98    LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYI  157

         7899********************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120

         v+++G+f++++dv+i+melm  t+ +k+ k++   ++ ipe++lgk++va+vkal ylke

Q: 158   VQCFGTFITNTDVFIAMELMG-TCAEKLKKRM---QGPIPERILGKMTVAIVKALYYLKE  213

         *********************.*****99996...9************************

S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg....  175

         k+ +iHRDvKPsNiL++++G++KlCDFG+sg+lvds Ak++ +G+++YmaPEri++

Q: 214   KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRsAGCAAYMAPERIDPpdpt  273

         *******************************************************99999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee.efseefqe  234

         k++Y++++dvWslG++lvelatg++py+++k+++e+l+++++eepp lp +  fs +fq+

Q: 274   KPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHmGFSGDFQS  333

         9************************************************9999*******

S: 235   fvskClkkdekeRpklkellkhafi  259

         fv++Cl+kd+++Rpk+++ll+h+fi

Q: 334   FVKDCLTKDHRKRPKYNKLLEHSFI  358

         ***********************97

Domain Sequence
(FASTA)

LENLGEMGSG TCGQVWKMRF RKTGHVIAVK QMRRSGNKEE NKRILMDLDV VLKSHDCPYI 60

VQCFGTFITN TDVFIAMELM GTCAEKLKKR MQGPIPERIL GKMTVAIVKA LYYLKEKHGV 120

IHRDVKPSNI LLDERGQIKL CDFGISGRLV DSKAKTRSAG CAAYMAPERI DPPDPTKPDY 180

DIRADVWSLG ISLVELATGQ FPYKNCKTDF EVLTKVLQEE PPLLPGHMGF SGDFQSFVKD 240

CLTKDHRKRP KYNKLLEHSF I 261

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007257	; P:activation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013