EKS-BOT-00410

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00410

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Trk	561.8	2.3E-169	555	822	268

Status

Unreviewed

Ensembl Protein

ENSBTAP00000053704

UniProt Accession

E1BCQ4;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

NTRK2

Gene Synonyms/Alias

NTRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000010647	ENSBTAP00000053704	ENSBTAT00000061120
ENSBTAG00000010647	ENSBTAP00000014097	ENSBTAT00000014097

Organism

Bos taurus

Functional Description

Protein Length

839

Protein Sequence
(FASTA)

MSSWTRWHGP AMARLWGFCW LIVGFWRAAL ACPTSCKCSA SRIWCGDPSP GIVAFPKLEA 60

TSADPENITE IYIANQKRLE IINEDDLEAY VGLKNLTIVD SGLKSVAHKA FLKNSNLQHI 120

NFTRNKLTIL SRKHFRHLDL SELILVGNPF TCSCDVMWIK TLQETKPSPE TQDLYCLDEN 180

SKNISLANLQ IPHCGLPSAN LAAPNLTVEE GKSITLSCTV AGDPVPNLYW DVGNLVSKHM 240

NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 300

WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYK 360

LVAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNKSNGTLPT 420

GVVDTGREHL SVYAVVVIAS VVGFCLLVML FLLKLARHSK FGMKDFSWFG FGKVKSRQGV 480

ASGPASVISN DDDSASPLHH ISNGSNTPSS SEGGPDAVII GMTKIPVIEN PQYFGITNSQ 540

LKPDTFVQHI KRHNIVLKRE LGEGAFGKVF LAECYNLCPE QDKILVAVKT LKDASDNARK 600

DFHREAELLT NLQHEHIVKF YGVCVEGDPL IMVFEYMKHG DLNKFLRAHG PDAVLMAEGN 660

PPTELTQSQM LHIAQQIAAG MVYLASQHFV HRDLATRNCL VGENLLVKIG DFGMSRDVYS 720

TDYYRVGGHT MLPIRWMPPE SIMYRKFTTE SDVWSLGVVL WEIFTYGKQP WYQLSNNEVI 780

ECITQGRVLQ RPRTCPQEVY ELMLGCWQRE PHMRKNIKGI HTLLQNLAKA SPVYLDILG 839

Nucleotide Sequence
(FASTA)

ATGTCGTCCT GGACCAGGTG GCATGGACCC GCCATGGCGC GGCTCTGGGG CTTCTGCTGG 60

TTGATTGTGG GCTTCTGGAG GGCCGCTCTT GCCTGTCCCA CATCCTGCAA GTGCAGCGCC 120

TCTCGGATCT GGTGCGGCGA TCCTTCTCCT GGCATCGTGG CATTTCCGAA GCTGGAGGCT 180

ACCAGTGCAG ATCCTGAGAA CATCACCGAA ATTTACATTG CAAATCAGAA AAGATTAGAA 240

ATCATCAACG AAGATGATCT TGAAGCTTAC GTGGGACTGA AAAACCTGAC CATTGTGGAT 300

TCTGGATTAA AATCTGTGGC TCATAAAGCA TTCCTAAAAA ACAGCAACTT ACAGCACATC 360

AATTTTACCC GAAATAAACT GACGATTTTG TCTAGGAAAC ATTTTCGTCA CCTTGACTTG 420

TCTGAGCTAA TCCTGGTGGG CAACCCATTT ACATGCTCCT GTGACGTTAT GTGGATCAAG 480

ACTCTTCAAG AGACTAAACC TAGTCCAGAA ACTCAGGATT TGTACTGTCT GGATGAAAAC 540

AGCAAGAATA TTTCACTGGC AAACCTGCAG ATACCCCATT GTGGTTTGCC ATCAGCAAAT 600

TTGGCCGCAC CTAACCTCAC CGTGGAGGAG GGAAAGTCTA TCACATTATC TTGTACTGTT 660

GCAGGTGACC CAGTTCCGAA TTTGTACTGG GATGTCGGTA ATCTGGTTTC CAAGCATATG 720

AATGAAACAA GCCACACACA GGGCTCCTTA AGGATAACTA ACATTTCATC TGATGACAGT 780

GGAAAGCAAA TCTCTTGTGT GGCAGAAAAT CTTGTAGGAG AAGATCAAGA TTCTGTCAAC 840

CTCACTGTAC ATTTTGCTCC AACTATCACA TTTCTCGAAT CTCCAACCTC AGACCACCAC 900

TGGTGCATTC CATTCACTGT GAAAGGCAAT CCCAAGCCAG CGCTTCAGTG GTTCTATAAC 960

GGGGCAATTT TGAATGAGTC CAAATACATC TGTACTAAAA TCCATGTTAC CAATCATACG 1020

GAGTACCACG GCTGCCTCCA GCTGGATAAC CCCACTCATA TGAACAATGG GGACTACAAG 1080

TTAGTAGCCA AGAATGAATA TGGGAAGGAT GAGAAACAGA TTTCTGCTCA CTTCATGGGC 1140

TGGCCTGGAA TCGATGATGG TGCAAATCCA AATTATCCTG ATGTAATTTA TGAAGATTAC 1200

GGGACCGCAG CAAATGACAT TGGGGACACC ACAAACAAAA GTAATGGAAC CCTTCCCACA 1260

GGTGTTGTTG ACACGGGTCG GGAACACCTC TCGGTCTATG CTGTGGTGGT AATTGCATCT 1320

GTAGTGGGAT TTTGTCTACT GGTAATGCTA TTTCTGCTGA AGTTGGCAAG ACACTCCAAG 1380

TTTGGCATGA AAGATTTCTC ATGGTTTGGA TTTGGGAAAG TAAAATCAAG ACAAGGTGTT 1440

GCTTCAGGCC CAGCCTCAGT TATCAGCAAT GATGATGACT CTGCCAGCCC ACTCCATCAC 1500

ATCTCCAATG GGAGTAACAC CCCGTCGTCT TCAGAGGGTG GCCCTGATGC TGTCATTATT 1560

GGAATGACCA AGATTCCTGT CATTGAAAAT CCCCAGTACT TTGGCATTAC CAACAGTCAG 1620

CTCAAGCCAG ACACATTTGT TCAGCACATC AAGCGACACA ACATTGTCTT GAAAAGGGAG 1680

CTAGGTGAAG GAGCCTTTGG AAAAGTTTTC CTTGCTGAAT GCTATAACCT CTGTCCTGAG 1740

CAGGACAAGA TCTTGGTGGC TGTGAAGACG CTGAAGGATG CCAGCGACAA TGCACGCAAG 1800

GACTTCCACC GCGAGGCCGA GCTGCTGACC AACCTCCAGC ACGAGCACAT TGTCAAGTTC 1860

TATGGCGTCT GCGTGGAGGG CGACCCACTC ATAATGGTCT TCGAGTACAT GAAGCACGGG 1920

GACCTAAACA AATTCCTCAG GGCGCATGGA CCGGATGCAG TGCTGATGGC TGAGGGCAAC 1980

CCACCGACGG AGCTGACGCA GTCGCAGATG CTGCACATTG CCCAGCAGAT CGCTGCGGGC 2040

ATGGTCTACC TGGCATCGCA GCACTTCGTG CACCGAGACC TAGCCACCCG GAACTGCCTG 2100

GTGGGCGAGA ACCTCCTGGT GAAGATCGGG GACTTCGGCA TGTCCCGGGA CGTGTACAGC 2160

ACCGACTACT ACAGGGTTGG TGGCCACACA ATGCTGCCCA TTCGCTGGAT GCCCCCAGAG 2220

AGCATCATGT ACAGGAAGTT CACCACCGAA AGTGACGTCT GGAGCCTGGG GGTCGTGTTG 2280

TGGGAGATCT TCACGTACGG GAAACAGCCC TGGTACCAGC TGTCGAACAA CGAGGTGATA 2340

GAATGCATCA CTCAGGGCCG AGTCCTGCAG CGACCTCGAA CATGCCCCCA GGAAGTCTAC 2400

GAGCTGATGC TGGGGTGCTG GCAGCGAGAG CCCCATATGA GGAAGAACAT CAAGGGCATC 2460

CACACCCTCC TTCAGAACTT AGCCAAGGCA TCCCCAGTCT ACCTGGATAT TCTAGGGTAG 2520

Domain Profile

S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60

         ivlkrelgegafgkvflaecynl+pe+dk+lvavk+lkdas++arkdf+reaelltnlqh

Q: 555   IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH  614

         89**********************************************************

S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegepkgelglsqllaia  120

         ehivk+yGvc+egdpl++vfeymkhGdlnkflrahgpda+l++eg+p++el++sq+l+ia

Q: 615   EHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIA  674

         ************************************************************

S: 121   kqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtmlpi  180

         +qiaaG+vylasqhfvhrdlatrnclvge+llvkigdfgmsrdvystdyyrvgg+tmlpi

Q: 675   QQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI  734

         ************************************************************

S: 181   rwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerpra  240

         rw+ppesi+yrkfttesdvwslGvvlwei+tyGkqp+yqlsn+eviecitqGrvl+rpr+

Q: 735   RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRT  794

         ************************************************************

S: 241   cpkevydlmlgcwqrepqkrlnikeiya  268

         cp+evy+lmlgcwqrep++r+nik i++

Q: 795   CPQEVYELMLGCWQREPHMRKNIKGIHT  822

         **************************97

Domain Sequence
(FASTA)

IVLKRELGEG AFGKVFLAEC YNLCPEQDKI LVAVKTLKDA SDNARKDFHR EAELLTNLQH 60

EHIVKFYGVC VEGDPLIMVF EYMKHGDLNK FLRAHGPDAV LMAEGNPPTE LTQSQMLHIA 120

QQIAAGMVYL ASQHFVHRDL ATRNCLVGEN LLVKIGDFGM SRDVYSTDYY RVGGHTMLPI 180

RWMPPESIMY RKFTTESDVW SLGVVLWEIF TYGKQPWYQL SNNEVIECIT QGRVLQRPRT 240

CPQEVYELML GCWQREPHMR KNIKGIHT 268

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005887	; C:integral to plasma membrane
GO:0043195	; C:terminal button
GO:0005524	; F:ATP binding
GO:0060175	; F:brain-derived neurotrophic factor-activated receptor activity
GO:0035584	; P:calcium-mediated signaling using intracellular calcium source
GO:0021954	; P:central nervous system neuron development
GO:0021987	; P:cerebral cortex development
GO:0007631	; P:feeding behavior
GO:0014047	; P:glutamate secretion
GO:0007612	; P:learning
GO:0060291	; P:long-term synaptic potentiation
GO:0042490	; P:mechanoreceptor differentiation
GO:2000811	; P:negative regulation of anoikis
GO:0001764	; P:neuron migration
GO:0048709	; P:oligodendrocyte differentiation
GO:0048935	; P:peripheral nervous system neuron development
GO:0010628	; P:positive regulation of gene expression
GO:0010976	; P:positive regulation of neuron projection development
GO:0051896	; P:regulation of protein kinase B signaling cascade
GO:0032314	; P:regulation of Rac GTPase activity
GO:0046548	; P:retinal rod cell development
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR000483	; Cys-rich_flank_reg_C.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000372	; LRR-contain_N.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020455	; Tyr_kin_neurotrophic_rcpt_2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR020777	; Tyr_kinase_NGF_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07679	; I-set; 2.
PF01462	; LRRNT; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 1.
SM00082	; LRRCT; 1.
SM00013	; LRRNT; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR01939	; NTKRECEPTOR.
PR01941	; NTKRECEPTOR2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013