EKS-BOT-00192
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00192
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK472.15.0E-142331599269
StatusUnreviewed
Ensembl ProteinENSBTAP00000041788
UniProt AccessionF1MGL9;
Protein Name
Protein Synonyms/Alias LIM domain kinase 2;
Gene NameLIMK2
Gene Synonyms/Alias LIMK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000010662ENSBTAP00000014102ENSBTAT00000014102
ENSBTAG00000010662ENSBTAP00000041788ENSBTAT00000044280
OrganismBos taurus
Functional Description
Protein Length638
Protein Sequence
(FASTA)
MAAQAGDDAW RCQGCGDYVA PNQRLYRTVS EAWPTSCFRC SECQDSLTNW YYEKDGKLYC 60
HKDYWGKFGE FCHGCSLLMT GPVMVAGEFK YHPECFACMS CKVIIEDGDA YALVQHATLY 120
CGKCHNEVVL APMFERLSTE SVQDQLPYSV THISMPATTE GRRGFSVSVE SACSNYATTV 180
QVREVNRMHI SPNNRNAIHP GDRILEINGA PVRTLRVEEV EDAISQTTQT LQLLIEHDPV 240
SQRLDQLQLD ARLSPCAQND RHAHTLSPLD TKENLEGTLR RRSLRRSNSI SKSPGPSSPK 300
EPLLLSRDIS RSESLRCSSS CSQQIFRPCD LIHGEVLGKG FFGQAIKVTH KATGKVMVMK 360
ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK FIGVLYKDKK LNLLTEYIEG GTLKDFLRNV 420
DPFPWQQKVR FAKGIASGMA YLHSMCIIHR DLNSHNCLIK LDKTVVVADF GLSRLIVEER 480
KKPPVEKATT KKRTLRKSDR KKRYTVVGNP YWMAPEMLNG KSYDETVDVF SFGIVLCEII 540
GQVYADPDCL PRTLDFGLNV KLFWEKFVPE ECPPAFFPLA AICCRLEPES RPAFSKLEDF 600
FEALSLYLGE LGIPLPTELE DLDHTVSMEY GLIRNPPP 638
Nucleotide Sequence
(FASTA)
ATGGCGGCGC AGGCAGGTGA CGATGCCTGG AGGTGTCAGG GCTGTGGAGA CTATGTCGCT 60
CCAAACCAGA GGTTGTACAG GACCGTCAGC GAAGCCTGGC CCACCTCCTG CTTCCGGTGT 120
TCTGAATGCC AGGATTCCCT CACCAACTGG TACTATGAGA AGGATGGGAA GCTGTACTGC 180
CACAAGGACT ACTGGGGGAA GTTTGGGGAG TTCTGCCACG GATGCTCTCT GTTGATGACG 240
GGGCCCGTCA TGGTGGCCGG GGAGTTCAAG TACCACCCAG AGTGCTTCGC CTGTATGAGC 300
TGCAAGGTGA TCATCGAGGA TGGGGACGCA TACGCCCTGG TGCAGCACGC CACCCTCTAC 360
TGTGGGAAGT GCCACAACGA GGTGGTACTG GCACCCATGT TTGAGAGGCT GTCCACGGAA 420
TCCGTCCAGG ACCAGCTGCC CTACTCCGTC ACACACATCT CCATGCCAGC CACCACCGAA 480
GGCAGGCGGG GCTTCTCCGT GTCCGTGGAG AGTGCCTGCT CAAACTACGC CACCACCGTG 540
CAAGTGAGAG AGGTCAACCG GATGCACATC AGTCCTAACA ACCGAAACGC CATCCACCCT 600
GGGGACCGCA TCCTGGAGAT CAATGGGGCC CCCGTGCGCA CGCTCCGCGT GGAGGAGGTG 660
GAGGACGCCA TTAGCCAGAC GACCCAGACA CTGCAGCTCC TGATTGAACA CGACCCCGTC 720
TCCCAGCGCC TGGACCAGCT GCAGCTGGAT GCACGGCTCT CTCCCTGCGC GCAGAATGAC 780
AGACACGCGC ACACCCTCAG CCCCCTGGAC ACCAAGGAGA ACCTGGAGGG GACACTGAGG 840
AGACGCTCCC TGAGACGCAG TAACAGCATC TCCAAGTCCC CCGGCCCCAG CTCCCCCAAG 900
GAGCCGCTCC TGCTCAGCCG TGACATCAGC CGCTCAGAGT CCCTGCGCTG CTCCAGTAGC 960
TGCTCACAGC AGATCTTCCG GCCCTGTGAC CTGATCCACG GCGAGGTCCT GGGGAAGGGC 1020
TTCTTCGGGC AGGCCATCAA GGTGACGCAC AAAGCCACGG GCAAAGTGAT GGTCATGAAG 1080
GAGCTGATCC GGTGTGATGA GGAGACACAG AAGACTTTTC TAACTGAGGT GAAGGTGATG 1140
CGCAGCCTGG ACCACCCCAA CGTGCTCAAG TTCATCGGCG TACTGTACAA GGATAAGAAG 1200
CTGAACCTGC TGACGGAGTA CATCGAAGGG GGCACGCTGA AGGACTTCCT GCGCAACGTG 1260
GACCCGTTCC CCTGGCAGCA GAAGGTCAGG TTTGCCAAAG GCATCGCCTC TGGAATGGCC 1320
TATTTGCATT CCATGTGTAT CATCCACCGG GATCTGAACT CGCACAACTG CCTCATCAAG 1380
CTGGACAAGA CCGTGGTGGT GGCTGACTTC GGGCTGTCAC GGCTCATAGT CGAGGAGAGA 1440
AAGAAGCCCC CCGTGGAAAA GGCCACCACC AAGAAGCGCA CCTTGCGCAA GAGCGACCGC 1500
AAGAAGCGCT ACACGGTGGT GGGGAACCCC TACTGGATGG CCCCGGAGAT GCTGAACGGA 1560
AAGAGCTACG ACGAGACAGT GGATGTCTTC TCTTTTGGGA TTGTCCTCTG CGAGATAATC 1620
GGGCAGGTGT ATGCAGATCC TGACTGCCTG CCCCGAACAC TGGACTTCGG CCTCAACGTG 1680
AAGCTCTTCT GGGAGAAGTT TGTCCCTGAA GAGTGTCCCC CAGCCTTCTT CCCCCTGGCA 1740
GCCATCTGCT GCAGACTGGA GCCTGAGAGC AGACCGGCAT TCTCCAAACT GGAGGACTTC 1800
TTTGAGGCAC TGTCCCTGTA CCTGGGGGAG CTGGGCATCC CACTGCCCAC AGAGCTGGAG 1860
GACCTGGACC ACACCGTGAG CATGGAGTAC GGCCTGATCC GGAACCCGCC TCCCTAG 1917
Domain Profile
S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60
         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk
Q: 331   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  390
         689*********************************************************
S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120
         fiGvl+kdkkl+llteyiegGtlk++l++ +++pw+q+vr+ak+iasG++ylhs++iihr
Q: 391   FIGVLYKDKKLNLLTEYIEGGTLKDFLRNVDPFPWQQKVRFAKGIASGMAYLHSMCIIHR  450
         ************************************************************
S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174
         dlns+ncl++ dk+vvvadfGl+rl+veerkk+      +k+r+l+k+drkkr+tvvG+P
Q: 451   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPpvekatTKKRTLRKSDRKKRYTVVGNP  510
         *******************************999999999********************
S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234
         ywmaPe+l+gksyde+vdvfsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v+e
Q: 511   YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPE  570
         ************************************************************
S: 235   dcPeaflklavvccdldpesrpsfeelek  263
         +cP+af++la++cc+l+pesrp+f++le+
Q: 571   ECPPAFFPLAAICCRLEPESRPAFSKLED  599
         **************************997
Domain Sequence
(FASTA)
LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60
FIGVLYKDKK LNLLTEYIEG GTLKDFLRNV DPFPWQQKVR FAKGIASGMA YLHSMCIIHR 120
DLNSHNCLIK LDKTVVVADF GLSRLIVEER KKPPVEKATT KKRTLRKSDR KKRYTVVGNP 180
YWMAPEMLNG KSYDETVDVF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPE 240
ECPPAFFPLA AICCRLEPES RPAFSKLED 269
KeywordComplete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00179
EKS-CAJ-00198
EKS-CAF-00198
EKS-CAP-00217
EKS-CHH-00035
EKS-CII-00124
EKS-DAR-00493
EKS-ECT-00068
EKS-EQC-00187
EKS-FEC-00180
EKS-GAG-00165
EKS-GAA-00235
EKS-GOG-00190
EKS-HOS-00198
EKS-ICT-00184
EKS-LOA-00188
EKS-MAM-00195
EKS-MEG-00148
EKS-MOD-00189
EKS-MUM-00195
EKS-MUP-00193
EKS-MYL-00197
EKS-NOL-00180
EKS-ORN-00243
EKS-ORA-00169
EKS-ORC-00175
EKS-ORL-00228
EKS-OTG-00198
EKS-PAT-00183
EKS-PES-00167
EKS-POA-00187
EKS-PRC-00065
EKS-PTV-00169
EKS-RAN-00186
EKS-SAH-00184
EKS-SUS-00166
EKS-TAG-00216
EKS-TAR-00247
EKS-TEN-00241
EKS-TUT-00178
EKS-XET-00222
EKS-XIM-00237
Gene Ontology
GO:0005801; C:cis-Golgi network
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0008270; F:zinc ion binding
GO:0007283; P:spermatogenesis
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781; Znf_LIM.
Pfam
PF00412; LIM; 2.
PF00595; PDZ; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00132; LIM; 2.
SM00228; PDZ; 1.
Prosites
PS00478; LIM_DOMAIN_1; 1.
PS50023; LIM_DOMAIN_2; 2.
PS50106; PDZ; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013