EKS-BOT-00175
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00175
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC437.61.8E-131380634255
StatusUnreviewed
Ensembl ProteinENSBTAP00000053216
UniProt AccessionE1BMG4;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCQ
Gene Synonyms/Alias PRKCQ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000010664ENSBTAP00000053216ENSBTAT00000060978
OrganismBos taurus
Functional Description
Protein Length706
Protein Sequence
(FASTA)
MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF 60
DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GKTEIWLELK PQGRMLMNAR 120
YFLEMSDTKD MNEFETDSFF ALHHRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 180
WGLNKQGYQC QQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 240
SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 300
ARCLRDSEHI FREGPVEIGL PCSIKGEAKP PYVPGPGKKE PQGISWESPL EEMEKVCHRP 360
EPEPNKERGS LRMKLKIEDF TLHKMLGKGS FGKVFLAEFK KTNQFFAIKA LKKDVVLMDD 420
DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLCR 480
ATFYAAEIIL GLQFLHSKGI VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDARTNTFC 540
GTPDYIAPEI LLGQKYNHSV DWWSFGVLLY EMLVGQSPFH GQDEEELFHS IRMDNPFYPR 600
WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPYD 660
CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFMNPG MEKLIS 706
Nucleotide Sequence
(FASTA)
ATGTCACCGT TTCTCCGAAT TGGCTTGTCC AACTTCGACT GTGGGTCCTG CCAGTCCTGC 60
CAGGGTGAGG CGGTTAACCC TTACTGTGCC GTGCTTGTCA AAGAGTATGT TGAATCAGAG 120
AATGGGCAGA TGTACATCCA GAAAAAGCCA ACCATGTACC CGCCCTGGGA CAGCACTTTC 180
GACGCCCACA TCAACAAGGG ACGAGTGATG CAGATCATCG TGAAGGGCAA AAACGTGGAC 240
CTGATCTCCG AGACCACCGT GGAGCTGTAC TCCCTGGCCG AGAGGTGCAG GAAAAACAAC 300
GGGAAGACAG AAATATGGCT AGAGCTGAAA CCTCAAGGCC GAATGCTGAT GAACGCAAGA 360
TACTTTCTGG AAATGAGTGA TACAAAGGAC ATGAACGAAT TCGAGACCGA CAGCTTCTTC 420
GCTCTGCATC ACCGCCGAGG AGCCATCAAG CAGGCCAAAG TCCACCATGT CAAGTGCCAT 480
GAGTTCACAG CCACCTTCTT CCCACAGCCC ACGTTTTGTT CCGTCTGCCA TGAATTTGTC 540
TGGGGTCTGA ACAAACAAGG CTACCAGTGT CAACAATGTA ATGCAGCAAT TCACAAGAAG 600
TGTATCGATA AAGTAATAGC AAAGTGCACA GGATCAGCTA TCAACAGCCG AGAAACTATG 660
TTCCACAAGG AGAGGTTCAA AATCGACATG CCGCACAGAT TTAAGGTCTA CAATTACAAG 720
AGCCCAACCT TCTGTGAGCA CTGTGGGACC CTGCTGTGGG GCCTGGCCAG GCAAGGACTC 780
AAGTGCGACG CATGTGGCAT GAATGTGCAT CACAGATGCC AGACAAAGGT GGCCAACCTT 840
TGTGGTATAA ACCAGAAGCT GATGGCTGAA GCACTGGCAA TGATCGAGAG CACTCAGCAG 900
GCTCGCTGCT TAAGAGATTC TGAGCACATC TTCAGAGAAG GTCCAGTTGA AATTGGTCTC 960
CCATGCTCCA TAAAAGGTGA AGCAAAGCCG CCGTACGTAC CAGGACCAGG GAAAAAAGAG 1020
CCTCAGGGGA TCTCCTGGGA GTCTCCCTTG GAAGAGATGG AGAAAGTATG CCATCGTCCA 1080
GAACCTGAGC CGAACAAAGA AAGAGGTTCT CTACGTATGA AACTAAAAAT CGAGGATTTC 1140
ACCTTGCACA AAATGCTGGG GAAAGGAAGT TTTGGCAAGG TCTTCCTAGC AGAGTTCAAG 1200
AAAACCAATC AGTTTTTCGC AATAAAAGCC TTAAAGAAAG ATGTGGTTTT GATGGATGAT 1260
GACGTGGAGT GCACAATGGT AGAGAAGAGG GTCCTCTCCT TGGCCTGGGA GCATCCGTTC 1320
TTAACACATA TGTTCTGCAC GTTCCAGACC AAGGAGAACC TCTTTTTTGT GATGGAGTAT 1380
CTCAACGGAG GAGACTTAAT GTACCACATC CAGAGCTGCC ACAAGTTCGA CCTCTGCAGG 1440
GCCACGTTCT ACGCTGCCGA AATCATCCTC GGTCTGCAGT TCCTTCATTC CAAAGGAATT 1500
GTCTACAGGG ACCTGAAGCT GGATAACATC CTCTTAGACA AAGATGGACA CATCAAAATC 1560
GCAGACTTCG GGATGTGCAA GGAGAACATG CTGGGAGACG CCAGGACCAA CACCTTCTGC 1620
GGGACCCCCG ACTACATCGC GCCGGAGATC CTCCTGGGTC AGAAGTACAA CCACTCTGTG 1680
GACTGGTGGT CCTTCGGTGT CCTCCTCTAC GAGATGCTAG TAGGCCAGTC CCCTTTCCAC 1740
GGGCAGGATG AAGAGGAGCT TTTCCACTCC ATCCGCATGG ACAATCCCTT TTACCCGCGA 1800
TGGCTCGAGA AGGAGGCGAA GGACCTTTTA GTGAAGCTCT TCGTAAGAGA GCCTGAGAAG 1860
CGGCTGGGGG TGAGGGGAGA CATCCGTCAG CACCCCTTGT TTCGGGAGAT CAATTGGGAA 1920
GAGCTGGAAA GGAAGGAGAT CGACCCGCCA TTCAGGCCTA AAGTGAAATC ACCATATGAC 1980
TGCAGCAATT TCGACAAGGA ATTCCTGAAT GAGAAGCCCC GGCTGTCCTT CGCAGACAGG 2040
GCGCTGATCA ACAGCATGGA CCAGAACATG TTCCGGAACT TTTCCTTCAT GAACCCAGGG 2100
ATGGAGAAGC TGATATCCTG A 2121
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+l+k+lGkGsfgkv+lae kkt++++aik lkkdvvl+dddve+t+vekrvl+la+++p
Q: 380   FTLHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP  439
         899*********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+++f++fqt+++lffv+ey+nGGdlm+hiq+++k++  ra+fyaaeiil+l+flh+kg
Q: 440   FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLCRATFYAAEIILGLQFLHSKG  499
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         i+yrdlkldn+lld++Ghik+adfG+cke++l +++t+tfcGtPdyiaPeil +++y++s
Q: 500   IVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDARTNTFCGTPDYIAPEILLGQKYNHS  559
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+de+elf+si++++++yP++l+kea+++l +l+ ++pe
Q: 560   VDWWSFGVLLYEMLVGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPE  619
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlGv  +g  di++h++f
Q: 620   KRLGV--RG--DIRQHPLF  634
         *****..55..89999987
Domain Sequence
(FASTA)
FTLHKMLGKG SFGKVFLAEF KKTNQFFAIK ALKKDVVLMD DDVECTMVEK RVLSLAWEHP 60
FLTHMFCTFQ TKENLFFVME YLNGGDLMYH IQSCHKFDLC RATFYAAEII LGLQFLHSKG 120
IVYRDLKLDN ILLDKDGHIK IADFGMCKEN MLGDARTNTF CGTPDYIAPE ILLGQKYNHS 180
VDWWSFGVLL YEMLVGQSPF HGQDEEELFH SIRMDNPFYP RWLEKEAKDL LVKLFVREPE 240
KRLGVRGDIR QHPLF 255
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-CAF-00182
EKS-CAP-00174
EKS-DAR-00470
EKS-EQC-00171
EKS-FEC-00165
EKS-GAM-00093
EKS-GAA-00211
EKS-GOG-00174
EKS-HOS-00181
EKS-LAC-00186
EKS-LOA-00174
EKS-MAM-00171
EKS-MOD-00173
EKS-MUM-00181
EKS-MUP-00179
EKS-MYL-00184
EKS-NOL-00167
EKS-ORN-00220
EKS-ORA-00152
EKS-ORC-00162
EKS-ORL-00206
EKS-OTG-00180
EKS-PAT-00165
EKS-PES-00155
EKS-POA-00168
EKS-RAN-00171
EKS-SUS-00153
EKS-TAG-00203
EKS-TEN-00220
EKS-XIM-00215
Gene Ontology
GO:0005737; C:cytoplasm
GO:0001772; C:immunological synapse
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0035556; P:intracellular signal transduction
GO:0006509; P:membrane protein ectodomain proteolysis
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0070233; P:negative regulation of T cell apoptotic process
GO:0032740; P:positive regulation of interleukin-17 production
GO:0045086; P:positive regulation of interleukin-2 biosynthetic process
GO:0032753; P:positive regulation of interleukin-4 production
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0042102; P:positive regulation of T cell proliferation
GO:2000318; P:positive regulation of T-helper 17 type immune response
GO:2000570; P:positive regulation of T-helper 2 cell activation
GO:0090330; P:regulation of platelet aggregation
KEGG
bta:505901;
InterPros
IPR000961; AGC-kinase_C.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013