EPS-BOT-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	192.8	9.5E-57	78	331	254

Status

Unreviewed

Ensembl Protein

ENSBTAP00000014279

UniProt Accession

F1N580;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000010788	ENSBTAP00000014279	ENSBTAT00000014279

Organism

Bos taurus

Functional Description

Protein Length

601

Protein Sequence
(FASTA)

NCPSFLAAAL ARATSDEVLQ SDLSAHYIPK ETDGTEGTVE IETVKLARSV FSKLHEICCS 60

WVKDFPLRRR PQLYYETSIH AIKNMRRKME DKHVCIPDFN MLFNLEDQEE QAYFAVFDGH 120

GGVDAAIYAS IHLHVNLVRQ ETFPHDPAEA LCRAFRVTDE RFVQKAARES LRCGTTGVVT 180

FIRGNMLHVA WVGDSQVMLV RKGQAVELMK PHKPDREDEK QRIEALGGCV VWFGAWRVNG 240

SLSVSRAIGD AEHKPYICGD ADSASTVLDG TEDYLILACD GFYDTVNPDE AVKVVSDHLK 300

ENNGDSSMVA HKLVASARDA GSSDNITVIV VFLRDMNKAV NVSEDSDWTE NSFQGGQEAG 360

GDDKESHGEC KRPWPQHQCS APADLGYEGR VDSFTDRTSL SPGSQGNVLE DPGYLDLTQI 420

ETSKPHGAQF LPPVEMFGPG APKRANLINE LIMEKKSVPS SLPEWSGAGE VLSSFNVGST 480

GQQVCSMGSL PPVCSRLENE QFKFLGKRVS RLSHLHYHYS KRRHGFRFNP KFYSFLSAQE 540

PSHKTGSSLS SLIRNGKRNS MLRSSLPWRQ NSWKGYSENV MRKPKKSNDP AHPELPWSFK 600

I 601

Nucleotide Sequence
(FASTA)

AACTGCCCTT CCTTTTTGGC TGCCGCTCTA GCCAGAGCCA CATCAGACGA AGTCCTTCAG 60

AGTGATCTTT CTGCACATTA TATCCCAAAG GAGACGGATG GCACAGAAGG GACTGTGGAG 120

ATTGAGACAG TGAAATTGGC CCGTTCTGTC TTCAGCAAAC TACACGAGAT TTGCTGCAGC 180

TGGGTGAAAG ACTTCCCTCT CCGCAGGAGA CCCCAGCTTT ATTATGAGAC ATCAATCCAT 240

GCCATCAAAA ACATGCGGAG GAAAATGGAG GACAAGCATG TCTGCATCCC GGACTTTAAC 300

ATGCTCTTCA ACCTAGAGGA CCAGGAAGAA CAAGCTTACT TTGCCGTGTT TGACGGCCAC 360

GGGGGAGTGG ATGCTGCCAT CTACGCCTCC ATCCACCTGC ACGTGAACCT AGTGCGCCAG 420

GAGACGTTCC CCCACGACCC TGCCGAGGCC CTGTGCCGAG CCTTCCGCGT CACCGACGAG 480

CGCTTTGTCC AGAAGGCCGC CAGGGAGAGC TTAAGATGTG GGACCACAGG AGTGGTGACT 540

TTTATCAGAG GCAACATGTT ACACGTGGCC TGGGTGGGTG ATTCCCAGGT TATGCTTGTG 600

CGGAAGGGCC AAGCTGTTGA ACTGATGAAG CCACACAAAC CGGACAGAGA GGATGAAAAG 660

CAGCGGATTG AGGCCCTTGG AGGTTGTGTG GTCTGGTTTG GCGCCTGGAG GGTGAATGGA 720

AGTCTGTCTG TCTCCAGAGC CATTGGAGAT GCTGAACATA AGCCATATAT CTGTGGGGAT 780

GCCGATTCTG CCTCTACTGT TCTGGATGGA ACTGAAGACT ACCTCATTCT GGCCTGTGAC 840

GGCTTCTACG ACACCGTGAA CCCTGACGAG GCAGTGAAAG TCGTGTCCGA CCACTTGAAG 900

GAGAATAATG GAGACAGCAG CATGGTTGCC CACAAGTTAG TGGCATCAGC TCGTGATGCA 960

GGGTCAAGTG ATAACATCAC TGTTATTGTG GTTTTCCTGA GGGACATGAA CAAAGCTGTA 1020

AATGTTAGTG AGGACTCAGA TTGGACAGAG AACTCTTTCC AAGGAGGGCA AGAAGCTGGT 1080

GGGGATGACA AGGAGAGTCA CGGGGAGTGC AAGCGCCCCT GGCCCCAGCA CCAGTGCTCC 1140

GCTCCAGCCG ATCTGGGCTA CGAGGGGCGT GTGGATTCTT TCACGGATAG AACCAGCCTG 1200

AGCCCAGGGT CCCAAGGCAA CGTGCTGGAA GACCCGGGCT ACCTAGATCT CACACAGATA 1260

GAAACAAGCA AGCCTCACGG TGCCCAGTTT TTGCCACCAG TTGAGATGTT TGGTCCTGGT 1320

GCACCAAAGA GAGCAAATCT TATTAATGAG CTAATAATGG AGAAAAAATC AGTTCCATCA 1380

TCATTGCCTG AATGGAGTGG TGCTGGAGAG GTTCTCTCTT CTTTTAACGT GGGTTCAACA 1440

GGGCAGCAGG TATGCAGCAT GGGGAGCTTG CCTCCTGTTT GTTCTAGGCT GGAAAATGAA 1500

CAGTTCAAGT TCCTGGGAAA GAGAGTTTCT AGGTTATCTC ATTTACATTA CCACTACTCA 1560

AAGAGGCGGC ATGGATTCAG GTTTAATCCA AAGTTTTATT CTTTTCTCTC TGCTCAAGAG 1620

CCTTCCCACA AAACAGGCAG TAGCCTGTCC TCACTTATTC GAAATGGGAA GAGAAATAGT 1680

ATGTTAAGAA GTTCTCTGCC ATGGAGGCAA AATAGCTGGA AAGGGTACAG TGAAAACGTG 1740

ATGAGGAAGC CCAAAAAGAG TAACGACCCT GCACACCCAG AGCTTCCCTG GAGCTTTAAA 1800

ATATAA 1806

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  l

Q: 78    SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNL  137

         567899**************99766555544459**************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++         +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 138   VRQET----FPHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  191

         **955....7888889999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         vGdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 192   VGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  250

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+  +++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 251   AEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKeNNGDSSMVA  310

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 311   HKLVASARDAGSSDNITVIVV  331

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNL 60

VRQETFPHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWVGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKQRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGTEDYLIL ACDGFYDTVN PDEAVKVVSD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013