EKS-BOT-00163
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00163
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb438.39.4E-132419678260
StatusUnreviewed
Ensembl ProteinENSBTAP00000014487
UniProt AccessionE1BN61;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000010906ENSBTAP00000014487ENSBTAT00000014487
OrganismBos taurus
Functional Description
Protein Length790
Protein Sequence
(FASTA)
MEEKGGSGGD AGGEQLRVVK HELRTANLTG HAEKVGIENF ELLKVLGTGA YGKVFLVRKV 60
SGHDAGKLYA MKVLKKATIV QKAKSAEHTR TERQVLEHIR QSPFLVTLHY AFQTETKLHL 120
ILDYINGGEL FTHLSQRERF TEREVQIYVG EIVLALGHLH KLGIIYRDIK LENILLDSNG 180
HVMLTDFGLS KEFVADEAER AYSFCGTIEY MAPDIVRGGD SGHDKAVDWW SLGVLMYELL 240
TGASPFTVDG EKNSQAEISR RILKSEPPYP QEMSAVAKDL IQRLLMKDPK KRLGCGPRDA 300
DEIKEHPFFQ KINWDDLAAK KVPAPFKPVI RDELDVSNFA EEFTEMDPTY SPAALPQSSE 360
RLFQGYSFVA PSILFKRNAA VMDPLQLHMG VDRPGVTHVA RSAMLKDSPF YQHYDLDLKD 420
TPLGEGSFSI CRKCIHKKSN QAFAVKIISK RMEASTQKEV TALRLCEGHP NIVKLHEVFH 480
DQLHTFLVME LLNGGELFER IKRKKHFSET EASYIMRKLV SAVSHMHDVG VVHRDLKPEN 540
LLFTDENDNL EIKVIDFGFA RLKPPDNQPL KTPCFTLHYA APELLNHSGY DESCDLWSLG 600
VILYTMLSGQ VPFQSHDKSL TCTSAVEIMK KIKKGDFSFE GEAWKNVSQE AKDLIQGLLT 660
VDPNKRLKMP DLRYNEWLQD GSQLSSNPLM TPDILGSSGA AVHTCVKATF HAFNKYKREG 720
FCLQNVDKAP LAKRRRMKKT STSTETRSSS SESSHSSSSH SHGKSTPTRA LQPGNPADGG 780
APESLFQFQD 790
Nucleotide Sequence
(FASTA)
ATGGAGGAGA AGGGCGGCAG CGGCGGGGAC GCCGGCGGAG AACAGCTCCG CGTCGTCAAG 60
CACGAGCTGC GGACGGCTAA TTTAACAGGA CATGCAGAGA AGGTGGGGAT TGAAAATTTT 120
GAGCTCCTGA AGGTCTTAGG AACTGGAGCT TACGGAAAGG TGTTTCTTGT GCGTAAAGTA 180
AGTGGCCACG ATGCTGGAAA GCTGTATGCC ATGAAAGTTC TGAAGAAGGC CACCATAGTG 240
CAGAAGGCCA AGAGCGCGGA GCACACGCGG ACGGAACGGC AGGTGCTGGA GCACATCCGG 300
CAGTCGCCCT TCCTGGTGAC GCTGCACTAC GCCTTCCAGA CGGAGACCAA GCTGCACCTC 360
ATCTTAGATT ATATAAATGG TGGAGAGCTT TTTACTCATC TTTCTCAGAG GGAGCGTTTC 420
ACAGAGCGCG AGGTGCAGAT CTATGTCGGA GAGATCGTGC TTGCCCTCGG ACACCTCCAC 480
AAGTTGGGGA TTATATACCG TGACATTAAG CTTGAGAATA TTCTGCTTGA TTCTAATGGC 540
CACGTGATGC TGACAGATTT TGGTCTGAGT AAGGAGTTTG TGGCTGACGA AGCTGAAAGA 600
GCATATTCCT TTTGTGGAAC AATTGAATAC ATGGCACCAG ATATTGTCAG AGGGGGAGAC 660
TCAGGACATG ACAAGGCAGT TGACTGGTGG AGTTTAGGTG TTCTAATGTA TGAATTACTA 720
ACTGGAGCAT CTCCGTTCAC TGTTGATGGC GAGAAGAACT CCCAAGCTGA GATATCTAGG 780
AGAATATTAA AGAGCGAGCC TCCGTATCCC CAGGAAATGA GTGCTGTAGC CAAAGACCTG 840
ATCCAGCGTC TCCTGATGAA AGATCCCAAG AAAAGACTGG GATGTGGTCC ACGCGACGCA 900
GATGAAATCA AAGAACACCC CTTTTTTCAG AAAATAAACT GGGATGATTT AGCTGCCAAG 960
AAAGTGCCCG CACCTTTTAA GCCAGTCATC CGAGATGAAT TAGATGTGAG TAACTTTGCG 1020
GAAGAATTCA CAGAAATGGA CCCCACCTAC TCTCCTGCAG CTCTGCCCCA GAGCTCCGAG 1080
AGGCTGTTCC AGGGCTATTC CTTTGTTGCC CCTTCCATTC TCTTCAAGCG CAACGCAGCC 1140
GTCATGGACC CTCTTCAGCT TCACATGGGA GTTGACCGCC CCGGGGTGAC GCATGTTGCG 1200
AGGAGCGCGA TGCTGAAGGA CTCTCCATTC TATCAGCACT ATGACCTGGA TCTGAAGGAC 1260
ACACCACTGG GAGAAGGAAG CTTTTCAATC TGTCGAAAGT GCATACACAA AAAAAGTAAC 1320
CAAGCATTTG CAGTCAAAAT AATCAGCAAA AGGATGGAAG CCAGCACTCA GAAAGAGGTA 1380
ACAGCGCTGA GACTCTGCGA AGGACATCCC AATATTGTGA AATTACATGA GGTTTTTCAC 1440
GATCAGCTTC ACACATTTCT CGTGATGGAA CTTCTGAATG GGGGAGAGCT GTTTGAACGC 1500
ATTAAGAGAA AGAAGCATTT TAGTGAGACG GAAGCCAGCT ACATCATGCG GAAGCTGGTT 1560
TCAGCTGTAA GCCACATGCA TGACGTCGGA GTGGTACACA GAGATCTGAA ACCCGAGAAT 1620
TTACTGTTCA CTGATGAAAA TGACAATTTG GAAATTAAAG TCATTGATTT TGGGTTTGCA 1680
CGCTTGAAGC CCCCTGATAA TCAGCCTCTG AAGACGCCTT GTTTCACTCT TCACTACGCT 1740
GCCCCAGAGC TCTTGAATCA CAGCGGCTAT GATGAGTCCT GCGACCTCTG GAGCTTGGGC 1800
GTCATTTTGT ATACAATGTT GTCAGGGCAA GTTCCATTTC AGTCTCATGA TAAAAGTCTG 1860
ACATGCACCA GTGCAGTGGA AATCATGAAG AAAATTAAAA AGGGAGATTT CTCCTTTGAA 1920
GGAGAAGCCT GGAAGAATGT ATCCCAAGAG GCTAAAGATT TGATCCAAGG ACTTCTCACA 1980
GTTGATCCAA ACAAAAGGCT TAAAATGCCT GACTTGAGAT ACAATGAATG GCTTCAAGAC 2040
GGCAGTCAGC TGTCCTCGAA TCCTCTGATG ACTCCAGACA TCCTGGGCTC TTCAGGAGCT 2100
GCGGTGCACA CGTGTGTGAA AGCCACTTTC CACGCCTTCA ACAAATACAA GAGAGAGGGG 2160
TTCTGCCTCC AGAACGTGGA CAAGGCCCCG CTGGCGAAGA GGCGGAGGAT GAAGAAGACG 2220
AGCACGAGCA CGGAGACGCG CAGCAGCTCC AGCGAGAGCT CGCACTCCTC ATCCTCCCAC 2280
TCGCACGGCA AGAGCACGCC CACAAGGGCG CTGCAGCCCG GCAACCCCGC CGACGGCGGC 2340
GCCCCCGAGA GCCTCTTCCA GTTCCAGGAC TGA 2373
Domain Profile
S: 3     vkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdv  61
         ++ +lG+Gs+s+c++c+hk++nq+favkii+k+ ++ t++e+++l+++e+hpniv+l++v
Q: 419   KDTPLGEGSFSICRKCIHKKSNQAFAVKIISKRmEASTQKEVTALRLCEGHPNIVKLHEV  478
         6789*****************************9**************************
S: 62    yddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkp  121
         ++d+++++lv+ell+GGel++rik+kk+fse+eas+i+r+lv+av+++h++Gvvhrdlkp
Q: 479   FHDQLHTFLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP  538
         ************************************************************
S: 122   enilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlw  181
         en+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l++ Gyde+cdlw
Q: 539   ENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHSGYDESCDLW  597
         *************.**********************************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl+++
Q: 598   SLGVILYTMLSGQVPFqshdKSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQG  657
         ****************98888899************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdp+krlk+ +l++++wl
Q: 658   LLTVDPNKRLKMPDLRYNEWL  678
         ********************7
Domain Sequence
(FASTA)
KDTPLGEGSF SICRKCIHKK SNQAFAVKII SKRMEASTQK EVTALRLCEG HPNIVKLHEV 60
FHDQLHTFLV MELLNGGELF ERIKRKKHFS ETEASYIMRK LVSAVSHMHD VGVVHRDLKP 120
ENLLFTDEND NLEIKVIDFG FARLKPPDNQ PLKTPCFTLH YAAPELLNHS GYDESCDLWS 180
LGVILYTMLS GQVPFQSHDK SLTCTSAVEI MKKIKKGDFS FEGEAWKNVS QEAKDLIQGL 240
LTVDPNKRLK MPDLRYNEWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MEG-00130
EKS-MOD-00162
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PEM-00087
EKS-POA-00160
EKS-SAH-00157
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
bta:504408;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013