EKS-BOT-00068

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00068

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	359.2	1.5E-107	12	295	284

Status

Unreviewed

Ensembl Protein

ENSBTAP00000014667

UniProt Accession

Q08DX5; F1N2N7;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase 7;

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000011046	ENSBTAP00000014667	ENSBTAT00000014667

Organism

Bos taurus

Functional Description

Protein Length

346

Protein Sequence
(FASTA)

MAVDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL 60

REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM 120

TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPSRAYT HQVVTRWYRA 180

PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM 240

CSLPDFVTFK SFPGIPLQHI FIAAGDDLLD LIQGLFLFNP CTRITATQAL KTKYFSNRPG 300

PTPGCQLPRP NCPAEALKEQ SNPAMATKRK RTEALEQGGL PKKLIF 346

Nucleotide Sequence
(FASTA)

ATGGCAGTGG ACGTGAAGTC GCGAGCGAAG CGTTATGAAA AACTGGACTT CCTCGGAGAG 60

GGACAGTTTG CCACGGTTTA CAAGGCCAGA GACAAGAACA CCAACCAAAT TGTCGCCATT 120

AAGAAAATCA AACTTGGACA TAGATCAGAA GCTAAAGATG GTATAAATAG AACAGCCTTA 180

AGAGAGATAA AATTATTACA GGAGCTAAGT CATCCAAATA TAATTGGTCT CCTTGATGCT 240

TTTGGACATA AATCTAACAT TAGTCTTGTC TTTGATTTTA TGGAAACTGA TCTAGAGGTT 300

ATAATAAAGG ATAACAGTCT TGTGCTAACA CCTTCACACA TCAAAGCCTA TATGTTGATG 360

ACTCTTCAAG GATTAGAATA TTTACATCAA CATTGGATTC TGCATAGGGA CCTAAAACCA 420

AACAACTTGT TGCTAGATGA AAATGGAGTT CTAAAACTGG CCGATTTTGG CCTGGCCAAA 480

TCATTTGGGA GCCCCAGTAG AGCTTATACA CATCAGGTTG TAACCAGGTG GTATCGGGCC 540

CCTGAGCTAC TGTTCGGAGC TAGAATGTAT GGTGTAGGTG TGGACATGTG GGCTGTGGGC 600

TGTATATTAG CAGAGTTGCT TCTAAGGGTT CCTTTTTTGC CAGGAGATTC AGACCTTGAT 660

CAACTAACAA GAATATTTGA AACTTTGGGC ACACCAACTG AAGAGCAGTG GCCTGACATG 720

TGTAGTCTTC CAGATTTCGT GACATTTAAG AGTTTTCCTG GAATCCCATT ACAACATATC 780

TTCATTGCAG CAGGAGATGA CTTGCTAGAT CTTATACAAG GCTTATTCTT ATTTAATCCA 840

TGTACTCGAA TTACAGCCAC ACAGGCGTTG AAAACTAAGT ATTTCAGTAA TCGGCCAGGG 900

CCAACACCTG GATGTCAGCT GCCAAGACCA AACTGTCCAG CGGAGGCTCT AAAGGAGCAG 960

TCCAATCCAG CCATGGCAAC AAAACGGAAG AGAACAGAGG CCTTGGAACA AGGAGGATTA 1020

CCCAAGAAGC TAATTTTTTA G 1041

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  71

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+ylH

Q: 72    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGLEYLH  129

         ***********.99**********************9.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp+++yt++vvT+wYraPelL+ga+

Q: 130   QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPSRAYTHQVVTRWYRAPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp++ +lp++  +

Q: 190   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDFV-T  248

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ + ++ ++ ldl++ l+ ++p +Ri+a++al++kyf

Q: 249   FKSFPGIPLQHIFIAAGDDLLDLIQGLFLFNPCTRITATQALKTKYF  295

         9999999******99999****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KNTNQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDNSLVLTP SHIKAYMLMT LQGLEYLHQH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPSRAYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPDMC SLPDFVTFKS 240

FPGIPLQHIF IAAGDDLLDL IQGLFLFNPC TRITATQALK TKYF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005675	; C:holo TFIIH complex
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0008094	; F:DNA-dependent ATPase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366	; P:transcription from RNA polymerase II promoter

KEGG

bta:515462

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013