EKS-BOT-00268
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00268
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK453.83.5E-136190518329
StatusUnreviewed
Ensembl ProteinENSBTAP00000015051
UniProt AccessionE1BQ34;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK1
Gene Synonyms/Alias HIPK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000011322ENSBTAP00000015051ENSBTAT00000015051
OrganismBos taurus
Functional Description
Protein Length1210
Protein Sequence
(FASTA)
MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP ATQGQANSSH 60
QVANFNIPAY DQGLLLPAPA VEHIVVTAAD SSASAATSTF QSSQTLTHRS NVSLLEPYQK 120
CGLKRKSEEV DSNGSVQIIE EHPPLMLQNR TVVGAAATTT TVTTKSSSSS GEGDYQLVQH 180
EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 240
LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 300
TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 360
PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 420
KTTRFFNRDP NLGYPLWRLK TPEEHELETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 480
MLAEKADRRE YIDLLKKMLT IDADKRITPL KTLNHQFVTM THLLDFPHSN HVKSCFQNME 540
ICKRRVHMYD TVSQIKSPFT THVAPNTSTN LTMSFSNQLN TVHNQASVLA SSSTAAAATL 600
SLANSDVSLL NYQSALYPSS AAPVPGVAQQ GVSLQPGTTQ ICTQTDPFQQ TFIVCPPAFQ 660
TGLQATTKHS GFPVRMDNAV PIVPQAPAAQ PLQIQSGVLT QGSCTPLMVA TLHPQVATIT 720
PQYAVPFTLS CAAGRPALVE QTAAVLQAWP GGTQQILLPS TWQQLPGVAL HNSVQPTAVI 780
PEAMGSGQQL TDWRNAHSHG NQYSTIMQQP SLLTNHVTLA TAQPLNVGVA HVVRQQQSSS 840
LPSKKNKQSA PVSSKSSLDV LPSQVYSLVG SSPLRTTSSY NSLVPVQDQH QPIIIPDTPS 900
PAVSVITIRS DTDEEEDNKY KPNSSGLKAR SNVISYVTVN DSPDSDSSLS SPYSTETLSA 960
LRGNSGSLPE GPGRVVGDGP GTRTIIVPPL KTQLGDCTVA TQASGLLSSK TKPVASVSGQ 1020
SSGCCITPTG YRAQRGGTSA AQPLNLSQNQ QSSSAPTSQE RSSNPAPRRQ QAFVAPLSQA 1080
PYAFQHGSPL HSTGHPHLAP APAHLPSQPH LYTYAAPTSA AALGPTTSIA HLFSPQGSSR 1140
HAAAYATHPS TLVHQVPVSV GPSLLTSASV APAQYQHQFA TQSYIGSSRG STIYTGYPLS 1200
PTKISQYSYL 1210
Nucleotide Sequence
(FASTA)
ATGGCATCAC AGCTGCAGGT GTTTTCCCCC CCATCAGTGT CGTCGAGTGC CTTCTGCAGT 60
GCGAAGAAGC TGAAAATAGA GCCCTCTGGC TGGGATGTTT CTGGACAGAG CAGCAACGAC 120
AAATATTATA CCCACAGCAA AACCCTCCCA GCCACACAAG GGCAAGCCAA CTCCTCTCAC 180
CAGGTAGCAA ATTTCAACAT CCCTGCTTAC GACCAGGGCC TGCTCCTCCC AGCTCCTGCA 240
GTGGAGCACA TTGTTGTAAC AGCTGCTGAT AGCTCGGCCA GTGCTGCTAC ATCAACCTTC 300
CAAAGCAGCC AGACCCTGAC TCACAGAAGC AACGTTTCTT TGCTTGAGCC ATATCAAAAA 360
TGTGGATTGA AAAGAAAAAG TGAGGAAGTT GACAGCAACG GTAGCGTGCA AATCATAGAA 420
GAACATCCCC CTCTCATGCT GCAAAACAGG ACTGTGGTGG GTGCTGCTGC CACGACCACC 480
ACTGTCACCA CAAAGAGTAG CAGCTCCAGC GGAGAAGGGG ATTACCAGCT GGTCCAGCAT 540
GAGATCCTTT GCTCTATGAC AAACAGCTAT GAAGTCTTGG AGTTCCTAGG CCGGGGAACA 600
TTTGGACAGG TGGCTAAGTG CTGGAAGCGG AGCACCAAGG AAATTGTGGC TATTAAAATC 660
TTGAAGAACC ACCCCTCCTA TGCCAGACAG GGACAGATTG AAGTGAGCAT CCTTTCCCGC 720
CTAAGCAGTG AAAATGCTGA TGAGTATAAT TTTGTCCGTT CTTATGAGTG CTTTCAGCAT 780
AAGAATCATA CCTGCCTTGT GTTCGAGATG CTGGAACAGA ACTTATATGA TTTTCTAAAG 840
CAGAACAAGT TTAGTCCACT GCCACTCAAG TACATCAGGC CAATCTTGCA GCAGGTGGCC 900
ACTGCCCTGA TGAAGCTCAA GAGCCTTGGT CTAATTCATG CTGACCTTAA GCCTGAAAAC 960
ATAATGCTGG TTGATCCAGT GCGCCAGCCC TACCGAGTGA AGGTCATTGA CTTTGGTTCT 1020
GCTAGTCACG TTTCCAAAGC TGTGTGCTCA ACCTACTTAC AGTCGCGTTA CTACAGAGCC 1080
CCTGAAATTA TTCTTGGCTT ACCATTTTGT GAAGCTATTG ATATGTGGTC ATTGGGCTGT 1140
GTGATAGCAG AGCTGTTCCT GGGATGGCCT CTTTATCCTG GTGCTTCAGA ATATGATCAG 1200
ATTCGTTACA TCTCACAAAC ACAAGGCCTG CCAGCTGAAT ATCTTCTCAG TGCCGGGACA 1260
AAAACTACTA GGTTTTTCAA CAGAGATCCT AATCTGGGGT ACCCGCTATG GAGACTTAAG 1320
ACACCTGAAG AACATGAATT GGAAACTGGG ATCAAGTCAA AAGAAGCTCG AAAGTACATT 1380
TTTAATTGTT TAGATGATAT GGCTCAGGTG AACATGTCTA CAGACTTAGA GGGAACAGAT 1440
ATGTTGGCAG AGAAGGCGGA TCGAAGAGAA TACATTGATC TGTTAAAAAA AATGCTAACA 1500
ATTGATGCAG ATAAGAGAAT TACTCCTCTG AAAACTCTTA ACCACCAGTT TGTGACAATG 1560
ACTCACCTTC TGGATTTTCC ACATAGCAAT CATGTTAAGT CTTGTTTCCA GAACATGGAG 1620
ATCTGCAAAC GGAGGGTCCA CATGTATGAT ACAGTGAGTC AGATCAAGAG TCCCTTCACC 1680
ACACATGTTG CCCCAAATAC AAGCACAAAT CTAACTATGA GCTTCAGCAA CCAACTCAAT 1740
ACAGTGCACA ATCAGGCCAG TGTTCTAGCT TCCAGTTCTA CTGCAGCAGC TGCTACTCTT 1800
TCTCTGGCTA ATTCCGACGT CTCCCTGCTA AACTACCAGT CAGCTTTGTA CCCATCATCT 1860
GCAGCACCCG TTCCTGGTGT CGCCCAGCAA GGTGTTTCCT TGCAGCCTGG AACTACCCAG 1920
ATTTGCACTC AGACAGATCC ATTCCAGCAA ACATTTATAG TATGTCCACC TGCTTTTCAA 1980
ACTGGACTAC AAGCAACAAC AAAACACTCT GGATTCCCTG TGAGGATGGA TAATGCAGTG 2040
CCAATTGTCC CCCAGGCACC AGCTGCTCAG CCACTGCAGA TACAGTCAGG GGTCCTCACG 2100
CAGGGAAGCT GTACACCACT AATGGTAGCA ACTCTTCACC CTCAAGTAGC CACCATCACA 2160
CCGCAGTATG CGGTGCCCTT TACTCTGAGC TGCGCAGCCG GCCGGCCGGC GCTGGTTGAA 2220
CAGACTGCCG CTGTACTGCA GGCTTGGCCT GGAGGAACCC AACAAATTCT CCTGCCTTCC 2280
ACTTGGCAAC AGTTGCCTGG GGTAGCTCTA CACAACTCTG TCCAGCCCAC TGCAGTGATC 2340
CCAGAGGCCA TGGGCAGCGG CCAGCAGCTC ACAGACTGGA GGAATGCCCA CTCTCATGGC 2400
AACCAGTACA GCACTATCAT GCAGCAGCCA TCCTTGCTGA CGAACCACGT GACATTGGCC 2460
ACTGCTCAGC CCCTTAATGT TGGCGTTGCC CATGTTGTCA GACAACAACA ATCCAGTTCC 2520
CTTCCTTCAA AGAAGAATAA ACAGTCTGCT CCAGTCTCTT CTAAGTCCTC TCTGGATGTT 2580
CTGCCGTCTC AAGTCTACTC TCTGGTTGGG AGCAGCCCCC TCCGTACTAC ATCTTCTTAT 2640
AATTCCCTAG TTCCTGTTCA GGATCAGCAT CAGCCAATCA TCATTCCAGA TACTCCCAGC 2700
CCTGCTGTGA GTGTCATCAC CATCCGCAGC GACACTGATG AGGAAGAGGA CAACAAATAC 2760
AAACCCAATA GCTCTGGCCT GAAGGCAAGG TCTAATGTCA TCAGTTACGT CACTGTCAAT 2820
GATTCTCCAG ACTCTGACTC TTCCTTGAGC AGTCCGTACT CCACTGAGAC CCTGAGTGCT 2880
CTCCGGGGCA ATAGTGGGTC CCTTCCAGAG GGGCCTGGCA GAGTCGTGGG AGATGGCCCT 2940
GGCACCCGCA CCATCATTGT ACCTCCACTG AAAACTCAGC TTGGTGACTG CACTGTAGCA 3000
ACCCAGGCCT CAGGTCTCCT GAGCAGTAAG ACCAAGCCAG TGGCTTCAGT GAGTGGGCAG 3060
TCATCTGGAT GCTGTATCAC CCCCACAGGG TACCGAGCTC AACGCGGGGG GACCAGTGCA 3120
GCGCAGCCAC TCAACCTTAG CCAGAACCAG CAGTCATCAT CAGCTCCAAC CTCGCAGGAG 3180
AGAAGCAGCA ACCCTGCCCC CCGCAGGCAG CAGGCATTTG TGGCCCCGCT CTCCCAAGCC 3240
CCCTACGCCT TCCAGCATGG CAGCCCACTA CACTCGACGG GGCACCCCCA CCTGGCCCCA 3300
GCCCCTGCTC ACCTGCCGAG CCAGCCTCAT CTGTATACGT ATGCTGCCCC CACCTCTGCG 3360
GCTGCATTGG GCCCCACCAC CTCCATTGCT CATCTCTTCT CCCCCCAGGG CTCCTCAAGG 3420
CACGCTGCAG CCTATGCCAC CCATCCGAGC ACTCTGGTGC ACCAGGTCCC TGTCAGTGTT 3480
GGGCCCAGTC TCCTCACTTC TGCCAGCGTG GCCCCTGCTC AGTACCAACA CCAGTTTGCC 3540
ACCCAGTCTT ACATTGGGTC TTCCCGAGGC TCGACCATTT ACACTGGATA CCCACTGAGT 3600
CCTACCAAGA TCAGCCAGTA TTCTTACTTG TAG 3633
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqV+k+++++tkeivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 190   YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENADE  248
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr +e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 249   YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  308
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 309   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  368
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 369   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  428
         **********************************************************66
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
           + ++p ++lkt          ks++++k+++n+ +++++++++++ e +++l+ek+d+
Q: 429   dPNLGYPLWRLKTPeeheletgiKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADR  488
         556778889998889********************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + ++dllk+ml++d++kRitp ++l+h+fv
Q: 489   ReYIDLLKKMLTIDADKRITPLKTLNHQFV  518
         99***************************7
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVAKCWK RSTKEIVAIK ILKNHPSYAR QGQIEVSILS RLSSENADEY 60
NFVRSYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240
PNLGYPLWRL KTPEEHELET GIKSKEARKY IFNCLDDMAQ VNMSTDLEGT DMLAEKADRR 300
EYIDLLKKML TIDADKRITP LKTLNHQFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00250
EKS-ANC-00257
EKS-CAE-00238
EKS-CAJ-00274
EKS-CAF-00275
EKS-CAP-00303
EKS-ECT-00028
EKS-EQC-00260
EKS-FEC-00254
EKS-GAM-00168
EKS-GAG-00225
EKS-GOG-00268
EKS-HOS-00274
EKS-LAC-00279
EKS-LOA-00278
EKS-MAM-00270
EKS-MEG-00213
EKS-MOD-00265
EKS-MUP-00265
EKS-MYL-00270
EKS-NOL-00245
EKS-ORC-00253
EKS-ORL-00328
EKS-OTG-00274
EKS-PAT-00253
EKS-PES-00238
EKS-POA-00259
EKS-PTV-00035
EKS-RAN-00283
EKS-SAH-00252
EKS-SUS-00239
EKS-TAG-00284
EKS-TUT-00033
EKS-VIP-00011
EKS-XET-00343
EKS-XIM-00339
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016607; C:nuclear speck
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009952; P:anterior/posterior pattern specification
GO:0048596; P:embryonic camera-type eye morphogenesis
GO:0060059; P:embryonic retina morphogenesis in camera-type eye
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072; P:iris morphogenesis
GO:0060235; P:lens induction in camera-type eye
GO:0030182; P:neuron differentiation
GO:0008284; P:positive regulation of cell proliferation
GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842; P:retina layer formation
GO:0007224; P:smoothened signaling pathway
KEGG
bta:512233;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013