EKS-BOT-00092

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00092

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	454.3	2.8E-136	2275	2601	327

Status

Unreviewed

Ensembl Protein

ENSBTAP00000015321

UniProt Accession

F1MLY7;

Protein Name

Protein Synonyms/Alias

Gene Name

ATR

Gene Synonyms/Alias

ATR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000011529	ENSBTAP00000015321	ENSBTAT00000015321

Organism

Bos taurus

Functional Description

Protein Length

2626

Protein Sequence
(FASTA)

SASPEEYNTV VQKPRQILCQ FIDRILTDVN VVALELVKKT DSQPTSVMLL DFIQHIMKSS 60

PLMFVNVNGS HGQNEAKGSC IEFSNWIITR LLRIAATPSC HMLHKKICEV ICALLFLFKS 120

KSPAIFGVLM KELLHLFEDL IYFHKRYAVE HFVEWPVVVH RFLSQFDEHV GYLQPAPLQL 180

MNMQNLEFIE VTLLTVLIRI IAIVFFRRQE LLLWQIGCVL LEYGSPKVKS LAISLLTELF 240

ELGGLPAQPA STFFSSFFEL LKQLVEMDAD QLKLYEEPLS KLIKTLFSSE TEAYRNIEPV 300

YLNMLLEKLC VMFEDGVLLQ LKSDLLKAAL CHLLQYFLKY VPAGYESALQ VRKVYMRNIC 360

KALVDVLGVQ ADVEYLLGPL YAALKMESME IIDEVQCQIQ QEDLSSNSNG LSPKRRRLSS 420

SLNASKRAPK QTEEIKHVDI NKKSILWSAL KQKAEDLQIF LESNNVKNPI IETLEGIAVI 480

LQLTALCTVH CSHQNMDCYN FKDCQQKCKK KPSVMITWMS VDFYTKVLKS CRTLLESVQK 540

PDLETVIDKV VKIYDALMYI QVNTSFEDHI LEDLCGMLSL PWICLHSDDD SLKLTTFALS 600

LLTLSQRISD SYSPQAQSRC VFLLTLFPRR IHLEWRTAVY SWALQSSHEV IRTSCINGFF 660

ILLQQQNPYN RVPKILVDKV KDDSDIVKKE FASVLGQLVC TLHGKFYLTS SLTEPLSEYG 720

HIDLLCKSLK VASQPECSSS RLKASVCKPF LFLLKKKTPS PVKLAFIENL HHLCKHLDFR 780

EDETDIKTVL GTLLNLMEDP DKDVRVAFSG NIKHILESLD AEDGFIKELF VLRMKEAYTH 840

AQISRNNELK DTLILTTGDI GRAAKGDLVP FALLHLLHCL LSKSASVSGA AYTEIRALVA 900

AKSVKLQNFF SQYKKPICQF LVESLHSSQM TALPSTPCQN AEMRKQDVAH QREMALNTLS 960

EIANVFDFPD LNRFLTRTLQ VLLPDLAAKA SPAASALIRT LGKQLNVNRR EILINNFKYI 1020

FSHLVCSCSK DELERALHYL KNETEIELGS LLRQDFQGLH NELLLRIGEH YQQVFNGLSI 1080

LASFASSDDP YQGPRDITSP ELMADYLQPK LLGILAFFNM QLLSSSVGIE DKKMALNSLM 1140

SLMKLMGPKH VSSVRVKMMT TLRTGLRFKD DFPELCCRAW DCFVRCLDHA YLGSLLSHVI 1200

VALLPLIHIQ PKETAAIFHY LIIENRDAVQ DFLHEIYFLP DHQELKKIKA VLQEYRKETS 1260

ESTDLQTTLQ LSMKAIQHEN VDVRIHALTS LKETLYKNQE KLIRYATDSE TVEPVISQLV 1320

TVLLKGCQDA NSQARLLCGE CLGELGAIDP GRLDFSTTDT QGKDFTFVTG VEDSNFAYGL 1380

LMELTRAYLA YADNSRAQDS AAYAIQELLS IYDCREMQTD GPGHQLWRRF PEHVREILEP 1440

HLNTRYKSSQ KSTDWSGVKK PIYLSKLGNN FAEWSASWAG YLITKVRHDL ASKIFTCCSI 1500

MMKHDFKVTI YLLPHILVYV LLGCNQEDRQ EVYAEIMAVL KHDDHHTLST QDSASDLCQL 1560

STQTVFSMLD HLTQWARHKF QALNAEKFAQ GKSHRDKVDS MVSSVDYEDY QSVTRFLDLI 1620

PQDTLAVASF RSKAYTRAVM HFESFITEKK QNIQEHLGFL QKLYAAMHEP DGVAGVSAIR 1680

KAEPSLKEQI LEHESIGLLR DATACYDRAI QLEPDQIIHY HGVVKSMLGL GQLSTVITQV 1740

NGVHANSRSE WTDELNTYRV EAAWKLSQWD LVENYLAADG KSTTWSVRLG QLLLSAKKRD 1800

TTAFYDTLKL VRAEQIVPLS AASFERGSYQ RGYEYIVRLH MLCELEHSIK PLFHQSPADS 1860

IQEDSLNWVA RLEMTQNSYR AKEPILALRR ALLSLNKRPD YSEMVGECWL QSARVARKAG 1920

HHQTAYNALL NAGDSRLAEL YVERAKWLWS KGDVHQALIV LQKGVELCFP ENKTPPEGKN 1980

MLIHGRATLL VGRFMEETAN FESNAVMKKY KDVTLFLPEW EDGHFYLAKY YDKLMPMVTD 2040

NKMEKQGDLI RYILLHFGRS LQYGNQFIYQ SMPRMLSLWL DFGAKAYEWE KAGRSDRVQM 2100

RNDLVKINKV ITEHTNQLAP YQFLTAFSQL ISRICHSHDE VFVVLMEIIA KVLLAYPQQA 2160

MWMMTAVSKS SYPMRVNRCK EILNKAIQMK KSLEKFVGDA TRLTDKLLEL CNKSVDGSSS 2220

TLSMSTHFKM LKKLVEEATF SEILIPLQSV MIPTLPSIPG AHANHEPFPG HWAYIAGFDD 2280

TVEILASLQK PKKISLKGSD GKFYIMMCKP KDDLRKDCRL MEFNSLINKC LRKDAESRRR 2340

ELHIRTYAVI PLNDECGIIE WVNNTAGLRP ILTKLYKEKG VYMTGKELRQ CMLPKSAALS 2400

EKLKVFQEFL LPRHPPVFHE WFLRTFPDPT SWYSSRSAYC RSTAVMSMVG YILGLGDRHG 2460

ENILFDSLTG ECVHVDFNCL FNKGETFEVP EIVPFRLTHN MVNGMGPMGT EGLFRRACEV 2520

TMRLMRDQRE PLMSVLKTFL HDPLVEWSKP VKGHSKAALN ETGEVVNEKA KTHVLDIEQR 2580

LRGVIKTRNR VTGLPLSIEG HVHYLIQEAT DENLLCQMYL GWTPYM 2626

Nucleotide Sequence
(FASTA)

AGTGCCAGTC CAGAGGAATA TAATACTGTT GTACAGAAGC CAAGACAAAT TCTATGTCAG 60

TTCATTGACC GAATACTTAC AGACGTAAAT GTTGTTGCTC TGGAACTTGT GAAGAAAACT 120

GACTCTCAAC CAACCTCTGT GATGTTGCTT GATTTCATCC AGCATATCAT GAAGTCCTCC 180

CCACTTATGT TTGTAAATGT GAATGGAAGC CATGGGCAAA ATGAAGCCAA AGGCAGTTGT 240

ATTGAGTTCA GTAATTGGAT CATAACAAGA CTTCTGCGGA TTGCAGCCAC TCCATCCTGT 300

CATATGTTAC ACAAAAAAAT CTGTGAAGTC ATCTGTGCAT TATTATTTCT TTTTAAAAGC 360

AAGAGTCCTG CTATTTTTGG AGTACTGATG AAGGAATTAT TACATCTTTT TGAAGACTTG 420

ATTTACTTCC ACAAAAGATA TGCAGTAGAA CACTTTGTGG AATGGCCAGT GGTAGTTCAC 480

CGGTTTTTAA GTCAATTCGA TGAACATGTA GGATATTTAC AGCCAGCTCC TTTGCAGCTC 540

ATGAACATGC AAAATTTAGA GTTTATTGAA GTCACTTTAT TGACAGTTCT TATTCGTATT 600

ATTGCAATTG TGTTTTTTAG AAGGCAAGAA CTCTTACTTT GGCAGATAGG TTGTGTTCTG 660

CTAGAGTATG GGAGTCCAAA AGTTAAATCC TTAGCAATTA GCCTTTTAAC TGAACTCTTT 720

GAGCTTGGAG GACTACCAGC ACAACCAGCC AGCACTTTTT TCAGCTCATT TTTTGAATTA 780

TTAAAACAAC TAGTAGAAAT GGATGCTGAC CAATTGAAAC TCTATGAAGA GCCATTATCA 840

AAGCTGATAA AGACCCTGTT CTCCTCTGAA ACAGAAGCTT ATAGAAATAT TGAGCCTGTC 900

TACTTAAATA TGCTGCTAGA AAAACTCTGT GTCATGTTTG AAGATGGTGT GCTTTTGCAG 960

CTTAAGTCTG ATTTGCTAAA AGCAGCTTTG TGCCACTTAC TGCAGTATTT CCTTAAATAT 1020

GTGCCAGCTG GGTATGAATC TGCTTTACAA GTCAGGAAGG TTTATATGAG AAATATTTGT 1080

AAAGCTCTTG TAGATGTGCT TGGAGTTCAG GCAGATGTGG AGTATTTGTT GGGCCCACTT 1140

TATGCAGCCT TAAAAATGGA AAGTATGGAA ATCATTGATG AAGTTCAGTG CCAAATTCAA 1200

CAGGAAGACC TCAGCAGTAA TAGCAATGGA CTGTCACCCA AAAGGCGTCG ACTCAGCTCA 1260

TCTTTAAACG CTTCCAAAAG AGCACCAAAA CAGACTGAGG AAATTAAACA TGTGGATATA 1320

AACAAAAAGA GCATATTATG GAGTGCACTG AAACAGAAGG CTGAGGACCT TCAAATTTTC 1380

CTTGAATCCA ATAATGTGAA GAATCCTATT ATTGAGACTT TAGAAGGAAT TGCCGTCATT 1440

CTACAACTGA CTGCTCTGTG TACTGTTCAC TGTTCTCATC AAAACATGGA CTGCTATAAT 1500

TTCAAGGACT GTCAACAGAA GTGTAAGAAG AAACCTTCAG TAATGATAAC TTGGATGTCT 1560

GTGGATTTTT ACACAAAGGT GCTTAAGAGC TGTAGGACTT TGTTAGAATC TGTTCAGAAA 1620

CCTGATCTGG AGACAGTTAT TGACAAAGTG GTAAAAATAT ATGATGCTTT GATGTATATT 1680

CAAGTAAACA CTTCATTTGA AGATCATATC CTGGAAGATT TATGTGGAAT GCTCTCACTT 1740

CCATGGATTT GTCTCCATTC TGATGATGAC TCTTTAAAGT TGACCACATT TGCCCTCAGT 1800

CTTCTAACAT TAAGCCAGAG GATTTCAGAT AGCTACTCAC CACAGGCCCA ATCACGATGT 1860

GTATTTCTTC TAACTCTGTT TCCAAGAAGA ATACACCTTG AGTGGAGAAC AGCAGTTTAC 1920

AGCTGGGCCC TGCAGAGTTC TCATGAAGTA ATCCGGACAA GTTGTATTAA TGGATTCTTT 1980

ATCTTACTGC AGCAGCAGAA TCCTTATAAC AGAGTTCCCA AGATTCTTGT AGATAAAGTC 2040

AAAGATGATT CTGACATTGT CAAAAAAGAA TTTGCATCTG TACTTGGTCA GCTTGTCTGT 2100

ACACTTCATG GCAAGTTTTA TTTGACAAGT TCTTTAACAG AACCTCTCTC TGAATATGGG 2160

CATATTGACC TCTTATGTAA GAGCCTAAAA GTCGCTTCTC AACCTGAATG TTCATCTTCT 2220

CGACTAAAAG CTTCTGTTTG CAAGCCATTC CTTTTCCTAC TGAAAAAAAA AACACCTAGC 2280

CCAGTGAAAC TTGCTTTCAT AGAAAATCTG CATCATCTTT GTAAGCATCT TGATTTTAGA 2340

GAAGATGAAA CAGATATAAA AACGGTTCTT GGAACTTTAT TAAATTTAAT GGAAGATCCA 2400

GACAAGGATG TTAGAGTGGC TTTTAGTGGA AATATCAAGC ATATATTGGA ATCCTTGGAT 2460

GCTGAGGATG GATTTATAAA AGAGCTTTTT GTCTTAAGGA TGAAGGAAGC ATATACACAC 2520

GCTCAGATCT CAAGAAATAA TGAATTGAAG GATACCTTGA TTCTTACAAC AGGGGATATT 2580

GGAAGGGCAG CAAAAGGAGA TTTGGTACCT TTTGCCCTCT TGCACTTATT GCACTGTTTA 2640

TTATCCAAGT CAGCATCTGT CTCTGGAGCA GCGTACACGG AAATTAGAGC ACTGGTTGCG 2700

GCTAAAAGTG TTAAACTGCA GAACTTTTTC AGCCAGTATA AGAAACCTAT CTGTCAGTTT 2760

TTGGTAGAAT CCCTCCACTC CAGTCAGATG ACGGCACTTC CTAGTACTCC ATGCCAGAAT 2820

GCTGAGATGC GAAAACAAGA TGTGGCTCAC CAGCGAGAAA TGGCTTTAAA TACCTTGTCT 2880

GAAATTGCCA ATGTTTTTGA CTTTCCTGAT CTTAATCGTT TCCTTACTAG AACATTACAA 2940

GTGTTGCTAC CTGACCTTGC TGCCAAAGCA AGCCCTGCAG CTTCTGCTCT CATTCGAACT 3000

TTAGGAAAAC AATTAAATGT CAATCGTAGA GAGATTTTAA TAAATAACTT CAAGTATATT 3060

TTTTCCCATT TGGTTTGCTC CTGTTCCAAG GATGAATTAG AACGTGCCCT TCATTATCTA 3120

AAGAATGAAA CAGAAATTGA ACTGGGGAGC CTGCTGAGAC AAGATTTCCA AGGACTGCAT 3180

AATGAATTAT TGCTCCGTAT TGGAGAACAC TATCAACAGG TTTTCAATGG TTTGTCAATA 3240

CTTGCCTCAT TTGCATCTAG TGATGATCCA TATCAAGGTC CAAGAGATAT CACATCACCT 3300

GAACTTATGG CTGATTATTT GCAACCCAAG TTGTTGGGCA TTTTGGCTTT TTTCAATATG 3360

CAGTTACTAA GCTCCAGTGT TGGCATTGAA GATAAGAAAA TGGCCTTGAA CAGTTTAATG 3420

TCTTTGATGA AATTGATGGG ACCCAAACAT GTCAGTTCTG TGAGGGTGAA GATGATGACC 3480

ACGCTGAGAA CTGGCCTTCG ATTCAAGGAT GATTTTCCTG AATTGTGTTG CAGAGCTTGG 3540

GACTGCTTTG TTCGTTGCCT GGATCATGCT TATCTAGGTT CCCTTCTCAG TCATGTAATA 3600

GTAGCTTTGT TACCACTCAT ACATATCCAG CCTAAAGAAA CTGCAGCTAT ATTTCACTAC 3660

CTCATAATTG AAAACAGGGA TGCTGTGCAA GATTTTCTTC ATGAAATATA TTTTTTACCT 3720

GATCATCAAG AATTAAAAAA GATAAAAGCG GTTCTACAGG AATATAGAAA GGAGACCTCT 3780

GAGAGTACTG ATCTTCAGAC AACTCTTCAG CTATCCATGA AAGCAATTCA GCATGAAAAT 3840

GTAGATGTCC GTATTCATGC TCTTACGAGC TTGAAGGAAA CCTTGTATAA AAATCAGGAA 3900

AAACTGATCA GATATGCAAC AGATAGTGAA ACCGTGGAAC CTGTTATCTC ACAGTTGGTG 3960

ACAGTGCTCT TGAAAGGTTG CCAAGATGCA AACTCTCAAG CTCGGTTGCT CTGTGGAGAA 4020

TGTTTAGGGG AATTGGGGGC AATAGACCCA GGTCGACTAG ATTTCTCAAC CACTGACACC 4080

CAAGGAAAAG ATTTTACATT TGTGACTGGA GTAGAAGATT CAAACTTTGC CTATGGATTA 4140

TTGATGGAAC TAACAAGAGC TTACCTTGCA TATGCAGATA ACAGCCGAGC TCAAGATTCA 4200

GCTGCTTATG CCATTCAGGA GTTACTTTCC ATTTATGACT GCAGAGAGAT GCAAACTGAT 4260

GGCCCCGGTC ACCAATTGTG GAGGCGATTT CCTGAGCATG TTCGAGAAAT ACTGGAACCA 4320

CATCTAAATA CTAGATATAA GAGTTCTCAG AAATCAACAG ATTGGTCTGG AGTAAAGAAG 4380

CCAATTTACT TAAGTAAATT AGGTAATAAT TTTGCGGAAT GGTCAGCATC TTGGGCAGGT 4440

TATCTTATAA CAAAGGTTCG GCATGATCTT GCCAGTAAAA TCTTCACCTG CTGTAGCATT 4500

ATGATGAAGC ATGATTTCAA GGTGACCATC TATCTTCTTC CACATATTTT AGTGTATGTT 4560

TTGTTGGGGT GTAATCAAGA AGATCGACAA GAGGTTTATG CAGAAATTAT GGCAGTTCTA 4620

AAGCATGATG ATCATCATAC CTTAAGTACC CAAGACAGTG CATCTGATCT GTGTCAACTC 4680

AGTACACAGA CTGTGTTCTC CATGCTTGAC CATCTCACAC AATGGGCAAG GCACAAGTTT 4740

CAGGCACTGA ATGCTGAAAA ATTCGCACAA GGCAAATCAC ATAGAGATAA GGTAGACTCC 4800

ATGGTGTCTA GTGTGGATTA TGAAGACTAT CAGAGTGTAA CTCGTTTTCT AGACCTCATA 4860

CCTCAGGATA CTCTGGCAGT AGCATCCTTT CGCTCCAAAG CATACACACG AGCTGTAATG 4920

CACTTTGAAT CATTTATTAC AGAAAAGAAG CAAAACATTC AAGAGCATCT TGGATTTTTA 4980

CAGAAATTAT ATGCTGCTAT GCATGAACCA GATGGAGTGG CTGGAGTAAG TGCAATTCGA 5040

AAGGCAGAGC CATCTCTGAA AGAACAAATC CTTGAACATG AAAGCATCGG CTTACTGAGG 5100

GATGCCACTG CTTGTTATGA CAGGGCTATT CAGTTAGAAC CAGACCAGAT CATTCACTAT 5160

CATGGTGTTG TGAAGTCCAT GTTAGGTCTT GGTCAACTGT CTACTGTAAT CACTCAGGTG 5220

AATGGAGTGC ATGCTAACAG TAGGTCTGAA TGGACAGATG AATTAAACAC ATACAGGGTG 5280

GAAGCAGCTT GGAAATTGTC ACAGTGGGAT TTAGTAGAAA ACTATTTGGC AGCAGATGGG 5340

AAATCTACAA CGTGGAGTGT CAGACTGGGA CAGCTATTAT TATCAGCTAA GAAAAGAGAT 5400

ACCACAGCTT TTTATGACAC ATTGAAACTA GTGAGAGCAG AGCAAATTGT GCCGCTTTCA 5460

GCTGCAAGCT TTGAAAGGGG CTCTTATCAA CGTGGATATG AATATATTGT GAGATTGCAC 5520

ATGTTGTGTG AGTTGGAGCA TAGCATCAAA CCACTCTTTC ACCAGTCTCC AGCTGACAGT 5580

ATTCAAGAAG ATTCACTAAA TTGGGTAGCG CGACTGGAAA TGACCCAGAA TTCCTACAGA 5640

GCGAAAGAGC CCATTCTGGC TCTCCGGAGA GCTTTATTAA GCCTCAACAA AAGACCAGAT 5700

TACAGTGAAA TGGTTGGAGA ATGCTGGCTA CAGAGTGCCA GAGTAGCTCG AAAGGCTGGT 5760

CACCACCAGA CAGCCTATAA TGCTCTCCTT AATGCTGGAG ATTCACGACT CGCTGAACTG 5820

TATGTGGAAA GAGCAAAGTG GCTCTGGTCC AAGGGTGATG TTCACCAGGC ACTAATTGTT 5880

CTTCAAAAGG GTGTTGAGTT ATGTTTTCCT GAAAATAAAA CCCCACCTGA GGGTAAGAAC 5940

ATGTTAATCC ATGGTCGAGC TACGCTACTA GTGGGCCGTT TTATGGAAGA AACAGCTAAT 6000

TTTGAAAGCA ATGCAGTTAT GAAAAAATAT AAGGATGTAA CCTTGTTTCT GCCGGAGTGG 6060

GAGGATGGAC ATTTCTACCT TGCCAAGTAT TATGACAAAT TGATGCCCAT GGTCACAGAT 6120

AACAAAATGG AAAAGCAGGG TGATCTCATT CGATATATAC TTCTTCACTT CGGAAGATCT 6180

TTACAGTATG GAAATCAGTT CATATATCAA TCAATGCCAC GAATGTTATC ATTATGGCTT 6240

GATTTTGGTG CTAAGGCATA CGAATGGGAA AAAGCTGGCC GCTCTGATCG TGTACAAATG 6300

AGAAATGATT TAGTTAAAAT AAACAAAGTT ATCACAGAGC ACACAAATCA GTTAGCTCCG 6360

TATCAGTTTT TGACTGCCTT TTCACAGCTG ATCTCCCGAA TTTGTCATTC TCATGATGAA 6420

GTTTTTGTTG TCTTGATGGA AATTATAGCC AAAGTACTTC TGGCCTATCC TCAGCAAGCA 6480

ATGTGGATGA TGACAGCTGT GTCAAAGTCT TCTTACCCCA TGCGTGTAAA CAGATGCAAG 6540

GAAATCCTAA ATAAAGCTAT TCAAATGAAA AAATCCTTAG AAAAGTTTGT TGGAGATGCA 6600

ACTCGCCTAA CAGATAAACT TCTAGAATTG TGCAACAAAT CGGTGGATGG AAGTAGTTCC 6660

ACACTGAGCA TGAGCACTCA TTTTAAAATG CTTAAAAAGC TGGTAGAAGA AGCAACGTTT 6720

AGTGAAATCC TCATTCCTTT ACAGTCAGTA ATGATACCTA CTCTTCCATC AATCCCAGGT 6780

GCCCATGCTA ACCATGAGCC GTTTCCTGGG CATTGGGCCT ATATTGCAGG CTTTGATGAT 6840

ACGGTAGAAA TTCTTGCTTC TCTTCAGAAA CCAAAGAAGA TCTCTTTAAA AGGATCTGAT 6900

GGAAAGTTCT ACATTATGAT GTGTAAGCCA AAAGATGACT TGAGAAAGGA TTGTAGACTA 6960

ATGGAATTCA ATTCCTTGAT TAATAAGTGC TTAAGAAAAG ATGCAGAATC TCGTAGAAGA 7020

GAACTTCATA TTCGAACATA TGCAGTTATT CCATTGAATG ATGAATGTGG GATTATTGAA 7080

TGGGTCAACA ACACTGCTGG TTTGAGACCT ATTCTGACCA AACTATATAA AGAAAAGGGA 7140

GTTTATATGA CAGGGAAGGA ACTTCGGCAG TGTATGCTGC CAAAATCAGC AGCTTTGTCT 7200

GAAAAACTCA AAGTATTCCA AGAATTTCTC CTGCCCAGGC ATCCTCCTGT TTTTCATGAG 7260

TGGTTTCTGA GAACATTCCC TGATCCTACA TCATGGTACA GTAGCAGATC AGCATACTGT 7320

CGTTCCACCG CAGTTATGTC AATGGTCGGT TATATCCTGG GCCTTGGAGA CCGTCATGGT 7380

GAAAACATTC TCTTTGATTC TTTGACTGGT GAATGTGTAC ATGTGGATTT CAACTGTCTC 7440

TTCAATAAGG GAGAAACCTT TGAGGTCCCA GAAATTGTTC CATTTCGCCT GACTCATAAT 7500

ATGGTTAACG GAATGGGTCC GATGGGAACG GAAGGTCTTT TTCGAAGAGC TTGTGAAGTT 7560

ACAATGAGAC TAATGCGAGA TCAGAGAGAG CCTTTAATGA GTGTCTTAAA GACTTTTCTA 7620

CATGATCCTC TTGTGGAATG GAGTAAACCA GTGAAAGGGC ATTCCAAAGC AGCACTGAAT 7680

GAAACAGGGG AAGTTGTCAA TGAAAAGGCC AAGACTCATG TTCTTGACAT CGAGCAGCGA 7740

CTACGAGGTG TAATCAAGAC CCGAAATAGA GTGACAGGGC TGCCATTATC TATCGAAGGA 7800

CACGTGCATT ACCTTATACA AGAAGCTACT GATGAAAACT TGCTATGCCA GATGTACCTT 7860

GGTTGGACCC CATATATGTA A 7881

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         iagfd++veilas+qkpkk++l+Gsdgk+y++++k+k+Dlr+d+r+++++sl+N++L+kd

Q: 2275  IAGFDDTVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKD  2334

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e++rr+L+irty+V+pl++++g+iewv+nt++L+ +l+kl+++k+v++        + +

Q: 2335  AESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYM--------TGK  2386

         *************************************************........599

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         + +q++ pk+++l+++l+vf+e+l +++p+ ++++++l++fp+p++w+++r+ay+rs+Av

Q: 2387  ELRQCMLPKSAALSEKLKVFQEFLLPRHPP-VFHEWFLRTFPDPTSWYSSRSAYCRSTAV  2445

         *****************************8.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

         +s+vgyiLgLgdrh en+l+d+ tge+vh+df++ f+k++t ++vpe+vPFRLT+n+vn+

Q: 2446  MSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGET-FEVPEIVPFRLTHNMVNG  2504

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk.....kkktsketee  295

         +g++g+eG+fr++ce ++r++r+++e l+++L++fl+dplv+w+k     +k+  +et+e

Q: 2505  MGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKpvkghSKAALNETGE  2564

         *************************************************99*********

S: 296   elaekakaealkikkllskvekaenavatrdllllee  332

         +++ekak++ l+i+++l++v k++n+v+ ++l+++++

Q: 2565  VVNEKAKTHVLDIEQRLRGVIKTRNRVTGLPLSIEGH  2601

         ********************************99987

Domain Sequence
(FASTA)

IAGFDDTVEI LASLQKPKKI SLKGSDGKFY IMMCKPKDDL RKDCRLMEFN SLINKCLRKD 60

AESRRRELHI RTYAVIPLND ECGIIEWVNN TAGLRPILTK LYKEKGVYMT GKELRQCMLP 120

KSAALSEKLK VFQEFLLPRH PPVFHEWFLR TFPDPTSWYS SRSAYCRSTA VMSMVGYILG 180

LGDRHGENIL FDSLTGECVH VDFNCLFNKG ETFEVPEIVP FRLTHNMVNG MGPMGTEGLF 240

RRACEVTMRL MRDQREPLMS VLKTFLHDPL VEWSKPVKGH SKAALNETGE VVNEKAKTHV 300

LDIEQRLRGV IKTRNRVTGL PLSIEGH 327

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0001741	; C:XY body
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071480	; P:cellular response to gamma radiation
GO:0034644	; P:cellular response to UV
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0008156	; P:negative regulation of DNA replication
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	; P:protein autophosphorylation
GO:0043393	; P:regulation of protein binding
GO:0090399	; P:replicative senescence

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013