EKS-BOT-00297
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00297
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.02.2E-149689946258
StatusUnreviewed
Ensembl ProteinENSBTAP00000015445
UniProt AccessionF1N7F3;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR
Gene Synonyms/Alias EGFR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000011628ENSBTAP00000015445ENSBTAT00000015445
OrganismBos taurus
Functional Description
Protein Length1185
Protein Sequence
(FASTA)
MKKHELLCQG TSNKLTQLGT FEDHFLSLQR MFNNCEVVLG NLEITYMQSS YNLSFLKTIQ 60
EVAGYVLIAL NTVEKIPLEN LQIIRGNVLY ENTHALAVLS NYGANKTGLR ELPLRNLQEI 120
LQGAVRFSNN PVLCNVETIQ WRDIVNPDFL SNMTGDFQNQ QGNCPKCDPA CLNRSCWGAG 180
EENCQKLTKI ICAQQCSGRC RGRSPSDCCH NQCAAGCTGP RESDCLVCRR FRDEATCKDT 240
CPPLMLYDPT TYEMKVNPLG KYSFGATCVK KCPRNYVVTD HGSCVRACSS DSQEVEEDGV 300
RKCKKCDGPC GKVCNGIGIG EFKDTLSINA TNIKHFRNCT SISGDLHILP VAFRGDSFTR 360
TAPLDPKELD ILRTVKEITG FLLIQAWPEN RTDLHAFENL EIIRGRTKQH GQFSLAVVGL 420
DITSLGLRSL KEISDGDVII SGNRNLCYAD TIRWKKLFGT STQKTKILNN RSEKQCKAAG 480
HICHPLCSSE GCWGPGPKYC MSCQNFSRGK ECVGKCNILE GEPREFVENS ECVQCHPECL 540
PQAMNVTCTG RGPGNCVKCA HYIDGPHCVK TCPAGVAGEN GTLIWKFADA NHVCLLCHPN 600
CTYGCEGPGL EGCPQKGPKI PSIATGIVGG LLLVVVLALS VGLFMRRRHI VRKRTLRRLL 660
QERELVEPLT PSGEAPNQAL LRILKETEFK KVKVLGSGAF GTVYKGLWIP EGEKVKIPVA 720
IKELREATSP KANKEILDEA YVMASVDNPH VCRLLGICLT STVQLITQLM PFGCLLDYVR 780
EHKDNVGSQY LLNWCVQIAK GMNYLEDRRL VHRDLAARNV LVKTPQHVKI TDFGLAKLLG 840
AEEKEYHAEG GKVPIKWMAL ESILHRIYTH QSDVWSYGVT VWELMTFGSK PYDGIPASEI 900
STVLEKGERL PQPPICTIDV YMIMVKCWMI DADSRPKFRE LILEFSKMAR DPQRYLVIQG 960
DERMHLPSPT DSNFYRALMD EEDMEDVVDA DEYLVPQQGF FHSPTTSRTP LLSSLSTSSN 1020
TPTVTCVDRN GSYPLKEDSF LQRYSSDPTG ALIEDSMDDT FLPVPEYVNQ SVPKRPAGSV 1080
QNPVYHNQPL YPAPGRDPQY QNSLSNAVDN PEYLNTTHPA CINGVLDGPA LWAQKGSHQF 1140
SLDNPDYQQA FFPKEAKSNG IFKGPAAENA EYLRAAPAGS DFTGA 1185
Nucleotide Sequence
(FASTA)
ATGAAAAAGC ACGAGTTACT TTGCCAAGGG ACAAGTAACA AGCTCACCCA GTTGGGCACT 60
TTTGAAGACC ACTTTCTGAG CCTACAGAGG ATGTTCAACA ACTGTGAGGT GGTCCTTGGG 120
AATTTGGAAA TTACCTACAT GCAGAGTAGT TACAACCTTT CTTTTCTCAA GACCATCCAG 180
GAGGTTGCCG GCTATGTACT CATTGCCCTC AACACAGTGG AGAAGATTCC GCTGGAAAAC 240
CTGCAGATCA TCCGAGGAAA TGTGCTTTAT GAAAACACCC ATGCCTTAGC CGTCTTATCC 300
AACTATGGAG CAAACAAAAC CGGACTGAGG GAGCTGCCCT TGAGAAACTT ACAGGAAATT 360
CTGCAAGGTG CCGTGCGATT CAGCAACAAC CCTGTCCTCT GCAACGTGGA GACCATCCAG 420
TGGCGGGACA TCGTCAACCC TGATTTTCTA AGCAACATGA CAGGAGACTT TCAGAACCAG 480
CAGGGCAACT GCCCAAAGTG TGATCCAGCC TGTCTCAACA GAAGCTGCTG GGGTGCCGGG 540
GAGGAGAACT GTCAGAAATT GACCAAAATC ATCTGTGCCC AGCAGTGTTC CGGGCGCTGC 600
CGTGGCAGGT CCCCCAGTGA CTGCTGCCAC AACCAGTGTG CCGCTGGCTG CACAGGGCCA 660
CGGGAGAGCG ACTGCCTGGT CTGCCGCAGG TTCCGTGATG AAGCCACCTG CAAGGACACG 720
TGTCCGCCAC TCATGCTCTA TGACCCTACC ACCTACGAAA TGAAGGTCAA CCCGCTGGGG 780
AAGTACAGCT TTGGCGCCAC CTGTGTCAAG AAGTGTCCCC GTAACTACGT GGTGACAGAC 840
CACGGCTCCT GCGTCCGCGC CTGCAGTTCT GACAGCCAGG AGGTAGAGGA AGACGGTGTC 900
CGCAAGTGTA AAAAGTGTGA CGGGCCTTGT GGCAAAGTTT GTAACGGAAT AGGAATCGGT 960
GAGTTTAAAG ACACACTTTC CATAAATGCT ACAAACATTA AACACTTCAG AAACTGCACA 1020
TCCATCAGTG GAGATCTTCA TATCCTGCCA GTAGCATTTA GGGGTGACTC CTTCACACGT 1080
ACTGCACCTC TGGACCCGAA AGAACTGGAC ATTCTAAGAA CTGTAAAAGA AATAACAGGG 1140
TTTTTGCTGA TTCAGGCCTG GCCCGAAAAC AGGACTGACC TCCATGCTTT TGAGAACCTG 1200
GAAATCATAC GTGGCAGAAC GAAGCAGCAT GGCCAGTTTT CTCTTGCGGT TGTCGGCCTG 1260
GATATAACAT CTTTGGGATT ACGCTCCCTC AAGGAGATAA GTGATGGTGA TGTGATAATT 1320
TCAGGAAATC GAAACTTGTG CTATGCAGAT ACAATACGCT GGAAAAAACT TTTTGGGACC 1380
TCAACTCAGA AAACCAAAAT TTTAAACAAC AGGAGTGAAA AACAGTGCAA GGCCGCAGGC 1440
CACATCTGTC ACCCGCTGTG CTCATCAGAG GGCTGCTGGG GACCTGGACC CAAATACTGC 1500
ATGTCCTGCC AGAACTTCAG TCGTGGCAAG GAGTGTGTGG GAAAGTGCAA CATTCTAGAG 1560
GGAGAGCCCA GAGAATTCGT GGAGAACTCC GAGTGTGTGC AGTGCCATCC AGAATGCCTG 1620
CCCCAGGCCA TGAACGTGAC CTGCACTGGA CGCGGACCAG GCAACTGTGT AAAGTGCGCC 1680
CACTACATTG ATGGCCCTCA CTGCGTCAAG ACCTGCCCTG CTGGAGTCGC GGGAGAGAAT 1740
GGCACCCTGA TCTGGAAGTT TGCAGATGCC AACCACGTGT GTCTCCTGTG CCACCCCAAC 1800
TGCACCTATG GCTGTGAAGG GCCAGGTCTC GAAGGCTGTC CACAGAAAGG GCCCAAGATC 1860
CCGTCCATTG CCACGGGCAT CGTGGGCGGC CTGCTGCTGG TGGTGGTGCT GGCCCTGAGC 1920
GTCGGCCTCT TCATGCGCAG GCGCCACATC GTGCGCAAGC GCACACTGCG CCGGCTGCTG 1980
CAGGAGCGTG AGCTCGTGGA GCCTCTGACG CCCAGCGGAG AAGCTCCCAA CCAAGCTCTC 2040
TTGAGGATCC TAAAGGAAAC AGAATTCAAG AAGGTCAAGG TGCTGGGCTC AGGAGCATTC 2100
GGCACCGTGT ACAAGGGACT CTGGATCCCA GAAGGCGAGA AGGTTAAAAT TCCTGTAGCT 2160
ATCAAGGAAT TAAGAGAAGC CACATCTCCA AAAGCCAACA AGGAAATTCT TGATGAGGCC 2220
TACGTGATGG CCAGTGTGGA CAACCCCCAT GTGTGCCGCC TCCTGGGCAT CTGCCTGACC 2280
TCCACCGTGC AGCTCATCAC ACAGCTCATG CCCTTCGGCT GCCTGCTGGA CTACGTCCGC 2340
GAGCACAAGG ACAACGTCGG CTCCCAGTAC CTGCTCAACT GGTGTGTGCA GATCGCAAAG 2400
GGCATGAATT ACCTGGAAGA CCGGCGCTTG GTGCATAGGG ACCTGGCAGC CAGGAACGTG 2460
CTGGTGAAGA CGCCGCAGCA CGTGAAGATC ACAGACTTCG GGCTGGCCAA GCTGCTGGGT 2520
GCCGAGGAGA AGGAGTATCA TGCAGAAGGA GGCAAGGTCC CTATCAAATG GATGGCTTTG 2580
GAATCAATTT TACACCGAAT TTATACCCAT CAGAGTGATG TCTGGAGCTA TGGAGTCACT 2640
GTTTGGGAGT TGATGACCTT TGGATCCAAG CCTTACGATG GAATCCCTGC GAGTGAGATC 2700
TCGACTGTCC TGGAGAAAGG AGAGCGCCTC CCACAGCCAC CCATCTGCAC CATCGACGTC 2760
TACATGATCA TGGTCAAGTG CTGGATGATA GATGCAGACA GTCGCCCAAA GTTCCGTGAG 2820
TTGATCCTTG AATTCTCCAA GATGGCCCGA GACCCCCAGC GCTACCTTGT CATCCAGGGG 2880
GACGAGAGAA TGCATTTGCC AAGCCCTACG GACTCCAACT TCTACCGCGC CCTGATGGAT 2940
GAGGAGGACA TGGAGGATGT TGTGGATGCT GATGAGTACC TCGTCCCCCA GCAGGGCTTC 3000
TTCCACAGCC CCACCACCTC CCGGACACCC CTCCTCAGCT CGCTGAGCAC CTCCAGCAAC 3060
ACTCCCACTG TGACTTGCGT TGATAGAAAT GGGAGCTACC CTCTCAAGGA AGACAGCTTC 3120
CTGCAGCGCT ACAGCTCAGA CCCCACTGGT GCCCTCATCG AGGACAGCAT GGACGACACT 3180
TTCCTCCCAG TACCCGAATA TGTAAACCAA TCTGTTCCCA AAAGACCCGC AGGCTCTGTC 3240
CAGAACCCTG TCTATCACAA TCAGCCTCTA TATCCAGCTC CTGGCAGAGA CCCTCAGTAC 3300
CAAAATTCAC TCAGCAACGC CGTGGACAAC CCTGAGTATC TCAACACCAC CCATCCTGCC 3360
TGTATCAATG GTGTGCTCGA CGGCCCTGCC CTCTGGGCTC AGAAGGGCAG TCACCAATTT 3420
AGCCTAGACA ACCCTGACTA CCAGCAGGCC TTCTTTCCCA AGGAAGCCAA GTCGAATGGC 3480
ATCTTTAAGG GGCCTGCAGC TGAAAATGCA GAATACCTGC GGGCAGCACC AGCAGGCAGT 3540
GACTTTACTG GGGCCTGA 3558
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+
Q: 689   FKKVKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  748
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++
Q: 749   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNVGSQYLLNWCVQIAKGMNYLEDR  808
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y
Q: 809   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  868
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+ +lekGerl+qppictidvym++vkcw
Q: 869   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISTVLEKGERLPQPPICTIDVYMIMVKCW  928
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkf+el+ efs
Q: 929   MIDADSRPKFRELILEFS  946
         ***************996
Domain Sequence
(FASTA)
FKKVKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60
PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VREHKDNVGS QYLLNWCVQI AKGMNYLEDR 120
RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180
THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISTVLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDADSRPKF RELILEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00290
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-CIS-00072
EKS-EQC-00289
EKS-FEC-00283
EKS-GAG-00251
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-NOL-00274
EKS-ORN-00386
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00359
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-PEM-00164
EKS-POA-00289
EKS-RAN-00314
EKS-SAH-00279
EKS-TAG-00314
EKS-TAR-00390
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0030139; C:endocytic vesicle
GO:0005768; C:endosome
GO:0016021; C:integral to membrane
GO:0045121; C:membrane raft
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005006; F:epidermal growth factor-activated receptor activity
GO:0030235; F:nitric-oxide synthase regulator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0000902; P:cell morphogenesis
GO:0008283; P:cell proliferation
GO:0016337; P:cell-cell adhesion
GO:0021795; P:cerebral cortex cell migration
GO:0048546; P:digestive tract morphogenesis
GO:0001892; P:embryonic placenta development
GO:0001942; P:hair follicle development
GO:0060571; P:morphogenesis of an epithelial fold
GO:0043066; P:negative regulation of apoptotic process
GO:0042177; P:negative regulation of protein catabolic process
GO:0035413; P:positive regulation of catenin import into nucleus
GO:0030335; P:positive regulation of cell migration
GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0045739; P:positive regulation of DNA repair
GO:0045740; P:positive regulation of DNA replication
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0046777; P:protein autophosphorylation
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0070141; P:response to UV-A
GO:0007435; P:salivary gland morphogenesis
GO:0023014; P:signal transduction by phosphorylation
KEGG
bta:407217;
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013