EKS-BOT-00034

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00034

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	316.6	1.6E-94	895	1164	270

Status

Unreviewed

Ensembl Protein

ENSBTAP00000015532

UniProt Accession

F1MCX4;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000011698	ENSBTAP00000015532	ENSBTAT00000015532

Organism

Bos taurus

Functional Description

Protein Length

1185

Protein Sequence
(FASTA)

MPLCQWRATT RGRKPSGDGA QPMATREGLK VLLHWAGPSG GEPWVTFTEP TLTAEDVCIH 60

VAHKVGITPP CFNLFALFDA QAQVWLPPNH ILDTSRDSSL TLYFRMRFYF RNWHGTNPQE 120

PAVYRCGPPG AETSSEQAEQ GVQLLDPASF EYLFEQGKHE FVNDVASLWE LSSEEEIHHF 180

QNESLGMALL HLCHLALRNG VPLEKVAKKT SFKDCIPRSF RRQMRQHNAL TRLRQRSIFR 240

KFLRAFQPGC LSQQVVMVKY LATLERLAPR FGTERVPVCH LELLSQADGE PCYIREGGQA 300

PPDPGSESAA GPPTHEVLVS GTEGIRWRLV PAEGPADGGA GGGSRMPDAD PSGKKMKAEE 360

VGSEPVDRPR ESPWSYFCDF QDITHMVLKE RHVSIHCQDN KCLELTLPSR AAALSLVSLV 420

DGYFRLTADS NHYLCHEVAP PRLVMSIQDG IHGPLLEPFV LAKLKPEAGL YLIHWSTSHL 480

HRLILTVAQR DQAPGTKGLR LRKFPIELQA GTVMLEGWGR SFPSVRDLRA ALQDCSLRAG 540

NDCFSLRRCC LPRPGEISNL IVTRGPQAST RPLNLSHLSF YRVRQEDITQ LSHLGQGTRT 600

NVYEGLLRVG GGGPEEDKAD GEEPPTPAGD RGQELRVVLK VLDPSHHDIA LAFYETASLM 660

SQVSHVHLAF VHGVFVHGSE NIMVTEYVEH GPLDVWLRRE RGRVPLAWKL AVAQQLASAL 720

SYLEDKSLVH GNVCGRNILL ARLGLAEGTS PFIKLSDPGV GLSALSREER VERIPWTAPE 780

CLSGGANSLS TAADKWGFGA TLLEICFDGE APLQGRSPSE KERFYQKQHK LPEPSCPELA 840

TLTSQCLTYE PAQRPSFRTI LRDFTQLQPQ NLADVLSVSP DSLASDPTVF HKRYLKKIRD 900

LGEGHFGKVS LYCYDPTNDG TGEMVAVKAL KAGCGPQLRT GWRREIDILR KLYHKHIVKY 960

KGCCEDQGEK SIQLVMEYMP LGSLRDYLPR HNVGLVQLLL FSLQICEGMA YLHSQHYVHR 1020

DLAARNVLLD NNRLVKIGDF GLTKAVPEGH EYYCVREDGD SPVFWYAPEC LKECKFYYAS 1080

DVWSFGVLMY ELLTYCDSSQ SPPSKFIELI GLTQGQMTVL RLTELLERGE RLPQPEKCPS 1140

EIYCLMKDCW KAEASFRPTF QNLVPILRSY HEKYQGQAPS VFSVC 1185

Nucleotide Sequence
(FASTA)

ATGCCTCTGT GCCAATGGAG GGCCACCACC AGGGGCAGGA AGCCCAGTGG GGACGGAGCT 60

CAGCCCATGG CCACCAGAGA AGGCCTGAAA GTGCTTCTGC ACTGGGCTGG CCCCAGTGGT 120

GGGGAGCCCT GGGTCACCTT CACTGAGCCC ACACTGACCG CGGAGGATGT CTGCATCCAC 180

GTCGCACACA AAGTCGGCAT CACTCCACCC TGCTTCAATC TTTTTGCCCT CTTCGATGCC 240

CAGGCCCAGG TCTGGCTGCC TCCAAATCAC ATTCTGGATA CCTCCAGGGA CTCCAGCCTG 300

ACGCTGTACT TCCGCATGAG GTTTTATTTC CGAAACTGGC ATGGCACGAA TCCTCAGGAG 360

CCAGCTGTGT ACCGCTGCGG GCCCCCAGGG GCCGAGACTT CCTCAGAACA GGCAGAGCAG 420

GGGGTGCAAC TCCTGGACCC TGCCTCCTTT GAGTACCTCT TTGAGCAGGG CAAGCATGAA 480

TTTGTAAATG ACGTGGCATC ACTATGGGAG CTATCCAGCG AGGAGGAGAT CCACCACTTT 540

CAGAATGAGA GCCTGGGCAT GGCCCTTTTG CACCTCTGCC ACCTCGCTCT CCGCAATGGT 600

GTCCCCCTTG AAAAGGTGGC GAAGAAAACC AGCTTCAAGG ATTGCATCCC ACGCTCCTTC 660

CGGCGGCAGA TGCGGCAGCA CAACGCTCTG ACACGGCTGC GCCAACGGAG CATCTTCCGC 720

AAGTTCCTGC GGGCCTTCCA GCCGGGCTGC CTCTCCCAGC AGGTCGTCAT GGTGAAGTAC 780

CTGGCCACGC TCGAGCGACT GGCACCCCGC TTTGGCACAG AGCGTGTGCC CGTGTGCCAC 840

CTGGAGCTGC TGTCCCAAGC CGACGGGGAG CCCTGCTACA TCCGGGAGGG TGGGCAGGCC 900

CCTCCTGACC CCGGGTCTGA GTCTGCTGCC GGACCCCCCA CCCACGAGGT GCTGGTGTCA 960

GGCACGGAAG GCATCCGGTG GCGGCTGGTA CCGGCGGAGG GGCCTGCTGA TGGTGGTGCT 1020

GGTGGCGGCA GCAGGATGCC TGATGCTGAC CCATCTGGGA AGAAAATGAA GGCCGAGGAG 1080

GTGGGCAGCG AGCCAGTGGA CAGGCCTCGG GAGAGCCCCT GGTCCTACTT CTGTGACTTC 1140

CAGGACATCA CCCACATGGT GCTGAAGGAA CGCCACGTCA GCATCCATTG TCAGGACAAC 1200

AAGTGCCTGG AGCTGACCCT GCCTTCCCGG GCCGCGGCCC TGTCCTTGGT GTCGCTGGTG 1260

GATGGCTACT TCCGCCTGAC CGCCGACTCA AACCACTACC TGTGCCACGA GGTGGCTCCT 1320

CCACGGCTGG TGATGAGTAT CCAGGATGGC ATCCACGGCC CCCTGCTGGA GCCATTTGTG 1380

CTGGCCAAGC TGAAGCCCGA GGCTGGCCTC TACCTTATCC ACTGGAGCAC CAGCCACCTC 1440

CACCGCCTCA TCCTCACAGT GGCCCAGCGC GACCAGGCTC CAGGCACTAA GGGCTTGCGC 1500

CTGCGGAAGT TCCCTATCGA GCTCCAGGCC GGGACAGTCA TGCTGGAGGG CTGGGGCCGG 1560

TCTTTCCCCA GCGTGCGGGA CCTGAGGGCT GCCCTGCAGG ACTGCTCGCT GCGGGCCGGC 1620

AACGACTGCT TTTCCCTGCG TCGCTGCTGC CTGCCCCGGC CCGGAGAGAT CTCCAACCTC 1680

ATCGTCACAC GGGGGCCTCA GGCCAGCACC AGACCGCTCA ACCTCAGTCA TCTCAGCTTC 1740

TACCGAGTCC GCCAGGAAGA CATCACCCAG CTGTCCCACT TGGGCCAGGG CACAAGGACC 1800

AACGTGTATG AGGGCCTCTT GCGAGTGGGG GGCGGAGGCC CCGAGGAGGA CAAGGCAGAT 1860

GGCGAGGAAC CCCCCACGCC CGCTGGGGAC CGTGGGCAGG AGCTGCGTGT GGTGCTCAAG 1920

GTGCTAGACC CCAGTCACCA CGACATCGCC CTGGCCTTCT ACGAGACAGC CAGCCTCATG 1980

AGCCAGGTCT CCCACGTGCA CCTGGCCTTC GTGCACGGCG TCTTCGTGCA CGGCTCCGAG 2040

AACATCATGG TGACCGAGTA CGTGGAGCAC GGGCCCCTGG ACGTATGGCT GCGGCGGGAG 2100

AGGGGCCGCG TGCCCCTGGC CTGGAAGTTG GCAGTGGCCC AGCAGCTGGC CAGCGCCCTC 2160

AGTTACCTGG AAGACAAAAG CCTGGTTCAT GGCAACGTGT GTGGCCGGAA CATCCTGCTG 2220

GCACGGCTGG GGCTGGCGGA GGGCACCAGC CCCTTCATCA AGCTGAGTGA CCCCGGCGTG 2280

GGCCTGAGTG CCCTCTCCAG GGAGGAGCGG GTGGAGCGGA TCCCCTGGAC AGCCCCCGAG 2340

TGCCTGTCTG GTGGAGCCAA CAGCCTGAGC ACCGCAGCCG ACAAGTGGGG CTTTGGTGCC 2400

ACCCTCCTGG AGATCTGCTT CGATGGCGAG GCCCCCCTGC AGGGCCGTAG TCCCTCTGAG 2460

AAAGAGCGCT TCTACCAGAA GCAGCACAAA CTGCCTGAGC CCTCGTGCCC AGAGCTGGCC 2520

ACACTCACCA GCCAGTGCCT GACCTACGAG CCAGCCCAGC GGCCATCCTT CCGCACCATC 2580

CTGCGTGACT TCACTCAGCT ACAGCCCCAG AATCTCGCTG ATGTCTTGTC TGTGAGCCCG 2640

GATTCACTGG CTTCAGATCC CACGGTTTTC CACAAGCGAT ACTTGAAAAA GATCCGGGAT 2700

CTGGGTGAGG GTCACTTCGG AAAGGTCAGC CTGTATTGCT ACGACCCCAC CAACGACGGC 2760

ACTGGTGAGA TGGTAGCCGT GAAGGCCCTC AAGGCAGGCT GCGGTCCCCA GCTCCGGACG 2820

GGCTGGAGGC GAGAAATCGA CATCCTACGC AAGCTCTACC ACAAGCACAT CGTCAAGTAC 2880

AAGGGCTGCT GCGAGGACCA AGGTGAGAAG TCGATACAGC TGGTCATGGA ATACATGCCC 2940

CTGGGCAGCC TCCGAGACTA CTTGCCCCGG CACAATGTCG GGCTGGTCCA GCTGCTGCTC 3000

TTCTCCCTGC AGATCTGCGA GGGTATGGCC TACCTGCACT CACAGCACTA CGTGCATCGA 3060

GACCTGGCTG CGCGCAACGT GCTGCTGGAC AACAACAGGC TAGTCAAGAT CGGGGACTTC 3120

GGCCTCACCA AGGCCGTGCC CGAAGGCCAC GAGTATTACT GCGTGCGCGA GGATGGGGAC 3180

AGTCCTGTGT TCTGGTATGC CCCGGAGTGC CTGAAGGAGT GTAAGTTCTA CTATGCATCA 3240

GACGTCTGGT CCTTTGGGGT CCTCATGTAT GAGCTGCTGA CCTACTGTGA CTCCAGCCAG 3300

AGCCCTCCCT CGAAATTCAT CGAGCTCATA GGCCTCACCC AAGGGCAGAT GACTGTGCTG 3360

AGGCTCACAG AGCTGCTGGA ACGAGGGGAG AGGCTGCCAC AACCAGAGAA ATGCCCCTCT 3420

GAGATCTATT GCCTCATGAA GGACTGCTGG AAGGCAGAGG CCTCATTCCG CCCGACCTTC 3480

CAGAACCTCG TACCCATCCT CAGATCATAC CACGAGAAAT ACCAAGGCCA GGCCCCCTCG 3540

GTGTTCAGTG TCTGCTGA 3558

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k+Lk  +g++ ++++ re++il++l+h

Q: 895   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKaGCGPQLRTGWRREIDILRKLYH  954

         6899*********************************99*********************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         +hivk+kg+c ++ge+  +lVmey++ GsL++yL+++  ++ l++ll ++ q++++m+YL

Q: 955   KHIVKYKGCCEDQGEKsiQLVMEYMPLGSLRDYLPRH--NVGLVQLLLFSLQICEGMAYL  1012

         ****************9********************..*********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvL+++++       vk++d+gl+kav+++ eYy vre++ds+++w+

Q: 1013  HSQHYVHRDLAARNVLLDNNRL------VKIGDFGLTKAVPEGhEYYCVREDGDSPVFWY  1066

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.........lrsesle.......  219

         apecl+e+k +++asdvWsFgv +yellt c++++sp         l     +

Q: 1067  APECLKECK-FYYASDVWSFGVLMYELLTyCDSSQSPpskfieligL-----Tqgqmtvl  1120

         *********.****************************999555443.....45555588

S: 220   rklelleekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         r++elle++erlp+p+ cp+e++ lm++c+++e+s+rp+F++++

Q: 1121  RLTELLERGERLPQPEkCPSEIYCLMKDCWKAEASFRPTFQNLV  1164

         *****************************************986

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKALKAGC GPQLRTGWRR EIDILRKLYH 60

KHIVKYKGCC EDQGEKSIQL VMEYMPLGSL RDYLPRHNVG LVQLLLFSLQ ICEGMAYLHS 120

QHYVHRDLAA RNVLLDNNRL VKIGDFGLTK AVPEGHEYYC VREDGDSPVF WYAPECLKEC 180

KFYYASDVWS FGVLMYELLT YCDSSQSPPS KFIELIGLTQ GQMTVLRLTE LLERGERLPQ 240

PEKCPSEIYC LMKDCWKAEA SFRPTFQNLV 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

bta:512484

;

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013