EKS-BOT-00371
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00371
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src430.02.9E-129261510250
StatusUnreviewed
Ensembl ProteinENSBTAP00000015646
UniProt AccessionA5PKG9;
Protein Name
Protein Synonyms/Alias FGR protein;
Gene NameFGR
Gene Synonyms/Alias FGR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000011784ENSBTAP00000015646ENSBTAT00000015646
OrganismBos taurus
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MGCVFCKKLE PGAKEDGGLE GDFRNYGAAD RYGPDPTQSR PASSFSHIPN YNSFSPQPAS 60
PAFLDAGTIR GISGIGVTMF IALYDYEART EDDLTFTKGE KFHILNNTEG DWWEARSLSS 120
GHTGYIPSNY VAPVDSIQAE EWYFGKIGRK DAERQLLSPG NSRGAFLIRE SETTKGAYSL 180
SIRDWDQTRG DHVKHYKIRK LDTGGYYITT RAQFDTVQEL VQHYLEVNDG LCHLLTAACT 240
TMKPQTLGLA KDAWEISRSS ITLEHRLGTG CFGDVWLGTW NGSTKVAVKT LKPGTMSPKA 300
FLAEAQIMKL LRHDKLVQLY AVVSEEPIYI VTEFMCHGSL LEFLKGPEGH VLKLPHLVDM 360
AAQVAEGMAY MERMNYIHRD LRAANILVGE RLVCKIADFG LARLIEDDEY NPQQGTKFPI 420
KWTAPEAALF CRFTIKSDVW SFGILITELI TKGRVPYPGM NNREVLEQVE HGYHMPCPPG 480
CPASLYEVME QTWRLDPEER PTFEYLQSFL EDYFTSTEPQ YQPGDDT 527
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTTCTGCAA GAAGTTGGAG CCAGGGGCCA AGGAGGATGG TGGCCTAGAA 60
GGGGACTTCA GGAACTATGG GGCTGCAGAC CGCTATGGCC CCGACCCTAC TCAGAGCCGG 120
CCTGCATCTT CCTTTTCCCA CATCCCCAAC TACAACAGCT TCTCCCCTCA GCCCGCCAGC 180
CCCGCCTTCC TCGATGCGGG CACCATCCGG GGCATCTCAG GGATTGGGGT GACCATGTTC 240
ATCGCCCTTT ATGACTATGA GGCCCGAACG GAGGACGATC TCACCTTCAC CAAGGGCGAG 300
AAGTTCCACA TCCTGAACAA CACCGAGGGT GACTGGTGGG AGGCTCGGTC CCTCAGCTCC 360
GGACACACTG GCTACATTCC CAGCAACTAC GTGGCCCCCG TGGACTCCAT CCAGGCTGAA 420
GAGTGGTACT TCGGAAAGAT CGGGAGGAAG GACGCTGAGA GGCAGCTGCT CTCCCCAGGG 480
AACTCCCGCG GGGCCTTTCT CATTAGAGAG AGCGAGACCA CCAAAGGCGC CTACTCCCTG 540
TCCATCCGGG ATTGGGACCA GACCAGAGGC GATCATGTGA AGCATTACAA GATCCGCAAA 600
CTGGACACCG GTGGCTACTA CATCACCACG AGGGCCCAGT TTGACACTGT GCAGGAGCTG 660
GTGCAGCACT ACCTTGAGGT GAACGATGGG CTGTGCCATC TGCTCACGGC GGCCTGCACC 720
ACCATGAAGC CGCAGACGCT GGGCCTGGCC AAGGACGCCT GGGAAATCAG CCGCAGCTCC 780
ATCACGCTGG AGCACCGACT GGGCACCGGC TGCTTCGGGG ATGTGTGGCT GGGCACGTGG 840
AACGGCAGCA CCAAGGTGGC GGTGAAGACG CTAAAGCCGG GCACCATGTC CCCGAAGGCC 900
TTCCTGGCAG AGGCGCAGAT CATGAAGCTG CTGCGGCACG ACAAGCTGGT GCAGCTGTAC 960
GCGGTGGTGT CAGAGGAGCC CATCTACATA GTGACCGAGT TCATGTGCCA CGGTAGCCTG 1020
CTGGAGTTCC TCAAGGGCCC GGAGGGTCAT GTTTTGAAGC TGCCCCATCT GGTGGACATG 1080
GCGGCACAGG TTGCTGAGGG CATGGCCTAC ATGGAGCGCA TGAACTATAT TCACCGTGAC 1140
CTCCGGGCAG CCAACATCCT CGTCGGGGAG CGGCTGGTGT GCAAGATCGC TGACTTCGGG 1200
CTGGCCCGAC TCATCGAAGA TGACGAGTAC AACCCCCAGC AAGGGACCAA GTTCCCCATC 1260
AAGTGGACAG CCCCTGAGGC TGCCCTCTTT TGCAGATTCA CTATCAAGTC AGATGTGTGG 1320
TCCTTTGGGA TCCTGATCAC TGAACTCATC ACCAAGGGCC GAGTCCCCTA CCCAGGCATG 1380
AATAACCGCG AAGTGTTGGA ACAAGTGGAG CATGGCTACC ACATGCCGTG CCCCCCAGGC 1440
TGCCCAGCAT CCCTGTACGA GGTCATGGAA CAAACCTGGC GTCTGGACCC AGAGGAGAGA 1500
CCCACCTTCG AGTACCTGCA GTCCTTCCTT GAGGACTATT TCACCTCCAC AGAACCCCAG 1560
TACCAGCCTG GGGATGACAC ATAG 1584
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         ++l+++lG+G+fG+vwlg+w+gs+kvavktlk+gt+sp+afl+eaqi+k lrh+klv+ly
Q: 261   ITLEHRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLAEAQIMKLLRHDKLVQLY  320
         57899*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m +Gsll+flk  eg+ lklp+lvd+aaqvaeGmay+e++n+ihr
Q: 321   AVVSE-EPIYIVTEFMCHGSLLEFLKGPEGHVLKLPHLVDMAAQVAEGMAYMERMNYIHR  379
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+k+adfGlarlieddey++++g+k+PikWtaPea+ + +ftiksdv
Q: 380   DLRAANILVGERLVCKIADFGLARLIEDDEYNPQQGTKFPIKWTAPEAALFCRFTIKSDV  439
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGil+te++tkG+vPypGm+n+evleqve+gy++p+p  cp++lye+++++w+ dpee
Q: 440   WSFGILITELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPASLYEVMEQTWRLDPEE  499
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 500   RPTFEYLQSFL  510
         ********986
Domain Sequence
(FASTA)
ITLEHRLGTG CFGDVWLGTW NGSTKVAVKT LKPGTMSPKA FLAEAQIMKL LRHDKLVQLY 60
AVVSEEPIYI VTEFMCHGSL LEFLKGPEGH VLKLPHLVDM AAQVAEGMAY MERMNYIHRD 120
LRAANILVGE RLVCKIADFG LARLIEDDEY NPQQGTKFPI KWTAPEAALF CRFTIKSDVW 180
SFGILITELI TKGRVPYPGM NNREVLEQVE HGYHMPCPPG CPASLYEVME QTWRLDPEER 240
PTFEYLQSFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>
EKS-AIM-00344
EKS-CAJ-00374
EKS-CAF-00373
EKS-CAP-00403
EKS-EQC-00362
EKS-FEC-00357
EKS-GOG-00361
EKS-HOS-00377
EKS-ICT-00349
EKS-LOA-00379
EKS-MAM-00370
EKS-MUM-00402
EKS-MUP-00364
EKS-ORA-00323
EKS-ORC-00348
EKS-OTG-00373
EKS-PAT-00350
EKS-POA-00360
EKS-RAN-00385
EKS-SAH-00341
EKS-TUT-00101
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
KEGG
bta:516133;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013