EKS-BOT-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	346.4	1.3E-103	850	1122	273

Status

Unreviewed

Ensembl Protein

ENSBTAP00000015986

UniProt Accession

E1BCP6;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000012047	ENSBTAP00000015986	ENSBTAT00000015986

Organism

Bos taurus

Functional Description

Protein Length

1133

Protein Sequence
(FASTA)

MGMACLTMTE MEGTSTSPVH QNGDISGNAN SVKQIDPVLQ VYLYHSLGNA EGDYLQFLTG 60

EYVAEEICIA ASKACGITPV YHSMFALMSE TERIWYPPNH VFHIDESTRQ NVLYRIRFYF 120

PYWYCNGSNR TYRHGIARGA EAPLLDDFVM SYLFAQWRHD FLHGWIKVPV THETQEECLG 180

MAVLDMMRIA KEKNQTPLDI YSSISYKTFL PKCVRAKIQE YHILTRKRIR YRFRRFIEQF 240

SHCKATARNL KLKYLINLET LQSAFYTEQF EVKEPGRGPS GEEIFATIII TGNGGIQWSR 300

GKHKESETLT EQDLQLYCDF PDIIDISIKQ ANQEGANESR IVTIHKQDGK SLEIELKSLR 360

EALSFVSLID GYYRLTADAH HYLCKEVAPP MVLENIQSNC HGPISMDFAI SKLKKTGNQT 420

GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENG EYNLSGTKKN FSNLKDLLNC 480

YQMETVRSDS IIFQFTKCCP PKPKDKSNLL VFRTNGISDV PTSPTLQRHN NVNQMVFHKI 540

RNEDLVFNES LGQGTFTKIF KGIRREIGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 600

MSQLSHKHLI LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK LEVAKQLAWA 660

MHFLEEKTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD KVLQERIPWV 720

PPECIENPKN LNLATDKWSF GTTLWEICSG GDKPLSALDS QRKLQFYEDR HQLPAPKWTE 780

LANLINNCMD YEPDFRPSFR AIIRDLNSLF TPDYELLTEN DMLPNMRIGA LGFSGAFEDR 840

DPTQFEERHL KFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTE EHLRDFEREI 900

EILKSLQHDN IVKYKGVCYS AGRHNLRLIM EYLPYGSLRD YLQKHKERID HKKLLQYTSQ 960

ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK VLPQDKEYYK VKEPGESPIF 1020

WYAPESLTES KFSVASDVWS FGVVLYELFT YIDKSKSPPA EFMRMIGNDK QGQMIVFHLI 1080

ELLKNNGRLP RPDGCPDEIY VIMTECWNNN VNQRPSFRDL AVRVDQIRDN MTG 1133

Nucleotide Sequence
(FASTA)

ATGGGAATGG CTTGCCTTAC AATGACAGAA ATGGAAGGAA CATCCACATC CCCTGTACAT 60

CAGAATGGTG ATATTTCTGG AAATGCTAAC TCTGTGAAGC AAATAGATCC AGTCCTACAG 120

GTCTATCTTT ATCATTCCCT TGGGAACGCT GAGGGGGATT ATCTGCAGTT TCTAACTGGA 180

GAGTATGTTG CTGAAGAGAT CTGTATTGCT GCTTCTAAAG CTTGTGGAAT CACACCTGTA 240

TATCACAGTA TGTTTGCTTT AATGAGTGAA ACAGAAAGGA TCTGGTATCC ACCCAACCAT 300

GTCTTCCATA TAGATGAATC AACCAGGCAA AACGTACTCT ACAGAATCAG ATTTTACTTC 360

CCTTACTGGT ATTGTAATGG CAGCAACAGA ACCTATCGAC ATGGAATAGC TCGAGGTGCT 420

GAAGCTCCTC TTCTTGATGA CTTTGTCATG TCTTACCTTT TTGCTCAGTG GCGGCATGAT 480

TTTTTACATG GATGGATAAA AGTACCTGTG ACTCATGAAA CACAGGAAGA ATGTCTTGGG 540

ATGGCAGTGT TAGATATGAT GAGAATAGCC AAAGAAAAAA ATCAAACCCC ACTGGACATC 600

TATAGCTCTA TCAGCTACAA GACATTTTTG CCAAAATGTG TTCGAGCAAA GATCCAAGAG 660

TATCATATTT TGACAAGGAA GAGAATAAGG TACAGATTTC GCAGATTTAT TGAGCAATTC 720

AGCCATTGCA AAGCCACTGC CAGAAACTTG AAACTTAAGT ATCTTATAAA TCTGGAAACT 780

CTTCAGTCTG CCTTCTACAC AGAGCAATTT GAAGTAAAAG AACCTGGAAG AGGTCCTTCA 840

GGTGAGGAGA TTTTTGCAAC CATTATAATA ACTGGAAACG GTGGAATTCA GTGGTCAAGA 900

GGGAAACATA AAGAAAGTGA GACACTGACA GAACAGGATT TACAGTTGTA TTGTGATTTT 960

CCTGATATTA TTGATATCAG TATTAAACAA GCAAATCAAG AAGGCGCAAA TGAAAGCAGA 1020

ATTGTAACTA TTCATAAGCA AGATGGTAAA AGTCTAGAAA TTGAGCTTAA GTCATTAAGA 1080

GAAGCTTTGT CTTTTGTGTC ATTAATTGAT GGATATTATA GATTAACTGC AGATGCACAT 1140

CATTATCTTT GTAAAGAAGT AGCACCTCCA ATGGTGCTTG AAAATATACA AAGCAACTGT 1200

CATGGCCCAA TTTCAATGGA TTTTGCTATC AGTAAACTGA AGAAAACAGG TAATCAGACT 1260

GGACTCTATG TACTTCGATG CAGTCCTAAG GACTTTAATA AATATTTTCT GACTTTTGCT 1320

GTTGAGCGAG AAAATGTTAT TGAATATAAG CACTGTTTGA TTACCAAAAA TGAGAATGGA 1380

GAATACAACC TCAGTGGTAC TAAGAAGAAC TTCAGTAATC TTAAAGATCT TCTGAATTGC 1440

TACCAGATGG AAACTGTTCG CTCAGACAGT ATAATTTTCC AGTTTACTAA ATGCTGTCCC 1500

CCAAAGCCAA AAGACAAATC AAACCTTCTA GTCTTCAGAA CCAATGGTAT TTCTGATGTA 1560

CCAACCTCAC CAACTTTACA AAGGCATAAT AATGTGAACC AAATGGTGTT CCACAAAATT 1620

AGAAATGAAG ATTTGGTATT TAATGAAAGC CTTGGCCAAG GAACTTTTAC AAAAATTTTT 1680

AAAGGTATAA GAAGAGAAAT AGGAGACTAT GGTCAGCTGC ATGAAACAGA AGTTCTTTTA 1740

AAAGTTCTGG ATAAAGCACA TAGAAACTAT TCAGAGTCTT TCTTTGAAGC AGCAAGCATG 1800

ATGAGCCAGC TTTCTCACAA ACATCTGATT TTAAATTATG GAGTATGTGT CTGTGGAGAG 1860

GAGAATATTC TGGTTCAGGA ATTTGTAAAA TTTGGATCAC TAGATACGTA TCTGAAAAAG 1920

AATAAAAATT CTATAAATAT ATTATGGAAA CTTGAAGTGG CTAAACAGTT GGCATGGGCC 1980

ATGCATTTTC TAGAAGAAAA AACCCTTATT CATGGGAATG TGTGCGCCAA AAATATTCTT 2040

CTTATCAGAG AAGAAGACAG GAAGACAGGA AATCCTCCTT TCATCAAACT TAGTGATCCT 2100

GGCATTAGTA TTACAGTTTT GCCAAAAGAC AAAGTCCTGC AGGAGAGAAT ACCATGGGTA 2160

CCACCTGAAT GCATTGAAAA TCCTAAAAAT CTAAACCTGG CAACAGACAA ATGGAGTTTT 2220

GGTACCACAT TGTGGGAAAT CTGCAGTGGA GGAGATAAGC CTCTGAGTGC TTTGGATTCT 2280

CAAAGAAAAC TACAGTTTTA TGAAGATAGG CACCAGCTTC CTGCGCCAAA GTGGACAGAA 2340

TTAGCAAATC TTATTAATAA TTGCATGGAT TATGAACCAG ATTTTAGGCC TTCTTTCAGA 2400

GCCATTATAA GAGATCTTAA TAGTTTGTTT ACTCCAGATT ATGAACTATT AACAGAAAAT 2460

GACATGTTAC CAAATATGAG AATAGGTGCC CTAGGATTTT CTGGTGCTTT TGAAGACCGA 2520

GACCCTACAC AATTTGAAGA AAGACACTTG AAATTTCTAC AGCAACTTGG CAAGGGTAAT 2580

TTTGGGAGTG TGGAGATGTG CCGGTATGAC CCTCTACAAG ACAATACTGG GGAGGTGGTG 2640

GCTGTGAAAA AGCTCCAGCA CAGTACTGAA GAGCACCTCA GAGACTTCGA AAGAGAAATT 2700

GAAATCCTTA AATCCTTGCA GCATGACAAC ATTGTAAAAT ACAAAGGAGT CTGCTACAGT 2760

GCTGGCCGGC ATAATCTAAG ATTAATTATG GAGTATTTAC CATATGGAAG TTTACGAGAC 2820

TATCTCCAAA AACATAAAGA ACGGATAGAT CATAAAAAAC TTCTGCAATA CACATCTCAG 2880

ATATGCAAGG GGATGGAATA TCTTGGTACA AAAAGATATA TCCACAGGGA TCTGGCAACA 2940

AGGAATATAT TAGTGGAGAA TGAAAACAGA GTTAAAATAG GAGATTTTGG ATTAACCAAA 3000

GTCTTGCCAC AAGACAAAGA GTACTACAAA GTGAAAGAGC CTGGTGAAAG TCCCATATTC 3060

TGGTATGCAC CAGAATCACT GACAGAGAGC AAGTTTTCTG TGGCTTCAGA TGTTTGGAGC 3120

TTTGGAGTGG TTCTGTATGA ACTTTTCACA TATATTGACA AGAGTAAAAG CCCACCAGCG 3180

GAATTTATGC GTATGATTGG CAATGACAAA CAAGGACAGA TGATTGTGTT CCATTTGATA 3240

GAACTCCTGA AGAATAATGG AAGATTACCA AGACCAGATG GATGCCCAGA TGAGATATAT 3300

GTGATTATGA CAGAATGCTG GAACAATAAT GTAAACCAGC GCCCCTCTTT CAGAGACCTA 3360

GCAGTTCGAG TTGATCAAAT AAGGGACAAC ATGACTGGAT GA 3402

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 850   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  909

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke++++++ll++++q++k+meYL+

Q: 910   NIVKYKGVCYSAGRHnlRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG  969

         ***********99999********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 970   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1023

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el

Q: 1024  PESLTESK-FSVASDVWSFGVVLYELFTyIDKSKSPpaefMRMIGNDkqgqmivfHLIEL  1082

         ********.*******************************999999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+++ rlp+p+ cp+e++++mt+c++++ +qrpsFr+++

Q: 1083  LKNNGRLPRPDgCPDEIYVIMTECWNNNVNQRPSFRDLAV  1122

         ************************************9965

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAGRHNLRLI MEYLPYGSLR DYLQKHKERI DHKKLLQYTS QICKGMEYLG 120

TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYIDKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240

PRPDGCPDEI YVIMTECWNN NVNQRPSFRD LAV 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0020037	; F:heme binding
GO:0035401	; F:histone kinase activity (H3-Y41 specific)
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915	; P:apoptotic process
GO:0060396	; P:growth hormone receptor signaling pathway
GO:0035722	; P:interleukin-12-mediated signaling pathway
GO:0061180	; P:mammary gland epithelium development
GO:0030099	; P:myeloid cell differentiation
GO:0008285	; P:negative regulation of cell proliferation
GO:0043392	; P:negative regulation of DNA binding
GO:0010811	; P:positive regulation of cell-substrate adhesion
GO:0050727	; P:regulation of inflammatory response
GO:0046677	; P:response to antibiotic
GO:0007262	; P:STAT protein import into nucleus
GO:0033209	; P:tumor necrosis factor-mediated signaling pathway
GO:0007260	; P:tyrosine phosphorylation of STAT protein

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013