EKS-BOT-00225

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00225

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	392.0	1.4E-117	115	380	266

Status

Unreviewed

Ensembl Protein

ENSBTAP00000041598

UniProt Accession

A5PJP8;

Protein Name

Protein Synonyms/Alias

MAP2K4 protein;

Gene Name

MAP2K4

Gene Synonyms/Alias

MAP2K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000012103	ENSBTAP00000041598	ENSBTAT00000044085

Organism

Bos taurus

Functional Description

Protein Length

412

Protein Sequence
(FASTA)

MAAPSPSGGG GGGGGSGGGS GTPGPAGSPA PGHPAVSSMQ GFQINFCEKA QSKRKALKLN 60

FANPPFKSTA RFTLNPNPAG VQNPHIERLR THSIESSGKL KISPEQHWDF TAEDLKDLGE 120

IGRGAYGSVN KMVHKPSGQI MAVKRIRSTV DEKEQKQLLM DLDVVMRSSD CPYIVQFYGA 180

LFREGDCWIC MELMSTSFDK FYKYVYSVLD DVIPEEILGK ITLATVKALN HLKENLKIIH 240

RDIKPSNILL DRSGNIKLCD FGISGQLVDS IAKTRDAGCR PYMAPERIDP SASRQGYDVR 300

SDVWSLGITL YELATGRFPY PKWNSVFDQL TQVVKGDPPQ LSNSEEREFS PSFINFVNLC 360

LTKDESKRPK YKELLKHPFI LMYEERAVEV ACYVCKILDQ MPATPSSPMY VD 412

Nucleotide Sequence
(FASTA)

ATGGCGGCTC CGAGCCCCAG CGGCGGCGGC GGCGGCGGCG GCGGCTCCGG GGGCGGCAGC 60

GGCACCCCGG GCCCCGCGGG GTCCCCGGCG CCCGGCCACC CGGCCGTCAG CAGCATGCAG 120

GGCTTTCAGA TAAACTTCTG TGAAAAGGCA CAAAGTAAAC GCAAAGCACT GAAGTTGAAT 180

TTTGCAAATC CACCTTTCAA ATCTACAGCA AGGTTTACTC TGAATCCCAA TCCTGCAGGA 240

GTTCAAAACC CACACATAGA GAGACTGAGA ACACACAGCA TTGAGTCGTC AGGAAAACTG 300

AAGATCTCCC CTGAGCAGCA CTGGGATTTC ACTGCAGAGG ATTTGAAAGA CCTTGGAGAG 360

ATTGGACGAG GAGCTTACGG TTCTGTCAAC AAAATGGTCC ACAAACCCAG TGGGCAAATA 420

ATGGCAGTTA AAAGAATCCG GTCGACAGTG GATGAAAAAG AGCAGAAGCA GCTCCTCATG 480

GATTTGGATG TAGTGATGCG GAGCAGTGAC TGCCCATACA TTGTTCAGTT CTATGGCGCG 540

CTCTTCCGAG AGGGTGACTG TTGGATCTGC ATGGAACTCA TGTCTACCTC GTTTGATAAG 600

TTTTACAAAT ATGTATATAG TGTATTAGAT GATGTTATTC CAGAAGAAAT TTTAGGCAAA 660

ATCACTTTAG CAACTGTGAA AGCACTAAAC CACTTAAAAG AAAACTTGAA AATCATTCAC 720

AGAGATATCA AACCTTCCAA TATTCTTCTG GATAGAAGTG GAAATATTAA ACTCTGTGAC 780

TTTGGCATCA GTGGACAGCT CGTGGACTCG ATCGCTAAGA CAAGAGATGC TGGCTGCAGG 840

CCCTACATGG CACCTGAAAG AATAGACCCA AGTGCGTCAC GCCAAGGCTA CGACGTCCGC 900

TCTGATGTCT GGAGTCTGGG GATCACATTG TACGAATTGG CCACTGGCCG CTTTCCTTAT 960

CCAAAGTGGA ATAGTGTATT TGATCAACTA ACACAAGTCG TGAAAGGGGA TCCGCCACAG 1020

CTGAGTAACT CTGAGGAAAG GGAGTTCTCC CCAAGTTTCA TCAACTTTGT CAACTTGTGC 1080

CTTACGAAGG ATGAATCCAA AAGGCCAAAG TATAAAGAAC TCCTGAAACA CCCCTTTATT 1140

TTGATGTACG AGGAGCGCGC CGTCGAGGTC GCATGCTACG TGTGTAAAAT CCTGGATCAA 1200

ATGCCAGCCA CCCCGAGCTC CCCCATGTAT GTCGATTGA 1239

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 115   LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI  174

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk

Q: 175   VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDVIPEEILGKITLATVKALNHLK  233

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 234   ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  293

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   efs++f

Q: 294   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSeerEFSPSF  353

         9***********************************************988788******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+kde++Rpk+kellkh+fi

Q: 354   INFVNLCLTKDESKRPKYKELLKHPFI  380

         **************************7

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSNS EEREFSPSFI 240

NFVNLCLTKD ESKRPKYKEL LKHPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0000165	; P:MAPK cascade

KEGG

bta:526469

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013