EKS-BOT-00300
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00300
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR283.21.9E-84511766256
StatusUnreviewed
Ensembl ProteinENSBTAP00000053668
UniProt AccessionF1N758;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000012647ENSBTAP00000053668ENSBTAT00000061483
OrganismBos taurus
Functional Description
Protein Length1110
Protein Sequence
(FASTA)
VTRTVCAEQC DGRCYGPYVS DCCHRECAGG CSGPKDTDCF ACMNFNDSGA CVTQCPQTFV 60
YNPTTFQLEH NFNAKYTYGA FCVKKCPHNF VVDSSSCVRA CPSSKMEVEE NGIKMCKPCT 120
DICPKACDGI GTGSLMSAQT VDSSNIDKFI NCTKINGNLI FLVTGIHGDP YNAIEAIDPE 180
KLNVFRTVRE ITGFLNIQSW PPNMTDFSVF SNLVTIGGRV LYSGLSLLIL KQQGITSLQF 240
QSLKEISAGN IYITDNSNLC YYHTINWTTL FSTANQRIVI RDNRKAENCT AEGMVCNHLC 300
SNDGCWGPGP DQCLSCRRFS RGRTCIESCN LYDGEFREFE NGSICVECDP QCEKMEDGIL 360
TCHGPGPDNC TKCSHFKDGP NCVEKCPDGL QGANSFIFKY ADQDRECHPC HPNCTQGCSG 420
PTSHDCIYYL WTGHSTLPQH ARTPLIAAGV IGGLFILVIV GLTFAVYARR KSIKKKRALR 480
RFLETELVEP LTPSGTAPNQ AQLRILKETE LKRVKVLGSG AFGTVYKGIW VPEGETVKIP 540
VAIKILNETT GPKANVEFMD EALIMASMDH PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY 600
VHEHKDNIGS QLLLNWCVQI AKSLIYLEKK RLVHRNINLK NILVKFPTYE KVNSFYLARV 660
VVGLQKEMKV SVEKQPVVLV LLFCINYNMF SHQHKLIWNH LQPDTEKMNY YGKEYSSQAT 720
TKIPSCLREE EAVVHPPAPR IDINMILAKL WAIFKDVAPS FKELMVKTNR MLLVPQGYLI 780
YKAKENRSLS SLGENVFLSN LKNDAFTIED GLAQIMNIDN KYIMVSPASN IIPMLLSSPL 840
RIEDSVKSEI GHSPPPAYTP MSGNQFVYRD GGFAAEQGVP MPYRATTSTI PEAPIAQGAT 900
AEIFDDSCCN GTLRKSMAPH VQEDSSTQRY SADPTVFAPE RSPRGELDEE GYMTPMRDKP 960
KQEYLNPVEE NPFVSRRKNG DLQALDNPEY HSASSGPPKA EDEYVNEPLY LNTFANALGN 1020
AEYLKNSVLS VPEKAKKAFD NPDYWNHSLP PRSTLQHPDY LQEYSTKYFY KQNGRIRPIV 1080
AENPEYLSEF SLKPGTVLPP PPYRHRNTVV 1110
Nucleotide Sequence
(FASTA)
GTGACAAGGA CCGTGTGTGC GGAACAGTGT GATGGCAGAT GCTATGGACC CTACGTGAGT 60
GATTGCTGTC ACCGAGAATG TGCTGGGGGC TGTTCGGGAC CGAAGGACAC CGACTGCTTT 120
GCATGCATGA ATTTCAATGA CAGTGGAGCA TGTGTTACTC AGTGTCCACA AACATTTGTC 180
TACAATCCCA CTACCTTTCA ACTGGAGCAT AACTTCAATG CAAAATACAC CTATGGAGCC 240
TTTTGTGTCA AGAAGTGCCC ACATAACTTT GTAGTTGATT CCAGTTCCTG TGTGCGTGCT 300
TGTCCTAGTT CCAAGATGGA AGTAGAAGAA AATGGGATTA AAATGTGTAA ACCTTGCACT 360
GACATTTGCC CAAAAGCTTG TGATGGCATT GGCACAGGAT CGTTGATGTC GGCTCAGACC 420
GTGGATTCTA GTAACATTGA CAAATTCATA AACTGCACCA AAATCAATGG GAATTTGATC 480
TTCCTTGTCA CTGGTATTCA TGGGGACCCT TACAATGCAA TTGAAGCCAT AGACCCAGAG 540
AAACTGAATG TCTTTCGGAC AGTCCGAGAG ATAACAGGTT TCTTGAACAT ACAGTCATGG 600
CCTCCAAACA TGACCGACTT CAGTGTTTTT TCAAACTTGG TAACCATTGG CGGAAGAGTA 660
CTCTATAGTG GCCTTTCCTT GCTTATCCTC AAGCAACAGG GCATCACATC TCTACAATTC 720
CAATCCTTGA AAGAAATCAG TGCGGGGAAC ATCTACATCA CTGACAACAG CAATCTGTGC 780
TATTATCACA CCATCAACTG GACAACACTG TTCAGCACAG CCAACCAAAG GATAGTGATT 840
CGGGACAACA GGAAAGCTGA AAACTGTACT GCTGAAGGAA TGGTGTGCAA CCATCTCTGT 900
TCAAATGATG GGTGCTGGGG ACCTGGGCCA GACCAGTGCT TGTCATGCCG TCGCTTCAGC 960
AGGGGAAGGA CCTGCATAGA GTCTTGTAAC CTCTATGACG GTGAATTTCG GGAGTTTGAG 1020
AATGGCTCCA TCTGTGTCGA GTGTGACCCC CAGTGTGAGA AGATGGAAGA TGGCATCCTC 1080
ACATGCCATG GACCGGGACC TGACAACTGT ACAAAGTGCT CCCATTTCAA GGATGGCCCG 1140
AACTGTGTGG AAAAATGTCC AGATGGCTTA CAGGGGGCAA ACAGTTTCAT TTTCAAGTAT 1200
GCTGATCAAG ATCGAGAGTG CCACCCGTGC CATCCAAACT GCACCCAAGG GTGTAGCGGC 1260
CCCACTAGTC ATGACTGCAT TTACTACCTT TGGACGGGCC ATTCCACTTT ACCACAACAT 1320
GCTAGGACTC CTCTAATTGC AGCTGGAGTC ATTGGTGGGC TCTTCATCCT GGTCATTGTG 1380
GGCCTAACAT TTGCAGTTTA TGCTCGAAGG AAGAGCATCA AAAAGAAAAG GGCCTTAAGA 1440
AGATTCCTGG AAACAGAGCT GGTAGAACCC TTAACTCCCA GTGGCACAGC ACCCAATCAA 1500
GCTCAACTTC GTATTTTGAA AGAAACTGAG CTCAAAAGAG TGAAAGTACT TGGCTCAGGT 1560
GCTTTTGGAA CTGTTTATAA AGGTATTTGG GTCCCTGAAG GAGAAACAGT GAAGATTCCT 1620
GTGGCTATTA AGATTCTTAA TGAAACAACT GGTCCCAAAG CCAATGTGGA ATTTATGGAT 1680
GAAGCCCTAA TCATGGCAAG TATGGACCAT CCACACTTAG TTCGATTATT GGGTGTGTGT 1740
CTGAGCCCAA CCATCCAGCT GGTTACACAG CTCATGCCCC ATGGCTGTCT GCTGGACTAT 1800
GTCCATGAAC ACAAGGATAA CATTGGATCA CAGTTGTTGC TTAACTGGTG TGTCCAGATA 1860
GCTAAGTCAC TGATTTATTT GGAAAAAAAG AGACTCGTAC ATAGAAATAT AAATCTTAAA 1920
AACATTTTAG TAAAATTTCC AACTTATGAG AAAGTAAATA GTTTCTATCT AGCTAGAGTA 1980
GTTGTTGGTT TGCAAAAGGA AATGAAAGTA TCAGTAGAAA AGCAACCTGT TGTTTTGGTG 2040
CTGCTGTTCT GCATTAACTA CAATATGTTT AGCCACCAGC ACAAATTGAT TTGGAATCAT 2100
CTTCAACCAG ATACTGAAAA GATGAACTAC TATGGAAAAG AGTATTCATC TCAGGCTACC 2160
ACAAAAATAC CATCCTGTCT ACGAGAAGAA GAGGCAGTTG TTCATCCACC AGCCCCTAGA 2220
ATTGATATAA ATATGATATT AGCCAAACTC TGGGCAATTT TTAAAGATGT TGCTCCTTCT 2280
TTTAAAGAAC TTATGGTCAA GACAAATAGG ATGCTGCTTG TTCCACAAGG TTATCTAATT 2340
TATAAAGCAA AGGAAAATAG ATCCTTGAGC TCATTGGGAG AAAATGTTTT TTTAAGTAAT 2400
TTGAAAAACG ATGCCTTTAC AATTGAAGAT GGCCTAGCCC AGATAATGAA TATAGATAAT 2460
AAATATATCA TGGTATCTCC AGCATCTAAC ATAATCCCTA TGCTTTTATC ATCTCCATTA 2520
AGAATAGAAG ACTCAGTTAA GAGTGAAATT GGACACAGCC CTCCTCCTGC CTACACCCCT 2580
ATGTCAGGAA ACCAGTTTGT CTACCGAGAC GGGGGCTTCG CTGCAGAACA AGGAGTGCCC 2640
ATGCCCTACA GGGCCACCAC CAGCACAATC CCAGAAGCCC CCATTGCTCA GGGGGCTACT 2700
GCAGAGATTT TTGATGACTC CTGCTGTAAT GGCACCTTAC GCAAATCCAT GGCACCCCAT 2760
GTCCAAGAGG ACAGTAGCAC CCAGAGATAC AGCGCTGACC CCACAGTGTT TGCCCCAGAA 2820
CGGAGCCCAC GAGGAGAGCT GGATGAAGAA GGTTACATGA CTCCTATGCG AGACAAACCC 2880
AAACAAGAAT ACCTGAACCC TGTGGAGGAG AACCCTTTCG TTTCTCGGAG GAAAAATGGA 2940
GACCTTCAGG CTTTGGATAA TCCCGAATAT CACAGCGCTT CCAGTGGTCC ACCCAAGGCA 3000
GAGGATGAGT ATGTAAACGA GCCGCTGTAC CTCAACACCT TTGCCAACGC CTTGGGGAAC 3060
GCCGAGTACC TGAAGAACAG CGTACTGTCT GTGCCAGAGA AAGCCAAGAA AGCATTCGAC 3120
AACCCCGACT ACTGGAACCA CAGCCTGCCA CCTCGGAGCA CCCTTCAGCA CCCAGACTAC 3180
CTGCAGGAGT ACAGCACAAA ATATTTTTAT AAACAAAATG GACGGATCCG GCCTATTGTG 3240
GCCGAGAATC CCGAATACCT CTCTGAGTTC TCGCTGAAGC CAGGCACTGT GCTGCCTCCG 3300
CCGCCCTACA GACACCGGAA TACTGTGGTG TGA 3333
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 511   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  570
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiak + yle+k
Q: 571   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKSLIYLEKK  630
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhr++  +n+lvk p   k+  f la+++   +ke+k++  k p+  + l +i+++++
Q: 631   RLVHRNINLKNILVKFPTYEKVNSFYLARVVVGLQKEMKVSVEKQPVVLVLLFCINYNMF  690
         ************************************************************
S: 181   thqsd.vwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkc  239
         +hq   +w +     e + +  k y + ++++ip+ l++ e +  pp   id+ m+l k 
Q: 691   SHQHKlIWNHLQPDTEKMNYYGKEYSSQATTKIPSCLREEEAVVHPPAPRIDINMILAKL  750
         **98748*****************************************************
S: 240   wmidaesrpkfkelae  255
         w i +++ p+fkel+ 
Q: 751   WAIFKDVAPSFKELMV  766
         *************986
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKSLIYLEKK 120
RLVHRNINLK NILVKFPTYE KVNSFYLARV VVGLQKEMKV SVEKQPVVLV LLFCINYNMF 180
SHQHKLIWNH LQPDTEKMNY YGKEYSSQAT TKIPSCLREE EAVVHPPAPR IDINMILAKL 240
WAIFKDVAPS FKELMV 256
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-DAR-00650
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MAM-00300
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0061026; P:cardiac muscle tissue regeneration
GO:0045165; P:cell fate commitment
GO:0021551; P:central nervous system morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0007507; P:heart development
GO:0007595; P:lactation
GO:0060749; P:mammary gland alveolus development
GO:0060644; P:mammary gland epithelial cell differentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0001755; P:neural crest cell migration
GO:0021889; P:olfactory bulb interneuron differentiation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 1.
SMARTs
SM00261; FU; 4.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013